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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018469
UUCD1 version UUC-CaE-00714
Ensembl Protein ID B0547.1
UniProt Accession P91001; CSN5_CAEEL
Genbank Protein ID CCD62206.1
Protein Name COP9 signalosome complex subunit 5; JAB1 homolog
Genbank Nucleotide ID FO080232
Gene Name csn-5; B0547.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00000817 B0547.1 B0547.1
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNA
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/JAMM 9.90e-08 32.1 139 152
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/JAMM
   S: 1    HSHPgftcwlSsVD 14
           HSHPg++cwlS++D
   Q: 139  HSHPGYGCWLSGID 152
           *************9 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3. May stabilize glh-1 protein levels by antagonising kgb-1 (PubMed:17699606).
 Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3. May stabilize glh-1 protein levels by antagonising kgb-1 (PubMed:17699606).
Protein Sequence
(Fasta)
MEVDNVKPSS SVPQRNWEKE NNVQNVDSIF EYNNKQQVEI RNAKPWDKDP HYFKQIKISA 60
IALLKMTMHA KRGGNLEIMG LLQGRIDANS FIILDVFALP VEGTETRVNA QAQAYEYMTV 120
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Protein Fasta Sequence


>IUUC-Cel-018469|DUB,JAMM|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
ACGATGGAAG TTGATAACGT CAAGCCATCC AGCTCAGTTC CGCAGAGAAA CTGGGAAAAA 60
GAAAATAACG TCAGTTTTTC TTAAATATTT TTAGATTTTT AATATTATTT GTGTTTCAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018469|DUB,JAMM|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0896--Oogenesis
KW-0645--Protease
KW-1185--Reference proteome
KW-0736--Signalosome
KW-0862--Zinc
Interpro

IPR000555--JAMM/MPN+_dom
Pfam

PF01398--JAB
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0031672--C:A band
GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0017151--F:DEAD/H-box RNA helicase binding
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0008022--F:protein C-terminus binding
GO:0008406--P:gonad development
GO:0048477--P:oogenesis
GO:0000338--P:protein deneddylation
GO:0000003--P:reproduction
KEGG cel:CELE_B0547.1
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000468 Aegilops tauschii 55.15 2.00e-103 367.00
IUUC-Aml-001429 Ailuropoda melanoleuca 57.63 4.00e-99 353.00
IUUC-Atr-003048 Amborella trichopoda 53.69 2.00e-105 374.00
IUUC-Apl-003610 Anas platyrhynchos 56.67 3.00e-90 323.00
IUUC-Aca-004662 Anolis carolinensis 58.78 3.00e-87 313.00
IUUC-Aly-005914 Arabidopsis lyrata 55.76 8.00e-108 382.00
IUUC-Ath-007612 Arabidopsis thaliana 55.03 2.00e-105 374.00
IUUC-Ago-007860 Ashbya gossypii 46.50 1.00e-52 199.00
IUUC-Acl-008155 Aspergillus clavatus 51.41 1.00e-95 341.00
IUUC-Afu-008820 Aspergillus fumigatus 50.16 6.00e-95 339.00
IUUC-Ani-009303 Aspergillus nidulans 51.38 1.00e-94 338.00
IUUC-Ang-009617 Aspergillus niger 53.05 2.00e-90 323.00
IUUC-Aor-009888 Aspergillus oryzae 51.99 3.00e-92 330.00
IUUC-Ate-010575 Aspergillus terreus 51.40 6.00e-94 335.00
IUUC-Ame-010617 Astyanax mexicanus 57.10 1.00e-100 357.00
IUUC-Bgr-012019 Blumeria graminis 50.46 3.00e-95 340.00
IUUC-Bta-013211 Bos taurus 57.54 4.00e-100 356.00
IUUC-Bci-013645 Botrytis cinerea 53.12 4.00e-101 360.00
IUUC-Bdi-014727 Brachypodium distachyon 49.19 4.00e-94 336.00
IUUC-Bol-015205 Brassica oleracea 54.01 1.00e-104 371.00
IUUC-Bra-017649 Brassica rapa 54.01 1.00e-104 371.00
IUUC-Cja-019703 Callithrix jacchus 57.23 6.00e-100 355.00
IUUC-Cfa-020181 Canis familiaris 57.23 5.00e-100 356.00
IUUC-Cpo-021499 Cavia porcellus 57.23 6.00e-100 355.00
IUUC-Cre-022735 Chlamydomonas reinhardtii 57.80 2.00e-105 374.00
IUUC-Csa-024200 Chlorocebus sabaeus 57.23 6.00e-100 355.00
IUUC-Cho-024915 Choloepus hoffmanni 56.16 7.00e-64 235.00
IUUC-Cin-025353 Ciona intestinalis 56.67 4.00e-95 340.00
IUUC-Csv-026118 Ciona savignyi 57.32 4.00e-95 339.00
IUUC-Cgl-026511 Colletotrichum gloeosporioides 48.49 4.00e-94 336.00
IUUC-Cne-026988 Cryptococcus neoformans 48.14 9.00e-85 305.00
IUUC-Dre-028134 Danio rerio 56.97 1.00e-99 355.00
IUUC-Dno-029658 Dasypus novemcinctus 57.23 6.00e-100 355.00
IUUC-Dor-031074 Dipodomys ordii 57.23 6.00e-100 355.00
IUUC-Dse-031497 Dothistroma septosporum 49.51 2.00e-90 324.00
IUUC-Dme-032199 Drosophila melanogaster 58.10 4.00e-104 369.00
IUUC-Ete-032739 Echinops telfairi 65.24 9.00e-55 205.00
IUUC-Eca-034095 Equus caballus 57.23 5.00e-100 356.00
IUUC-Eeu-034934 Erinaceus europaeus 67.49 1.00e-94 338.00
IUUC-Fca-035569 Felis catus 57.23 6.00e-100 355.00
IUUC-Fal-037553 Ficedula albicollis 58.78 3.00e-87 313.00
IUUC-Fox-037945 Fusarium oxysporum 47.53 1.00e-91 328.00
IUUC-Fso-038385 Fusarium solani 49.07 4.00e-96 343.00
IUUC-Gmo-039438 Gadus morhua 57.45 4.00e-98 349.00
IUUC-Ggr-039968 Gaeumannomyces graminis 57.04 2.00e-95 341.00
IUUC-Gga-040344 Gallus gallus 57.68 5.00e-99 352.00
IUUC-Gac-042256 Gasterosteus aculeatus 56.97 1.00e-97 348.00
IUUC-Gma-043226 Glycine max 51.77 4.00e-107 380.00
IUUC-Ggo-044523 Gorilla gorilla 52.92 7.00e-85 305.00
IUUC-Hsa-046659 Homo sapiens 57.23 6.00e-100 355.00
IUUC-Itr-048834 Ictidomys tridecemlineatus 57.23 6.00e-100 355.00
IUUC-Kpa-049139 Komagataella pastoris 56.52 4.00e-56 211.00
IUUC-Lch-049562 Latimeria chalumnae 57.89 1.00e-100 358.00
IUUC-Lpe-050737 Leersia perrieri 49.32 6.00e-104 369.00
IUUC-Loc-051798 Lepisosteus oculatus 57.05 2.00e-96 344.00
IUUC-Lma-052979 Leptosphaeria maculans 48.08 6.00e-88 316.00
IUUC-Laf-053391 Loxodonta africana 68.06 1.00e-82 297.00
IUUC-Mcc-055667 Macaca mulatta 57.23 6.00e-100 355.00
IUUC-Meu-056067 Macropus eugenii 54.12 2.00e-41 160.00
IUUC-Mor-057084 Magnaporthe oryzae 52.94 2.00e-95 340.00
IUUC-Mpo-057347 Magnaporthe poae 56.36 1.00e-96 344.00
IUUC-Mtr-057781 Medicago truncatula 54.78 3.00e-108 383.00
IUUC-Mla-059106 Melampsora laricipopulina 57.30 3.00e-95 340.00
IUUC-Mga-059473 Meleagris gallopavo 58.78 3.00e-87 313.00
IUUC-Mvi-060540 Microbotryum violaceum 53.55 5.00e-96 343.00
IUUC-Mmr-061138 Microcebus murinus 70.27 7.00e-73 265.00
IUUC-Mdo-062893 Monodelphis domestica 57.23 5.00e-100 355.00
IUUC-Mmu-063637 Mus musculus 57.23 5.00e-100 356.00
IUUC-Mac-064683 Musa acuminata 52.92 2.00e-104 370.00
IUUC-Mpu-066096 Mustela putorius furo 57.45 1.00e-82 298.00
IUUC-Mlu-067872 Myotis lucifugus 55.38 6.00e-95 339.00
IUUC-Nfi-068443 Neosartorya fischeri 49.84 1.00e-93 334.00
IUUC-Ncr-068953 Neurospora crassa 44.67 2.00e-90 323.00
IUUC-Nle-068972 Nomascus leucogenys 57.23 6.00e-100 355.00
IUUC-Opr-070215 Ochotona princeps 50.62 4.00e-80 290.00
IUUC-Ont-072538 Oreochromis niloticus 56.97 3.00e-97 347.00
IUUC-Oan-073143 Ornithorhynchus anatinus 57.23 5.00e-100 355.00
IUUC-Ocu-074197 Oryctolagus cuniculus 57.23 6.00e-100 355.00
IUUC-Oba-075884 Oryza barthii 47.04 3.00e-99 353.00
IUUC-Obr-076874 Oryza brachyantha 49.18 4.00e-102 363.00
IUUC-Ogl-077169 Oryza glaberrima 50.00 4.00e-102 363.00
IUUC-Ogu-078258 Oryza glumaepatula 50.00 5.00e-102 362.00
IUUC-Oin-079101 Oryza indica 47.30 1.00e-99 354.00
IUUC-Olo-080708 Oryza longistaminata 48.38 1.00e-77 281.00
IUUC-Ome-081571 Oryza meridionalis 47.30 1.00e-99 354.00
IUUC-Oni-082888 Oryza nivara 47.30 1.00e-99 354.00
IUUC-Opu-083182 Oryza punctata 50.00 4.00e-102 363.00
IUUC-Oru-084895 Oryza rufipogon 47.30 1.00e-99 354.00
IUUC-Osa-085331 Oryza sativa 50.00 4.00e-102 363.00
IUUC-Ola-086850 Oryzias latipes 57.28 6.00e-98 349.00
IUUC-Olu-087607 Ostreococcus lucimarinus 59.04 3.00e-91 326.00
IUUC-Oga-088640 Otolemur garnettii 57.63 4.00e-99 353.00
IUUC-Oar-090299 Ovis aries 57.94 3.00e-99 353.00
IUUC-Ptr-091499 Pan troglodytes 57.23 6.00e-100 355.00
IUUC-Pan-091751 Papio anubis 58.72 6.00e-87 312.00
IUUC-Psi-092978 Pelodiscus sinensis 57.01 2.00e-98 350.00
IUUC-Pma-094634 Petromyzon marinus 57.94 1.00e-99 355.00
IUUC-Pno-095094 Phaeosphaeria nodorum 46.04 4.00e-89 320.00
IUUC-Ppa-095440 Physcomitrella patens 51.47 6.00e-109 385.00
IUUC-Pfo-097332 Poecilia formosa 57.28 8.00e-98 348.00
IUUC-Pab-097998 Pongo abelii 57.23 6.00e-100 355.00
IUUC-Pop-098905 Populus trichocarpa 52.53 6.00e-113 399.00
IUUC-Pca-100521 Procavia capensis 57.30 2.00e-26 111.00
IUUC-Ppe-101309 Prunus persica 51.18 3.00e-112 396.00
IUUC-Pva-102953 Pteropus vampyrus 57.23 6.00e-100 355.00
IUUC-Pgr-103452 Puccinia graminis 56.93 1.00e-87 315.00
IUUC-Ptt-103777 Puccinia triticina 59.11 5.00e-85 306.00
IUUC-Pte-104273 Pyrenophora teres 47.58 2.00e-88 317.00
IUUC-Pyt-104627 Pyrenophora triticirepentis 48.06 8.00e-89 318.00
IUUC-Rno-105666 Rattus norvegicus 57.23 1.00e-99 355.00
IUUC-Sce-106319 Saccharomyces cerevisiae 51.02 1.00e-41 162.00
IUUC-Sha-106602 Sarcophilus harrisii 57.23 5.00e-100 355.00
IUUC-Sja-107822 Schizosaccharomyces japonicus 44.61 5.00e-49 186.00
IUUC-Spo-108318 Schizosaccharomyces pombe 45.75 4.00e-66 243.00
IUUC-Ssl-108428 Sclerotinia sclerotiorum 53.12 3.00e-100 357.00
IUUC-Smo-108821 Selaginella moellendorffii 50.13 3.00e-105 373.00
IUUC-Sit-110526 Setaria italica 52.57 1.00e-96 345.00
IUUC-Sly-111466 Solanum lycopersicum 50.53 7.00e-113 399.00
IUUC-Stu-112151 Solanum tuberosum 50.79 6.00e-113 399.00
IUUC-Sar-113459 Sorex araneus 57.23 5.00e-100 355.00
IUUC-Sbi-114873 Sorghum bicolor 53.17 5.00e-101 359.00
IUUC-Sre-114919 Sporisorium reilianum 59.92 2.00e-88 318.00
IUUC-Ssc-116102 Sus scrofa 57.23 6.00e-100 355.00
IUUC-Tgu-116937 Taeniopygia guttata 66.67 4.00e-86 309.00
IUUC-Tru-118615 Takifugu rubripes 57.59 1.00e-98 351.00
IUUC-Tsy-119173 Tarsius syrichta 64.00 5.00e-99 352.00
IUUC-Tni-120246 Tetraodon nigroviridis 57.59 1.00e-98 351.00
IUUC-Tca-121859 Theobroma cacao 54.89 2.00e-112 397.00
IUUC-Tre-122030 Trichoderma reesei 51.40 1.00e-97 348.00
IUUC-Tvi-122506 Trichoderma virens 50.62 5.00e-96 342.00
IUUC-Tae-125382 Triticum aestivum 55.15 2.00e-103 367.00
IUUC-Tur-126517 Triticum urartu 56.86 3.00e-101 360.00
IUUC-Tme-127122 Tuber melanosporum 52.87 8.00e-99 352.00
IUUC-Tbe-128108 Tupaia belangeri 56.31 5.00e-96 342.00
IUUC-Ttr-128644 Tursiops truncatus 57.23 6.00e-100 355.00
IUUC-Uma-129390 Ustilago maydis 59.70 2.00e-90 325.00
IUUC-Vda-129932 Verticillium dahliae 46.09 8.00e-92 328.00
IUUC-Vpa-130110 Vicugna pacos 57.23 6.00e-100 355.00
IUUC-Vvi-131534 Vitis vinifera 51.05 4.00e-113 399.00
IUUC-Xtr-132739 Xenopus tropicalis 57.54 8.00e-101 358.00
IUUC-Xma-133919 Xiphophorus maculatus 57.28 7.00e-98 348.00
IUUC-Yli-134677 Yarrowia lipolytica 43.57 2.00e-83 301.00
IUUC-Zma-135578 Zea mays 50.13 4.00e-101 360.00
Created Date 25-Jun-2017

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