iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-022232

Ensembl Protein ID

ENSCPOP00000001372.2

UniProt Accession

H0UWE2; H0UWE2_CAVPO

Genbank Protein ID

ENSCPOP00000001372

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02003915

Gene Name

OTUD7B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000001517.3	ENSCPOT00000001537.2	ENSCPOP00000001372.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.90e-36	124.5	159	340
UBD/ZnF/ZnF_A20	2.70e-16	59.2	771	805

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++ l+  + + +++++ k+++++++++++k           ++e++++ kl+++e    
   Q: 159  LPLATTGDGNCLLHAASLGMWGFHDRDLaLRKSLYALMEKGVEKEALKRRWRWQQTQQNKesglvyteeewQKEWNELIKLASSEprmh 247
           6899********************************************************************************98877 PP
   S: 75   ...akg.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYd 133
                g                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p ++ +++p+vL+Y+++H++
   Q: 248  lgtN-GasgggvesseepvyeslEEFHVFVLAHVLKRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPVSQcHRSPLVLAYDQAHFS 335
           7640.256689****************************************************************************** PP
   S: 134  aLval 138
           aLv++
   Q: 336  ALVSM 340
           **986 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +p++++Ck+ +C fYG+petn++CS+Cyreelrrr
   Q: 771  PPTQTKCKQpNCNFYGHPETNNFCSCCYREELRRR 805
           59********************************9 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

LLTGKNWDVS AALNDFEQIR QVHAGHLPPP FSEGSSSSKT PEKGCSDREC ARPSRPTLQR 60
QDDVIQEKRL SRGISHASSS IVSLARSQVS SSGGGGGSSE HPLEMPICAF QLPDLTVYSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCTGACAG GAAAAAATTG GGATGTGAGT GCTGCCCTCA ATGATTTTGA ACAGATACGT 60
CAAGTCCATG CTGGGCACCT GCCACCACCC TTTAGTGAAG GAAGTAGTAG CTCCAAGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0002385--P:mucosal immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002119	Ailuropoda melanoleuca	90.23	0.00e+00	1350.00
IUUC-Apl-003567	Anas platyrhynchos	64.53	0.00e+00	915.00
IUUC-Bta-013398	Bos taurus	91.08	0.00e+00	1313.00
IUUC-Cel-018468	Caenorhabditis elegans	35.82	9.00e-85	307.00
IUUC-Cja-019965	Callithrix jacchus	88.90	0.00e+00	1285.00
IUUC-Cfa-020191	Canis familiaris	90.95	0.00e+00	1360.00
IUUC-Csa-023593	Chlorocebus sabaeus	90.83	0.00e+00	1382.00
IUUC-Cho-024729	Choloepus hoffmanni	82.25	7.00e-174	604.00
IUUC-Csv-026177	Ciona savignyi	30.56	6.00e-03	33.90
IUUC-Dno-029900	Dasypus novemcinctus	89.85	0.00e+00	1307.00
IUUC-Dor-031121	Dipodomys ordii	82.02	0.00e+00	633.00
IUUC-Ete-032473	Echinops telfairi	84.41	0.00e+00	956.00
IUUC-Eca-033946	Equus caballus	91.61	0.00e+00	971.00
IUUC-Eeu-034670	Erinaceus europaeus	88.39	0.00e+00	1293.00
IUUC-Fca-035871	Felis catus	90.83	0.00e+00	1265.00
IUUC-Fso-038203	Fusarium solani	30.93	5.80e-02	33.10
IUUC-Gmo-039373	Gadus morhua	75.74	0.00e+00	632.00
IUUC-Gga-041105	Gallus gallus	66.97	0.00e+00	964.00
IUUC-Gac-041806	Gasterosteus aculeatus	55.74	0.00e+00	780.00
IUUC-Ggo-045472	Gorilla gorilla	90.71	0.00e+00	1337.00
IUUC-Hsa-046473	Homo sapiens	90.46	0.00e+00	1342.00
IUUC-Itr-048841	Ictidomys tridecemlineatus	92.30	0.00e+00	1373.00
IUUC-Lch-050432	Latimeria chalumnae	62.57	0.00e+00	914.00
IUUC-Mcc-055261	Macaca mulatta	90.59	0.00e+00	1384.00
IUUC-Meu-056477	Macropus eugenii	77.52	0.00e+00	894.00
IUUC-Mga-059533	Meleagris gallopavo	67.64	0.00e+00	948.00
IUUC-Mdo-062847	Monodelphis domestica	80.85	0.00e+00	1105.00
IUUC-Mmu-064260	Mus musculus	87.30	0.00e+00	1257.00
IUUC-Mpu-066876	Mustela putorius furo	86.10	0.00e+00	1250.00
IUUC-Mlu-068039	Myotis lucifugus	90.60	0.00e+00	1323.00
IUUC-Nle-069260	Nomascus leucogenys	90.22	0.00e+00	1340.00
IUUC-Opr-070564	Ochotona princeps	88.94	0.00e+00	722.00
IUUC-Ocu-073824	Oryctolagus cuniculus	91.38	0.00e+00	880.00
IUUC-Oga-088124	Otolemur garnettii	90.96	0.00e+00	1323.00
IUUC-Oar-090086	Ovis aries	91.32	0.00e+00	1317.00
IUUC-Ptr-091622	Pan troglodytes	91.15	0.00e+00	1015.00
IUUC-Pan-092724	Papio anubis	90.46	0.00e+00	1374.00
IUUC-Psi-093333	Pelodiscus sinensis	62.28	0.00e+00	897.00
IUUC-Pab-098667	Pongo abelii	90.71	0.00e+00	1327.00
IUUC-Pca-100701	Procavia capensis	88.84	0.00e+00	729.00
IUUC-Pva-102136	Pteropus vampyrus	89.61	0.00e+00	1306.00
IUUC-Rno-105546	Rattus norvegicus	87.91	0.00e+00	1280.00
IUUC-Sha-106732	Sarcophilus harrisii	81.39	0.00e+00	1064.00
IUUC-Sar-113562	Sorex araneus	78.63	0.00e+00	1065.00
IUUC-Ssc-116191	Sus scrofa	91.44	0.00e+00	1344.00
IUUC-Tgu-116942	Taeniopygia guttata	76.46	0.00e+00	796.00
IUUC-Tsy-119343	Tarsius syrichta	82.48	0.00e+00	1163.00
IUUC-Tbe-127283	Tupaia belangeri	92.59	0.00e+00	757.00
IUUC-Ttr-128692	Tursiops truncatus	87.65	0.00e+00	1235.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence