iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000115808.11	ENST00000263918.8	ENSP00000263918.4
ENSG00000115808.11	ENST00000379213.3	ENSP00000368513.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.50e-29	100.6	567	599
UBD/Beta-Prp	4.20e-45	155.9	563	777

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlr 31
           gHtd v++la+   +  +l+s+s Dgt+++W+++
   Q: 567  GHTDAVWGLAYsaaH-QRLLSCSADGTLRLWNTT 599
           8**********9853.89**************76 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk......ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
             l gh+++v+ + +s   + l+++s D+t+++w+     +  ++       g  +sv ++s++p  +++v+  +  +  ++++et+q + +
   Q: 563  GPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFndtkelGIPASVDLVSSDP--SHMVASFSKGYTSIFNMETQQRILT 652
           5689******************************7775555444442666667777777788888..888888889**************** PP
   S: 132  ......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrt 217
                 t ++ +  +n v +hp+  + ++++ Dr ++++d +tgkl++ +   h ++v+sl++d+ng +l+sgs+d +++lw+l++++c+++
   Q: 653  lesnvdTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVA-HLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQE 743
           9999998888888999999***99**************************98.*************************************** PP
   S: 218  lnght....dnvksvrfspnderlvsgssDgsir 247
           +++h+    + + +v+f+p + +++s+++D   +
   Q: 744  FTAHRkkfeESIHDVAFHPSKCYIASAGADALAK 777
           *****999999******************97655 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity).

Protein Sequence
(Fasta)

MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAAGDGAAAA GAARAQYSLP GILHFLQHEW 60
ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR RIKMLEYALK QERAKYHKLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCCGCCA TGGACGAGCA GGCGGGTCCC GGCGTCTTCT TCAGCAACAA CCACCCGGGC 60
GCCGGCGGTG CCAAGGGGCT CGGGCCTCTG GCGGAGGCTG CCGCGGCCGG CGACGGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0112--Calmodulin-binding
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR013258--Striatin_N
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08232--Striatin
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005923--C:bicellular tight junction
GO:0005737--C:cytoplasm
GO:0043197--C:dendritic spine
GO:0016020--C:membrane
GO:0043025--C:neuronal cell body
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0070016--F:armadillo repeat domain binding
GO:0005516--F:calmodulin binding
GO:0030331--F:estrogen receptor binding
GO:0032403--F:protein complex binding
GO:0051721--F:protein phosphatase 2A binding
GO:0070830--P:bicellular tight junction assembly
GO:0016358--P:dendrite development
GO:0007626--P:locomotory behavior
GO:0008285--P:negative regulation of cell proliferation
GO:0016055--P:Wnt signaling pathway

KEGG

hsa:6801

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001899	Ailuropoda melanoleuca	97.82	0.00e+00	1362.00
IUUC-Apl-003927	Anas platyrhynchos	88.09	0.00e+00	1125.00
IUUC-Aca-004933	Anolis carolinensis	81.02	0.00e+00	1153.00
IUUC-Ate-010457	Aspergillus terreus	26.24	3.00e-29	124.00
IUUC-Ame-010997	Astyanax mexicanus	73.53	0.00e+00	1073.00
IUUC-Bta-013077	Bos taurus	97.44	0.00e+00	1382.00
IUUC-Cja-018973	Callithrix jacchus	99.36	0.00e+00	1402.00
IUUC-Cfa-020988	Canis familiaris	94.17	0.00e+00	1231.00
IUUC-Cpo-022496	Cavia porcellus	97.18	0.00e+00	1383.00
IUUC-Csa-023829	Chlorocebus sabaeus	98.59	0.00e+00	1392.00
IUUC-Dre-028560	Danio rerio	69.05	0.00e+00	972.00
IUUC-Dno-029742	Dasypus novemcinctus	91.79	0.00e+00	1313.00
IUUC-Dor-030721	Dipodomys ordii	89.49	0.00e+00	1263.00
IUUC-Eca-033760	Equus caballus	97.72	0.00e+00	1286.00
IUUC-Eeu-034953	Erinaceus europaeus	97.40	0.00e+00	755.00
IUUC-Fca-036530	Felis catus	97.16	0.00e+00	1288.00
IUUC-Fal-037353	Ficedula albicollis	81.49	0.00e+00	894.00
IUUC-Gga-040132	Gallus gallus	87.89	0.00e+00	1137.00
IUUC-Gac-041713	Gasterosteus aculeatus	73.46	0.00e+00	1058.00
IUUC-Ggo-045455	Gorilla gorilla	87.50	0.00e+00	1200.00
IUUC-Lch-050475	Latimeria chalumnae	81.52	0.00e+00	1184.00
IUUC-Loc-051859	Lepisosteus oculatus	77.34	0.00e+00	1131.00
IUUC-Laf-053537	Loxodonta africana	96.79	0.00e+00	1389.00
IUUC-Mcc-055817	Macaca mulatta	98.34	0.00e+00	1391.00
IUUC-Meu-055946	Macropus eugenii	70.04	0.00e+00	911.00
IUUC-Mga-059694	Meleagris gallopavo	87.93	0.00e+00	1115.00
IUUC-Mmr-060768	Microcebus murinus	98.33	0.00e+00	1412.00
IUUC-Mdo-061901	Monodelphis domestica	86.67	0.00e+00	1310.00
IUUC-Mmu-064154	Mus musculus	96.79	0.00e+00	1372.00
IUUC-Mpu-065827	Mustela putorius furo	92.95	0.00e+00	1375.00
IUUC-Mlu-067102	Myotis lucifugus	97.41	0.00e+00	1353.00
IUUC-Ncr-068831	Neurospora crassa	39.60	7.00e-22	99.80
IUUC-Nle-070008	Nomascus leucogenys	99.43	0.00e+00	1310.00
IUUC-Opr-071067	Ochotona princeps	61.62	4.00e-179	621.00
IUUC-Ont-072025	Oreochromis niloticus	73.16	0.00e+00	1047.00
IUUC-Oan-072950	Ornithorhynchus anatinus	91.62	0.00e+00	1165.00
IUUC-Ocu-074316	Oryctolagus cuniculus	97.01	0.00e+00	1273.00
IUUC-Ola-087279	Oryzias latipes	71.07	0.00e+00	1025.00
IUUC-Oga-088284	Otolemur garnettii	97.56	0.00e+00	1381.00
IUUC-Oar-090304	Ovis aries	97.95	0.00e+00	1387.00
IUUC-Ptr-091052	Pan troglodytes	99.87	0.00e+00	1406.00
IUUC-Pan-092270	Papio anubis	92.84	0.00e+00	1350.00
IUUC-Psi-093907	Pelodiscus sinensis	88.18	0.00e+00	1048.00
IUUC-Pfo-097042	Poecilia formosa	72.31	0.00e+00	1129.00
IUUC-Pab-098110	Pongo abelii	99.87	0.00e+00	1406.00
IUUC-Pca-100266	Procavia capensis	85.08	0.00e+00	990.00
IUUC-Pva-102824	Pteropus vampyrus	95.38	0.00e+00	1357.00
IUUC-Pgr-103483	Puccinia graminis	36.99	1.00e-56	215.00
IUUC-Rno-105638	Rattus norvegicus	96.79	0.00e+00	1377.00
IUUC-Sha-107004	Sarcophilus harrisii	87.98	0.00e+00	1122.00
IUUC-Ssc-115280	Sus scrofa	98.21	0.00e+00	1395.00
IUUC-Tgu-116759	Taeniopygia guttata	88.78	0.00e+00	1144.00
IUUC-Tru-117944	Takifugu rubripes	73.16	0.00e+00	1053.00
IUUC-Tsy-119405	Tarsius syrichta	86.61	0.00e+00	1085.00
IUUC-Tni-120571	Tetraodon nigroviridis	72.60	0.00e+00	1060.00
IUUC-Vpa-130294	Vicugna pacos	97.15	0.00e+00	1273.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence