• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046718
Ensembl Protein ID ENSP00000325074.7
UniProt Accession P63151; B2RBU8; B4E1T7; P50409; Q00007; 2ABA_HUMAN
Genbank Protein ID AAA36490.1; BAG64899.1; BAG37345.1; EAW63578.1; AAH41071.1
Protein Name Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform alpha
Genbank Nucleotide ID M64929; AK303981; AK314823; AC022911; BC041071
Gene Name PPP2R2A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000221914.8 ENST00000380737.7 ENSP00000370113.3
ENSG00000221914.8 ENST00000518254.5 ENSP00000428164.1
ENSG00000221914.8 ENST00000520329.5 ENSP00000428542.1
ENSG00000221914.8 ENST00000518397.5 ENSP00000429279.1
ENSG00000221914.8 ENST00000315985.7 ENSP00000325074.7
ENSG00000221914.8 ENST00000630149.1 ENSP00000486025.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkmiRecordsRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Drug and target
DrugBank
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.60e-11 45.0 237 267
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 4    dsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           + +t+ +f  ++ +++v +s  gti+++D+r
   Q: 237  EVITAAEFhpNScNTFVYSSSKGTIRLCDMR 267
           5689999**744799999999********87 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TP53 (PubMed:17245430). Interacts with IER5 (PubMed:25816751).
 Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TP53 (PubMed:17245430). Interacts with IER5 (PubMed:25816751).
Protein Sequence
(Fasta)
MFPKFSLRSM FHGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG 60
RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046718|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGTGACGTC ACTGGCCAGG CCAGCCGGCG CCATTTTGAA AGTGGAGTCG CCTGCCCCTG 60
CCGCTGCCGC CGCCGCCGTC GCTGTCGTAG TCGCCGCCGC CGCTGCCGGA GAAAGAGCAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046718|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR000009--PP2A_PR55
IPR018067--PP2A_PR55_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS01024--PR55_1
PS01025--PR55_2
PRINTS

PR00600--PP2APR55
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0000159--C:protein phosphatase type 2A complex
GO:0019888--F:protein phosphatase regulator activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0032502--P:developmental process
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0000278--P:mitotic cell cycle
GO:0007084--P:mitotic nuclear envelope reassembly
GO:0000184--P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0006470--P:protein dephosphorylation
GO:0043278--P:response to morphine
KEGG hsa:5520
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001197 Ailuropoda melanoleuca 98.89 0.00e+00 883.00
IUUC-Atr-002517 Amborella trichopoda 50.00 4.00e-127 448.00
IUUC-Apl-004226 Anas platyrhynchos 99.11 0.00e+00 882.00
IUUC-Aca-005147 Anolis carolinensis 98.44 0.00e+00 877.00
IUUC-Ame-011776 Astyanax mexicanus 91.96 0.00e+00 822.00
IUUC-Bta-012702 Bos taurus 99.34 0.00e+00 902.00
IUUC-Cja-019036 Callithrix jacchus 100.00 0.00e+00 909.00
IUUC-Cfa-021248 Canis familiaris 99.56 0.00e+00 904.00
IUUC-Cpo-022172 Cavia porcellus 100.00 0.00e+00 884.00
IUUC-Csa-023864 Chlorocebus sabaeus 100.00 0.00e+00 884.00
IUUC-Cin-025380 Ciona intestinalis 77.32 0.00e+00 703.00
IUUC-Dre-027406 Danio rerio 91.33 0.00e+00 815.00
IUUC-Eca-033584 Equus caballus 100.00 0.00e+00 851.00
IUUC-Fca-035565 Felis catus 95.19 0.00e+00 853.00
IUUC-Fal-036821 Ficedula albicollis 97.81 0.00e+00 890.00
IUUC-Gmo-038834 Gadus morhua 92.15 0.00e+00 809.00
IUUC-Gga-041009 Gallus gallus 99.32 0.00e+00 877.00
IUUC-Ggo-044599 Gorilla gorilla 99.78 0.00e+00 908.00
IUUC-Itr-048651 Ictidomys tridecemlineatus 100.00 0.00e+00 884.00
IUUC-Lch-050528 Latimeria chalumnae 95.12 0.00e+00 825.00
IUUC-Loc-052663 Lepisosteus oculatus 88.94 0.00e+00 826.00
IUUC-Laf-053403 Loxodonta africana 98.67 0.00e+00 883.00
IUUC-Mcc-055776 Macaca mulatta 100.00 0.00e+00 880.00
IUUC-Mtr-058561 Medicago truncatula 49.50 1.00e-125 443.00
IUUC-Mga-059946 Meleagris gallopavo 99.11 0.00e+00 882.00
IUUC-Mvi-060503 Microbotryum violaceum 60.61 2.00e-107 382.00
IUUC-Mmr-061095 Microcebus murinus 91.68 0.00e+00 806.00
IUUC-Mdo-062340 Monodelphis domestica 99.55 0.00e+00 880.00
IUUC-Mmu-064151 Mus musculus 100.00 0.00e+00 884.00
IUUC-Mpu-066190 Mustela putorius furo 98.89 0.00e+00 884.00
IUUC-Mlu-068197 Myotis lucifugus 99.76 0.00e+00 848.00
IUUC-Nle-069966 Nomascus leucogenys 98.03 0.00e+00 879.00
IUUC-Ont-071603 Oreochromis niloticus 90.62 0.00e+00 806.00
IUUC-Oan-073540 Ornithorhynchus anatinus 97.65 2.00e-168 584.00
IUUC-Ocu-074222 Oryctolagus cuniculus 100.00 0.00e+00 884.00
IUUC-Obr-076686 Oryza brachyantha 51.87 1.00e-134 473.00
IUUC-Ola-087128 Oryzias latipes 89.82 0.00e+00 789.00
IUUC-Oga-089168 Otolemur garnettii 99.78 0.00e+00 882.00
IUUC-Oar-089815 Ovis aries 93.80 0.00e+00 887.00
IUUC-Ptr-091110 Pan troglodytes 100.00 0.00e+00 890.00
IUUC-Pan-092884 Papio anubis 100.00 0.00e+00 884.00
IUUC-Pfo-097312 Poecilia formosa 90.56 0.00e+00 831.00
IUUC-Pab-098146 Pongo abelii 100.00 0.00e+00 884.00
IUUC-Pca-100882 Procavia capensis 99.60 2.00e-140 492.00
IUUC-Pva-102176 Pteropus vampyrus 91.35 0.00e+00 825.00
IUUC-Ptt-103844 Puccinia triticina 56.82 2.00e-142 499.00
IUUC-Rno-105484 Rattus norvegicus 99.78 0.00e+00 883.00
IUUC-Sha-107382 Sarcophilus harrisii 99.52 0.00e+00 849.00
IUUC-Ssc-115355 Sus scrofa 100.00 0.00e+00 884.00
IUUC-Tgu-116737 Taeniopygia guttata 98.88 0.00e+00 880.00
IUUC-Tru-118130 Takifugu rubripes 90.83 0.00e+00 804.00
IUUC-Tsy-119206 Tarsius syrichta 96.85 0.00e+00 837.00
IUUC-Tni-120009 Tetraodon nigroviridis 90.83 0.00e+00 805.00
IUUC-Tae-125564 Triticum aestivum 50.83 1.00e-126 446.00
IUUC-Ttr-128725 Tursiops truncatus 98.67 0.00e+00 876.00
IUUC-Vpa-130425 Vicugna pacos 95.95 0.00e+00 862.00
IUUC-Vvi-130930 Vitis vinifera 51.51 2.00e-128 452.00
IUUC-Xtr-131852 Xenopus tropicalis 94.00 0.00e+00 862.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved