iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115923

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

CT737179

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000009860.2	ENSSSCT00000010808.2	ENSSSCP00000010525.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.50e-12	45.0	474	504
E3 adaptor/Cullin RING/SCF/F-box	6.00e-06	26.7	111	159

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrt 32
           H+ +v++++ +d+ +vsG+ Dg + vWD+r 
   Q: 474  HQLGVSAVQMDDWKVVSGGEDGLVSVWDYRM 504
           7778999999669***************875 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 98   pdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
                 ++lp+e+ ++i+++ld++el+r+a+v+++w+ +a+++ lw ++
   Q: 111  DVPFFNSQLPYEVAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 159
           44567789*****************************999999999765 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MDDYNLDEFR RRWQEELAQA QTLRKRRWPE AAERRPRRPE VGPGRSEQQA LGYLPLVQGL 60
LAGAGRPPVA RATQAERQEA DSAPRPSALE APGGGEQLVD QLIQDLNEMD DVPFFNSQLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGACT ACAACCTGGA CGAGTTCCGC CGGCGCTGGC AGGAGGAGCT GGCGCAGGCC 60
CAGACTCTGA GGAAGCGGCG GTGGCCGGAG GCTGCCGAGA GGCGGCCGCG GCGACCAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	84.23	0.00e+00	910.00
IUUC-Apl-003239	Anas platyrhynchos	59.81	0.00e+00	671.00
IUUC-Aca-004756	Anolis carolinensis	58.91	5.00e-130	457.00
IUUC-Ame-011198	Astyanax mexicanus	41.89	2.00e-57	215.00
IUUC-Bta-012430	Bos taurus	53.08	2.00e-144	506.00
IUUC-Cja-019131	Callithrix jacchus	76.51	0.00e+00	845.00
IUUC-Cfa-021022	Canis familiaris	75.58	0.00e+00	895.00
IUUC-Cpo-021898	Cavia porcellus	73.64	0.00e+00	867.00
IUUC-Csa-023452	Chlorocebus sabaeus	78.69	0.00e+00	906.00
IUUC-Cho-024759	Choloepus hoffmanni	69.13	0.00e+00	786.00
IUUC-Dre-028123	Danio rerio	42.74	3.00e-143	501.00
IUUC-Dno-029045	Dasypus novemcinctus	85.71	0.00e+00	813.00
IUUC-Dor-030433	Dipodomys ordii	73.60	0.00e+00	732.00
IUUC-Ete-032465	Echinops telfairi	80.20	0.00e+00	697.00
IUUC-Eca-034134	Equus caballus	85.71	0.00e+00	882.00
IUUC-Eeu-035047	Erinaceus europaeus	74.90	0.00e+00	752.00
IUUC-Fca-036574	Felis catus	84.08	0.00e+00	859.00
IUUC-Fal-037665	Ficedula albicollis	58.72	7.00e-170	590.00
IUUC-Gmo-039137	Gadus morhua	38.90	9.00e-64	236.00
IUUC-Gga-040711	Gallus gallus	61.58	0.00e+00	647.00
IUUC-Gac-041675	Gasterosteus aculeatus	52.69	1.00e-53	202.00
IUUC-Ggo-045331	Gorilla gorilla	80.00	0.00e+00	816.00
IUUC-Hsa-046240	Homo sapiens	79.23	0.00e+00	899.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	85.92	0.00e+00	858.00
IUUC-Loc-052631	Lepisosteus oculatus	50.26	2.00e-165	575.00
IUUC-Laf-054127	Loxodonta africana	73.38	2.00e-56	210.00
IUUC-Mcc-055083	Macaca mulatta	79.23	0.00e+00	890.00
IUUC-Mga-060113	Meleagris gallopavo	61.74	0.00e+00	632.00
IUUC-Mmr-061780	Microcebus murinus	78.02	0.00e+00	874.00
IUUC-Mdo-063066	Monodelphis domestica	59.97	0.00e+00	706.00
IUUC-Mmu-063524	Mus musculus	72.36	0.00e+00	806.00
IUUC-Mpu-066913	Mustela putorius furo	85.21	0.00e+00	902.00
IUUC-Mlu-067924	Myotis lucifugus	79.60	0.00e+00	890.00
IUUC-Nle-069558	Nomascus leucogenys	78.65	0.00e+00	842.00
IUUC-Opr-070506	Ochotona princeps	75.17	0.00e+00	867.00
IUUC-Ont-071514	Oreochromis niloticus	44.74	5.00e-140	491.00
IUUC-Ocu-074477	Oryctolagus cuniculus	81.52	0.00e+00	834.00
IUUC-Ola-087416	Oryzias latipes	43.16	5.00e-140	491.00
IUUC-Oga-088643	Otolemur garnettii	77.68	0.00e+00	899.00
IUUC-Oar-090172	Ovis aries	85.71	0.00e+00	883.00
IUUC-Ptr-090870	Pan troglodytes	79.36	0.00e+00	904.00
IUUC-Pan-092017	Papio anubis	78.22	0.00e+00	895.00
IUUC-Psi-093794	Pelodiscus sinensis	62.88	0.00e+00	642.00
IUUC-Pfo-096192	Poecilia formosa	48.92	2.00e-142	499.00
IUUC-Pab-097882	Pongo abelii	78.02	0.00e+00	877.00
IUUC-Pca-100902	Procavia capensis	77.23	1.00e-141	496.00
IUUC-Pva-103139	Pteropus vampyrus	81.77	0.00e+00	930.00
IUUC-Rno-105798	Rattus norvegicus	77.84	0.00e+00	821.00
IUUC-Sha-106576	Sarcophilus harrisii	64.61	0.00e+00	666.00
IUUC-Tgu-116667	Taeniopygia guttata	55.76	3.00e-113	401.00
IUUC-Tru-118323	Takifugu rubripes	42.16	5.00e-133	468.00
IUUC-Tsy-118818	Tarsius syrichta	70.40	2.00e-97	348.00
IUUC-Tni-120438	Tetraodon nigroviridis	41.42	5.00e-128	451.00
IUUC-Tbe-127784	Tupaia belangeri	83.98	8.00e-101	360.00
IUUC-Ttr-128288	Tursiops truncatus	74.79	0.00e+00	830.00
IUUC-Vpa-130307	Vicugna pacos	77.40	0.00e+00	781.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence