iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-116183

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEMK01179608

Gene Name

FBXW4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000010566.2	ENSSSCT00000011558.2	ENSSSCP00000011256.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.50e-17	61.8	353	386
E3 adaptor/Cullin RING/SCF/F-box	1.50e-07	31.9	125	223

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H+ +v+c++  ++++vsGs+D t kvW l +g+l
   Q: 353  HEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRL 386
           99*******9449***************999875 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 48   praqrrasrrtprqpprgpsa...aakpkaglrseaaaapapapaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrw 133
            r+  r   r  r   rg  a    a+  a + +eaa   a a  pt  p  gp    l rlpee+l+ i+++ld + l+r+a+vcr +
   Q: 125  VRTGWREEARPARAQGRGGQAwghLARTGAAMAAEAAEEEAAAREPTGRPAAGPA---LLRLPEELLLLICSYLDMQALGRLAQVCRWL 210
           56666777788888888887733358899999********************995...79***************************** PP
   S: 134  qelasqkalwktv 146
           ++++s + lw+++
   Q: 211  RRFTSCDLLWRRI 223
           ****999999976 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MGSQGGSGPP GNGGPGEGES GEARKLQEGR AARGKRRKGK RKGKAGAGQD GRGSGAERKP 60
GATTGEGGCG AGGEAGARAG LGEEGEGGGS VQKXARRIVR GEEGSAGAGK EAEGRDDGKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCATGTGAC CCGGTCCGGC ATGGTGTCGC CTCCTCCCGG GGCGGCGGCG GCGCTGGCGG 60
CGGCTCCGGC TTGGCTCCGC AGCGGGCCGG CCCCGCGGCC GCTCATGGGC AGCCAGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0019005--C:SCF ubiquitin ligase complex
GO:0051216--P:cartilage development
GO:0042733--P:embryonic digit morphogenesis
GO:0002053--P:positive regulation of mesenchymal cell proliferation
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002129	Ailuropoda melanoleuca	98.93	0.00e+00	781.00
IUUC-Apl-003837	Anas platyrhynchos	72.53	1.00e-144	505.00
IUUC-Aca-004776	Anolis carolinensis	68.19	7.00e-142	496.00
IUUC-Ame-010651	Astyanax mexicanus	62.11	9.00e-114	402.00
IUUC-Bta-013495	Bos taurus	97.86	0.00e+00	735.00
IUUC-Cja-018901	Callithrix jacchus	98.37	0.00e+00	729.00
IUUC-Cfa-021251	Canis familiaris	97.86	0.00e+00	764.00
IUUC-Cpo-021750	Cavia porcellus	94.77	0.00e+00	654.00
IUUC-Csa-024026	Chlorocebus sabaeus	98.10	0.00e+00	758.00
IUUC-Cho-024496	Choloepus hoffmanni	76.69	5.00e-161	560.00
IUUC-Cin-025142	Ciona intestinalis	30.17	9.00e-22	96.70
IUUC-Csv-025883	Ciona savignyi	36.62	3.00e-62	231.00
IUUC-Dre-027447	Danio rerio	59.79	2.00e-129	455.00
IUUC-Dno-029572	Dasypus novemcinctus	75.42	5.00e-177	613.00
IUUC-Dor-030982	Dipodomys ordii	89.16	0.00e+00	677.00
IUUC-Dme-031804	Drosophila melanogaster	23.01	2.00e-11	63.20
IUUC-Ete-032917	Echinops telfairi	96.31	0.00e+00	662.00
IUUC-Eca-033969	Equus caballus	98.47	0.00e+00	738.00
IUUC-Eeu-034850	Erinaceus europaeus	86.45	0.00e+00	659.00
IUUC-Fca-036182	Felis catus	93.58	0.00e+00	701.00
IUUC-Fal-037391	Ficedula albicollis	69.60	6.00e-151	526.00
IUUC-Gmo-038632	Gadus morhua	57.64	8.00e-127	446.00
IUUC-Gga-040783	Gallus gallus	73.85	3.00e-163	567.00
IUUC-Gac-042314	Gasterosteus aculeatus	57.18	6.00e-110	390.00
IUUC-Ggo-044739	Gorilla gorilla	98.10	0.00e+00	764.00
IUUC-Hsa-046705	Homo sapiens	98.10	0.00e+00	729.00
IUUC-Itr-048014	Ictidomys tridecemlineatus	99.31	1.00e-175	607.00
IUUC-Loc-052397	Lepisosteus oculatus	66.94	4.00e-140	490.00
IUUC-Laf-054544	Loxodonta africana	96.13	0.00e+00	671.00
IUUC-Meu-056363	Macropus eugenii	59.38	2.00e-103	368.00
IUUC-Mga-059275	Meleagris gallopavo	73.98	6.00e-146	509.00
IUUC-Mmr-060906	Microcebus murinus	94.21	0.00e+00	789.00
IUUC-Mdo-062400	Monodelphis domestica	78.34	6.00e-178	616.00
IUUC-Mmu-063556	Mus musculus	93.50	0.00e+00	725.00
IUUC-Mpu-066500	Mustela putorius furo	98.66	0.00e+00	780.00
IUUC-Mlu-068074	Myotis lucifugus	98.46	0.00e+00	677.00
IUUC-Nle-069601	Nomascus leucogenys	98.37	0.00e+00	765.00
IUUC-Opr-070904	Ochotona princeps	88.97	1.00e-148	518.00
IUUC-Ont-072679	Oreochromis niloticus	56.55	7.00e-121	426.00
IUUC-Oan-073434	Ornithorhynchus anatinus	73.36	3.00e-85	307.00
IUUC-Ocu-074649	Oryctolagus cuniculus	96.21	0.00e+00	737.00
IUUC-Ola-087336	Oryzias latipes	50.13	6.00e-102	363.00
IUUC-Oga-088590	Otolemur garnettii	95.12	0.00e+00	711.00
IUUC-Oar-090178	Ovis aries	95.20	0.00e+00	686.00
IUUC-Pan-092881	Papio anubis	98.37	0.00e+00	765.00
IUUC-Pfo-096176	Poecilia formosa	57.07	7.00e-112	397.00
IUUC-Pab-098285	Pongo abelii	98.37	0.00e+00	759.00
IUUC-Pca-100888	Procavia capensis	92.25	0.00e+00	705.00
IUUC-Pva-102184	Pteropus vampyrus	83.74	2.00e-180	624.00
IUUC-Rno-105668	Rattus norvegicus	94.04	0.00e+00	729.00
IUUC-Sha-106629	Sarcophilus harrisii	78.26	2.00e-156	544.00
IUUC-Tgu-116630	Taeniopygia guttata	72.78	2.00e-165	575.00
IUUC-Tru-118761	Takifugu rubripes	53.37	2.00e-115	409.00
IUUC-Tni-120651	Tetraodon nigroviridis	52.97	2.00e-60	224.00
IUUC-Ttr-128582	Tursiops truncatus	97.06	0.00e+00	726.00
IUUC-Vpa-130431	Vicugna pacos	76.62	5.00e-99	353.00
IUUC-Xtr-132655	Xenopus tropicalis	67.21	3.00e-150	524.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence