iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000009726.5	ENSBTAT00000040284.4	ENSBTAP00000040061.4
ENSBTAG00000009726.5	ENSBTAT00000012826.2	ENSBTAP00000012826.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	2.80e-19	69.4	33	96
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	6.70e-14	50.8	132	163

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +Dv+l v+++ f+ah+ivLaa+S++F a+f++el+e+  k+ v+i+++ ++ ++ ll+F+Yt ++
   Q: 33   CDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKG-KPYVDIQGLTASTMEILLDFVYTETV 96
           9***********************************98.***********************987 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Nclgi++fA++++c dL++aa+ f +khF+
   Q: 132  PSNCLGIRDFAETHNCVDLMQAAEVFSQKHFP 163
           89*****************************6 PP

Organism

Bos taurus

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins.

Protein Sequence
(Fasta)

MRGIMAPKDI MTNTHAKSIL NSMNSLRKSN TLCDVTLRVE QKDFPAHRIV LAACSDYFCA 60
MFTSELSEKG KPYVDIQGLT ASTMEILLDF VYTETVHVTV ENVQELLPAA CLLQLKGVKQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGGCGCGCG GCCGCGGGCG CGGCGCCGGA GCCTCCGGGT CCGGGCGGCG GCGCTTGGGC 60
ACCTCCCCGG CCGTCCGCTC GCCCCGCGCC CGCTCGGCGG GCCGGAGCAC AGGTGAGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0030134--C:ER to Golgi transport vesicle
GO:0000139--C:Golgi membrane
GO:0005815--C:microtubule organizing center
GO:0048208--P:COPII vesicle coating
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006513--P:protein monoubiquitination
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002301	Ailuropoda melanoleuca	97.50	0.00e+00	1105.00
IUUC-Apl-003339	Anas platyrhynchos	94.99	0.00e+00	1009.00
IUUC-Aca-004418	Anolis carolinensis	94.50	0.00e+00	1095.00
IUUC-Ame-011906	Astyanax mexicanus	73.94	0.00e+00	858.00
IUUC-Cja-019582	Callithrix jacchus	96.99	0.00e+00	1115.00
IUUC-Cfa-020716	Canis familiaris	97.54	0.00e+00	1125.00
IUUC-Cpo-022013	Cavia porcellus	97.71	0.00e+00	1129.00
IUUC-Cre-022752	Chlamydomonas reinhardtii	28.76	9.00e-16	80.10
IUUC-Csa-023424	Chlorocebus sabaeus	98.10	0.00e+00	1052.00
IUUC-Cho-024586	Choloepus hoffmanni	79.58	0.00e+00	875.00
IUUC-Dre-028344	Danio rerio	87.06	9.00e-165	572.00
IUUC-Dno-028854	Dasypus novemcinctus	97.54	0.00e+00	1126.00
IUUC-Dor-030403	Dipodomys ordii	97.36	0.00e+00	1122.00
IUUC-Ete-032963	Echinops telfairi	95.63	0.00e+00	969.00
IUUC-Eca-033282	Equus caballus	97.36	0.00e+00	1125.00
IUUC-Eeu-034933	Erinaceus europaeus	96.86	5.00e-139	487.00
IUUC-Fca-035487	Felis catus	97.54	0.00e+00	1126.00
IUUC-Fal-037059	Ficedula albicollis	94.00	0.00e+00	1091.00
IUUC-Gmo-039564	Gadus morhua	87.96	0.00e+00	1065.00
IUUC-Gga-040629	Gallus gallus	94.66	0.00e+00	1093.00
IUUC-Gac-042526	Gasterosteus aculeatus	88.34	0.00e+00	1064.00
IUUC-Ggo-044839	Gorilla gorilla	97.36	0.00e+00	1125.00
IUUC-Hsa-046742	Homo sapiens	97.36	0.00e+00	1125.00
IUUC-Itr-048958	Ictidomys tridecemlineatus	97.36	0.00e+00	1123.00
IUUC-Lch-049540	Latimeria chalumnae	91.49	0.00e+00	1096.00
IUUC-Loc-051923	Lepisosteus oculatus	91.49	0.00e+00	1070.00
IUUC-Laf-054370	Loxodonta africana	97.01	0.00e+00	1123.00
IUUC-Mcc-054852	Macaca mulatta	97.36	0.00e+00	1125.00
IUUC-Mor-057181	Magnaporthe oryzae	25.75	7.00e-10	58.20
IUUC-Mga-059486	Meleagris gallopavo	93.35	0.00e+00	998.00
IUUC-Mmr-061777	Microcebus murinus	97.36	0.00e+00	1122.00
IUUC-Mdo-061990	Monodelphis domestica	95.76	0.00e+00	1108.00
IUUC-Mmu-064053	Mus musculus	97.01	0.00e+00	1123.00
IUUC-Mpu-066623	Mustela putorius furo	84.41	0.00e+00	806.00
IUUC-Mlu-067648	Myotis lucifugus	96.65	0.00e+00	1145.00
IUUC-Nle-069714	Nomascus leucogenys	97.18	0.00e+00	1124.00
IUUC-Opr-071143	Ochotona princeps	90.85	0.00e+00	1030.00
IUUC-Ont-071848	Oreochromis niloticus	89.36	0.00e+00	1073.00
IUUC-Oan-073041	Ornithorhynchus anatinus	94.64	8.00e-160	555.00
IUUC-Ocu-074379	Oryctolagus cuniculus	96.83	0.00e+00	1119.00
IUUC-Oin-079973	Oryza indica	30.74	3.00e-33	136.00
IUUC-Ola-087469	Oryzias latipes	89.01	0.00e+00	1071.00
IUUC-Oga-088004	Otolemur garnettii	97.91	2.00e-139	488.00
IUUC-Oar-090144	Ovis aries	97.54	0.00e+00	1126.00
IUUC-Ptr-091406	Pan troglodytes	97.36	0.00e+00	1125.00
IUUC-Pan-092762	Papio anubis	96.31	0.00e+00	1105.00
IUUC-Psi-093391	Pelodiscus sinensis	94.15	0.00e+00	1093.00
IUUC-Pma-094134	Petromyzon marinus	73.27	0.00e+00	815.00
IUUC-Pfo-096404	Poecilia formosa	89.05	0.00e+00	1071.00
IUUC-Pab-098425	Pongo abelii	96.64	0.00e+00	1111.00
IUUC-Pca-101093	Procavia capensis	97.59	8.00e-170	590.00
IUUC-Pva-102239	Pteropus vampyrus	86.80	0.00e+00	1006.00
IUUC-Rno-104921	Rattus norvegicus	97.18	0.00e+00	1125.00
IUUC-Sha-106625	Sarcophilus harrisii	96.64	0.00e+00	1115.00
IUUC-Sar-113468	Sorex araneus	86.32	0.00e+00	706.00
IUUC-Ssc-116106	Sus scrofa	97.18	0.00e+00	1122.00
IUUC-Tgu-117402	Taeniopygia guttata	73.63	0.00e+00	741.00
IUUC-Tru-117546	Takifugu rubripes	88.48	0.00e+00	1066.00
IUUC-Tsy-118802	Tarsius syrichta	88.34	0.00e+00	986.00
IUUC-Tni-119999	Tetraodon nigroviridis	88.14	0.00e+00	1059.00
IUUC-Tca-121074	Theobroma cacao	31.03	3.00e-37	150.00
IUUC-Tbe-127987	Tupaia belangeri	97.84	0.00e+00	950.00
IUUC-Ttr-128613	Tursiops truncatus	90.83	0.00e+00	1027.00
IUUC-Xtr-132401	Xenopus tropicalis	90.29	3.00e-171	593.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence