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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045866
UUCD1 version UUC-HoS-00174
Ensembl Protein ID ENSP00000296490.3
UniProt Accession Q6UXN9; A8K5R5; Q8TEB2; WDR82_HUMAN
Genbank Protein ID AAQ88631.1; BAB85039.1; BAF84069.1; EAW65202.1
Protein Name WD repeat-containing protein 82; Protein TMEM113; Swd2
Genbank Nucleotide ID AY358264; AK074290; AK291380; CH471055
Gene Name WDR82; TMEM113; WDR82A; UNQ9342/PRO34047
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164091.11 ENST00000296490.7 ENSP00000296490.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.90e-24 85.3 105 141
UBD/Beta-Prp 6.60e-40 138.8 16 307
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvl 35
           gH+ +v +l+    d++++sGs D+ti++WDlr+ ++
   Q: 105  GHSKRVVALSMspVDDTFISGSLDKTIRLWDLRSPNC 141
           799999999999755899**************99876 PP
   

   UBD/Beta-Prp
   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgse..Drtikvwdlstgkcvhtlkghe 94
           ++ ++++ i+c +fsp+++ ++++s+d++i ++d ++gk  r+l++++ +v  +++ + +++ v +s+  D+ti+  +l ++k+++ + gh+
   Q: 16   VFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRYLSLHDNKYIRYFPGHS 107
           56678899*****************************************************9999998668********************* PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl....ktgkllrtltgghtds 182
           ++v++ls+sp +d+++sGs d+tir+wdl++  c       h +   + +++p+g ++++G + ++v+l+dl    k  +   +++ + t  
   Q: 108  KRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQG---LMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLrsfdKGPFATFKMQYDRTCE 196
           ***********************************8...4455555677899*9******************66554455555558888899 PP
   S: 183  vyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght...dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisva 271
            + l+f+ +gk ++   + + ++l d  +g +++t+ g+    + ++   f+p++++++ gs+Dg i +W+ +sg  + +l +++    +++
   Q: 197  WTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYAnskAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGKH--TGPIT 286
           99999******************************99977333556677899*******************************66..88999 PP
   S: 272  vlsfgdnvlvlgsedskvniw 292
           +l+f+ + +  +s+ s+  +w
   Q: 287  CLQFNPKFMTFASACSNMAFW 307
           999998888888877666665 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
 Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
Protein Sequence
(Fasta)
MKLTDSVLRS FRVAKVFREN SDKINCFDFS PNGETVISSS DDDSIVLYDC QEGKPKRTLY 60
SKKYGVDLIR YTHAANTVVY SSNKIDDTIR YLSLHDNKYI RYFPGHSKRV VALSMSPVDD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045866|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGGTAGGGC CTTAGCGAGG GAAATGGCTG CCGCGTAATG CCCGGTGATG CGAGAAAGAA 60
GGGCCTGCTG CCACCAGGAC CCGTCATCGC CCAGCCCAGG GACCGCTTCT GAAGGCCATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045866|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0000785--C:chromatin
GO:0035097--C:histone methyltransferase complex
GO:0005730--C:nucleolus
GO:0072357--C:PTW/PP1 phosphatase complex
GO:0048188--C:Set1C/COMPASS complex
GO:0003682--F:chromatin binding
GO:0051568--P:histone H3-K4 methylation
GO:0080182--P:histone H3-K4 trimethylation
KEGG hsa:80335
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000390 Aegilops tauschii 39.62 1.00e-62 233.00
IUUC-Aml-001221 Ailuropoda melanoleuca 100.00 0.00e+00 636.00
IUUC-Atr-002607 Amborella trichopoda 40.38 1.00e-70 259.00
IUUC-Apl-003817 Anas platyrhynchos 97.70 3.00e-175 608.00
IUUC-Aca-005383 Anolis carolinensis 94.89 7.00e-176 609.00
IUUC-Aly-005437 Arabidopsis lyrata 39.42 8.00e-69 253.00
IUUC-Ath-006793 Arabidopsis thaliana 39.42 2.00e-68 253.00
IUUC-Ago-007804 Ashbya gossypii 33.97 2.00e-49 189.00
IUUC-Acl-008217 Aspergillus clavatus 36.66 6.00e-55 207.00
IUUC-Afl-008539 Aspergillus flavus 35.67 5.00e-56 211.00
IUUC-Afu-009105 Aspergillus fumigatus 36.66 5.00e-56 211.00
IUUC-Ani-009474 Aspergillus nidulans 35.93 4.00e-53 201.00
IUUC-Ang-009858 Aspergillus niger 37.13 3.00e-57 215.00
IUUC-Aor-009955 Aspergillus oryzae 35.67 5.00e-56 211.00
IUUC-Ate-010364 Aspergillus terreus 36.95 3.00e-57 215.00
IUUC-Ame-010661 Astyanax mexicanus 92.43 7.00e-169 587.00
IUUC-Bgr-012008 Blumeria graminis 35.84 8.00e-57 214.00
IUUC-Bta-013022 Bos taurus 100.00 5.00e-178 617.00
IUUC-Bci-013966 Botrytis cinerea 35.58 8.00e-51 194.00
IUUC-Bdi-015066 Brachypodium distachyon 41.48 1.00e-72 266.00
IUUC-Bol-016019 Brassica oleracea 40.06 3.00e-69 255.00
IUUC-Bra-017871 Brassica rapa 40.06 4.00e-69 254.00
IUUC-Cel-018276 Caenorhabditis elegans 43.09 3.00e-73 268.00
IUUC-Cja-019309 Callithrix jacchus 100.00 0.00e+00 636.00
IUUC-Cfa-020345 Canis familiaris 100.00 0.00e+00 636.00
IUUC-Cpo-022227 Cavia porcellus 92.38 1.00e-164 572.00
IUUC-Csa-023267 Chlorocebus sabaeus 94.25 5.00e-178 616.00
IUUC-Cho-024409 Choloepus hoffmanni 89.83 4.00e-146 510.00
IUUC-Cin-025628 Ciona intestinalis 70.16 5.00e-138 483.00
IUUC-Csv-026164 Ciona savignyi 70.06 8.00e-138 483.00
IUUC-Cgl-026516 Colletotrichum gloeosporioides 35.13 6.00e-52 197.00
IUUC-Cne-026890 Cryptococcus neoformans 28.39 3.00e-35 142.00
IUUC-Cme-027288 Cyanidioschyzon merolae 37.91 3.00e-65 242.00
IUUC-Dre-028001 Danio rerio 93.61 8.00e-175 605.00
IUUC-Dno-029056 Dasypus novemcinctus 100.00 0.00e+00 636.00
IUUC-Dor-031078 Dipodomys ordii 100.00 3.00e-121 427.00
IUUC-Dse-031152 Dothistroma septosporum 36.93 9.00e-58 217.00
IUUC-Dme-032085 Drosophila melanogaster 69.01 8.00e-140 489.00
IUUC-Ete-033158 Echinops telfairi 96.17 2.00e-178 617.00
IUUC-Eca-033879 Equus caballus 99.60 1.00e-150 526.00
IUUC-Eeu-035229 Erinaceus europaeus 88.82 3.00e-153 533.00
IUUC-Fca-035896 Felis catus 100.00 0.00e+00 636.00
IUUC-Fal-036843 Ficedula albicollis 97.70 3.00e-175 608.00
IUUC-Fox-037858 Fusarium oxysporum 36.81 6.00e-57 214.00
IUUC-Fso-038386 Fusarium solani 35.57 2.00e-48 186.00
IUUC-Gmo-038506 Gadus morhua 92.13 2.00e-167 582.00
IUUC-Ggr-040090 Gaeumannomyces graminis 37.87 6.00e-57 214.00
IUUC-Gga-040192 Gallus gallus 97.76 1.00e-180 625.00
IUUC-Gac-042494 Gasterosteus aculeatus 90.52 9.00e-164 570.00
IUUC-Gma-042835 Glycine max 41.72 8.00e-70 257.00
IUUC-Ggo-045204 Gorilla gorilla 100.00 8.00e-179 620.00
IUUC-Hvu-047690 Hordeum vulgare 39.30 8.00e-62 230.00
IUUC-Itr-048338 Ictidomys tridecemlineatus 100.00 0.00e+00 636.00
IUUC-Kpa-049249 Komagataella pastoris 36.53 6.00e-57 214.00
IUUC-Lch-050431 Latimeria chalumnae 94.81 2.00e-173 602.00
IUUC-Lpe-050830 Leersia perrieri 41.48 4.00e-72 265.00
IUUC-Loc-052505 Lepisosteus oculatus 96.59 2.00e-41 160.00
IUUC-Lma-053026 Leptosphaeria maculans 35.82 3.00e-59 222.00
IUUC-Laf-054265 Loxodonta africana 78.43 3.00e-130 457.00
IUUC-Mcc-055583 Macaca mulatta 100.00 0.00e+00 636.00
IUUC-Meu-056113 Macropus eugenii 85.30 3.00e-149 521.00
IUUC-Mor-057267 Magnaporthe oryzae 35.07 2.00e-50 192.00
IUUC-Mpo-057502 Magnaporthe poae 37.57 1.00e-55 210.00
IUUC-Mtr-058607 Medicago truncatula 41.40 1.00e-69 256.00
IUUC-Mla-058815 Melampsora laricipopulina 39.11 6.00e-70 258.00
IUUC-Mga-059407 Meleagris gallopavo 97.31 3.00e-153 533.00
IUUC-Mvi-060411 Microbotryum violaceum 37.02 3.00e-63 236.00
IUUC-Mmr-061470 Microcebus murinus 100.00 0.00e+00 636.00
IUUC-Mdo-062860 Monodelphis domestica 97.76 4.00e-180 623.00
IUUC-Mmu-063105 Mus musculus 100.00 0.00e+00 636.00
IUUC-Mac-065314 Musa acuminata 41.03 4.00e-70 258.00
IUUC-Mpu-066472 Mustela putorius furo 100.00 1.00e-155 541.00
IUUC-Mlu-067073 Myotis lucifugus 100.00 2.00e-180 624.00
IUUC-Nfi-068284 Neosartorya fischeri 36.66 4.00e-56 211.00
IUUC-Ncr-068702 Neurospora crassa 34.20 8.00e-46 177.00
IUUC-Nle-069451 Nomascus leucogenys 100.00 0.00e+00 636.00
IUUC-Opr-071112 Ochotona princeps 100.00 1.00e-155 541.00
IUUC-Ont-071988 Oreochromis niloticus 91.78 1.00e-167 583.00
IUUC-Oan-072947 Ornithorhynchus anatinus 97.68 5.00e-153 533.00
IUUC-Ocu-074969 Oryctolagus cuniculus 100.00 0.00e+00 636.00
IUUC-Oba-075229 Oryza barthii 37.70 1.00e-56 214.00
IUUC-Obr-076456 Oryza brachyantha 41.80 1.00e-72 266.00
IUUC-Ogl-076973 Oryza glaberrima 41.80 7.00e-73 267.00
IUUC-Ogu-078068 Oryza glumaepatula 37.38 8.00e-57 214.00
IUUC-Oin-079656 Oryza indica 41.80 1.00e-72 266.00
IUUC-Olo-080893 Oryza longistaminata 36.33 1.00e-53 203.00
IUUC-Ome-081559 Oryza meridionalis 36.65 7.00e-34 136.00
IUUC-Oni-082990 Oryza nivara 37.38 2.00e-56 213.00
IUUC-Opu-083374 Oryza punctata 38.02 8.00e-57 213.00
IUUC-Oru-084354 Oryza rufipogon 37.38 2.00e-56 213.00
IUUC-Osa-086296 Oryza sativa 41.80 1.00e-72 266.00
IUUC-Ola-087095 Oryzias latipes 92.33 2.00e-173 601.00
IUUC-Olu-087603 Ostreococcus lucimarinus 36.39 1.00e-55 210.00
IUUC-Oga-088766 Otolemur garnettii 100.00 0.00e+00 636.00
IUUC-Oar-089565 Ovis aries 97.76 6.00e-179 619.00
IUUC-Ptr-091219 Pan troglodytes 92.33 2.00e-174 604.00
IUUC-Pan-091733 Papio anubis 100.00 0.00e+00 636.00
IUUC-Psi-092972 Pelodiscus sinensis 97.38 3.00e-174 605.00
IUUC-Pma-094332 Petromyzon marinus 86.58 5.00e-169 586.00
IUUC-Pno-094960 Phaeosphaeria nodorum 38.89 2.00e-61 229.00
IUUC-Ppa-095292 Physcomitrella patens 45.19 9.00e-82 296.00
IUUC-Pfo-096775 Poecilia formosa 91.45 6.00e-167 580.00
IUUC-Pab-097721 Pongo abelii 97.76 2.00e-176 610.00
IUUC-Pop-098907 Populus trichocarpa 41.35 5.00e-70 258.00
IUUC-Pca-100635 Procavia capensis 98.84 3.00e-151 527.00
IUUC-Ppe-101860 Prunus persica 41.35 6.00e-71 260.00
IUUC-Pva-102798 Pteropus vampyrus 99.36 0.00e+00 632.00
IUUC-Pgr-103395 Puccinia graminis 38.76 8.00e-71 260.00
IUUC-Ptt-103747 Puccinia triticina 37.39 4.00e-67 248.00
IUUC-Pte-104129 Pyrenophora teres 38.00 5.00e-56 213.00
IUUC-Pyt-104773 Pyrenophora triticirepentis 35.14 3.00e-58 219.00
IUUC-Rno-106127 Rattus norvegicus 97.13 2.00e-175 608.00
IUUC-Sce-106257 Saccharomyces cerevisiae 33.75 6.00e-45 174.00
IUUC-Sha-106573 Sarcophilus harrisii 86.82 4.00e-160 557.00
IUUC-Sja-107724 Schizosaccharomyces japonicus 35.98 4.00e-47 181.00
IUUC-Spo-108206 Schizosaccharomyces pombe 34.65 2.00e-50 192.00
IUUC-Smo-108979 Selaginella moellendorffii 44.55 3.00e-80 291.00
IUUC-Sit-109858 Setaria italica 41.67 4.00e-72 265.00
IUUC-Sly-111267 Solanum lycopersicum 42.31 3.00e-71 262.00
IUUC-Sar-113079 Sorex araneus 100.00 1.00e-155 541.00
IUUC-Sbi-114094 Sorghum bicolor 37.70 1.00e-59 223.00
IUUC-Sre-115157 Sporisorium reilianum 34.46 4.00e-54 205.00
IUUC-Ssc-116386 Sus scrofa 100.00 0.00e+00 636.00
IUUC-Tgu-116465 Taeniopygia guttata 93.89 6.00e-147 514.00
IUUC-Tru-117604 Takifugu rubripes 91.45 2.00e-167 582.00
IUUC-Tsy-119314 Tarsius syrichta 76.80 9.00e-108 382.00
IUUC-Tni-120237 Tetraodon nigroviridis 91.12 2.00e-165 575.00
IUUC-Tca-121853 Theobroma cacao 41.35 3.00e-70 258.00
IUUC-Tre-122205 Trichoderma reesei 35.34 6.00e-54 204.00
IUUC-Tvi-122471 Trichoderma virens 31.61 1.00e-40 160.00
IUUC-Tae-124944 Triticum aestivum 41.80 7.00e-74 270.00
IUUC-Tur-126512 Triticum urartu 42.55 2.00e-59 222.00
IUUC-Tme-126883 Tuber melanosporum 40.37 4.00e-61 228.00
IUUC-Tbe-127310 Tupaia belangeri 93.18 1.00e-70 259.00
IUUC-Ttr-128307 Tursiops truncatus 100.00 1.00e-155 541.00
IUUC-Uma-129579 Ustilago maydis 34.59 2.00e-53 202.00
IUUC-Vda-129826 Verticillium dahliae 34.97 1.00e-51 196.00
IUUC-Vpa-130091 Vicugna pacos 100.00 1.00e-155 541.00
IUUC-Vvi-131040 Vitis vinifera 41.67 9.00e-71 261.00
IUUC-Xtr-132660 Xenopus tropicalis 94.52 3.00e-172 598.00
IUUC-Xma-133496 Xiphophorus maculatus 91.69 1.00e-172 598.00
IUUC-Yli-134509 Yarrowia lipolytica 38.32 4.00e-62 231.00
IUUC-Zma-134685 Zea mays 41.48 4.00e-72 264.00
Created Date 25-Jun-2017

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