iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011946

Ensembl Protein ID

ENSAMXP00000014218.1

UniProt Accession

W5L306; W5L306_ASTMX

Genbank Protein ID

ENSAMXP00000014218

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

APWO01024281

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000013817.1	ENSAMXT00000014218.1	ENSAMXP00000014218.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.80e-159	531.0	3	768

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q pv+g+++lFk++e+r+s+rk+++++++++v+d+di++ +ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QSPVYGFIFLFKWIEERRSRRKVSTLVDETSVIDDDIVNDMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+ +  +lG tlsr+k++tk++ pe+k++a+gn+++l+++hns+ar+e+r++pe+q++ ++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSGV--ELGMTLSRMKTFTKGFNPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGISAVRTMEAFHFVSY 173
           ******************99..9****************************************************************** PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i++rl+eldglk +P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr++++ rl+vlk +         
   Q: 174  VPIKDRLFELDGLKTYPIDHGPWGEEEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRMKYESRLEVLKRNrqivleglq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qaikasqpdaqqerkqpdssedtpttvkkeetsetpvsaeqtpptdadgagvtaapcssdkaksvsksssvpaggatpgpppppappap 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  pppitspnpivqrlpafldnhnyakspmqeeedlaagvgrprvpgppqtsysddedyedeeeeeceptaapsrfcrksslrtrsvaras 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  taaagasgvegqlalnvlteklkkeiqkkdtmamvagstplnvrtegrtggisitsasqpsptpsnestdtaseigsafnsplrspars 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  qattrpsspvashlsrvlfgedegllrldarhnravrdlgsvvgctrlqlkddgtmhalppvegpsegvkktngmektekiekkeaisg 616
           ***************************************************************************************** PP
   S: 260  ....................................................keLlkLlkdieseeekieaqlddekekrkkfkiddir 296
                                                               keLl+Llk +e+ + + e +l++e+ekrkk+kidd+r
   Q: 617  gaqetagkegaqeekkvkeeskemtdnkpitesgtfaepeavikptgekyspKELLALLKYVEADISNCEVCLKEEVEKRKKYKIDDQR 705
           ***************************************************************************************** PP
   S: 297  Rtenydeficifikdlaregilrklveetisevrefgvnegrlakqrkqgrekkirplkrkrk 359
           Rt+nydefic+fi++la+eg+l+ lve++is++r++gv++grl+kqrk++r+k++rp+k kr+
   Q: 706  RTHNYDEFICTFISMLAQEGMLASLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKTKRQ 768
           *************************************************************97 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ SPVYGFIFLF KWIEERRSRR 60
KVSTLVDETS VIDDDIVNDM FFAHQLIPNS CATHALLSVL LNCSGVELGM TLSRMKTFTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCGCCCTC TAGCGGCCGC CAAATCCTGT GCACCCACGG GTTTGTCTCG GACCGATGAC 60
GCTAAAAGAC CTCGCCGCAG TGTTTTCCTC CTTTGTGTTT ATGAGTGACT GTAAATAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005622--C:intracellular
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	63.94	0.00e+00	845.00
IUUC-Apl-003405	Anas platyrhynchos	52.75	4.00e-84	305.00
IUUC-Aca-004836	Anolis carolinensis	62.00	0.00e+00	862.00
IUUC-Bta-013131	Bos taurus	58.94	0.00e+00	712.00
IUUC-Cja-019599	Callithrix jacchus	63.84	0.00e+00	874.00
IUUC-Cfa-021003	Canis familiaris	62.90	0.00e+00	841.00
IUUC-Cpo-022143	Cavia porcellus	64.59	0.00e+00	868.00
IUUC-Csa-023477	Chlorocebus sabaeus	63.46	0.00e+00	863.00
IUUC-Cho-024734	Choloepus hoffmanni	50.52	1.00e-65	244.00
IUUC-Csv-025842	Ciona savignyi	63.86	5.00e-92	330.00
IUUC-Dre-027793	Danio rerio	74.16	0.00e+00	1062.00
IUUC-Dno-029253	Dasypus novemcinctus	63.35	0.00e+00	845.00
IUUC-Dor-030891	Dipodomys ordii	58.50	0.00e+00	791.00
IUUC-Dme-031796	Drosophila melanogaster	60.55	7.00e-95	340.00
IUUC-Ete-032646	Echinops telfairi	86.01	1.00e-116	413.00
IUUC-Eca-033805	Equus caballus	63.24	0.00e+00	856.00
IUUC-Eeu-035216	Erinaceus europaeus	58.90	2.00e-89	323.00
IUUC-Fca-035611	Felis catus	64.10	0.00e+00	632.00
IUUC-Fal-037186	Ficedula albicollis	61.28	0.00e+00	747.00
IUUC-Gmo-038824	Gadus morhua	73.17	0.00e+00	673.00
IUUC-Gga-040875	Gallus gallus	91.42	2.00e-152	532.00
IUUC-Gac-042226	Gasterosteus aculeatus	70.69	0.00e+00	986.00
IUUC-Ggo-045122	Gorilla gorilla	63.32	0.00e+00	867.00
IUUC-Hsa-045882	Homo sapiens	63.32	0.00e+00	867.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	63.32	0.00e+00	864.00
IUUC-Lch-049960	Latimeria chalumnae	75.97	7.00e-125	441.00
IUUC-Loc-052408	Lepisosteus oculatus	68.15	2.00e-170	592.00
IUUC-Laf-054187	Loxodonta africana	62.52	0.00e+00	884.00
IUUC-Mcc-055273	Macaca mulatta	62.44	0.00e+00	841.00
IUUC-Meu-056267	Macropus eugenii	88.89	1.00e-141	497.00
IUUC-Mga-059958	Meleagris gallopavo	91.05	2.00e-144	504.00
IUUC-Mmr-061280	Microcebus murinus	63.45	0.00e+00	861.00
IUUC-Mdo-062625	Monodelphis domestica	65.43	0.00e+00	910.00
IUUC-Mmu-063853	Mus musculus	65.39	0.00e+00	686.00
IUUC-Mlu-067771	Myotis lucifugus	66.39	0.00e+00	682.00
IUUC-Opr-070741	Ochotona princeps	63.74	0.00e+00	858.00
IUUC-Ont-072172	Oreochromis niloticus	71.47	0.00e+00	1021.00
IUUC-Oan-073167	Ornithorhynchus anatinus	75.00	6.00e-172	597.00
IUUC-Ocu-074176	Oryctolagus cuniculus	62.58	0.00e+00	843.00
IUUC-Ola-087203	Oryzias latipes	88.64	3.00e-141	494.00
IUUC-Oga-089153	Otolemur garnettii	64.05	0.00e+00	851.00
IUUC-Oar-090008	Ovis aries	62.23	0.00e+00	855.00
IUUC-Ptr-091234	Pan troglodytes	63.32	0.00e+00	867.00
IUUC-Pan-092005	Papio anubis	63.45	0.00e+00	870.00
IUUC-Psi-093995	Pelodiscus sinensis	73.70	2.00e-161	563.00
IUUC-Pma-094110	Petromyzon marinus	83.06	1.00e-60	227.00
IUUC-Pfo-097418	Poecilia formosa	70.66	0.00e+00	995.00
IUUC-Pab-098267	Pongo abelii	63.46	0.00e+00	843.00
IUUC-Pca-101084	Procavia capensis	61.29	0.00e+00	815.00
IUUC-Pva-102292	Pteropus vampyrus	65.87	5.00e-174	604.00
IUUC-Rno-105251	Rattus norvegicus	62.94	0.00e+00	854.00
IUUC-Sha-107100	Sarcophilus harrisii	64.52	0.00e+00	891.00
IUUC-Sar-113559	Sorex araneus	91.36	3.00e-113	402.00
IUUC-Ssc-115688	Sus scrofa	63.57	0.00e+00	852.00
IUUC-Tgu-117424	Taeniopygia guttata	65.18	0.00e+00	887.00
IUUC-Tru-118585	Takifugu rubripes	71.89	0.00e+00	996.00
IUUC-Tsy-119299	Tarsius syrichta	53.58	2.00e-172	599.00
IUUC-Tni-120808	Tetraodon nigroviridis	71.01	0.00e+00	985.00
IUUC-Tbe-127705	Tupaia belangeri	72.40	3.00e-141	494.00
IUUC-Ttr-128225	Tursiops truncatus	62.53	0.00e+00	836.00
IUUC-Vpa-130193	Vicugna pacos	72.69	2.00e-89	323.00
IUUC-Xtr-132449	Xenopus tropicalis	59.16	0.00e+00	798.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence