iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tgu-117472

Ensembl Protein ID

ENSTGUP00000016332.1

UniProt Accession

H1A0C4; H1A0C4_TAEGU

Genbank Protein ID

ENSTGUP00000016332

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01059597

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000015985.1	ENSTGUT00000016648.1	ENSTGUP00000016332.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.10e-13	47.8	438	489

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            +lydy++  dde ++   d+++ i  e  degW++g  + +g+ GlfP+n+v+ l
   Q: 438  VALYDYQGDGDDEISFDPDDTITHI--EMVDEGWWRG--QCHGRVGLFPANYVKLL 489
           58***********************..9*********..7*************977 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

MWKAVVGHNV SVKVEAQGDD WDTDPDFVND ISEREQRWGA KTIEGSGHAG HIDIHQLRNK 60
VSEEHEVIKK KELETGPKAS YGYGGKFGTE RDRMDKCAVG HEYVADVGKH SSQTDAAQGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGAAAG CAGTTGTGGG ACACAATGTG TCAGTGAAAG TGGAGGCTCA GGGAGACGAC 60
TGGGACACGG ACCCTGATTT CGTGGTGAGT GTCTGCTGTG GAAACTCTCA TACTGATGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	54.84	1.00e-142	499.00
IUUC-Bta-012591	Bos taurus	60.89	2.00e-113	402.00
IUUC-Cja-019982	Callithrix jacchus	61.06	1.00e-118	419.00
IUUC-Cfa-020262	Canis familiaris	75.92	7.00e-113	400.00
IUUC-Cpo-021362	Cavia porcellus	78.05	3.00e-116	411.00
IUUC-Csa-023911	Chlorocebus sabaeus	62.89	3.00e-122	431.00
IUUC-Dor-030437	Dipodomys ordii	48.80	3.00e-115	408.00
IUUC-Ete-033160	Echinops telfairi	48.28	1.00e-102	366.00
IUUC-Eca-033269	Equus caballus	56.55	6.00e-136	476.00
IUUC-Eeu-035032	Erinaceus europaeus	43.65	2.00e-67	249.00
IUUC-Fca-035999	Felis catus	61.56	1.00e-120	426.00
IUUC-Fal-037107	Ficedula albicollis	67.00	2.00e-170	591.00
IUUC-Gga-040335	Gallus gallus	76.76	1.00e-116	413.00
IUUC-Ggo-044505	Gorilla gorilla	61.47	4.00e-121	427.00
IUUC-Hsa-046728	Homo sapiens	62.32	3.00e-121	428.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	59.75	2.00e-101	362.00
IUUC-Laf-054202	Loxodonta africana	77.37	1.00e-112	399.00
IUUC-Mcc-055824	Macaca mulatta	62.32	3.00e-121	428.00
IUUC-Mmr-061281	Microcebus murinus	67.76	3.00e-91	328.00
IUUC-Mdo-062515	Monodelphis domestica	55.56	1.00e-122	432.00
IUUC-Mmu-064341	Mus musculus	51.54	1.00e-136	479.00
IUUC-Mpu-066565	Mustela putorius furo	76.33	1.00e-112	399.00
IUUC-Mlu-066942	Myotis lucifugus	76.73	2.00e-112	399.00
IUUC-Nle-069436	Nomascus leucogenys	62.04	7.00e-121	427.00
IUUC-Opr-070288	Ochotona princeps	51.53	1.00e-114	405.00
IUUC-Ocu-074686	Oryctolagus cuniculus	78.19	3.00e-114	405.00
IUUC-Ola-086894	Oryzias latipes	58.74	1.00e-91	330.00
IUUC-Oga-088585	Otolemur garnettii	51.29	8.00e-132	463.00
IUUC-Oar-089686	Ovis aries	57.29	7.00e-140	489.00
IUUC-Ptr-090461	Pan troglodytes	62.32	9.00e-122	429.00
IUUC-Pan-091887	Papio anubis	62.61	1.00e-122	432.00
IUUC-Psi-093785	Pelodiscus sinensis	56.62	8.00e-158	549.00
IUUC-Pab-098222	Pongo abelii	60.91	4.00e-119	421.00
IUUC-Pca-100668	Procavia capensis	56.94	7.00e-137	480.00
IUUC-Pva-102767	Pteropus vampyrus	62.96	6.00e-88	317.00
IUUC-Rno-106001	Rattus norvegicus	55.58	1.00e-142	499.00
IUUC-Sar-113338	Sorex araneus	47.54	5.00e-111	394.00
IUUC-Ssc-116027	Sus scrofa	56.55	2.00e-140	491.00
IUUC-Tre-122167	Trichoderma reesei	59.18	7.00e-12	65.90

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence