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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063950
UUCD1 version UUC-MuM-00006
Ensembl Protein ID ENSMUSP00000107732.1
UniProt Accession O70583; B1AV00; O35418; Q7TPT6; TRI18_MOUSE
Genbank Protein ID CAA75113.1; AAB83986.1; CAM15638.1; CAM15638.1; CAM28195.1; CAM28195.1; AAH53704.1
Protein Name E3 ubiquitin-protein ligase Midline-1; Midin; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; Tripartite motif-containing protein 18
Genbank Nucleotide ID Y14848; AF026565; AL672015; CR478112; CR478112; AL672015; BC053704
Gene Name Mid1; Fxy; Trim18
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000035299.16 ENSMUST00000112104.7 ENSMUSP00000107732.1
ENSMUSG00000035299.16 ENSMUST00000078947.11 ENSMUSP00000077974.5
ENSMUSG00000035299.16 ENSMUST00000112107.7 ENSMUSP00000107735.1
ENSMUSG00000035299.16 ENSMUST00000079443.5 ENSMUSP00000078412.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20181585
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.20e-07 33.2 10 60
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw......pglknssskefrCPlCr 46
           C+iCle f+d pl+lpC H  +++C +++       + + +s ++f+CP+Cr
   Q: 10   CPICLELFED-PLLLPCAHSLCFNCAHRIlvshcaTNEPVESINAFQCPTCR 60
           **********.999************99999****999999**********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
 Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
Protein Sequence
(Fasta)
METLESELTC PICLELFEDP LLLPCAHSLC FNCAHRILVS HCATNEPVES INAFQCPTCR 60
HVITLSQRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSET RRERAFDANT MSSAEKVLCQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063950|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATTCCCAGC TGGACAGAGC AAGCTTCCTG AACGCCCCAG CCATTCAGCT GATCCGAGGC 60
GAAGAGCAGT CTGTACTTGC CCCGGAGCAG CCTCCTTGGA GGACCCACAG GTTTGATTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063950|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003649--Bbox_C
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR027727--MID1
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50853--FN3
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00041--fn3
PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00502--BBC
SM00336--BBOX
SM00060--FN3
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005881--C:cytoplasmic microtubule
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0042802--F:identical protein binding
GO:0008017--F:microtubule binding
GO:0051219--F:phosphoprotein binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0016740--F:transferase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0032874--P:positive regulation of stress-activated MAPK cascade
GO:0035372--P:protein localization to microtubule
KEGG mmu:17318
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001734 Ailuropoda melanoleuca 91.03 0.00e+00 1265.00
IUUC-Apl-004060 Anas platyrhynchos 90.41 0.00e+00 1262.00
IUUC-Aca-005182 Anolis carolinensis 90.29 0.00e+00 1269.00
IUUC-Ame-010973 Astyanax mexicanus 78.23 0.00e+00 1108.00
IUUC-Bta-013266 Bos taurus 92.94 0.00e+00 1296.00
IUUC-Cja-019993 Callithrix jacchus 93.24 0.00e+00 1295.00
IUUC-Cfa-020747 Canis familiaris 93.09 0.00e+00 1299.00
IUUC-Cpo-021998 Cavia porcellus 93.53 0.00e+00 1305.00
IUUC-Csa-023229 Chlorocebus sabaeus 93.38 0.00e+00 1303.00
IUUC-Cin-025118 Ciona intestinalis 40.94 9.00e-154 537.00
IUUC-Csv-026320 Ciona savignyi 40.96 1.00e-152 533.00
IUUC-Dre-027831 Danio rerio 75.76 0.00e+00 1075.00
IUUC-Dno-028977 Dasypus novemcinctus 92.65 0.00e+00 1294.00
IUUC-Dor-030720 Dipodomys ordii 97.90 0.00e+00 837.00
IUUC-Ete-032898 Echinops telfairi 85.15 0.00e+00 1161.00
IUUC-Eca-033732 Equus caballus 92.79 0.00e+00 1295.00
IUUC-Fca-036267 Felis catus 93.09 0.00e+00 1300.00
IUUC-Fal-037274 Ficedula albicollis 90.56 0.00e+00 1263.00
IUUC-Gga-040837 Gallus gallus 90.27 0.00e+00 1256.00
IUUC-Gac-041958 Gasterosteus aculeatus 78.14 0.00e+00 1136.00
IUUC-Ggo-044572 Gorilla gorilla 83.72 0.00e+00 1177.00
IUUC-Hsa-045947 Homo sapiens 93.38 0.00e+00 1303.00
IUUC-Lch-049502 Latimeria chalumnae 87.73 0.00e+00 1032.00
IUUC-Loc-052454 Lepisosteus oculatus 85.90 0.00e+00 1192.00
IUUC-Laf-053708 Loxodonta africana 93.54 0.00e+00 1313.00
IUUC-Mcc-055664 Macaca mulatta 93.24 0.00e+00 1300.00
IUUC-Meu-056180 Macropus eugenii 86.32 0.00e+00 1199.00
IUUC-Mga-059764 Meleagris gallopavo 89.71 0.00e+00 1242.00
IUUC-Mmr-060771 Microcebus murinus 92.94 0.00e+00 1298.00
IUUC-Mdo-062566 Monodelphis domestica 91.18 0.00e+00 1276.00
IUUC-Mpu-065690 Mustela putorius furo 92.79 0.00e+00 1296.00
IUUC-Mlu-067067 Myotis lucifugus 90.95 0.00e+00 1291.00
IUUC-Nle-069446 Nomascus leucogenys 93.24 0.00e+00 1302.00
IUUC-Ont-072567 Oreochromis niloticus 79.68 0.00e+00 1118.00
IUUC-Oan-073348 Ornithorhynchus anatinus 90.59 0.00e+00 1268.00
IUUC-Ola-087138 Oryzias latipes 77.91 0.00e+00 1109.00
IUUC-Oga-088162 Otolemur garnettii 92.79 0.00e+00 1298.00
IUUC-Oar-090200 Ovis aries 91.67 0.00e+00 1296.00
IUUC-Ptr-091126 Pan troglodytes 93.24 0.00e+00 1296.00
IUUC-Pan-091898 Papio anubis 93.38 0.00e+00 1303.00
IUUC-Psi-093184 Pelodiscus sinensis 89.56 0.00e+00 1262.00
IUUC-Pma-094517 Petromyzon marinus 25.69 2.00e-50 194.00
IUUC-Pfo-097477 Poecilia formosa 78.27 0.00e+00 1117.00
IUUC-Pab-098582 Pongo abelii 93.24 0.00e+00 1301.00
IUUC-Pca-100517 Procavia capensis 97.63 0.00e+00 738.00
IUUC-Pva-103254 Pteropus vampyrus 94.86 0.00e+00 1078.00
IUUC-Rno-105259 Rattus norvegicus 93.68 0.00e+00 1301.00
IUUC-Sha-107060 Sarcophilus harrisii 91.39 0.00e+00 1267.00
IUUC-Sar-113538 Sorex araneus 91.15 0.00e+00 1273.00
IUUC-Ssc-115887 Sus scrofa 92.79 0.00e+00 1295.00
IUUC-Tgu-116818 Taeniopygia guttata 90.56 0.00e+00 1263.00
IUUC-Tru-117868 Takifugu rubripes 78.65 0.00e+00 1075.00
IUUC-Tsy-119648 Tarsius syrichta 93.38 0.00e+00 1303.00
IUUC-Tni-120841 Tetraodon nigroviridis 77.37 0.00e+00 1099.00
IUUC-Tbe-127963 Tupaia belangeri 87.94 0.00e+00 1242.00
IUUC-Ttr-129089 Tursiops truncatus 92.65 0.00e+00 1293.00
IUUC-Vpa-130092 Vicugna pacos 89.12 0.00e+00 1226.00
IUUC-Xtr-132778 Xenopus tropicalis 87.46 0.00e+00 1033.00
Created Date 25-Jun-2017

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