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Tag Content
UUCD2 ID IUUC-Bta-013455
UUCD1 version UUC-BoT-00943
Ensembl Protein ID ENSBTAP00000029915.2
UniProt Accession Q3SWX8; RBBP7_BOVIN
Genbank Protein ID AAI04614.1
Protein Name Histone-binding protein RBBP7; Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7
Genbank Nucleotide ID BC104613
Gene Name RBBP7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000002820.3 ENSBTAT00000029923.2 ENSBTAP00000029915.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 9.70e-38 126.7 271 305
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtg 33
           Ht++v+cl+f   s+ +l++Gs D+t+ +WDlr  
   Q: 271  HTAEVNCLSFnpySEFILATGSADKTVALWDLRNL 305
           **********96554568*************9875 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity).
 Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity).
Protein Sequence
(Fasta)
MASKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALQ WPSLTVQWLP EVTKPEGKDY 60
ALHWLVLGTH TSDEQNHLVV ARVHIPNDDA QFDASHCDSE KGEFGGFGSV TGKIECEIKI 120
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Protein Fasta Sequence


>IUUC-Bta-013455|E3,WD_repeat|Bos taurus
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Nucleotide Sequence
(Fasta)
CTGGGAGGCG CGGGTTGAAA AGTCTCGTTC CAAGTTTGGA GAGAGAGAGA AGAGCGCCTC 60
AGACCTCGGT ACCCGCAAGC GGGGAGGAGG CATCAGAGAA GGACGCAGCG TCTGGGGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-013455|E3,WD_repeat|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0143--Chaperone
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0235--DNA replication
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0035098--C:ESC/E(Z) complex
GO:0016581--C:NuRD complex
GO:0003723--F:RNA binding
GO:0070370--P:cellular heat acclimation
GO:0016569--P:covalent chromatin modification
GO:0006260--P:DNA replication
GO:0030308--P:negative regulation of cell growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG bta:537402
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001256 Ailuropoda melanoleuca 99.05 0.00e+00 867.00
IUUC-Apl-003357 Anas platyrhynchos 92.31 0.00e+00 809.00
IUUC-Cja-019957 Callithrix jacchus 98.82 0.00e+00 864.00
IUUC-Cfa-020917 Canis familiaris 99.05 0.00e+00 867.00
IUUC-Cpo-022173 Cavia porcellus 99.53 0.00e+00 877.00
IUUC-Csa-023738 Chlorocebus sabaeus 99.53 0.00e+00 877.00
IUUC-Dno-029206 Dasypus novemcinctus 99.29 0.00e+00 875.00
IUUC-Dor-030733 Dipodomys ordii 85.55 0.00e+00 733.00
IUUC-Eca-034138 Equus caballus 99.05 0.00e+00 867.00
IUUC-Fca-035977 Felis catus 99.05 0.00e+00 867.00
IUUC-Fal-037538 Ficedula albicollis 90.28 0.00e+00 798.00
IUUC-Gga-040764 Gallus gallus 93.88 0.00e+00 828.00
IUUC-Hsa-045677 Homo sapiens 99.53 0.00e+00 877.00
IUUC-Itr-048060 Ictidomys tridecemlineatus 99.52 0.00e+00 864.00
IUUC-Kpa-049258 Komagataella pastoris 36.65 5.00e-71 261.00
IUUC-Laf-053973 Loxodonta africana 98.83 0.00e+00 868.00
IUUC-Mcc-055687 Macaca mulatta 99.53 0.00e+00 877.00
IUUC-Mga-059209 Meleagris gallopavo 91.06 0.00e+00 795.00
IUUC-Mmr-061008 Microcebus murinus 98.82 0.00e+00 866.00
IUUC-Mdo-062817 Monodelphis domestica 96.24 0.00e+00 849.00
IUUC-Mmu-063773 Mus musculus 99.29 0.00e+00 875.00
IUUC-Mpu-066722 Mustela putorius furo 99.05 0.00e+00 866.00
IUUC-Mlu-067813 Myotis lucifugus 99.05 0.00e+00 867.00
IUUC-Nle-070023 Nomascus leucogenys 98.82 0.00e+00 866.00
IUUC-Oan-073579 Ornithorhynchus anatinus 95.29 0.00e+00 842.00
IUUC-Ocu-074778 Oryctolagus cuniculus 99.29 0.00e+00 876.00
IUUC-Oga-088987 Otolemur garnettii 91.73 0.00e+00 781.00
IUUC-Oar-090250 Ovis aries 99.29 0.00e+00 865.00
IUUC-Ptr-091598 Pan troglodytes 99.29 0.00e+00 865.00
IUUC-Pan-092412 Papio anubis 99.53 0.00e+00 877.00
IUUC-Psi-093162 Pelodiscus sinensis 95.13 0.00e+00 771.00
IUUC-Pab-097865 Pongo abelii 99.53 0.00e+00 877.00
IUUC-Pva-102369 Pteropus vampyrus 99.05 0.00e+00 868.00
IUUC-Rno-105892 Rattus norvegicus 99.53 0.00e+00 877.00
IUUC-Sha-107575 Sarcophilus harrisii 95.29 0.00e+00 839.00
IUUC-Sar-113236 Sorex araneus 90.60 0.00e+00 765.00
IUUC-Ssc-116352 Sus scrofa 99.05 0.00e+00 868.00
IUUC-Tsy-118854 Tarsius syrichta 98.82 0.00e+00 865.00
IUUC-Tbe-128010 Tupaia belangeri 87.68 0.00e+00 758.00
IUUC-Ttr-128558 Tursiops truncatus 87.14 0.00e+00 740.00
IUUC-Vpa-130664 Vicugna pacos 99.29 0.00e+00 864.00
Created Date 25-Jun-2017

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