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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046351
Ensembl Protein ID ENSP00000365543.5
UniProt Accession Q9Y484; A6NGH5; B7WPI2; Q5MNZ5; Q6IBS7; Q6NT94; Q96H03; WIPI4_HUMAN
Genbank Protein ID AAV80764.1; CAA06754.1; CAG33006.1; EAW50697.1; EAW50702.1; AAH00464.1; AAH03037.1; AAH09027.1; AAH69206.1
Protein Name WD repeat domain phosphoinositide-interacting protein 4; WD repeat-containing protein 45
Genbank Nucleotide ID AY691428; AJ005897; CR456725; AF196779; CH471224; BC000464; BC003037; BC009027; BC069206
Gene Name WDR45; WDRX1; WDRXI4; WIPI4; JM5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000196998.17 ENST00000376358.4 ENSP00000365536.3
ENSG00000196998.17 ENST00000376372.8 ENSP00000365551.3
ENSG00000196998.17 ENST00000475977.2 ENSP00000417754.2
ENSG00000196998.17 ENST00000635003.1 ENSP00000489080.1
ENSG00000196998.17 ENST00000634838.1 ENSP00000489268.1
ENSG00000196998.17 ENST00000486337.6 ENSP00000419453.2
ENSG00000196998.17 ENST00000634559.1 ENSP00000488986.1
ENSG00000196998.17 ENST00000322995.13 ENSP00000365543.5
ENSG00000196998.17 ENST00000356463.7 ENSP00000348848.3
ENSG00000196998.17 ENST00000485908.6 ENSP00000419897.1
ENSG00000196998.17 ENST00000367375.8 ENSP00000356345.4
ENSG00000196998.17 ENST00000473974.5 ENSP00000417211.1
ENSG00000196998.17 ENST00000396681.9 ENSP00000379913.5
ENSG00000196998.17 ENST00000634736.1 ENSP00000489561.1
ENSG00000196998.17 ENST00000635666.1 ENSP00000489128.1
ENSG00000196998.17 ENST00000475880.6 ENSP00000418919.2
ENSG00000196998.17 ENST00000635344.1 ENSP00000489553.1
ENSG00000196998.17 ENST00000419567.7 ENSP00000393640.3
ENSG00000196998.17 ENST00000634522.1 ENSP00000489330.1
ENSG00000196998.17 ENST00000474053.6 ENSP00000420728.1
ENSG00000196998.17 ENST00000423215.3 ENSP00000397657.3
ENSG00000196998.17 ENST00000476728.5 ENSP00000419324.1
ENSG00000196998.17 ENST00000634849.1 ENSP00000489150.1
ENSG00000196998.17 ENST00000634671.1 ENSP00000489040.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDHINTMentha
Disease-associated Variation
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMPhosphositePlusdbPTMBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.20e-09 38.0 202 234
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgt.ikvWDlr 31
           H++++ c+++  ++t ++s+s  gt i+++D+ 
   Q: 202  HQSDIACVSLnqPGTVVASASQKGTlIRLFDTQ 234
           9*********9877*****************76 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.
 Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.
Protein Sequence
(Fasta)
MTQQPLRGVT SLRFNQDQSC FCCAMETGVR IYNVEPLMEK GHLDHEQVGS MGLVEMLHRS 60
NLLALVGGGS SPKFSEISVL IWDDAREGKD SKEKLVLEFT FTKPVLSVRM RHDKIVIVLK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046351|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTCAGTGCCT GGGCTCCGGG AAAGTCGTGC TTTTACGGTT CCGGGTACTG GCTCCCACAC 60
CACTGCCTCG TGTGGGGTTG TTCGCCCGTG AAGGGGCAGG ACAGGGTGCG CGCTGGTGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046351|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0523--Neurodegeneration
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR032910--WIPI4
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0006914--P:autophagy
KEGG hsa:11152
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001633 Ailuropoda melanoleuca 95.69 0.00e+00 734.00
IUUC-Aca-005110 Anolis carolinensis 90.84 0.00e+00 699.00
IUUC-Bta-013273 Bos taurus 96.23 0.00e+00 736.00
IUUC-Cja-018761 Callithrix jacchus 98.92 0.00e+00 761.00
IUUC-Cfa-020565 Canis familiaris 95.15 0.00e+00 727.00
IUUC-Cpo-021801 Cavia porcellus 95.42 0.00e+00 730.00
IUUC-Csa-023657 Chlorocebus sabaeus 97.04 0.00e+00 739.00
IUUC-Cin-025682 Ciona intestinalis 57.85 6.00e-122 430.00
IUUC-Dre-027718 Danio rerio 87.33 0.00e+00 674.00
IUUC-Dno-029199 Dasypus novemcinctus 95.15 0.00e+00 725.00
IUUC-Dor-030931 Dipodomys ordii 95.38 0.00e+00 708.00
IUUC-Ete-032303 Echinops telfairi 97.86 0.00e+00 660.00
IUUC-Eca-034053 Equus caballus 95.42 0.00e+00 731.00
IUUC-Fca-036502 Felis catus 95.70 0.00e+00 730.00
IUUC-Gmo-038583 Gadus morhua 87.06 0.00e+00 672.00
IUUC-Gac-042546 Gasterosteus aculeatus 87.15 0.00e+00 645.00
IUUC-Ggo-045610 Gorilla gorilla 100.00 0.00e+00 772.00
IUUC-Itr-048533 Ictidomys tridecemlineatus 95.69 0.00e+00 733.00
IUUC-Lch-050439 Latimeria chalumnae 85.91 0.00e+00 663.00
IUUC-Loc-052269 Lepisosteus oculatus 88.14 0.00e+00 679.00
IUUC-Laf-054475 Loxodonta africana 95.42 0.00e+00 730.00
IUUC-Mcc-055829 Macaca mulatta 97.04 0.00e+00 739.00
IUUC-Mmr-061021 Microcebus murinus 95.76 0.00e+00 745.00
IUUC-Mmu-063935 Mus musculus 94.88 0.00e+00 727.00
IUUC-Mpu-066555 Mustela putorius furo 95.96 0.00e+00 736.00
IUUC-Mlu-067797 Myotis lucifugus 94.07 0.00e+00 716.00
IUUC-Ont-071532 Oreochromis niloticus 87.60 0.00e+00 677.00
IUUC-Ola-086343 Oryzias latipes 86.25 0.00e+00 667.00
IUUC-Oga-088001 Otolemur garnettii 95.96 0.00e+00 734.00
IUUC-Oar-090011 Ovis aries 97.57 0.00e+00 743.00
IUUC-Pan-092470 Papio anubis 97.04 0.00e+00 739.00
IUUC-Pma-094403 Petromyzon marinus 78.12 8.00e-168 583.00
IUUC-Pfo-096982 Poecilia formosa 86.79 0.00e+00 671.00
IUUC-Pca-100176 Procavia capensis 87.60 0.00e+00 656.00
IUUC-Pva-102156 Pteropus vampyrus 97.04 0.00e+00 744.00
IUUC-Rno-105782 Rattus norvegicus 95.42 0.00e+00 731.00
IUUC-Ssc-116318 Sus scrofa 96.23 0.00e+00 736.00
IUUC-Tru-118633 Takifugu rubripes 87.33 0.00e+00 673.00
IUUC-Tsy-119533 Tarsius syrichta 99.03 2.00e-120 424.00
IUUC-Tni-119984 Tetraodon nigroviridis 88.49 0.00e+00 675.00
IUUC-Ttr-128703 Tursiops truncatus 97.76 9.00e-128 449.00
IUUC-Xtr-131754 Xenopus tropicalis 84.91 2.00e-180 624.00
Created Date 25-Jun-2017

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