iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000089820.15	ENST00000393721.5	ENSP00000377322.1
ENSG00000089820.15	ENST00000370028.7	ENSP00000359045.3
ENSG00000089820.15	ENST00000420383.5	ENSP00000397533.1
ENSG00000089820.15	ENST00000350060.9	ENSP00000203786.7
ENSG00000089820.15	ENST00000370016.5	ENSP00000359033.1
ENSG00000089820.15	ENST00000404127.6	ENSP00000385042.2
ENSG00000089820.15	ENST00000454164.5	ENSP00000412437.1
ENSG00000089820.15	ENST00000442172.1	ENSP00000408656.1
ENSG00000089820.15	ENST00000422918.5	ENSP00000398019.1
ENSG00000089820.15	ENST00000418750.5	ENSP00000411712.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
HINT	InWeb_IM
Disease-associated Variation
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.60e-10	40.7	175	223

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           + + y++ +  eL++++Gdv+++   e  + +W++g  e +g rGl+P+ +++
   Q: 175  ACFAYTGRTAQELSFRRGDVLRLH--ERASSDWWRG--EHNGMRGLIPHKYIT 223
           789********************5..99********..9************96 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

XLAPSTQFPA PGMGGHPGGA GEDAQCPPAP CPPTGLQHEG IFRVSGAQLR VSEIRDAFER 60
GEDPLVEGCT AHDLDSVAGV LKLYFRSLEP PLFPPDLFGE LLASSELEAT AERVEHVSRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCCAGCCC CGGCCGTCCC GGCGTCGCTT CGGAGCGCGG CGGCAGCTGA CTGCGCCTTC 60
ACGATCCGCT GGGACCCGCG AGCCCCGCCG CCGTTATGAA CATCCGCAAT GCGAGGGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
IPR001452--SH3_domain

PROSITE

PS50238--RHOGAP
PS50002--SH3

Pfam

PF00620--RhoGAP
PF00018--SH3_1

SMART

SM00324--RhoGAP
SM00326--SH3

Gene Ontology

GO:0007165--P:signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011131	Astyanax mexicanus	52.73	5.00e-30	126.00
IUUC-Bta-012780	Bos taurus	87.39	2.00e-41	164.00
IUUC-Mmu-064211	Mus musculus	80.63	5.00e-76	276.00
IUUC-Ssc-115790	Sus scrofa	87.39	2.00e-42	168.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence