iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020430

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

AAEX03011649

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000014729.3	ENSCAFT00000023395.3	ENSCAFP00000021726.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.30e-51	174.1	81	271

Active Site

Position(s)	Description	Evidence
88	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
91	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
265		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 81   YIRKTRPDGNCFYRAFGFShleallddskelqrfkavsakskedlvsqgfteftiedfhntfmdlieqvekqtsvadLLASFNDQSTSD 169
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +
   Q: 170  YLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHIFPEGS-E 254
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 255  PKVYLLYRPGHYDILYK 271
           ***************96 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

KAAEEPQQQK QELFGFLLPG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE 60
YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGGCGGCGG AGGAGCCTCA GCAGCAGAAG CAGGAGCTGC CGCCGCCGCC GCCGCCGCGA 60
CCCCCGGCCC GTGGGGCGGA CGGGCGAGCG GGCCGGGCGG GCCCGGGCCC GTGGCTCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	96.69	3.00e-153	534.00
IUUC-Apl-003233	Anas platyrhynchos	58.46	5.00e-19	85.10
IUUC-Aca-004648	Anolis carolinensis	85.66	4.00e-136	476.00
IUUC-Aly-005710	Arabidopsis lyrata	42.22	9.00e-52	196.00
IUUC-Ath-007112	Arabidopsis thaliana	42.07	9.00e-51	193.00
IUUC-Afl-008439	Aspergillus flavus	34.18	2.00e-08	52.80
IUUC-Ame-010662	Astyanax mexicanus	85.32	9.00e-129	452.00
IUUC-Bta-013533	Bos taurus	98.81	1.00e-148	518.00
IUUC-Bol-016100	Brassica oleracea	42.05	3.00e-50	192.00
IUUC-Bra-017705	Brassica rapa	39.15	4.00e-45	174.00
IUUC-Cel-018295	Caenorhabditis elegans	35.78	3.00e-41	161.00
IUUC-Cja-019190	Callithrix jacchus	100.00	5.00e-150	523.00
IUUC-Cpo-022355	Cavia porcellus	99.60	8.00e-150	522.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	39.56	4.00e-46	177.00
IUUC-Csa-023286	Chlorocebus sabaeus	96.55	2.00e-147	514.00
IUUC-Cin-025507	Ciona intestinalis	43.33	2.00e-44	171.00
IUUC-Csv-026273	Ciona savignyi	49.80	7.00e-69	253.00
IUUC-Dre-027843	Danio rerio	79.32	1.00e-125	442.00
IUUC-Dno-029165	Dasypus novemcinctus	99.00	1.00e-117	414.00
IUUC-Dor-030943	Dipodomys ordii	99.60	8.00e-150	522.00
IUUC-Dme-031922	Drosophila melanogaster	56.40	3.00e-78	284.00
IUUC-Ete-032296	Echinops telfairi	96.23	1.00e-89	322.00
IUUC-Eca-033695	Equus caballus	98.82	2.00e-149	521.00
IUUC-Fca-036441	Felis catus	98.82	1.00e-149	521.00
IUUC-Gmo-038908	Gadus morhua	78.97	7.00e-126	442.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.41	1.00e-32	134.00
IUUC-Gga-040460	Gallus gallus	80.37	2.00e-129	454.00
IUUC-Gac-042417	Gasterosteus aculeatus	81.20	2.00e-122	431.00
IUUC-Gma-043712	Glycine max	42.01	6.00e-51	194.00
IUUC-Ggo-044552	Gorilla gorilla	100.00	1.00e-92	332.00
IUUC-Hsa-046766	Homo sapiens	100.00	5.00e-150	523.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	99.60	8.00e-150	522.00
IUUC-Lch-050602	Latimeria chalumnae	78.36	2.00e-120	425.00
IUUC-Laf-053705	Loxodonta africana	99.60	8.00e-150	522.00
IUUC-Mcc-055745	Macaca mulatta	93.33	2.00e-146	511.00
IUUC-Meu-056569	Macropus eugenii	83.33	2.00e-129	454.00
IUUC-Mtr-057712	Medicago truncatula	43.49	1.00e-46	179.00
IUUC-Mvi-060358	Microbotryum violaceum	33.94	4.00e-15	75.50
IUUC-Mmr-061123	Microcebus murinus	99.53	1.00e-123	435.00
IUUC-Mdo-062613	Monodelphis domestica	85.19	3.00e-118	417.00
IUUC-Mmu-063658	Mus musculus	99.60	8.00e-150	522.00
IUUC-Mac-065274	Musa acuminata	37.60	3.00e-39	155.00
IUUC-Mpu-066172	Mustela putorius furo	100.00	5.00e-150	523.00
IUUC-Mlu-066966	Myotis lucifugus	99.60	2.00e-149	521.00
IUUC-Nle-069519	Nomascus leucogenys	88.17	3.00e-93	335.00
IUUC-Ont-071901	Oreochromis niloticus	82.47	6.00e-125	439.00
IUUC-Ola-087331	Oryzias latipes	80.90	7.00e-86	309.00
IUUC-Oga-088064	Otolemur garnettii	100.00	5.00e-150	523.00
IUUC-Oar-089251	Ovis aries	98.80	4.00e-147	513.00
IUUC-Ptr-091430	Pan troglodytes	100.00	5.00e-150	523.00
IUUC-Psi-093823	Pelodiscus sinensis	89.49	5.00e-135	473.00
IUUC-Pma-094366	Petromyzon marinus	71.64	2.00e-102	365.00
IUUC-Pfo-096734	Poecilia formosa	80.88	6.00e-114	403.00
IUUC-Pab-097919	Pongo abelii	100.00	3.00e-123	434.00
IUUC-Pop-099401	Populus trichocarpa	41.24	2.00e-48	185.00
IUUC-Ppe-101977	Prunus persica	42.38	2.00e-51	196.00
IUUC-Pva-102499	Pteropus vampyrus	100.00	5.00e-149	519.00
IUUC-Rno-105233	Rattus norvegicus	99.60	8.00e-150	522.00
IUUC-Sha-107081	Sarcophilus harrisii	98.41	3.00e-148	517.00
IUUC-Sly-111640	Solanum lycopersicum	42.01	3.00e-49	188.00
IUUC-Ssc-116202	Sus scrofa	100.00	5.00e-150	523.00
IUUC-Tru-117664	Takifugu rubripes	76.09	2.00e-121	428.00
IUUC-Tca-121467	Theobroma cacao	41.54	2.00e-50	192.00
IUUC-Tbe-128116	Tupaia belangeri	98.76	2.00e-93	335.00
IUUC-Ttr-128622	Tursiops truncatus	99.21	2.00e-147	514.00
IUUC-Vvi-131389	Vitis vinifera	43.75	6.00e-53	200.00
IUUC-Xma-134191	Xiphophorus maculatus	81.27	5.00e-115	407.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence