iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093595

Ensembl Protein ID

ENSPSIP00000011135.1

UniProt Accession

K7FSX5; K7FSX5_PELSI

Genbank Protein ID

ENSPSIP00000011135

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01143480

Gene Name

VAV1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000009779.1	ENSPSIT00000011191.1	ENSPSIP00000011135.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.80e-13	49.6	789	825

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgv 44
           ++ yd+ a +  eLtlk+Gd+++++  ++  +gW+kg+
   Q: 789  KARYDFCARDWTELTLKEGDIMKIL-SKKGQQGWWKGE 825
           688**********************.88999*****94 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MELWKQCAHW LIQCRVLPPN HRVTWPSAQV CDLAQALRDG VLLCQLLNNL MPHAVNLREI 60
NLRPQMSQFL CLKNIRTFLS TCCEKFGLRK NELFEVFDLF DVRDFGKVIE TLSILSWTQI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCTGT GGAAGCAATG CGCCCACTGG CTGATCCAGT GCCGGGTGCT GCCCCCCAAC 60
CACCGGGTGA CCTGGCCCAG CGCCCAGGTG TGCGACCTGG CCCAGGCCCT GCGGGACGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR028530--Vav

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0045785--P:positive regulation of cell adhesion
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013049	Bos taurus	66.88	0.00e+00	1003.00
IUUC-Cja-020009	Callithrix jacchus	79.21	0.00e+00	1340.00
IUUC-Cfa-020768	Canis familiaris	78.49	0.00e+00	1294.00
IUUC-Dno-029602	Dasypus novemcinctus	77.34	0.00e+00	1298.00
IUUC-Eca-033682	Equus caballus	78.85	0.00e+00	1304.00
IUUC-Fca-035629	Felis catus	77.79	0.00e+00	1343.00
IUUC-Gmo-039693	Gadus morhua	58.98	0.00e+00	938.00
IUUC-Gac-041567	Gasterosteus aculeatus	64.36	0.00e+00	982.00
IUUC-Hsa-045886	Homo sapiens	79.21	0.00e+00	1342.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	75.72	0.00e+00	1237.00
IUUC-Loc-051761	Lepisosteus oculatus	70.93	0.00e+00	1199.00
IUUC-Laf-054537	Loxodonta africana	78.49	0.00e+00	1335.00
IUUC-Mcc-054726	Macaca mulatta	78.97	0.00e+00	1339.00
IUUC-Mmr-060980	Microcebus murinus	77.03	0.00e+00	1288.00
IUUC-Mdo-061926	Monodelphis domestica	76.48	0.00e+00	1136.00
IUUC-Mmu-063942	Mus musculus	77.64	0.00e+00	1293.00
IUUC-Mpu-066000	Mustela putorius furo	78.49	0.00e+00	1293.00
IUUC-Mlu-067818	Myotis lucifugus	77.09	0.00e+00	1298.00
IUUC-Ont-072213	Oreochromis niloticus	65.95	0.00e+00	1074.00
IUUC-Obr-076170	Oryza brachyantha	37.78	1.30e-01	30.00
IUUC-Ola-087345	Oryzias latipes	63.09	0.00e+00	1033.00
IUUC-Oga-089104	Otolemur garnettii	78.73	0.00e+00	1309.00
IUUC-Oar-089459	Ovis aries	78.34	0.00e+00	1319.00
IUUC-Ptr-090766	Pan troglodytes	78.53	0.00e+00	1231.00
IUUC-Pan-091994	Papio anubis	77.91	0.00e+00	1314.00
IUUC-Pfo-097210	Poecilia formosa	64.71	0.00e+00	1058.00
IUUC-Pab-098630	Pongo abelii	79.18	0.00e+00	1340.00
IUUC-Pva-102406	Pteropus vampyrus	76.39	0.00e+00	1244.00
IUUC-Rno-105763	Rattus norvegicus	75.60	0.00e+00	1244.00
IUUC-Sha-106683	Sarcophilus harrisii	77.07	0.00e+00	1328.00
IUUC-Ssc-115338	Sus scrofa	78.43	0.00e+00	1227.00
IUUC-Tru-118199	Takifugu rubripes	62.51	0.00e+00	995.00
IUUC-Tni-120548	Tetraodon nigroviridis	63.50	0.00e+00	1013.00
IUUC-Vpa-130066	Vicugna pacos	56.19	4.00e-62	232.00
IUUC-Xtr-132410	Xenopus tropicalis	70.13	0.00e+00	1192.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence