iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013083

UUCD1 version

UUC-BoT-00504

Ensembl Protein ID

ENSBTAP00000054004.1

UniProt Accession

Q7YRV4; A4FV39; RO52_BOVIN

Genbank Protein ID

AAP79314.1; AAX46732.1; AAI23701.1

Protein Name

E3 ubiquitin-protein ligase TRIM21; 52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; RING-type E3 ubiquitin transferase TRIM21; Ro(SS-A); Sjoegren syndrome type A antigen; Tripartite motif-containing protein 21

Genbank Nucleotide ID

AY312278; BT021885; BC123700

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000013900.5	ENSBTAT00000063640.1	ENSBTAP00000054004.1
ENSBTAG00000013900.5	ENSBTAT00000018459.4	ENSBTAP00000018459.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.00e-08	33.7	24	86
E3 activity/RING/RING	6.80e-08	33.0	28	67

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliq 66
           ee  C+I l++M +P+ +++G+++ +++I +  ++gg+ cPv+r+++  ++l Pn  + ++++
   Q: 24   EEVTCSICLDPMVEPMSIECGHSFCQECISEVGKEGGSVCPVCRRHFLLQNLRPNRQVANMVD 86
           6889***************************99**********************99888776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+++ + p++  CgH f+++C+  +      + +   CP+Cr
   Q: 28   CSICLDPMVE-PMSIECGHSFCQECISEV-----GKEGGSVCPVCR 67
           ********99.***************999.....6778888****8 PP

Organism

Bos taurus

Functional Description
(View)

Functional Description

E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses.

Protein Sequence
(Fasta)

ISPALLKRSI TPMASAVPLT MMWEEVTCSI CLDPMVEPMS IECGHSFCQE CISEVGKEGG 60
SVCPVCRRHF LLQNLRPNRQ VANMVDNLRK ISQGAKESPH GELCVVHREK IHLFCEEDGK 120

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Nucleotide Sequence
(Fasta)

CAGCTCCTTA TTTCACTTTC CTGGCTGCTC GAAAAGGTGA GTGAACTTGG CTAGACCGAG 60
GTACCCCAGC TCTCCCTGGG GGACCTCTCT CCCCTGCCCC GGGTCTGAAA AGCCTCATCC 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0694--RNA-binding
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0003677--F:DNA binding
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0034341--P:response to interferon-gamma

KEGG

bta:359715

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	74.05	0.00e+00	766.00
IUUC-Cel-018124	Caenorhabditis elegans	21.85	2.00e-11	63.20
IUUC-Cja-019002	Callithrix jacchus	73.20	0.00e+00	731.00
IUUC-Cfa-020415	Canis familiaris	69.40	0.00e+00	715.00
IUUC-Cpo-021948	Cavia porcellus	63.80	0.00e+00	642.00
IUUC-Csa-023135	Chlorocebus sabaeus	74.40	0.00e+00	677.00
IUUC-Cho-024493	Choloepus hoffmanni	57.86	1.00e-89	322.00
IUUC-Dno-030061	Dasypus novemcinctus	71.88	0.00e+00	723.00
IUUC-Ete-033168	Echinops telfairi	62.76	6.00e-161	560.00
IUUC-Eca-033578	Equus caballus	72.62	0.00e+00	726.00
IUUC-Eeu-034749	Erinaceus europaeus	51.59	2.00e-122	432.00
IUUC-Fca-035468	Felis catus	68.97	0.00e+00	689.00
IUUC-Ggo-045190	Gorilla gorilla	72.60	0.00e+00	692.00
IUUC-Hsa-046583	Homo sapiens	72.60	0.00e+00	695.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	70.72	0.00e+00	675.00
IUUC-Laf-053455	Loxodonta africana	69.46	0.00e+00	655.00
IUUC-Mcc-054609	Macaca mulatta	74.20	0.00e+00	674.00
IUUC-Mmr-061369	Microcebus murinus	67.60	1.00e-173	602.00
IUUC-Mmu-063166	Mus musculus	63.97	2.00e-177	615.00
IUUC-Mpu-066889	Mustela putorius furo	71.80	0.00e+00	744.00
IUUC-Mlu-067647	Myotis lucifugus	72.29	0.00e+00	664.00
IUUC-Nle-069567	Nomascus leucogenys	72.80	0.00e+00	694.00
IUUC-Oar-090413	Ovis aries	90.20	0.00e+00	844.00
IUUC-Ptr-091187	Pan troglodytes	72.60	0.00e+00	695.00
IUUC-Pan-092231	Papio anubis	74.20	0.00e+00	672.00
IUUC-Pab-098079	Pongo abelii	67.80	1.00e-137	482.00
IUUC-Pca-100639	Procavia capensis	65.47	4.00e-137	481.00
IUUC-Ppe-101755	Prunus persica	46.00	3.00e-09	54.30
IUUC-Pva-102476	Pteropus vampyrus	70.66	0.00e+00	697.00
IUUC-Rno-105054	Rattus norvegicus	63.58	3.00e-159	554.00
IUUC-Sar-113204	Sorex araneus	68.20	0.00e+00	627.00
IUUC-Ssc-116291	Sus scrofa	76.65	0.00e+00	750.00
IUUC-Tsy-118803	Tarsius syrichta	68.77	1.00e-132	466.00
IUUC-Ttr-128914	Tursiops truncatus	76.65	0.00e+00	695.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence