iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045571

UUCD1 version

UUC-GoG-01102

Ensembl Protein ID

ENSGGOP00000022583.1

UniProt Accession

G3S3D3; G3S3D3_GORGO

Protein Name

Uncharacterized protein

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000014335.2	ENSGGOT00000022855.1	ENSGGOP00000022583.1
ENSGGOG00000014335.2	ENSGGOT00000014399.2	ENSGGOP00000013996.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.20e-89	299.5	290	899

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++l++ +++l+ +    +s++k+   +++++a++++ae+fsgy
   Q: 290  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLVKKDicNSETKKDLLKKVKNAISATAERFSGY 373
           69*****************************...*****9..679999999999999776567************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+e+++k  nk++++e  + +++++d+   + ++ +++++ ++++++++++i+c++c+++  ++e+f+dls+++
   Q: 374  MQNDAHEFLSQCLDQLKEDMEK-LNKTWKTEPVSGEENSPDI---SATRAYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDL 458
           ********************55.9999999999999999999...7999**************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP+vLilhLkR+sf+ + + ++ki ++v +p+ L+ls++
   Q: 459  PRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSH 542
           *999886545***************9....*********9.89999******************************************* PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 543  CTEntkppftlgwsahmaisrplkasqmvnscitspstpskkftfkskssltlcldsdsedelkrsvalsqrlcemlgneqqqedlekd 631
           ***9999*******999999999999999999999999999999999999999999999999999999999999999988888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 632  sklcpiepdkselensgfdrmseeellaavleiskrdaspslshedddkptsspdtgfaeddiqempenpdtmetekpktiteldpasf 720
           88888888888888888888888888888888888877777777777777777777777777777777777776666666666666666 PP
   S: 268  .............peekqke..................................................................... 274
                        +     +                                                                     
   Q: 721  teitkdcdenkenK-----Tpegsqgevdwlqqydmerereeqelqqalaqslqeqeywrqkysknfykilslyssefnnsfvdalgsd 804
           66666665555550.....0555555566666666666666666666777777777777777777777777777777777777778888 PP
   S: 275  ..............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaY 331
                                         +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e+ v++++++++Y
   Q: 805  edsgnedvfdmeyteaeaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEAAVQSDRDRSGY 893
           888888888888888888888889999999****************************99999************************** PP
   S: 332  vlfYkr 337
           ++fY++
   Q: 894  IFFYMH 899
           ****98 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

LSHNIKNVVL RPSGAKQSRL MLTLQDNSFL SIDKVPSKDA EEMRLFLDAV HQNRLPAAAM 60
KPSQGSGSFG GILGSRTSQK ETSRQLSYSD NQASAKRGSL ETKDDIPFRK VLGNPGRGSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAAGTCATA ACATTAAAAA TGTGGTGCTT CGACCCAGTG GAGCGAAACA AAGCCGCCTA 60
ATGTTAACTC TGCAAGATAA CAGCTTCTTG TCTATTGACA AAGTACCAAG TAAGGATGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N

SMART

SM00726--UIM

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	91.18	0.00e+00	1548.00
IUUC-Apl-004033	Anas platyrhynchos	73.85	0.00e+00	1266.00
IUUC-Aca-005370	Anolis carolinensis	66.24	0.00e+00	1165.00
IUUC-Ame-011884	Astyanax mexicanus	55.39	0.00e+00	886.00
IUUC-Bta-012725	Bos taurus	90.65	0.00e+00	1524.00
IUUC-Cja-019939	Callithrix jacchus	92.79	0.00e+00	1520.00
IUUC-Cfa-020835	Canis familiaris	91.39	0.00e+00	1602.00
IUUC-Cpo-022067	Cavia porcellus	88.82	0.00e+00	1374.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.63	2.00e-24	107.00
IUUC-Csa-023085	Chlorocebus sabaeus	94.52	0.00e+00	1628.00
IUUC-Cho-024390	Choloepus hoffmanni	79.84	3.00e-124	439.00
IUUC-Cin-025496	Ciona intestinalis	37.25	8.00e-43	168.00
IUUC-Csv-025812	Ciona savignyi	36.22	6.00e-42	165.00
IUUC-Dre-028255	Danio rerio	54.39	0.00e+00	827.00
IUUC-Dno-028986	Dasypus novemcinctus	90.20	0.00e+00	1503.00
IUUC-Dor-031062	Dipodomys ordii	76.52	0.00e+00	843.00
IUUC-Ete-032359	Echinops telfairi	76.70	0.00e+00	659.00
IUUC-Eca-033964	Equus caballus	90.00	0.00e+00	1544.00
IUUC-Eeu-034492	Erinaceus europaeus	91.73	0.00e+00	668.00
IUUC-Fca-036359	Felis catus	90.53	0.00e+00	1539.00
IUUC-Fal-037640	Ficedula albicollis	74.17	0.00e+00	1263.00
IUUC-Gmo-039600	Gadus morhua	51.99	0.00e+00	828.00
IUUC-Gga-040126	Gallus gallus	73.64	0.00e+00	1220.00
IUUC-Gac-041557	Gasterosteus aculeatus	51.68	0.00e+00	808.00
IUUC-Hsa-046043	Homo sapiens	95.69	0.00e+00	1606.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	90.52	0.00e+00	1510.00
IUUC-Lch-050357	Latimeria chalumnae	61.00	0.00e+00	902.00
IUUC-Loc-052849	Lepisosteus oculatus	58.37	0.00e+00	875.00
IUUC-Laf-054570	Loxodonta africana	88.09	0.00e+00	1458.00
IUUC-Mcc-054989	Macaca mulatta	93.94	0.00e+00	1488.00
IUUC-Meu-056273	Macropus eugenii	61.61	2.00e-138	486.00
IUUC-Mga-059814	Meleagris gallopavo	72.04	0.00e+00	1228.00
IUUC-Mmr-061726	Microcebus murinus	91.18	0.00e+00	1558.00
IUUC-Mdo-062974	Monodelphis domestica	81.41	0.00e+00	1394.00
IUUC-Mmu-064069	Mus musculus	86.67	0.00e+00	1435.00
IUUC-Mpu-066008	Mustela putorius furo	90.74	0.00e+00	1510.00
IUUC-Nle-069259	Nomascus leucogenys	94.95	0.00e+00	1593.00
IUUC-Opr-070882	Ochotona princeps	73.25	2.00e-129	456.00
IUUC-Ont-072441	Oreochromis niloticus	51.94	0.00e+00	816.00
IUUC-Oan-073151	Ornithorhynchus anatinus	81.67	9.00e-119	419.00
IUUC-Ocu-074879	Oryctolagus cuniculus	89.46	0.00e+00	1523.00
IUUC-Ola-087007	Oryzias latipes	50.74	0.00e+00	775.00
IUUC-Oga-088385	Otolemur garnettii	89.72	0.00e+00	1550.00
IUUC-Oar-090305	Ovis aries	88.82	0.00e+00	1548.00
IUUC-Ptr-091299	Pan troglodytes	95.47	0.00e+00	1614.00
IUUC-Pan-091996	Papio anubis	94.46	0.00e+00	1573.00
IUUC-Psi-093176	Pelodiscus sinensis	74.23	0.00e+00	1265.00
IUUC-Pma-094331	Petromyzon marinus	46.66	0.00e+00	685.00
IUUC-Ppa-095732	Physcomitrella patens	30.58	9.00e-25	108.00
IUUC-Pfo-096503	Poecilia formosa	53.79	0.00e+00	813.00
IUUC-Pab-098543	Pongo abelii	95.10	0.00e+00	929.00
IUUC-Pca-101099	Procavia capensis	85.30	0.00e+00	1268.00
IUUC-Pva-103163	Pteropus vampyrus	83.76	0.00e+00	1419.00
IUUC-Rno-105766	Rattus norvegicus	87.74	0.00e+00	1456.00
IUUC-Sha-106610	Sarcophilus harrisii	77.47	0.00e+00	1294.00
IUUC-Ssc-116353	Sus scrofa	90.55	0.00e+00	1514.00
IUUC-Tgu-116971	Taeniopygia guttata	73.96	0.00e+00	1232.00
IUUC-Tru-117932	Takifugu rubripes	43.68	2.00e-167	583.00
IUUC-Tsy-119185	Tarsius syrichta	86.71	0.00e+00	974.00
IUUC-Tni-119842	Tetraodon nigroviridis	60.13	1.00e-110	393.00
IUUC-Tbe-127281	Tupaia belangeri	77.51	2.00e-154	539.00
IUUC-Ttr-128177	Tursiops truncatus	90.29	0.00e+00	1274.00
IUUC-Vpa-130031	Vicugna pacos	90.65	0.00e+00	1581.00
IUUC-Xtr-132949	Xenopus tropicalis	62.90	0.00e+00	1031.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence