iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066008

Ensembl Protein ID

ENSMPUP00000016433.1

UniProt Accession

M3YYM3; M3YYM3_MUSPF

Genbank Protein ID

ENSMPUP00000016433

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01056818

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000016536.1	ENSMPUT00000016678.1	ENSMPUP00000016433.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.90e-87	293.6	342	951

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++l++ +++l+ +    +s++k+   +++++a++++ae+fsgy
   Q: 342  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLVKKDicNSETKKDLLKKVKNAISATAERFSGY 425
           69*****************************...*****9..679999999999999776567************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+e+++k  nk++++e    ++++sd+   + ++ +++++ ++++++++++i+c++c+++  ++e+f+dls+++
   Q: 426  MQNDAHEFLSQCLDQLKEDMEK-LNKTWKTEPVPGEENSSDI---SATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDL 510
           ********************55.8888888888887777777...7999**************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP++LilhLkR+sf+ + + ++ki ++v +p+ L+ls++
   Q: 511  PRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRILILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSH 594
           *999886545***************9....*********9.89999******************************************* PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 595  CTEntkppftlgwsahmaisrplkasqmvnscitspstpsknfpfksksslalcldsdsedelkrsvalsqricemsgceqqpedlekd 683
           ***99****************99999999999999999999999999999999999999999999999999999999999999999999 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 684  srscrvdpdkselensgfdgmseeellaavlemskreasptlshedddkptsspdtgfaeddiqempenqdpvetekpkpvtepdsasf 772
           99999998888888888888888888888888888888888888888888888877777777777777777777777777777777777 PP
   S: 268  ....................peekqke.............................................................. 274
                                     e                                                              
   Q: 773  teitkdcdenkenktpegsqG-----Evdwlqqydmerereeqelqqalaqslqeqeaweqkedddlkratelslqefnnsfldslgsd 856
           777766666555555555550.....055555555555555555666666666666667777777777777777777777888888888 PP
   S: 275  ..............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaY 331
                                         +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e++v++++++++Y
   Q: 857  edsgnedvldmeyteaeaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEASVQSDRDRSGY 945
           888888888888888888888899999999****************************99999************************** PP
   S: 332  vlfYkr 337
           ++fY++
   Q: 946  IFFYMH 951
           ****98 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MSPLKIHGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLVV HYNTGGIPRI FQLSHNIKNV 60
VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLHAA MKPSQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAGTTGAT GGCTTCCGGA GAACTGGCAT AGCTGCAAAA TATGAGTAGT TCCCCAAGAA 60
GAGTGCATTG CCTTTGGCAC AAGGATCAGA ATAAAGGTGA ATTGTTATTA CATAGGGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	98.78	0.00e+00	1819.00
IUUC-Apl-004033	Anas platyrhynchos	76.97	0.00e+00	1435.00
IUUC-Aca-005370	Anolis carolinensis	69.94	0.00e+00	1328.00
IUUC-Ame-011884	Astyanax mexicanus	57.33	0.00e+00	982.00
IUUC-Bta-012725	Bos taurus	95.31	0.00e+00	1726.00
IUUC-Cja-019939	Callithrix jacchus	94.80	0.00e+00	1682.00
IUUC-Cfa-020835	Canis familiaris	98.37	0.00e+00	1851.00
IUUC-Cpo-022067	Cavia porcellus	93.32	0.00e+00	1565.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.22	4.00e-24	106.00
IUUC-Csa-023085	Chlorocebus sabaeus	95.00	0.00e+00	1751.00
IUUC-Cho-024390	Choloepus hoffmanni	87.68	4.00e-168	585.00
IUUC-Cin-025496	Ciona intestinalis	37.65	1.00e-43	171.00
IUUC-Csv-025812	Ciona savignyi	36.61	7.00e-42	165.00
IUUC-Dre-028255	Danio rerio	57.76	0.00e+00	949.00
IUUC-Dno-028986	Dasypus novemcinctus	94.50	0.00e+00	1703.00
IUUC-Dor-031062	Dipodomys ordii	78.78	0.00e+00	872.00
IUUC-Ete-032359	Echinops telfairi	83.16	0.00e+00	822.00
IUUC-Eca-033964	Equus caballus	95.10	0.00e+00	1749.00
IUUC-Eeu-034492	Erinaceus europaeus	85.48	0.00e+00	825.00
IUUC-Fca-036359	Felis catus	96.74	0.00e+00	1777.00
IUUC-Fal-037640	Ficedula albicollis	76.85	0.00e+00	1402.00
IUUC-Gmo-039600	Gadus morhua	54.40	0.00e+00	934.00
IUUC-Gga-040126	Gallus gallus	76.74	0.00e+00	1370.00
IUUC-Gac-041557	Gasterosteus aculeatus	54.35	0.00e+00	917.00
IUUC-Ggo-045571	Gorilla gorilla	89.77	0.00e+00	1514.00
IUUC-Hsa-046043	Homo sapiens	93.99	0.00e+00	1702.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	93.36	0.00e+00	1701.00
IUUC-Lch-050357	Latimeria chalumnae	64.47	0.00e+00	1038.00
IUUC-Loc-052849	Lepisosteus oculatus	60.93	0.00e+00	1001.00
IUUC-Laf-054570	Loxodonta africana	93.69	0.00e+00	1666.00
IUUC-Mcc-054989	Macaca mulatta	94.85	0.00e+00	1612.00
IUUC-Meu-056273	Macropus eugenii	65.53	9.00e-173	600.00
IUUC-Mga-059814	Meleagris gallopavo	75.35	0.00e+00	1368.00
IUUC-Mmr-061726	Microcebus murinus	93.78	0.00e+00	1726.00
IUUC-Mdo-062974	Monodelphis domestica	84.62	0.00e+00	1568.00
IUUC-Mmu-064069	Mus musculus	89.68	0.00e+00	1614.00
IUUC-Nle-069259	Nomascus leucogenys	95.00	0.00e+00	1706.00
IUUC-Opr-070882	Ochotona princeps	78.42	2.00e-140	493.00
IUUC-Ont-072441	Oreochromis niloticus	55.06	0.00e+00	932.00
IUUC-Oan-073151	Ornithorhynchus anatinus	76.98	2.00e-120	425.00
IUUC-Ocu-074879	Oryctolagus cuniculus	93.27	0.00e+00	1696.00
IUUC-Ola-087007	Oryzias latipes	53.34	0.00e+00	889.00
IUUC-Oga-088385	Otolemur garnettii	92.79	0.00e+00	1711.00
IUUC-Oar-090305	Ovis aries	95.61	0.00e+00	1759.00
IUUC-Ptr-091299	Pan troglodytes	94.69	0.00e+00	1707.00
IUUC-Pan-091996	Papio anubis	94.85	0.00e+00	1701.00
IUUC-Psi-093176	Pelodiscus sinensis	77.70	0.00e+00	1445.00
IUUC-Pma-094331	Petromyzon marinus	48.16	0.00e+00	751.00
IUUC-Ppa-095732	Physcomitrella patens	30.25	3.00e-24	107.00
IUUC-Pfo-096503	Poecilia formosa	56.35	0.00e+00	932.00
IUUC-Pab-098543	Pongo abelii	92.75	0.00e+00	903.00
IUUC-Pca-101099	Procavia capensis	87.92	0.00e+00	1305.00
IUUC-Pva-103163	Pteropus vampyrus	89.59	0.00e+00	1634.00
IUUC-Rno-105766	Rattus norvegicus	91.11	0.00e+00	1638.00
IUUC-Sha-106610	Sarcophilus harrisii	81.27	0.00e+00	1474.00
IUUC-Sar-113256	Sorex araneus	91.38	6.00e-113	402.00
IUUC-Ssc-116353	Sus scrofa	95.21	0.00e+00	1700.00
IUUC-Tgu-116971	Taeniopygia guttata	76.85	0.00e+00	1374.00
IUUC-Tru-117932	Takifugu rubripes	44.85	0.00e+00	656.00
IUUC-Tsy-119185	Tarsius syrichta	89.74	0.00e+00	1129.00
IUUC-Tni-119842	Tetraodon nigroviridis	59.81	2.00e-110	392.00
IUUC-Tbe-127281	Tupaia belangeri	84.38	0.00e+00	662.00
IUUC-Ttr-128177	Tursiops truncatus	96.01	0.00e+00	1358.00
IUUC-Vpa-130031	Vicugna pacos	95.61	0.00e+00	1785.00
IUUC-Xtr-132949	Xenopus tropicalis	65.46	0.00e+00	1165.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence