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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064407
Ensembl Protein ID ENSMUSP00000140566.1
UniProt Accession Q9QYI5; Q3TB24; Q8BPF6; Q921S2; DNJB2_MOUSE
Genbank Protein ID BAA88306.1; BAC36155.1; BAE33579.1; BAE42490.1; AAH11090.1
Protein Name DnaJ homolog subfamily B member 2; DnaJ homolog subfamily B member 10; mDj8
Genbank Nucleotide ID AB028858; AK076061; AK156083; AK171494; AC166150
Gene Name Dnajb2; Dnajb10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026203.16 ENSMUST00000188931.6 ENSMUSP00000140566.1
ENSMUSG00000026203.16 ENSMUST00000188346.6 ENSMUSP00000140588.1
ENSMUSG00000026203.16 ENSMUST00000185403.6 ENSMUSP00000139982.1
ENSMUSG00000026203.16 ENSMUST00000187058.6 ENSMUSP00000140637.1
ENSMUSG00000026203.16 ENSMUST00000190445.1 ENSMUSP00000139573.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/DUIM 85.19 2.00e-107 386.00 IUUC-Hsa-046474
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PARK2, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins.
 Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PARK2, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins.
Protein Sequence
(Fasta)
MASYYEILDV PRSASPDDIK KAYRKKALQW HPDKNPDNKE FAEKKFKEVA EAYEVLSDKH 60
KREIYDRYGR EGLTGAGSGP SRSETGGAGP GFTFTFRSPE EVFREFFGSG DPFSELFDDL 120
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Protein Fasta Sequence


>IUUC-Mmu-064407|UBD,DUIM|Mus musculus
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Nucleotide Sequence
(Fasta)
CGCCCCCGCC CCCTCGTGTG ACCGGCCGAG CCGGCCCTCT GAGTCTCTAG TAGTTTCCAG 60
GGCGCTGACG CATGCTTGCG CACACAACCC AGCCTGGCGT GTCGTACGCA GTGGCCGCGA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064407|UBD,DUIM|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0488--Methylation
KW-0539--Nucleus
KW-0636--Prenylation
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR001623--DnaJ_domain
IPR018253--DnaJ_domain_CS
IPR003903--UIM_dom
PROSITE

PS00636--DNAJ_1
PS50076--DNAJ_2
PS50330--UIM
Pfam

PF00226--DnaJ
PF02809--UIM
PRINTS

PR00625--JDOMAIN
SMART

SM00271--DnaJ
SM00726--UIM
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016234--C:inclusion body
GO:0031227--C:intrinsic component of endoplasmic reticulum membrane
GO:0005634--C:nucleus
GO:0001671--F:ATPase activator activity
GO:0051087--F:chaperone binding
GO:0030544--F:Hsp70 protein binding
GO:0031593--F:polyubiquitin binding
GO:0070628--F:proteasome binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0051082--F:unfolded protein binding
GO:0061077--P:chaperone-mediated protein folding
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0090084--P:negative regulation of inclusion body assembly
GO:0032091--P:negative regulation of protein binding
GO:0090086--P:negative regulation of protein deubiquitination
GO:0032781--P:positive regulation of ATPase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042026--P:protein refolding
GO:1903644--P:regulation of chaperone-mediated protein folding
GO:0032880--P:regulation of protein localization
GO:0031396--P:regulation of protein ubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG mmu:56812
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001535 Ailuropoda melanoleuca 83.38 1.00e-102 365.00
IUUC-Bta-012474 Bos taurus 46.67 1.00e-02 38.50
IUUC-Cja-019459 Callithrix jacchus 83.44 2.00e-92 332.00
IUUC-Cfa-020252 Canis familiaris 50.00 4.00e-03 39.70
IUUC-Cpo-022195 Cavia porcellus 84.31 8.00e-121 426.00
IUUC-Csa-023838 Chlorocebus sabaeus 50.00 5.00e-03 39.70
IUUC-Cho-024785 Choloepus hoffmanni 80.62 1.00e-110 392.00
IUUC-Dno-029927 Dasypus novemcinctus 50.00 5.00e-03 39.70
IUUC-Dor-030267 Dipodomys ordii 82.10 7.00e-122 429.00
IUUC-Fca-035566 Felis catus 50.00 5.00e-03 39.70
IUUC-Fal-037220 Ficedula albicollis 59.22 6.00e-67 247.00
IUUC-Gmo-038998 Gadus morhua 54.10 1.00e-52 199.00
IUUC-Gga-041119 Gallus gallus 62.84 9.00e-67 246.00
IUUC-Gac-041756 Gasterosteus aculeatus 42.86 8.70e-02 35.40
IUUC-Ggo-044728 Gorilla gorilla 50.00 5.00e-03 39.70
IUUC-Hsa-046474 Homo sapiens 85.19 4.00e-117 414.00
IUUC-Itr-047899 Ictidomys tridecemlineatus 88.53 5.00e-93 333.00
IUUC-Lch-050678 Latimeria chalumnae 53.02 1.00e-70 259.00
IUUC-Loc-052924 Lepisosteus oculatus 56.14 1.00e-66 246.00
IUUC-Laf-053924 Loxodonta africana 83.33 7.00e-92 330.00
IUUC-Meu-056813 Macropus eugenii 64.15 5.00e-53 201.00
IUUC-Mla-058991 Melampsora laricipopulina 47.62 5.60e-01 29.30
IUUC-Mga-059404 Meleagris gallopavo 56.93 3.00e-63 234.00
IUUC-Mdo-061987 Monodelphis domestica 62.72 8.00e-73 267.00
IUUC-Mpu-066202 Mustela putorius furo 82.77 1.00e-102 365.00
IUUC-Mlu-067902 Myotis lucifugus 78.15 2.00e-112 398.00
IUUC-Nle-069173 Nomascus leucogenys 70.53 4.00e-92 330.00
IUUC-Ont-071647 Oreochromis niloticus 46.67 9.40e-02 35.00
IUUC-Oga-089055 Otolemur garnettii 84.00 1.00e-116 412.00
IUUC-Oar-090400 Ovis aries 82.72 1.00e-106 379.00
IUUC-Ptr-091562 Pan troglodytes 85.19 4.00e-117 414.00
IUUC-Pan-092313 Papio anubis 50.00 5.00e-03 39.70
IUUC-Psi-093797 Pelodiscus sinensis 46.67 7.20e-02 35.40
IUUC-Pab-098730 Pongo abelii 88.73 2.00e-98 352.00
IUUC-Pca-100425 Procavia capensis 84.31 1.00e-97 349.00
IUUC-Sha-107349 Sarcophilus harrisii 58.24 4.00e-73 268.00
IUUC-Sar-113078 Sorex araneus 50.00 5.00e-03 39.30
IUUC-Ssc-115552 Sus scrofa 84.31 1.00e-95 343.00
IUUC-Tgu-116678 Taeniopygia guttata 62.32 9.00e-65 239.00
IUUC-Tni-120479 Tetraodon nigroviridis 55.60 3.00e-47 181.00
IUUC-Tbe-127946 Tupaia belangeri 75.36 6.00e-74 271.00
IUUC-Ttr-128304 Tursiops truncatus 82.46 6.00e-101 360.00
IUUC-Vpa-130308 Vicugna pacos 72.00 5.00e-23 101.00
Created Date 25-Jun-2017

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