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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046897
UUCD1 version UUC-HoS-00171
Ensembl Protein ID ENSP00000349959.3
UniProt Accession Q6R327; B2RNX0; B7ZMF7; Q68DT5; Q86UB7; Q8N3A0; Q8NCM6; RICTR_HUMAN
Genbank Protein ID AAS79796.1; CAD39155.1; CAH18135.1; EAW55980.1; AAH51729.1; AAI37164.1; AAI37165.1; AAI44510.1; BAC02708.1
Protein Name Rapamycin-insensitive companion of mTOR; AVO3 homolog
Genbank Nucleotide ID AY515854; AL834497; CR749280; AC008964; BC051729; BC137163; BC137164; BC144509; AB082530
Gene Name RICTOR; KIAA1999
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164327.12 ENST00000357387.7 ENSP00000349959.3
ENSG00000164327.12 ENST00000511516.5 ENSP00000423019.1
ENSG00000164327.12 ENST00000296782.9 ENSP00000296782.5
ENSG00000164327.12 ENST00000514735.1 ENSP00000423162.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/Other E3 adaptor/Cullin RING/Other 21204013; 20832730
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
 Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Protein Sequence
(Fasta)
MAAIGRGRSL KNLRVRGRND SGEENVPLDL TREPSDNLRE ILQNVARLQG VSNMRKLGHL 60
NNFTKLLCDI GHSEEKLGFH YEDIIICLRL ALLNEAKEVR AAGLRALRYL IQDSSILQKV 120
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Protein Fasta Sequence


>IUUC-Hsa-046897|E3,Cullin RING/Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
GTTTCCGGTG TTGTGACTGA AACCCGTCAA TATGGCGGCG ATCGGCCGCG GCCGCTCTCT 60
GAAGAACCTC CGAGTACGAG GTAAGCCCGC TGCAACCCTC ACTCCCCACC GCCCGGCGCC 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046897|E3,Cullin RING/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR028268--Pianissimo_fam
IPR028267--Pianissimo_N
IPR029453--Rictor_IV
IPR029451--RICTOR_M
IPR029259--RICTOR_phospho
IPR029452--RICTOR_V
Pfam

PF14663--RasGEF_N_2
PF14666--RICTOR_M
PF14664--RICTOR_N
PF14665--RICTOR_phospho
PF14668--RICTOR_V
SMART

SM01307--RICTOR_M
SM01308--RICTOR_N
SM01309--RICTOR_phospho
SM01310--RICTOR_V
Gene Ontology

GO:0005829--C:cytosol
GO:0031932--C:TORC2 complex
GO:0008047--F:enzyme activator activity
GO:0019901--F:protein kinase binding
GO:0043022--F:ribosome binding
GO:0031532--P:actin cytoskeleton reorganization
GO:0009790--P:embryo development
GO:0030010--P:establishment of cell polarity
GO:0030950--P:establishment or maintenance of actin cytoskeleton polarity
GO:0018105--P:peptidyl-serine phosphorylation
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0030838--P:positive regulation of actin filament polymerization
GO:0001938--P:positive regulation of endothelial cell proliferation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0032008--P:positive regulation of TOR signaling
GO:0032956--P:regulation of actin cytoskeleton organization
GO:2000114--P:regulation of establishment of cell polarity
GO:0010468--P:regulation of gene expression
GO:0043087--P:regulation of GTPase activity
GO:0050727--P:regulation of inflammatory response
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:0042325--P:regulation of phosphorylation
GO:0051896--P:regulation of protein kinase B signaling
GO:0031295--P:T cell costimulation
GO:0031929--P:TOR signaling
KEGG hsa:253260
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004111 Anas platyrhynchos 75.63 0.00e+00 2336.00
IUUC-Aca-004885 Anolis carolinensis 83.92 0.00e+00 2793.00
IUUC-Ago-007975 Ashbya gossypii 28.24 3.00e-43 171.00
IUUC-Afu-008889 Aspergillus fumigatus 28.93 2.00e-102 368.00
IUUC-Ang-009838 Aspergillus niger 28.59 5.00e-101 363.00
IUUC-Ate-010586 Aspergillus terreus 28.91 1.00e-99 358.00
IUUC-Bgr-012287 Blumeria graminis 28.76 3.00e-101 363.00
IUUC-Bta-013347 Bos taurus 97.89 0.00e+00 3155.00
IUUC-Bci-013718 Botrytis cinerea 30.05 3.00e-111 397.00
IUUC-Bol-016394 Brassica oleracea 30.77 1.60e-02 32.30
IUUC-Cja-019360 Callithrix jacchus 99.18 0.00e+00 3248.00
IUUC-Cpo-022258 Cavia porcellus 98.50 3.00e-155 540.00
IUUC-Cho-024748 Choloepus hoffmanni 86.43 0.00e+00 1358.00
IUUC-Cin-025491 Ciona intestinalis 39.81 1.00e-103 371.00
IUUC-Csv-025990 Ciona savignyi 38.79 3.00e-152 532.00
IUUC-Cgl-026666 Colletotrichum gloeosporioides 28.33 2.00e-99 357.00
IUUC-Cne-026882 Cryptococcus neoformans 30.89 1.00e-80 295.00
IUUC-Dre-027391 Danio rerio 84.54 0.00e+00 1774.00
IUUC-Dno-029612 Dasypus novemcinctus 93.94 0.00e+00 2974.00
IUUC-Dor-030974 Dipodomys ordii 96.70 0.00e+00 1400.00
IUUC-Ete-032905 Echinops telfairi 89.99 0.00e+00 2888.00
IUUC-Eca-033490 Equus caballus 94.75 0.00e+00 3000.00
IUUC-Eeu-035218 Erinaceus europaeus 86.47 0.00e+00 1397.00
IUUC-Fca-035568 Felis catus 96.67 0.00e+00 3050.00
IUUC-Fal-037265 Ficedula albicollis 87.01 0.00e+00 2803.00
IUUC-Fox-037847 Fusarium oxysporum 29.92 4.00e-97 350.00
IUUC-Fso-038392 Fusarium solani 29.18 3.00e-103 370.00
IUUC-Gmo-039569 Gadus morhua 74.02 0.00e+00 1722.00
IUUC-Ggr-039786 Gaeumannomyces graminis 28.67 3.00e-98 353.00
IUUC-Gga-040814 Gallus gallus 87.22 0.00e+00 2842.00
IUUC-Gac-042152 Gasterosteus aculeatus 67.16 0.00e+00 2089.00
IUUC-Itr-047870 Ictidomys tridecemlineatus 95.40 0.00e+00 3008.00
IUUC-Kpa-049264 Komagataella pastoris 29.46 9.00e-50 192.00
IUUC-Lch-049566 Latimeria chalumnae 80.56 0.00e+00 2527.00
IUUC-Loc-052514 Lepisosteus oculatus 77.94 0.00e+00 2501.00
IUUC-Lma-053045 Leptosphaeria maculans 30.36 1.00e-86 315.00
IUUC-Laf-053388 Loxodonta africana 97.54 0.00e+00 3190.00
IUUC-Mcc-055195 Macaca mulatta 97.67 0.00e+00 3183.00
IUUC-Meu-056687 Macropus eugenii 92.04 3.00e-90 327.00
IUUC-Mor-056999 Magnaporthe oryzae 28.07 8.00e-101 362.00
IUUC-Mpo-057301 Magnaporthe poae 28.97 1.00e-102 368.00
IUUC-Mla-058853 Melampsora laricipopulina 27.09 8.00e-74 272.00
IUUC-Mga-059725 Meleagris gallopavo 76.40 0.00e+00 2137.00
IUUC-Mmr-060679 Microcebus murinus 98.36 0.00e+00 3070.00
IUUC-Mmu-063859 Mus musculus 95.38 0.00e+00 3077.00
IUUC-Mlu-067734 Myotis lucifugus 96.55 0.00e+00 3088.00
IUUC-Nfi-068380 Neosartorya fischeri 28.83 4.00e-101 363.00
IUUC-Ncr-068779 Neurospora crassa 28.56 7.00e-100 359.00
IUUC-Opr-071025 Ochotona princeps 87.35 0.00e+00 1966.00
IUUC-Ont-072104 Oreochromis niloticus 77.01 0.00e+00 1794.00
IUUC-Ocu-074388 Oryctolagus cuniculus 97.66 0.00e+00 3184.00
IUUC-Oru-084208 Oryza rufipogon 22.48 4.10e-02 32.30
IUUC-Ola-087503 Oryzias latipes 69.99 0.00e+00 2282.00
IUUC-Oar-089642 Ovis aries 98.19 0.00e+00 3171.00
IUUC-Ptr-090779 Pan troglodytes 99.42 0.00e+00 3270.00
IUUC-Pan-092099 Papio anubis 99.41 0.00e+00 3254.00
IUUC-Psi-093606 Pelodiscus sinensis 86.78 0.00e+00 2840.00
IUUC-Pno-094990 Phaeosphaeria nodorum 29.04 7.00e-87 316.00
IUUC-Ppa-095840 Physcomitrella patens 28.38 8.70e-02 33.10
IUUC-Pab-098429 Pongo abelii 98.42 0.00e+00 3200.00
IUUC-Pca-101045 Procavia capensis 92.16 0.00e+00 3063.00
IUUC-Pva-102675 Pteropus vampyrus 91.26 0.00e+00 1410.00
IUUC-Pgr-103341 Puccinia graminis 27.97 1.00e-42 169.00
IUUC-Ptt-103999 Puccinia triticina 29.13 2.00e-42 168.00
IUUC-Rno-104957 Rattus norvegicus 96.54 0.00e+00 3020.00
IUUC-Sce-106173 Saccharomyces cerevisiae 29.51 3.00e-43 171.00
IUUC-Sha-107121 Sarcophilus harrisii 90.82 0.00e+00 2944.00
IUUC-Sja-107806 Schizosaccharomyces japonicus 27.53 2.00e-78 288.00
IUUC-Spo-108187 Schizosaccharomyces pombe 27.90 5.00e-90 326.00
IUUC-Ssl-108665 Sclerotinia sclerotiorum 36.14 5.00e-64 239.00
IUUC-Sar-113499 Sorex araneus 87.88 0.00e+00 2650.00
IUUC-Sre-114992 Sporisorium reilianum 28.27 5.00e-95 343.00
IUUC-Ssc-115246 Sus scrofa 98.07 0.00e+00 3166.00
IUUC-Tgu-116455 Taeniopygia guttata 86.52 0.00e+00 2788.00
IUUC-Tru-118605 Takifugu rubripes 69.08 0.00e+00 2223.00
IUUC-Tsy-119061 Tarsius syrichta 91.69 0.00e+00 2949.00
IUUC-Tni-119726 Tetraodon nigroviridis 76.56 0.00e+00 1624.00
IUUC-Tre-121918 Trichoderma reesei 29.41 5.00e-101 363.00
IUUC-Tvi-122587 Trichoderma virens 29.15 7.00e-96 346.00
IUUC-Tbe-127960 Tupaia belangeri 92.53 0.00e+00 2389.00
IUUC-Ttr-128848 Tursiops truncatus 96.55 0.00e+00 2727.00
IUUC-Uma-129394 Ustilago maydis 28.67 2.00e-99 357.00
IUUC-Vda-129772 Verticillium dahliae 28.29 7.00e-95 342.00
IUUC-Vpa-130325 Vicugna pacos 95.15 0.00e+00 2928.00
IUUC-Xtr-132777 Xenopus tropicalis 79.48 0.00e+00 2509.00
IUUC-Xma-133798 Xiphophorus maculatus 69.68 0.00e+00 2273.00
IUUC-Yli-134450 Yarrowia lipolytica 28.35 1.00e-74 275.00
Created Date 25-Jun-2017

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