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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045801
UUCD1 version UUC-HoS-00068
Ensembl Protein ID ENSP00000231524.9
UniProt Accession P36406; Q9BZY4; Q9BZY5; TRI23_HUMAN
Genbank Protein ID AAA35940.1; AAG50176.1; AAG50177.1; AAG50178.1; AAH22510.1
Protein Name E3 ubiquitin-protein ligase TRIM23; ADP-ribosylation factor domain-containing protein 1; GTP-binding protein ARD-1; RING finger protein 46; RING-type E3 ubiquitin transferase TRIM23; Tripartite motif-containing protein 23
Genbank Nucleotide ID L04510; AF230397; AF230398; AF230399; BC022510
Gene Name TRIM23; ARD1; ARFD1; RNF46
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000113595.14 ENST00000231524.13 ENSP00000231524.9
ENSG00000113595.14 ENST00000381018.7 ENSP00000370406.3
ENSG00000113595.14 ENST00000274327.11 ENSP00000274327.7
ENSG00000113595.14 ENST00000506400.1 ENSP00000427103.1
ENSG00000113595.14 ENST00000505205.1 ENSP00000424044.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRID
DNA Methylation
MethyCancer
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 15684077; 18398435; 20724660; 25905670
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.00041 22.5 31 76
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf....kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C + f    ++ p++l CgH+ ++dCl ++     +  +++rCP +r
   Q: 31   CGVCEDVFslqgDKVPRLLLCGHTVCHDCLTRL----PLHGRAIRCPFDR 76
           999*99889998888***************999....6678999***876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.
 Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.
Protein Sequence
(Fasta)
MATLVVNKLG AGVDSGRQGS RGTAVVKVLE CGVCEDVFSL QGDKVPRLLL CGHTVCHDCL 60
TRLPLHGRAI RCPFDRQVTD LGDSGVWGLK KNFALLELLE RLQNGPIGQY GAAEESIGIS 120
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Protein Fasta Sequence


>IUUC-Hsa-045801|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GATGACTACA TCATAATGGG AAGGATAAGG CGTTCCTCAA AATGGATGCC ATAAGTAAAG 60
TAAGCGCAAT TCAATTGAAC CCGAATGTTT ATTGAGCATT TCCTCAGCTC ATTCAAGAAG 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-045801|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0342--GTP-binding
KW-0945--Host-virus interaction
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003649--Bbox_C
IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR024156--Small_GTPase_ARF
IPR006689--Small_GTPase_ARF/SAR
IPR000315--Znf_B-box
IPR013087--Znf_C2H2_type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51417--ARF
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00025--Arf
PF00643--zf-B_box
PF14634--zf-RING_5
PRINTS

PR00328--SAR1GTPBP
SMART

SM00502--BBC
SM00336--BBOX
SM00184--RING
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0005765--C:lysosomal membrane
GO:0005634--C:nucleus
GO:0008047--F:enzyme activator activity
GO:0019003--F:GDP binding
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0042802--F:identical protein binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination
GO:0007264--P:small GTPase mediated signal transduction
GO:0016032--P:viral process
KEGG hsa:373
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001685 Ailuropoda melanoleuca 97.74 0.00e+00 1125.00
IUUC-Apl-003280 Anas platyrhynchos 94.58 0.00e+00 1092.00
IUUC-Aca-004587 Anolis carolinensis 92.04 0.00e+00 1006.00
IUUC-Ame-010760 Astyanax mexicanus 88.31 0.00e+00 1048.00
IUUC-Bta-013139 Bos taurus 95.16 0.00e+00 1097.00
IUUC-Cel-018197 Caenorhabditis elegans 36.16 2.00e-95 342.00
IUUC-Cja-019407 Callithrix jacchus 99.65 0.00e+00 1144.00
IUUC-Cfa-020758 Canis familiaris 97.19 0.00e+00 1109.00
IUUC-Cpo-022050 Cavia porcellus 97.04 0.00e+00 1150.00
IUUC-Csa-023938 Chlorocebus sabaeus 100.00 0.00e+00 1147.00
IUUC-Cho-024793 Choloepus hoffmanni 76.02 0.00e+00 741.00
IUUC-Cin-025424 Ciona intestinalis 56.79 0.00e+00 635.00
IUUC-Csv-025949 Ciona savignyi 55.77 3.00e-179 621.00
IUUC-Dre-028835 Danio rerio 87.83 0.00e+00 1045.00
IUUC-Dno-029080 Dasypus novemcinctus 88.49 0.00e+00 1019.00
IUUC-Dor-031092 Dipodomys ordii 90.59 0.00e+00 1058.00
IUUC-Ete-033169 Echinops telfairi 83.97 0.00e+00 944.00
IUUC-Eca-033509 Equus caballus 98.08 0.00e+00 1129.00
IUUC-Eeu-034669 Erinaceus europaeus 99.12 6.00e-132 464.00
IUUC-Fca-035813 Felis catus 97.74 0.00e+00 1125.00
IUUC-Fal-037222 Ficedula albicollis 95.99 0.00e+00 1102.00
IUUC-Gmo-038996 Gadus morhua 87.65 0.00e+00 1040.00
IUUC-Gga-040181 Gallus gallus 93.43 0.00e+00 1114.00
IUUC-Gac-041763 Gasterosteus aculeatus 86.96 0.00e+00 1031.00
IUUC-Ggo-044808 Gorilla gorilla 94.10 0.00e+00 1081.00
IUUC-Itr-048568 Ictidomys tridecemlineatus 97.74 0.00e+00 1125.00
IUUC-Lch-049531 Latimeria chalumnae 91.32 0.00e+00 1058.00
IUUC-Loc-052929 Lepisosteus oculatus 90.21 0.00e+00 1053.00
IUUC-Laf-053593 Loxodonta africana 97.56 0.00e+00 1123.00
IUUC-Mcc-055065 Macaca mulatta 100.00 0.00e+00 1147.00
IUUC-Meu-056372 Macropus eugenii 98.67 1.00e-130 460.00
IUUC-Mga-059665 Meleagris gallopavo 94.35 0.00e+00 954.00
IUUC-Mmr-061643 Microcebus murinus 97.74 0.00e+00 1124.00
IUUC-Mdo-062624 Monodelphis domestica 92.97 0.00e+00 1107.00
IUUC-Mmu-064210 Mus musculus 97.74 0.00e+00 1156.00
IUUC-Mpu-066292 Mustela putorius furo 97.64 0.00e+00 1082.00
IUUC-Mlu-066952 Myotis lucifugus 97.56 0.00e+00 1123.00
IUUC-Nle-069002 Nomascus leucogenys 100.00 0.00e+00 1147.00
IUUC-Opr-070405 Ochotona princeps 87.28 0.00e+00 1019.00
IUUC-Ont-071487 Oreochromis niloticus 88.00 0.00e+00 1041.00
IUUC-Oan-073274 Ornithorhynchus anatinus 95.95 0.00e+00 987.00
IUUC-Ocu-074788 Oryctolagus cuniculus 97.39 0.00e+00 1119.00
IUUC-Ola-086339 Oryzias latipes 86.11 0.00e+00 1030.00
IUUC-Oga-089037 Otolemur garnettii 97.74 0.00e+00 1123.00
IUUC-Oar-089458 Ovis aries 97.32 0.00e+00 1096.00
IUUC-Pan-092120 Papio anubis 99.31 0.00e+00 1134.00
IUUC-Psi-093157 Pelodiscus sinensis 91.54 0.00e+00 1091.00
IUUC-Pfo-096904 Poecilia formosa 88.87 0.00e+00 1033.00
IUUC-Pab-098358 Pongo abelii 100.00 0.00e+00 1147.00
IUUC-Pva-102674 Pteropus vampyrus 95.82 0.00e+00 1100.00
IUUC-Rno-105352 Rattus norvegicus 97.74 0.00e+00 1156.00
IUUC-Sha-106532 Sarcophilus harrisii 86.89 1.00e-61 228.00
IUUC-Sar-113483 Sorex araneus 95.29 2.00e-149 522.00
IUUC-Ssc-116170 Sus scrofa 97.56 0.00e+00 1123.00
IUUC-Tgu-116968 Taeniopygia guttata 92.70 0.00e+00 1092.00
IUUC-Tru-118246 Takifugu rubripes 88.73 0.00e+00 1032.00
IUUC-Tni-120692 Tetraodon nigroviridis 89.25 0.00e+00 1028.00
IUUC-Ttr-128956 Tursiops truncatus 97.91 0.00e+00 1126.00
IUUC-Vpa-130291 Vicugna pacos 90.94 0.00e+00 1063.00
IUUC-Xtr-132331 Xenopus tropicalis 91.08 0.00e+00 916.00
Created Date 25-Jun-2017

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