iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028189

Ensembl Protein ID

ENSDARP00000009190.5

UniProt Accession

Q7ZWB2; UBL4A_DANRE

Genbank Protein ID

CAX14238.1; AAH49498.1

Protein Name

Ubiquitin-like protein 4A

Genbank Nucleotide ID

CR855300; BC049498

Gene Name

UBL4B; ubl4a; si:dkey-32e23.2; zgc:56596

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000007359.5	ENSDART00000013870.5	ENSDARP00000009190.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	8.80e-20	71.4	1	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkks 74
           m ltvk l+gke++++v+e+++v+ +Ke+++++ ++p++qq+L+y+Gk L D+  Ls++ i  + ++ lvv+++
   Q: 1    MILTVKPLQGKECNVQVTENEKVSTVKELVSERLNIPASQQRLLYKGKALADEHRLSDYSIGPEAKLNLVVRPA 74
           89********************************************************************9975 PP

Organism

Danio rerio

Functional Description
(View)

As part of a cytosolic protein quality control complex, the bag6/bat3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Similarly, the bag6/bat3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The bag6/bat3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.

Protein Sequence
(Fasta)

MILTVKPLQG KECNVQVTEN EKVSTVKELV SERLNIPASQ QRLLYKGKAL ADEHRLSDYS 60
IGPEAKLNLV VRPAGERSSG AVGTSSANND KGGSGVWQLL STVLAKHFSP ADAAKVQEQL 120

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Nucleotide Sequence
(Fasta)

ATGCGCAGTA GCGAGACATT GACGTCATGT CCGTGGGAAA CATCGGCTGC TAGTTTACGA 60
ATGTTCAACG AGATAACTAT TTATTGCTTA TTTAGTATTT AATTTTTTAT ATATGTAAAA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0813--Transport

Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00213--UBQ

Gene Ontology

GO:0071818--C:BAT3 complex
GO:0005829--C:cytosol
GO:0071816--P:tail-anchored membrane protein insertion into ER membrane
GO:0006810--P:transport

KEGG

dre:393270

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001829	Ailuropoda melanoleuca	57.75	5.00e-35	140.00
IUUC-Aca-005306	Anolis carolinensis	60.76	9.00e-51	192.00
IUUC-Ame-010823	Astyanax mexicanus	84.38	2.00e-69	254.00
IUUC-Bta-013094	Bos taurus	55.41	2.00e-41	161.00
IUUC-Cja-018762	Callithrix jacchus	61.87	9.00e-38	149.00
IUUC-Cfa-020432	Canis familiaris	55.41	1.00e-41	162.00
IUUC-Cpo-021312	Cavia porcellus	58.60	1.00e-40	159.00
IUUC-Csa-023983	Chlorocebus sabaeus	62.18	4.00e-44	170.00
IUUC-Dno-029710	Dasypus novemcinctus	42.67	4.00e-27	114.00
IUUC-Dor-030848	Dipodomys ordii	62.86	1.00e-45	175.00
IUUC-Dme-031909	Drosophila melanogaster	30.82	6.00e-14	69.70
IUUC-Ete-032719	Echinops telfairi	58.70	2.00e-35	141.00
IUUC-Eca-033402	Equus caballus	60.84	2.00e-41	161.00
IUUC-Eeu-034802	Erinaceus europaeus	54.65	1.00e-19	87.40
IUUC-Fca-035600	Felis catus	55.41	9.00e-42	162.00
IUUC-Gmo-038655	Gadus morhua	81.53	3.00e-70	257.00
IUUC-Gga-040933	Gallus gallus	45.39	3.00e-28	117.00
IUUC-Gac-041809	Gasterosteus aculeatus	79.14	3.00e-68	250.00
IUUC-Ggo-044574	Gorilla gorilla	62.14	5.00e-38	150.00
IUUC-Hsa-046633	Homo sapiens	62.18	3.00e-44	170.00
IUUC-Itr-048284	Ictidomys tridecemlineatus	61.54	3.00e-44	170.00
IUUC-Loc-051925	Lepisosteus oculatus	77.22	9.00e-66	242.00
IUUC-Laf-053420	Loxodonta africana	58.44	7.00e-44	169.00
IUUC-Mcc-055841	Macaca mulatta	62.14	7.00e-43	166.00
IUUC-Meu-056392	Macropus eugenii	46.38	2.00e-29	120.00
IUUC-Mmr-061224	Microcebus murinus	63.89	4.00e-41	160.00
IUUC-Mdo-062067	Monodelphis domestica	54.43	2.00e-35	141.00
IUUC-Mmu-063667	Mus musculus	60.26	5.00e-44	169.00
IUUC-Mpu-066384	Mustela putorius furo	57.04	2.00e-34	137.00
IUUC-Mlu-067611	Myotis lucifugus	57.96	1.00e-39	155.00
IUUC-Nle-069287	Nomascus leucogenys	59.62	4.00e-22	97.10
IUUC-Opr-070425	Ochotona princeps	62.77	4.00e-43	166.00
IUUC-Oan-073168	Ornithorhynchus anatinus	51.85	5.00e-24	103.00
IUUC-Ocu-074452	Oryctolagus cuniculus	65.36	8.00e-51	192.00
IUUC-Ola-086473	Oryzias latipes	81.53	8.00e-73	265.00
IUUC-Oga-088650	Otolemur garnettii	62.18	2.00e-44	171.00
IUUC-Oar-089593	Ovis aries	54.23	4.00e-33	134.00
IUUC-Ptr-090659	Pan troglodytes	62.14	5.00e-38	150.00
IUUC-Pan-092760	Papio anubis	62.18	7.00e-49	186.00
IUUC-Psi-092996	Pelodiscus sinensis	56.48	4.00e-27	112.00
IUUC-Pfo-096839	Poecilia formosa	80.25	2.00e-68	250.00
IUUC-Pab-098410	Pongo abelii	61.70	2.00e-37	148.00
IUUC-Pca-100665	Procavia capensis	52.38	2.00e-15	73.60
IUUC-Rno-104898	Rattus norvegicus	57.05	1.00e-43	169.00
IUUC-Sha-107088	Sarcophilus harrisii	53.85	3.00e-28	117.00
IUUC-Ssc-116266	Sus scrofa	54.78	1.00e-40	159.00
IUUC-Tru-117619	Takifugu rubripes	73.29	5.00e-59	219.00
IUUC-Ttr-128314	Tursiops truncatus	38.19	4.00e-23	100.00
IUUC-Xtr-131815	Xenopus tropicalis	53.16	3.00e-42	163.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence