iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042538

UUCD1 version

UUC-GaA-00227

Ensembl Protein ID

ENSGACP00000006187.2

UniProt Accession

G3NLH4; G3NLH4_GASAC

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000004642.2	ENSGACT00000006230.1	ENSGACP00000006213.1
ENSGACG00000004642.2	ENSGACT00000006204.2	ENSGACP00000006187.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.80e-76	255.7	2447	2769

Active Site

Position(s)	Description	Evidence
2739	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 17   egldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           e+ + +G+tr ++++ +++  + d  ++lf +  +++ ++ +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k l
   Q: 2447 ENRKRHGSTRSVVDMELDDPDDGDdnAPLFyQPGKRGFYSPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVL 2529
           556677888888888888877777767788233333666666666554....89********************************* PP
   S: 101  lgkklsledleevdpelykslkeikena...esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
           lg+k++++d++ +dp +y+sl ++ ++    e+d   +++dl+f ++ ++ + + ++eL++gG n+pVt  N +eYv++++e+r+  
   Q: 2530 LGRKVNWHDFAFFDPVMYESLRQLIRHSqagEADAVFAAMDLAFAIDLCKEEGAGQVELLSGGVNMPVTPLNVYEYVRKYAEHRMLV 2616
           ********************777766654777799999************************************************* PP
   S: 185  gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqF 267
             ++ ++a+r+G+ +v+p++ l+ +t+e+++ll++G+ e++v++l ++t+++++  e+  ++    +wFw+++e++s++er++++ F
   Q: 2617 VAEQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENADKLlqfkRWFWSIVEKMSMTERQDLVYF 2703
           ***************************************************9999999888888999******************** PP
   S: 268  vTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2704 WTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2769
           *********999******..799999.99**********************************9.99875 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

RLREVSEKLN KYSYNSHPHL SLLEQATLKQ CVVGPNHAGF LLEDGRVCRI SFAVQPDRLE 60
LSKPDGGDGS KLSSGSGTGR SSRPGRTSDP PWFLSGSDTL GRLAGNTLGS RWSSGVGGGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCTCCGCG AGGTCTCGGA GAAACTCAAC AAGTACAGCT ATAACAGGCA AGTTTGGGTC 60
AGCGTGGAAA CACTGCTTTT TTCTAATTGG ATAAATTGTT GCTGTTTTGT AATTGTAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	88.82	0.00e+00	4068.00
IUUC-Apl-004165	Anas platyrhynchos	88.80	0.00e+00	4056.00
IUUC-Aca-004577	Anolis carolinensis	88.06	0.00e+00	3552.00
IUUC-Ame-010702	Astyanax mexicanus	89.48	0.00e+00	2595.00
IUUC-Bta-012313	Bos taurus	88.12	0.00e+00	4083.00
IUUC-Cel-018165	Caenorhabditis elegans	26.75	1.00e-84	309.00
IUUC-Cja-019858	Callithrix jacchus	88.13	0.00e+00	4101.00
IUUC-Cfa-020973	Canis familiaris	88.16	0.00e+00	4086.00
IUUC-Cpo-022108	Cavia porcellus	89.94	0.00e+00	1740.00
IUUC-Csa-023985	Chlorocebus sabaeus	89.04	0.00e+00	4114.00
IUUC-Cho-025034	Choloepus hoffmanni	78.61	0.00e+00	916.00
IUUC-Cin-025715	Ciona intestinalis	39.68	0.00e+00	894.00
IUUC-Csv-026131	Ciona savignyi	47.49	0.00e+00	677.00
IUUC-Dre-027730	Danio rerio	91.88	0.00e+00	4179.00
IUUC-Dno-029123	Dasypus novemcinctus	85.78	0.00e+00	3952.00
IUUC-Dor-030757	Dipodomys ordii	84.66	0.00e+00	2551.00
IUUC-Dme-032192	Drosophila melanogaster	53.04	5.00e-176	613.00
IUUC-Ete-032292	Echinops telfairi	85.54	0.00e+00	1872.00
IUUC-Eca-034347	Equus caballus	88.01	0.00e+00	4034.00
IUUC-Eeu-034873	Erinaceus europaeus	84.26	0.00e+00	3879.00
IUUC-Fca-036485	Felis catus	86.39	0.00e+00	3967.00
IUUC-Fal-037071	Ficedula albicollis	89.36	0.00e+00	4069.00
IUUC-Gmo-039589	Gadus morhua	95.24	0.00e+00	4291.00
IUUC-Gga-041195	Gallus gallus	87.11	0.00e+00	3972.00
IUUC-Ggo-045351	Gorilla gorilla	87.50	0.00e+00	4135.00
IUUC-Hsa-045941	Homo sapiens	88.16	0.00e+00	4123.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	88.08	0.00e+00	4081.00
IUUC-Lch-050480	Latimeria chalumnae	87.76	0.00e+00	4018.00
IUUC-Loc-052664	Lepisosteus oculatus	89.09	0.00e+00	4071.00
IUUC-Laf-053960	Loxodonta africana	87.49	0.00e+00	1412.00
IUUC-Mcc-054703	Macaca mulatta	89.11	0.00e+00	4121.00
IUUC-Meu-056431	Macropus eugenii	80.23	0.00e+00	727.00
IUUC-Mga-059289	Meleagris gallopavo	88.63	0.00e+00	3246.00
IUUC-Mmr-061737	Microcebus murinus	87.80	0.00e+00	4015.00
IUUC-Mdo-062499	Monodelphis domestica	87.98	0.00e+00	4035.00
IUUC-Mmu-063273	Mus musculus	87.54	0.00e+00	4019.00
IUUC-Mpu-066907	Mustela putorius furo	88.92	0.00e+00	3778.00
IUUC-Mlu-067942	Myotis lucifugus	88.59	0.00e+00	4098.00
IUUC-Nle-069527	Nomascus leucogenys	88.09	0.00e+00	4125.00
IUUC-Opr-070626	Ochotona princeps	83.59	0.00e+00	1123.00
IUUC-Ont-071951	Oreochromis niloticus	95.32	0.00e+00	4285.00
IUUC-Oan-072958	Ornithorhynchus anatinus	89.15	0.00e+00	3786.00
IUUC-Ocu-074503	Oryctolagus cuniculus	87.25	0.00e+00	3995.00
IUUC-Ola-086757	Oryzias latipes	95.47	0.00e+00	4344.00
IUUC-Oga-088781	Otolemur garnettii	87.87	0.00e+00	4066.00
IUUC-Oar-089274	Ovis aries	88.89	0.00e+00	4066.00
IUUC-Ptr-090669	Pan troglodytes	88.78	0.00e+00	3612.00
IUUC-Pan-092226	Papio anubis	87.73	0.00e+00	4091.00
IUUC-Psi-093502	Pelodiscus sinensis	87.78	0.00e+00	4046.00
IUUC-Pma-094454	Petromyzon marinus	81.90	0.00e+00	728.00
IUUC-Pfo-096173	Poecilia formosa	94.29	0.00e+00	4025.00
IUUC-Pab-098355	Pongo abelii	88.81	0.00e+00	2851.00
IUUC-Pca-100570	Procavia capensis	88.94	0.00e+00	1004.00
IUUC-Pva-102572	Pteropus vampyrus	85.36	0.00e+00	1163.00
IUUC-Rno-104916	Rattus norvegicus	86.52	0.00e+00	3532.00
IUUC-Sha-106653	Sarcophilus harrisii	87.92	0.00e+00	4037.00
IUUC-Sar-113517	Sorex araneus	80.14	0.00e+00	1163.00
IUUC-Ssc-115470	Sus scrofa	89.22	0.00e+00	2296.00
IUUC-Tgu-116932	Taeniopygia guttata	89.01	0.00e+00	4044.00
IUUC-Tru-117682	Takifugu rubripes	95.56	0.00e+00	2795.00
IUUC-Tsy-119417	Tarsius syrichta	85.26	0.00e+00	2236.00
IUUC-Tni-120442	Tetraodon nigroviridis	90.71	0.00e+00	3924.00
IUUC-Tbe-127456	Tupaia belangeri	77.78	0.00e+00	1704.00
IUUC-Ttr-128606	Tursiops truncatus	83.51	0.00e+00	1385.00
IUUC-Vpa-130112	Vicugna pacos	86.01	0.00e+00	3328.00
IUUC-Xtr-131929	Xenopus tropicalis	87.57	0.00e+00	4031.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence