iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000003009.2	ENSORLT00000003769.1	ENSORLP00000003768.1
ENSORLG00000003009.2	ENSORLT00000003767.2	ENSORLP00000003766.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.20e-76	255.8	2475	2798

Active Site

Position(s)	Description	Evidence
2768	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 16   EegldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykl 99
           +e+ + +G+tr ++++ +++  + d  ++lf +  +++ ++ +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k 
   Q: 2475 QENRKRHGSTRSVVDMELDDPDDGDdnAPLFyQPGKRGFYSPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKV 2557
           5667777999988888888888777767888233333666666666554....89******************************** PP
   S: 100  llgkklsledleevdpelykslkeikena...esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlk 183
           llg+k++++d++ +dp +y+sl ++ ++    e+d   +++dl+f ++ ++ + + ++eL++gG n+pVt  N +eYv++++e+r+ 
   Q: 2558 LLGRKVNWHDFAFFDPVMYESLRQLIRHSqtgEADAVFAAMDLAFAIDLCKEEGAGQVELVSGGVNMPVTPLNVYEYVRRYAEHRML 2644
           *********************777766654777799999************************************************ PP
   S: 184  egikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLq 266
              ++ ++a+r+G+ +v+p++ l+ +t+e+++ll++G+ e++v++l ++t+++++  e+  ++    +wFw+++e++s++er++++ 
   Q: 2645 VVAEQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENADKLlqfkRWFWSIVEKMSMTERQDLVY 2731
           ****************************************************9999999888888999******************* PP
   S: 267  FvTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2732 FWTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2798
           **********999******..799999.99**********************************9.99875 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYSYNSHPHL NLLEQATLKQ CVVGPNHAGF 60
LLEDGRVCRI SFSVQPDRME LSKPDGSDGS KLSSGSGTGR SSRAGRTSDP PWFLSGSDTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACATCAA TACACTTCGT TGTCCACCCG TTGCCCGGGA CCGAGGATCA GCTCAATGAC 60
AGGTATTTTG TTGCAGCCCA CAGAAAAGAC CGAGTAGAAT AAATATTTAT GAACCACATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	87.41	0.00e+00	4054.00
IUUC-Apl-004165	Anas platyrhynchos	87.75	0.00e+00	4041.00
IUUC-Aca-004577	Anolis carolinensis	87.78	0.00e+00	3534.00
IUUC-Ame-010702	Astyanax mexicanus	88.41	0.00e+00	2581.00
IUUC-Bta-012313	Bos taurus	88.93	0.00e+00	4113.00
IUUC-Cel-018165	Caenorhabditis elegans	26.88	3.00e-85	311.00
IUUC-Cja-019858	Callithrix jacchus	88.96	0.00e+00	4100.00
IUUC-Cfa-020973	Canis familiaris	89.04	0.00e+00	4120.00
IUUC-Cpo-022108	Cavia porcellus	90.05	0.00e+00	1733.00
IUUC-Csa-023985	Chlorocebus sabaeus	88.25	0.00e+00	4148.00
IUUC-Cho-025034	Choloepus hoffmanni	78.92	0.00e+00	910.00
IUUC-Cin-025715	Ciona intestinalis	40.30	0.00e+00	919.00
IUUC-Csv-026131	Ciona savignyi	46.91	0.00e+00	676.00
IUUC-Dre-027730	Danio rerio	92.19	0.00e+00	4233.00
IUUC-Dno-029123	Dasypus novemcinctus	86.10	0.00e+00	3951.00
IUUC-Dor-030757	Dipodomys ordii	86.00	0.00e+00	2547.00
IUUC-Dme-032192	Drosophila melanogaster	51.72	3.00e-179	624.00
IUUC-Ete-032292	Echinops telfairi	86.05	0.00e+00	1868.00
IUUC-Eca-034347	Equus caballus	88.78	0.00e+00	4024.00
IUUC-Eeu-034873	Erinaceus europaeus	85.17	0.00e+00	3879.00
IUUC-Fca-036485	Felis catus	87.15	0.00e+00	3959.00
IUUC-Fal-037071	Ficedula albicollis	88.35	0.00e+00	4043.00
IUUC-Gmo-039589	Gadus morhua	92.99	0.00e+00	4237.00
IUUC-Gga-041195	Gallus gallus	87.96	0.00e+00	4012.00
IUUC-Gac-042538	Gasterosteus aculeatus	94.82	0.00e+00	4318.00
IUUC-Ggo-045351	Gorilla gorilla	88.56	0.00e+00	4133.00
IUUC-Hsa-045941	Homo sapiens	89.18	0.00e+00	4169.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	88.85	0.00e+00	4074.00
IUUC-Lch-050480	Latimeria chalumnae	88.32	0.00e+00	4001.00
IUUC-Loc-052664	Lepisosteus oculatus	89.07	0.00e+00	4111.00
IUUC-Laf-053960	Loxodonta africana	86.18	0.00e+00	1409.00
IUUC-Mcc-054703	Macaca mulatta	88.25	0.00e+00	4143.00
IUUC-Meu-056431	Macropus eugenii	80.87	0.00e+00	711.00
IUUC-Mga-059289	Meleagris gallopavo	88.50	0.00e+00	3227.00
IUUC-Mmr-061737	Microcebus murinus	88.60	0.00e+00	4016.00
IUUC-Mdo-062499	Monodelphis domestica	88.92	0.00e+00	4034.00
IUUC-Mmu-063273	Mus musculus	88.54	0.00e+00	4063.00
IUUC-Mpu-066907	Mustela putorius furo	87.85	0.00e+00	3761.00
IUUC-Mlu-067942	Myotis lucifugus	87.44	0.00e+00	4068.00
IUUC-Nle-069527	Nomascus leucogenys	89.03	0.00e+00	4128.00
IUUC-Opr-070626	Ochotona princeps	78.80	0.00e+00	1271.00
IUUC-Ont-071951	Oreochromis niloticus	93.57	0.00e+00	4307.00
IUUC-Oan-072958	Ornithorhynchus anatinus	88.28	0.00e+00	3765.00
IUUC-Ocu-074503	Oryctolagus cuniculus	86.27	0.00e+00	4025.00
IUUC-Oga-088781	Otolemur garnettii	88.86	0.00e+00	4112.00
IUUC-Oar-089274	Ovis aries	87.77	0.00e+00	4044.00
IUUC-Ptr-090669	Pan troglodytes	89.03	0.00e+00	3600.00
IUUC-Pan-092226	Papio anubis	88.83	0.00e+00	4130.00
IUUC-Psi-093502	Pelodiscus sinensis	88.65	0.00e+00	4040.00
IUUC-Pma-094454	Petromyzon marinus	81.90	0.00e+00	727.00
IUUC-Pfo-096173	Poecilia formosa	94.83	0.00e+00	4028.00
IUUC-Pab-098355	Pongo abelii	90.31	0.00e+00	2849.00
IUUC-Pca-100570	Procavia capensis	89.24	0.00e+00	1003.00
IUUC-Pva-102572	Pteropus vampyrus	86.09	0.00e+00	1160.00
IUUC-Rno-104916	Rattus norvegicus	86.86	0.00e+00	3533.00
IUUC-Sha-106653	Sarcophilus harrisii	88.73	0.00e+00	4074.00
IUUC-Sar-113517	Sorex araneus	82.63	0.00e+00	1166.00
IUUC-Ssc-115470	Sus scrofa	89.10	0.00e+00	2281.00
IUUC-Tgu-116932	Taeniopygia guttata	87.96	0.00e+00	4026.00
IUUC-Tru-117682	Takifugu rubripes	94.23	0.00e+00	2764.00
IUUC-Tsy-119417	Tarsius syrichta	85.20	0.00e+00	2224.00
IUUC-Tni-120442	Tetraodon nigroviridis	90.57	0.00e+00	3905.00
IUUC-Tbe-127456	Tupaia belangeri	78.62	0.00e+00	1852.00
IUUC-Ttr-128606	Tursiops truncatus	85.60	0.00e+00	1422.00
IUUC-Vpa-130112	Vicugna pacos	85.97	0.00e+00	3322.00
IUUC-Xtr-131929	Xenopus tropicalis	86.98	0.00e+00	4053.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence