iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012553

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 14; Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14

Genbank Nucleotide ID

BC122666

Gene Name

USP14

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000019214.5	ENSBTAT00000025580.5	ENSBTAP00000025580.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.10e-65	219.2	105	480
ULD/UDP/UBQ/UBQ_Other	6.90e-09	35.6	5	74

Active Site

Position(s)	Description	Evidence
114	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
435	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f     
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekge 191
           7******************************.****************************.99999******************999*9 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             +y qqDa+E++ +++  l+++l+  ++ +++e+ ++       +a+  +++k+ksli++ F++++++++kc e +++ +++ +  +l
   Q: 192  qgQYLQQDANECWVQMMRVLQQKLEAIEDDTVKETDSS-------SASAVTPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKESQL 273
           999*********************66555555554333.......47788999*********************999999888777777 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+   ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+
   Q: 274  QLSCFINQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDV 355
           7777766643..57999999999999998.....58899999999******************************************** PP
   S: 262  spfcts.....................peekqke..............................kkkYeLiavvvHsG.slssGHYvay 298
            + ct                      +     +                              +  Y+L av+ H+G s+ssGHYv++
   Q: 356  YELCTPelqekmvsfrskfkdledkkvN-----QqpktgdkdsspqkevkyepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYVSW 439
           ******6666666666666666555550.....0555555556666667777777777777777************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           vk   ++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 440  VKRXXDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 480
           **************************988************ PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           +vtvk+ + +  ++++n +++  ++K +++ ++g++p++q+ ++kG  L+dd ++++ ++k+g+t++++ +
   Q: 5    SVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDD-DWGNIKMKNGMTVLMMGS 74
           69********99*************************************999.9**************965 PP

Organism

Bos taurus

Functional Description
(View)

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity).

Protein Sequence
(Fasta)

MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 60
IKMKNGMTVL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCGCAGTG CGCACGCGCG CACCTGTGCG GCGAAGGGGC CGCGCGCGCG CCCCCTTTCC 60
CGCCGCCCTC GCCGCCCTGG TCTCTCCACC CGCAGGCCCC GCCTCGCTTC CTCCCCGCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0070628--F:proteasome binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:505106

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	30.66	9.00e-65	241.00
IUUC-Aml-002053	Ailuropoda melanoleuca	97.35	0.00e+00	927.00
IUUC-Atr-002725	Amborella trichopoda	42.03	1.00e-101	363.00
IUUC-Apl-004031	Anas platyrhynchos	90.65	0.00e+00	894.00
IUUC-Aca-004361	Anolis carolinensis	88.89	0.00e+00	910.00
IUUC-Aly-006078	Arabidopsis lyrata	41.98	2.00e-112	399.00
IUUC-Ath-007623	Arabidopsis thaliana	42.55	5.00e-113	400.00
IUUC-Ago-007796	Ashbya gossypii	32.64	9.00e-59	221.00
IUUC-Acl-008258	Aspergillus clavatus	37.19	2.00e-67	249.00
IUUC-Afl-008732	Aspergillus flavus	34.03	8.00e-82	297.00
IUUC-Afu-008755	Aspergillus fumigatus	34.95	9.00e-82	297.00
IUUC-Ani-009148	Aspergillus nidulans	38.88	1.00e-72	267.00
IUUC-Ang-009878	Aspergillus niger	37.99	1.00e-67	250.00
IUUC-Aor-010239	Aspergillus oryzae	34.03	8.00e-82	298.00
IUUC-Ate-010243	Aspergillus terreus	33.74	2.00e-72	266.00
IUUC-Ame-011327	Astyanax mexicanus	50.20	2.00e-126	445.00
IUUC-Bgr-012231	Blumeria graminis	33.98	2.00e-76	280.00
IUUC-Bci-013606	Botrytis cinerea	40.21	8.00e-71	261.00
IUUC-Bdi-014567	Brachypodium distachyon	43.93	5.00e-113	401.00
IUUC-Bol-016127	Brassica oleracea	42.60	2.00e-114	405.00
IUUC-Bra-017501	Brassica rapa	42.40	9.00e-114	403.00
IUUC-Cel-018140	Caenorhabditis elegans	42.09	8.00e-101	360.00
IUUC-Cja-019516	Callithrix jacchus	96.57	0.00e+00	947.00
IUUC-Cfa-020808	Canis familiaris	97.98	0.00e+00	964.00
IUUC-Cpo-021688	Cavia porcellus	96.15	0.00e+00	940.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	37.53	7.00e-83	300.00
IUUC-Csa-023429	Chlorocebus sabaeus	97.36	0.00e+00	929.00
IUUC-Cho-024347	Choloepus hoffmanni	96.55	0.00e+00	952.00
IUUC-Cin-025198	Ciona intestinalis	55.01	1.00e-152	532.00
IUUC-Csv-026007	Ciona savignyi	53.41	2.00e-154	538.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	38.44	3.00e-64	239.00
IUUC-Cne-026963	Cryptococcus neoformans	34.68	1.00e-75	276.00
IUUC-Cme-027240	Cyanidioschyzon merolae	31.20	4.00e-60	225.00
IUUC-Dre-027647	Danio rerio	82.45	0.00e+00	831.00
IUUC-Dno-029967	Dasypus novemcinctus	96.56	0.00e+00	927.00
IUUC-Dor-030886	Dipodomys ordii	91.14	0.00e+00	755.00
IUUC-Dse-031466	Dothistroma septosporum	35.56	1.00e-57	218.00
IUUC-Dme-032079	Drosophila melanogaster	55.14	2.00e-159	555.00
IUUC-Ete-032351	Echinops telfairi	85.22	0.00e+00	852.00
IUUC-Eca-033461	Equus caballus	96.56	0.00e+00	995.00
IUUC-Eeu-035220	Erinaceus europaeus	73.36	0.00e+00	690.00
IUUC-Fca-036210	Felis catus	98.18	0.00e+00	965.00
IUUC-Fal-037528	Ficedula albicollis	90.26	0.00e+00	874.00
IUUC-Fox-037805	Fusarium oxysporum	40.16	1.00e-71	264.00
IUUC-Fso-038177	Fusarium solani	38.64	8.00e-69	254.00
IUUC-Gmo-038953	Gadus morhua	77.39	0.00e+00	769.00
IUUC-Ggr-039972	Gaeumannomyces graminis	39.10	1.00e-64	240.00
IUUC-Gga-040462	Gallus gallus	89.68	0.00e+00	886.00
IUUC-Gac-041312	Gasterosteus aculeatus	81.93	0.00e+00	802.00
IUUC-Gma-043255	Glycine max	42.83	1.00e-108	386.00
IUUC-Ggo-045458	Gorilla gorilla	80.81	0.00e+00	783.00
IUUC-Hsa-045706	Homo sapiens	97.57	0.00e+00	932.00
IUUC-Hvu-047821	Hordeum vulgare	46.30	2.00e-57	215.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	96.76	0.00e+00	954.00
IUUC-Lch-050464	Latimeria chalumnae	82.24	0.00e+00	827.00
IUUC-Lpe-051419	Leersia perrieri	42.92	9.00e-109	387.00
IUUC-Loc-052732	Lepisosteus oculatus	81.05	0.00e+00	843.00
IUUC-Lma-053177	Leptosphaeria maculans	41.28	1.00e-71	263.00
IUUC-Laf-053822	Loxodonta africana	97.16	0.00e+00	953.00
IUUC-Mcc-055893	Macaca mulatta	97.57	0.00e+00	930.00
IUUC-Meu-056307	Macropus eugenii	81.63	0.00e+00	793.00
IUUC-Mor-057171	Magnaporthe oryzae	39.64	1.00e-68	253.00
IUUC-Mpo-057415	Magnaporthe poae	36.64	2.00e-83	302.00
IUUC-Mtr-057901	Medicago truncatula	42.80	3.00e-111	395.00
IUUC-Mla-058897	Melampsora laricipopulina	35.51	2.00e-81	296.00
IUUC-Mga-060016	Meleagris gallopavo	90.45	0.00e+00	891.00
IUUC-Mvi-060562	Microbotryum violaceum	39.57	3.00e-68	252.00
IUUC-Mmr-060624	Microcebus murinus	97.17	0.00e+00	1000.00
IUUC-Mdo-061809	Monodelphis domestica	92.14	0.00e+00	895.00
IUUC-Mmu-063869	Mus musculus	96.36	0.00e+00	947.00
IUUC-Mac-064876	Musa acuminata	39.68	1.00e-95	343.00
IUUC-Mpu-066480	Mustela putorius furo	97.57	0.00e+00	962.00
IUUC-Mlu-067866	Myotis lucifugus	96.36	0.00e+00	960.00
IUUC-Nfi-068393	Neosartorya fischeri	37.65	4.00e-67	248.00
IUUC-Ncr-068815	Neurospora crassa	35.66	1.00e-83	303.00
IUUC-Nle-070121	Nomascus leucogenys	98.02	2.00e-140	491.00
IUUC-Opr-070712	Ochotona princeps	76.69	2.00e-173	602.00
IUUC-Ont-071544	Oreochromis niloticus	81.87	0.00e+00	770.00
IUUC-Oan-073635	Ornithorhynchus anatinus	91.12	0.00e+00	748.00
IUUC-Ocu-074926	Oryctolagus cuniculus	95.55	0.00e+00	922.00
IUUC-Oba-075633	Oryza barthii	41.98	3.00e-109	388.00
IUUC-Obr-076423	Oryza brachyantha	42.83	1.00e-111	396.00
IUUC-Ogl-077913	Oryza glaberrima	41.82	1.00e-111	396.00
IUUC-Ogu-078435	Oryza glumaepatula	41.98	3.00e-109	388.00
IUUC-Oin-080072	Oryza indica	41.94	2.00e-109	389.00
IUUC-Olo-080535	Oryza longistaminata	39.24	4.00e-93	335.00
IUUC-Ome-081309	Oryza meridionalis	41.98	3.00e-109	388.00
IUUC-Oni-083113	Oryza nivara	41.98	3.00e-109	388.00
IUUC-Opu-083168	Oryza punctata	41.03	5.00e-104	370.00
IUUC-Oru-084253	Oryza rufipogon	41.98	3.00e-109	388.00
IUUC-Osa-085554	Oryza sativa	41.82	1.00e-111	396.00
IUUC-Ola-086998	Oryzias latipes	80.73	0.00e+00	795.00
IUUC-Olu-087818	Ostreococcus lucimarinus	36.57	5.00e-71	261.00
IUUC-Oga-088571	Otolemur garnettii	97.37	0.00e+00	952.00
IUUC-Oar-089526	Ovis aries	98.98	0.00e+00	966.00
IUUC-Ptr-091433	Pan troglodytes	97.57	0.00e+00	930.00
IUUC-Pan-091966	Papio anubis	97.36	0.00e+00	929.00
IUUC-Psi-093458	Pelodiscus sinensis	88.36	0.00e+00	846.00
IUUC-Pma-094343	Petromyzon marinus	68.86	7.00e-122	429.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.65	1.00e-66	247.00
IUUC-Ppa-095756	Physcomitrella patens	43.64	9.00e-113	400.00
IUUC-Pfo-096514	Poecilia formosa	82.28	0.00e+00	786.00
IUUC-Pab-098477	Pongo abelii	85.32	0.00e+00	734.00
IUUC-Pop-099221	Populus trichocarpa	41.57	1.00e-103	370.00
IUUC-Pca-100791	Procavia capensis	79.72	5.00e-179	620.00
IUUC-Ppe-101812	Prunus persica	41.82	2.00e-107	382.00
IUUC-Pva-102462	Pteropus vampyrus	92.54	0.00e+00	773.00
IUUC-Pgr-103623	Puccinia graminis	40.40	2.00e-74	273.00
IUUC-Ptt-103767	Puccinia triticina	39.40	7.00e-68	251.00
IUUC-Pte-104109	Pyrenophora teres	39.45	5.00e-71	261.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	40.05	3.00e-71	263.00
IUUC-Rno-105351	Rattus norvegicus	96.36	0.00e+00	904.00
IUUC-Sce-106168	Saccharomyces cerevisiae	33.00	5.00e-63	235.00
IUUC-Sha-107491	Sarcophilus harrisii	92.32	0.00e+00	915.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	35.17	6.00e-79	288.00
IUUC-Spo-108174	Schizosaccharomyces pombe	37.22	2.00e-80	293.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	35.56	4.00e-84	305.00
IUUC-Smo-108805	Selaginella moellendorffii	43.62	5.00e-111	394.00
IUUC-Sit-110361	Setaria italica	42.94	1.00e-114	406.00
IUUC-Sly-110965	Solanum lycopersicum	40.94	1.00e-108	387.00
IUUC-Sar-113355	Sorex araneus	84.38	0.00e+00	662.00
IUUC-Sbi-114778	Sorghum bicolor	44.24	2.00e-114	406.00
IUUC-Sre-115011	Sporisorium reilianum	36.90	8.00e-63	234.00
IUUC-Ssc-116273	Sus scrofa	96.74	0.00e+00	940.00
IUUC-Tgu-117063	Taeniopygia guttata	89.63	0.00e+00	871.00
IUUC-Tru-118381	Takifugu rubripes	79.47	0.00e+00	797.00
IUUC-Tsy-119076	Tarsius syrichta	81.41	1.00e-116	412.00
IUUC-Tni-119941	Tetraodon nigroviridis	81.10	0.00e+00	788.00
IUUC-Tca-121246	Theobroma cacao	41.49	1.00e-109	389.00
IUUC-Tre-121969	Trichoderma reesei	39.23	7.00e-70	258.00
IUUC-Tvi-122543	Trichoderma virens	35.04	2.00e-79	290.00
IUUC-Tae-125484	Triticum aestivum	42.66	3.00e-110	392.00
IUUC-Tur-126128	Triticum urartu	32.75	4.00e-68	252.00
IUUC-Tbe-128030	Tupaia belangeri	89.96	0.00e+00	853.00
IUUC-Ttr-128701	Tursiops truncatus	96.70	0.00e+00	776.00
IUUC-Uma-129657	Ustilago maydis	37.36	1.00e-65	243.00
IUUC-Vda-129723	Verticillium dahliae	32.65	1.00e-71	264.00
IUUC-Vpa-130284	Vicugna pacos	69.88	0.00e+00	638.00
IUUC-Vvi-131037	Vitis vinifera	42.80	1.00e-108	386.00
IUUC-Xtr-132235	Xenopus tropicalis	85.28	0.00e+00	879.00
IUUC-Xma-133840	Xiphophorus maculatus	82.28	0.00e+00	811.00
IUUC-Yli-134453	Yarrowia lipolytica	36.78	1.00e-82	300.00
IUUC-Zma-135669	Zea mays	36.79	2.00e-96	346.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence