iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000154277.12	ENST00000503431.5	ENSP00000422542.1
ENSG00000154277.12	ENST00000512419.5	ENSP00000425714.1
ENSG00000154277.12	ENST00000505232.5	ENSP00000423348.1
ENSG00000154277.12	ENST00000508768.5	ENSP00000426895.1
ENSG00000154277.12	ENST00000512788.1	ENSP00000423623.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	12408865
DUB/UCH	UCH	12408865; 19707515
UBD/Other/Other	UBD/Other/Other	9521656; 23359680

Classification

Family	E-value	Score	Start	End
DUB/UCH	5.50e-65	221.6	2	222

Active Site

Position(s)	Description	Evidence
90	Nucleophile	{ECO:0000269\|PubMed:20439756}
161	Proton donor	{ECO:0000269\|PubMed:20439756}

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNs 98
           ++ ++e +P++++++++++gv +++++ ++ +L++e+lg+++ p ++llllF+++ ++e++rk+q++    e +++++  +++f+kq+igNs
   Q: 2    QLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIE----ELKGQEVSPKVYFMKQTIGNS 89
           5789*************************************************************99....99******************* PP
   S: 99   CatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningr 189
           C+t++l+++++n++dkl ++ G+ l++++++t+++spe++a++++++++++++h+++a++++++ +          +k +fhf+++ n++g+
   Q: 90   CGTIGLIHAVANNQDKLgFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVD----------DKVNFHFILFNNVDGH 171
           ****************************************************************99..........5679************ PP
   S: 190  lyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
           lyeldg++pfP+++g+++e++ lkd++kv+r+f+er    e++e+rf+++a++++
   Q: 172  LYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTER----EQGEVRFSAVALCKA 222
           ************************************....************987 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE 60
NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTATTCT AGGTAGTCAC TTAAAAACGA ACCTCGGTAC TGGTCTGACT TAACATGGAG 60
GAGGAATTGT CTAAGGTTAA ACGCAAACTG CTGAGAGATT TGGGGCGGGG GGCACACATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0890--Hereditary spastic paraplegia
KW-0378--Hydrolase
KW-0436--Ligase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0523--Neurodegeneration
KW-0558--Oxidation
KW-0907--Parkinson disease
KW-0908--Parkinsonism
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0636--Prenylation
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0031694--F:alpha-2A adrenergic receptor binding
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0016241--P:regulation of macroautophagy
GO:0002931--P:response to ischemia
GO:0019233--P:sensory perception of pain

KEGG

hsa:7345

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001376	Ailuropoda melanoleuca	80.08	2.00e-112	398.00
IUUC-Apl-003693	Anas platyrhynchos	69.64	3.00e-91	327.00
IUUC-Aca-004716	Anolis carolinensis	77.68	5.00e-103	366.00
IUUC-Ame-011806	Astyanax mexicanus	68.16	7.00e-86	309.00
IUUC-Bta-013521	Bos taurus	81.75	1.00e-114	405.00
IUUC-Cja-018752	Callithrix jacchus	98.66	8.00e-120	422.00
IUUC-Cfa-020442	Canis familiaris	95.54	2.00e-116	411.00
IUUC-Cpo-021723	Cavia porcellus	96.99	3.00e-94	337.00
IUUC-Csa-023626	Chlorocebus sabaeus	99.10	1.00e-120	425.00
IUUC-Cho-024548	Choloepus hoffmanni	85.19	4.00e-40	157.00
IUUC-Dre-027854	Danio rerio	66.07	2.00e-84	305.00
IUUC-Dno-029325	Dasypus novemcinctus	95.96	5.00e-118	416.00
IUUC-Dor-030114	Dipodomys ordii	94.62	1.00e-126	444.00
IUUC-Ete-033092	Echinops telfairi	77.58	4.00e-97	347.00
IUUC-Eca-033854	Equus caballus	96.48	3.00e-79	286.00
IUUC-Eeu-034493	Erinaceus europaeus	93.27	2.00e-113	401.00
IUUC-Fal-036693	Ficedula albicollis	74.29	1.00e-92	332.00
IUUC-Gmo-038848	Gadus morhua	61.32	1.00e-74	272.00
IUUC-Gga-041078	Gallus gallus	75.00	1.00e-101	362.00
IUUC-Gac-042064	Gasterosteus aculeatus	62.27	7.00e-78	283.00
IUUC-Ggo-044827	Gorilla gorilla	100.00	5.00e-122	429.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	95.96	3.00e-117	414.00
IUUC-Lch-050121	Latimeria chalumnae	74.32	2.00e-98	351.00
IUUC-Loc-052342	Lepisosteus oculatus	70.35	2.00e-92	331.00
IUUC-Laf-053916	Loxodonta africana	94.22	1.00e-115	409.00
IUUC-Mcc-054838	Macaca mulatta	99.10	1.00e-120	425.00
IUUC-Meu-056478	Macropus eugenii	89.24	3.00e-121	427.00
IUUC-Mga-059878	Meleagris gallopavo	73.73	2.00e-95	341.00
IUUC-Mdo-062544	Monodelphis domestica	87.89	6.00e-110	389.00
IUUC-Mmu-063300	Mus musculus	95.52	3.00e-127	447.00
IUUC-Mpu-066128	Mustela putorius furo	95.00	3.00e-103	367.00
IUUC-Mlu-067778	Myotis lucifugus	94.17	1.00e-125	441.00
IUUC-Nle-069686	Nomascus leucogenys	99.55	1.00e-121	428.00
IUUC-Opr-070535	Ochotona princeps	78.48	4.00e-99	353.00
IUUC-Ont-071510	Oreochromis niloticus	62.61	9.00e-80	289.00
IUUC-Ocu-074590	Oryctolagus cuniculus	96.41	2.00e-118	417.00
IUUC-Ola-087552	Oryzias latipes	59.21	3.00e-74	271.00
IUUC-Oga-089013	Otolemur garnettii	82.14	9.00e-114	402.00
IUUC-Oar-089861	Ovis aries	81.75	1.00e-114	405.00
IUUC-Ptr-091536	Pan troglodytes	98.21	1.00e-119	421.00
IUUC-Pan-092909	Papio anubis	99.10	1.00e-120	425.00
IUUC-Psi-093818	Pelodiscus sinensis	79.91	9.00e-105	372.00
IUUC-Pfo-097335	Poecilia formosa	60.44	3.00e-79	287.00
IUUC-Pab-098048	Pongo abelii	100.00	5.00e-122	429.00
IUUC-Pca-100818	Procavia capensis	72.31	2.00e-66	244.00
IUUC-Pva-102954	Pteropus vampyrus	95.07	6.00e-113	399.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	37.50	6.00e-31	127.00
IUUC-Rno-105966	Rattus norvegicus	95.52	3.00e-127	447.00
IUUC-Sha-107111	Sarcophilus harrisii	87.27	3.00e-87	313.00
IUUC-Sar-113190	Sorex araneus	74.56	2.00e-38	150.00
IUUC-Ssc-115908	Sus scrofa	78.22	4.00e-99	353.00
IUUC-Tgu-117465	Taeniopygia guttata	70.14	3.00e-86	311.00
IUUC-Tru-118565	Takifugu rubripes	60.78	5.00e-70	256.00
IUUC-Tsy-119561	Tarsius syrichta	77.58	1.00e-96	345.00
IUUC-Tbe-128048	Tupaia belangeri	95.15	2.00e-92	330.00
IUUC-Ttr-128494	Tursiops truncatus	95.05	3.00e-114	404.00
IUUC-Vda-129850	Verticillium dahliae	34.20	8.00e-29	120.00
IUUC-Xtr-132286	Xenopus tropicalis	69.96	1.00e-92	332.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence