iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000044381.7	ENSDART00000065169.5	ENSDARP00000065168.4
ENSDARG00000044381.7	ENSDART00000113813.2	ENSDARP00000099847.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	91.70	9.00e-140	493.00	IUUC-Hsa-046179
E3 activity/RING/RING	91.70	4.00e-140	494.00	IUUC-Mmu-063206
E3 activity/RING/RING	91.70	3.00e-140	494.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRPSSAGGA AGGLGAGKAG GSKHGGSGGT TASAAAAAAA AAAAAAAAAA AGVSGSVAGS 60
GTVPAAAVAL PVAALPGQSP ELTALFECPV CFDYVLPPIL QCQAGHLVCN QCRQKLSCCP 120

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Nucleotide Sequence
(Fasta)

ATGGCGGCCA TGTTGTATCC GCGGGGGATT GGAGGAGGCT ACTCGGAACC GAGTCCGTGT 60
TCAGTCGGGA GTGGACGGTG AGGCTCTCGG GCTTCAGCTA CTCGGGGTTT TACACCATCA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dre:378728

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	91.70	2.00e-141	494.00
IUUC-Ame-011678	Astyanax mexicanus	98.43	4.00e-153	533.00
IUUC-Bta-012750	Bos taurus	91.30	3.00e-141	494.00
IUUC-Cja-019800	Callithrix jacchus	91.70	2.00e-141	495.00
IUUC-Cfa-020505	Canis familiaris	91.30	4.00e-141	493.00
IUUC-Cpo-021394	Cavia porcellus	91.70	1.00e-141	495.00
IUUC-Csa-023374	Chlorocebus sabaeus	91.70	2.00e-141	495.00
IUUC-Cho-024933	Choloepus hoffmanni	91.70	2.00e-141	494.00
IUUC-Dno-029260	Dasypus novemcinctus	92.59	1.00e-137	482.00
IUUC-Dor-030489	Dipodomys ordii	91.80	2.00e-101	361.00
IUUC-Ete-032946	Echinops telfairi	91.70	3.00e-141	494.00
IUUC-Eca-033546	Equus caballus	91.70	4.00e-142	496.00
IUUC-Eeu-034861	Erinaceus europaeus	88.93	1.00e-136	479.00
IUUC-Gmo-039091	Gadus morhua	95.67	7.00e-147	513.00
IUUC-Gga-040252	Gallus gallus	89.72	4.00e-138	484.00
IUUC-Gac-041673	Gasterosteus aculeatus	96.44	9.00e-148	516.00
IUUC-Ggo-044618	Gorilla gorilla	91.70	2.00e-141	495.00
IUUC-Hsa-046179	Homo sapiens	91.70	2.00e-141	495.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	90.91	2.00e-140	491.00
IUUC-Lch-049496	Latimeria chalumnae	91.70	6.00e-142	496.00
IUUC-Loc-052107	Lepisosteus oculatus	98.80	1.00e-151	529.00
IUUC-Laf-054257	Loxodonta africana	91.30	2.00e-139	488.00
IUUC-Mcc-055023	Macaca mulatta	91.70	2.00e-141	495.00
IUUC-Meu-055922	Macropus eugenii	90.51	3.00e-138	484.00
IUUC-Mga-060070	Meleagris gallopavo	88.19	5.00e-135	473.00
IUUC-Mmr-061494	Microcebus murinus	91.70	2.00e-141	495.00
IUUC-Mdo-061971	Monodelphis domestica	91.70	3.00e-141	494.00
IUUC-Mmu-063206	Mus musculus	91.70	1.00e-141	495.00
IUUC-Mpu-066597	Mustela putorius furo	91.70	2.00e-141	495.00
IUUC-Mlu-067199	Myotis lucifugus	91.30	8.00e-141	493.00
IUUC-Nle-069342	Nomascus leucogenys	91.70	2.00e-141	495.00
IUUC-Opr-070341	Ochotona princeps	58.17	5.00e-51	194.00
IUUC-Ont-071906	Oreochromis niloticus	97.24	1.00e-149	522.00
IUUC-Oan-073701	Ornithorhynchus anatinus	55.13	9.00e-51	193.00
IUUC-Ocu-073950	Oryctolagus cuniculus	91.30	4.00e-141	493.00
IUUC-Oga-089154	Otolemur garnettii	91.70	2.00e-141	495.00
IUUC-Oar-089446	Ovis aries	91.30	4.00e-141	493.00
IUUC-Ptr-091088	Pan troglodytes	91.70	2.00e-141	495.00
IUUC-Psi-093079	Pelodiscus sinensis	91.70	4.00e-141	493.00
IUUC-Pfo-097007	Poecilia formosa	91.30	2.00e-141	494.00
IUUC-Pab-098092	Pongo abelii	91.70	2.00e-141	495.00
IUUC-Pca-100328	Procavia capensis	89.33	3.00e-137	481.00
IUUC-Pva-102368	Pteropus vampyrus	98.18	1.00e-61	229.00
IUUC-Rno-105477	Rattus norvegicus	91.70	1.00e-141	495.00
IUUC-Sha-107630	Sarcophilus harrisii	91.30	8.00e-141	492.00
IUUC-Ssc-116441	Sus scrofa	91.30	5.00e-141	493.00
IUUC-Tru-118004	Takifugu rubripes	93.70	2.00e-144	504.00
IUUC-Tsy-119548	Tarsius syrichta	87.79	1.00e-64	239.00
IUUC-Tni-120846	Tetraodon nigroviridis	95.26	1.00e-146	512.00
IUUC-Vpa-130799	Vicugna pacos	94.15	1.00e-97	348.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence