iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120846

UUCD1 version

UUC-TeN-00882

Ensembl Protein ID

ENSTNIP00000010489.1

UniProt Accession

H3CQF5; H3CQF5_TETNG

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000007673.1	ENSTNIT00000010670.1	ENSTNIP00000010489.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	88.93	6.00e-136	480.00	IUUC-Hsa-046179
E3 activity/RING/RING	88.93	3.00e-136	481.00	IUUC-Mmu-063206
E3 activity/RING/RING	88.93	2.00e-136	481.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Tetraodon nigroviridis

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

SVGSVAGSVS GTPSSAVSLT SSSLPGQTPE LTALFECPVC FDYVLPPILQ CQAGHLVCNL 60
CRQKLSCCPT CRGPLTPSIR NLAMEKVAST LPFPCKYSSA GCLLNLHHSE KPDHEEVCEF 120

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Nucleotide Sequence
(Fasta)

AGCGTCGGCT CCGTGGCTGG GTCGGTGTCA GGGACGCCTT CTTCCGCGGT GTCCCTCACC 60
TCCAGCAGCC TGCCCGGCCA GACTCCCGAG CTCACGGCAC TCTTCGAGTG CCCAGTATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	88.93	1.00e-137	482.00
IUUC-Ame-011678	Astyanax mexicanus	94.49	5.00e-146	509.00
IUUC-Bta-012750	Bos taurus	88.54	2.00e-137	481.00
IUUC-Cja-019800	Callithrix jacchus	88.93	9.00e-138	482.00
IUUC-Cfa-020505	Canis familiaris	88.54	3.00e-137	480.00
IUUC-Cpo-021394	Cavia porcellus	88.93	6.00e-138	483.00
IUUC-Csa-023374	Chlorocebus sabaeus	88.93	9.00e-138	482.00
IUUC-Cho-024933	Choloepus hoffmanni	88.93	1.00e-137	481.00
IUUC-Dre-027711	Danio rerio	95.28	3.00e-147	514.00
IUUC-Dno-029260	Dasypus novemcinctus	89.71	3.00e-134	470.00
IUUC-Dor-030489	Dipodomys ordii	87.98	4.00e-98	349.00
IUUC-Ete-032946	Echinops telfairi	89.33	1.00e-137	482.00
IUUC-Eca-033546	Equus caballus	88.28	2.00e-138	484.00
IUUC-Eeu-034861	Erinaceus europaeus	86.17	6.00e-133	466.00
IUUC-Gmo-039091	Gadus morhua	95.31	1.00e-147	514.00
IUUC-Gga-040252	Gallus gallus	87.75	3.00e-135	474.00
IUUC-Gac-041673	Gasterosteus aculeatus	96.05	1.00e-147	514.00
IUUC-Ggo-044618	Gorilla gorilla	88.93	9.00e-138	482.00
IUUC-Hsa-046179	Homo sapiens	88.93	9.00e-138	482.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	88.14	1.00e-136	478.00
IUUC-Lch-049496	Latimeria chalumnae	88.93	3.00e-139	487.00
IUUC-Loc-052107	Lepisosteus oculatus	95.20	4.00e-145	506.00
IUUC-Laf-054257	Loxodonta africana	88.54	8.00e-136	475.00
IUUC-Mcc-055023	Macaca mulatta	88.93	9.00e-138	482.00
IUUC-Meu-055922	Macropus eugenii	87.75	8.00e-135	472.00
IUUC-Mga-060070	Meleagris gallopavo	85.16	7.00e-132	462.00
IUUC-Mmr-061494	Microcebus murinus	88.93	9.00e-138	482.00
IUUC-Mdo-061971	Monodelphis domestica	88.93	2.00e-137	481.00
IUUC-Mmu-063206	Mus musculus	88.93	7.00e-138	483.00
IUUC-Mpu-066597	Mustela putorius furo	88.93	9.00e-138	482.00
IUUC-Mlu-067199	Myotis lucifugus	88.54	4.00e-137	480.00
IUUC-Nle-069342	Nomascus leucogenys	88.93	9.00e-138	482.00
IUUC-Opr-070341	Ochotona princeps	56.21	7.00e-50	190.00
IUUC-Ont-071906	Oreochromis niloticus	96.48	8.00e-150	522.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.21	6.00e-49	187.00
IUUC-Ocu-073950	Oryctolagus cuniculus	88.54	3.00e-137	481.00
IUUC-Oga-089154	Otolemur garnettii	88.93	9.00e-138	482.00
IUUC-Oar-089446	Ovis aries	88.54	2.00e-137	480.00
IUUC-Ptr-091088	Pan troglodytes	88.93	9.00e-138	482.00
IUUC-Psi-093079	Pelodiscus sinensis	88.93	1.00e-137	481.00
IUUC-Pfo-097007	Poecilia formosa	91.70	1.00e-141	495.00
IUUC-Pab-098092	Pongo abelii	88.93	9.00e-138	482.00
IUUC-Pca-100328	Procavia capensis	86.56	1.00e-133	469.00
IUUC-Pva-102368	Pteropus vampyrus	95.45	4.00e-60	224.00
IUUC-Rno-105477	Rattus norvegicus	88.93	7.00e-138	483.00
IUUC-Sha-107630	Sarcophilus harrisii	88.54	4.00e-137	479.00
IUUC-Ssc-116441	Sus scrofa	88.54	2.00e-137	481.00
IUUC-Tru-118004	Takifugu rubripes	95.70	6.00e-148	516.00
IUUC-Tsy-119548	Tarsius syrichta	85.50	5.00e-63	233.00
IUUC-Vpa-130799	Vicugna pacos	90.64	6.00e-95	338.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence