iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120001

UUCD1 version

UUC-TeN-01138

Ensembl Protein ID

ENSTNIP00000010309.1

UniProt Accession

H3CPX5; H3CPX5_TETNG

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000007500.1	ENSTNIT00000010490.1	ENSTNIP00000010309.1
ENSTNIG00000007500.1	ENSTNIT00000003180.1	ENSTNIP00000000494.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-110	369.9	149	692

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kN+gN+CYmN++LQ+Lsn+p+l++++l+     ++   ++++k +l+ks+qkl++elw k++ ++v p++l + +k ++++f+gy+
   Q: 149  TGMKNIGNSCYMNAALQALSNCPPLTQFFLD-----CSGLVRTDKKPALCKSYQKLISELWhKKRPSYVVPTSLSNGIKLVNPMFRGYA 232
           7******************************.....9999999******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqD+qEfl++l+dql+eelk+                 e++d +e  d                                         
   Q: 233  QQDTQEFLRCLMDQLHEELKEplaecstsG--------EGSDGEEVRDGeqspsedeflscdsgsssdrgegggageselllqdecdgi 313
           *******************98555554432........3333333333345555566899999999999******************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 314  wpptggsvghsppgvisekerlkekkgsgsplhggsqemdedadvdtaaeetvpergeeevlmpasntetqkpdneasmahpqsthcsp 402
           ***************************************************************************************** PP
   S: 130  ......................................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
                                                 +++kk+++ +s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke
   Q: 403  vrtlqelhpklssspprssplrsagpsysfkksqmmlsSKKKKQSHFRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKE 491
           *************************************999999999******************************************* PP
   S: 181  etkke.................................................slqdcLesftkeeelegenkyycekckkkqeaekk 220
           + +k+                                                 +l+dcL++f++++el+g+n+y+cekckk+++ +k 
   Q: 492  DLAKLhssihqnlpvktgtcpesynsqgwisyimesirrfvvsciptwfwgpmvTLEDCLAAFFAADELKGDNMYSCEKCKKLRNGVKY 580
           99888************************************************************************************ PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWl 307
           +k+ klPe+L++hLkRf  ++e + + ki+++v+fple L+++pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W+
   Q: 581  CKVLKLPEILCIHLKRF--RHEVMYSFKISSHVSFPLEgLNMQPFLAKDSPSQ--VTTYDLLSVICHHGTAGSGHYIAYCQNvINGQWY 665
           *****************..9999*************************88887..9**************************78999** PP
   S: 308  lfdDskVtevkeeevleetgstaYvlfYkr 337
           +fdD++Vtev+e+ v++   ++aYvlfY++
   Q: 666  EFDDQYVTEVHETVVQN---AEAYVLFYRK 692
           *****************...********98 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

KQDICPHVDS IGETTKEDLL LKAKGTCQSC TAGGPNLWAC LQTDCSYVGC GESYSDHSTL 60
HAQAKKHNLT VNLTTFRIWC YVCEREVFLD HRATLVPIPA VSHHCKAAEQ DAASQPAGHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACAAGACA TTTGCCCGCA CGTTGACTCC ATAGGAGAGA CAACCAAAGA AGACCTTCTC 60
CTGAAAGCTA AGGTGGGTTT ACTTCCTTCC CCAACAGTGT CTCCTTTGCA TACTGTTACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	71.61	0.00e+00	1286.00
IUUC-Apl-003351	Anas platyrhynchos	74.44	0.00e+00	1344.00
IUUC-Aca-005077	Anolis carolinensis	69.09	0.00e+00	1001.00
IUUC-Ame-011777	Astyanax mexicanus	80.06	0.00e+00	1434.00
IUUC-Bta-013063	Bos taurus	73.75	0.00e+00	1329.00
IUUC-Cja-019868	Callithrix jacchus	73.47	0.00e+00	1329.00
IUUC-Cfa-020761	Canis familiaris	72.53	0.00e+00	1306.00
IUUC-Cpo-022267	Cavia porcellus	72.18	0.00e+00	1296.00
IUUC-Csa-024251	Chlorocebus sabaeus	73.33	0.00e+00	1330.00
IUUC-Cho-024483	Choloepus hoffmanni	89.20	2.00e-116	412.00
IUUC-Dre-028061	Danio rerio	70.42	0.00e+00	1268.00
IUUC-Dno-029423	Dasypus novemcinctus	73.68	0.00e+00	1336.00
IUUC-Dor-030877	Dipodomys ordii	75.21	0.00e+00	883.00
IUUC-Dme-031837	Drosophila melanogaster	48.72	1.00e-133	470.00
IUUC-Ete-032802	Echinops telfairi	59.02	1.00e-101	364.00
IUUC-Eca-034283	Equus caballus	72.10	0.00e+00	1292.00
IUUC-Eeu-034620	Erinaceus europaeus	68.53	0.00e+00	871.00
IUUC-Fca-036357	Felis catus	73.68	0.00e+00	1317.00
IUUC-Fal-037411	Ficedula albicollis	74.71	0.00e+00	1345.00
IUUC-Gmo-038563	Gadus morhua	81.00	0.00e+00	894.00
IUUC-Gga-041101	Gallus gallus	74.03	0.00e+00	1333.00
IUUC-Gac-041315	Gasterosteus aculeatus	87.22	0.00e+00	1516.00
IUUC-Ggo-045600	Gorilla gorilla	73.05	0.00e+00	1305.00
IUUC-Hsa-045825	Homo sapiens	73.01	0.00e+00	1317.00
IUUC-Lch-050002	Latimeria chalumnae	70.92	0.00e+00	1244.00
IUUC-Loc-052574	Lepisosteus oculatus	80.95	0.00e+00	1449.00
IUUC-Laf-054428	Loxodonta africana	72.62	0.00e+00	1329.00
IUUC-Mcc-055736	Macaca mulatta	73.23	0.00e+00	1328.00
IUUC-Mga-059781	Meleagris gallopavo	74.73	0.00e+00	1338.00
IUUC-Mmr-061328	Microcebus murinus	83.26	0.00e+00	815.00
IUUC-Mdo-063048	Monodelphis domestica	74.36	0.00e+00	1309.00
IUUC-Mmu-064079	Mus musculus	72.47	0.00e+00	1301.00
IUUC-Mpu-066616	Mustela putorius furo	72.81	0.00e+00	1326.00
IUUC-Mlu-067294	Myotis lucifugus	72.65	0.00e+00	1283.00
IUUC-Nle-070015	Nomascus leucogenys	73.44	0.00e+00	1316.00
IUUC-Opr-070328	Ochotona princeps	72.66	0.00e+00	1310.00
IUUC-Ont-071464	Oreochromis niloticus	86.57	0.00e+00	1492.00
IUUC-Oan-073259	Ornithorhynchus anatinus	68.02	0.00e+00	1143.00
IUUC-Ocu-074630	Oryctolagus cuniculus	70.74	0.00e+00	1253.00
IUUC-Ola-087240	Oryzias latipes	85.67	0.00e+00	1464.00
IUUC-Oga-088761	Otolemur garnettii	73.47	0.00e+00	1337.00
IUUC-Oar-089490	Ovis aries	71.14	0.00e+00	1222.00
IUUC-Ptr-091662	Pan troglodytes	73.23	0.00e+00	1316.00
IUUC-Pan-092199	Papio anubis	73.50	0.00e+00	1321.00
IUUC-Psi-093726	Pelodiscus sinensis	74.89	0.00e+00	1341.00
IUUC-Pma-094389	Petromyzon marinus	63.39	2.00e-97	348.00
IUUC-Pfo-096522	Poecilia formosa	88.27	0.00e+00	1139.00
IUUC-Pab-098632	Pongo abelii	73.08	0.00e+00	1316.00
IUUC-Pca-100614	Procavia capensis	67.59	0.00e+00	1042.00
IUUC-Pva-102922	Pteropus vampyrus	66.11	0.00e+00	705.00
IUUC-Rno-105215	Rattus norvegicus	72.68	0.00e+00	1294.00
IUUC-Sha-106601	Sarcophilus harrisii	72.92	0.00e+00	1295.00
IUUC-Ssc-115533	Sus scrofa	72.73	0.00e+00	1306.00
IUUC-Tgu-117364	Taeniopygia guttata	74.20	0.00e+00	1340.00
IUUC-Tru-117770	Takifugu rubripes	93.60	0.00e+00	1605.00
IUUC-Ttr-128732	Tursiops truncatus	74.09	0.00e+00	1331.00
IUUC-Xtr-132157	Xenopus tropicalis	70.10	0.00e+00	1241.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence