iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013478

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Sterol regulatory element-binding protein cleavage-activating protein

Genbank Nucleotide ID

DAAA02054449

Gene Name

SCAP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000015782.5	ENSBTAT00000020961.5	ENSBTAP00000020961.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.40e-14	53.0	1116	1149

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tl.lvsGsdDgtikvWDlrtg 33
           gH++ +t +   d t+ l+sG+ Dg i +WD+ tg
   Q: 1116 GHSGAITTVYI-DqTMvLASGGQDGAICLWDVLTG 1149
           8********88.446648*************9887 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MTLTERLREK ISQAFYNHGL FCASYPIPII LFTGLCILAC CYPLLKLPLP GTGPVEFTTP 60
VKDYSPPPLT SDHKPGEPNE QPEWYVGAPV AYIQQIFVKS SVSPWHKNLL AVDVFRSPLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCCTGA CTGAAAGGCT GCGTGAGAAG ATATCCCAGG CCTTCTACAA CCATGGGCTG 60
TTCTGTGCGT CCTACCCCAT CCCCATCATT CTCTTCACGG GGCTCTGCAT CTTAGCCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR030225--SCAP
IPR000731--SSD
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50156--SSD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12349--Sterol-sensing
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0015485--F:cholesterol binding
GO:0008203--P:cholesterol metabolic process
GO:0045540--P:regulation of cholesterol biosynthetic process
GO:0042304--P:regulation of fatty acid biosynthetic process
GO:0001666--P:response to hypoxia
GO:0032868--P:response to insulin
GO:0032933--P:SREBP signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001802	Ailuropoda melanoleuca	95.67	0.00e+00	1101.00
IUUC-Apl-003294	Anas platyrhynchos	76.32	0.00e+00	1721.00
IUUC-Aca-004424	Anolis carolinensis	69.50	0.00e+00	1478.00
IUUC-Cel-018160	Caenorhabditis elegans	29.20	5.00e-65	243.00
IUUC-Cja-019123	Callithrix jacchus	90.86	0.00e+00	2020.00
IUUC-Cfa-021082	Canis familiaris	91.72	0.00e+00	2018.00
IUUC-Cpo-022477	Cavia porcellus	84.17	0.00e+00	1868.00
IUUC-Csa-023176	Chlorocebus sabaeus	90.15	0.00e+00	2017.00
IUUC-Cin-025490	Ciona intestinalis	36.83	8.00e-89	322.00
IUUC-Csv-026115	Ciona savignyi	37.31	6.00e-134	472.00
IUUC-Dre-028008	Danio rerio	68.24	0.00e+00	1535.00
IUUC-Dno-028887	Dasypus novemcinctus	91.73	0.00e+00	1208.00
IUUC-Dor-030467	Dipodomys ordii	93.28	0.00e+00	884.00
IUUC-Dme-032087	Drosophila melanogaster	32.93	3.00e-113	403.00
IUUC-Ete-032372	Echinops telfairi	77.92	0.00e+00	1660.00
IUUC-Eca-033896	Equus caballus	93.04	0.00e+00	2135.00
IUUC-Eeu-035099	Erinaceus europaeus	85.07	0.00e+00	1208.00
IUUC-Fca-035616	Felis catus	87.91	0.00e+00	1930.00
IUUC-Fal-037231	Ficedula albicollis	74.47	0.00e+00	1649.00
IUUC-Gmo-039439	Gadus morhua	74.52	0.00e+00	684.00
IUUC-Gac-041516	Gasterosteus aculeatus	67.46	0.00e+00	1503.00
IUUC-Hsa-046674	Homo sapiens	92.58	0.00e+00	2145.00
IUUC-Itr-048879	Ictidomys tridecemlineatus	91.48	0.00e+00	2083.00
IUUC-Lch-049689	Latimeria chalumnae	70.55	0.00e+00	1637.00
IUUC-Loc-052417	Lepisosteus oculatus	53.90	3.00e-128	452.00
IUUC-Laf-053795	Loxodonta africana	91.06	0.00e+00	2061.00
IUUC-Mcc-055502	Macaca mulatta	93.04	0.00e+00	2111.00
IUUC-Mga-059805	Meleagris gallopavo	77.79	0.00e+00	1746.00
IUUC-Mmr-060997	Microcebus murinus	92.19	0.00e+00	2121.00
IUUC-Mdo-062940	Monodelphis domestica	81.30	0.00e+00	1786.00
IUUC-Mmu-063255	Mus musculus	90.23	0.00e+00	2056.00
IUUC-Mpu-066158	Mustela putorius furo	92.65	0.00e+00	2092.00
IUUC-Mlu-067201	Myotis lucifugus	87.70	0.00e+00	2021.00
IUUC-Nle-069145	Nomascus leucogenys	93.88	0.00e+00	1358.00
IUUC-Opr-070797	Ochotona princeps	86.56	0.00e+00	1898.00
IUUC-Ont-071553	Oreochromis niloticus	67.39	0.00e+00	1497.00
IUUC-Ocu-074598	Oryctolagus cuniculus	92.49	0.00e+00	2041.00
IUUC-Ola-086650	Oryzias latipes	85.19	2.00e-110	391.00
IUUC-Oar-089287	Ovis aries	91.54	0.00e+00	1189.00
IUUC-Pan-092004	Papio anubis	92.91	0.00e+00	2103.00
IUUC-Psi-093028	Pelodiscus sinensis	70.69	0.00e+00	1496.00
IUUC-Pma-094145	Petromyzon marinus	50.99	0.00e+00	1126.00
IUUC-Pfo-096320	Poecilia formosa	67.44	0.00e+00	1519.00
IUUC-Pab-097862	Pongo abelii	92.96	0.00e+00	2155.00
IUUC-Pca-100862	Procavia capensis	78.91	0.00e+00	1612.00
IUUC-Pva-103050	Pteropus vampyrus	92.71	0.00e+00	1353.00
IUUC-Rno-105852	Rattus norvegicus	90.77	0.00e+00	2078.00
IUUC-Sha-107312	Sarcophilus harrisii	81.62	0.00e+00	1797.00
IUUC-Sar-113311	Sorex araneus	88.87	0.00e+00	823.00
IUUC-Ssc-116356	Sus scrofa	94.14	0.00e+00	2167.00
IUUC-Tgu-116896	Taeniopygia guttata	61.34	4.00e-149	522.00
IUUC-Tru-118197	Takifugu rubripes	67.73	0.00e+00	1515.00
IUUC-Tni-119823	Tetraodon nigroviridis	65.64	0.00e+00	1497.00
IUUC-Ttr-129164	Tursiops truncatus	95.39	0.00e+00	2169.00
IUUC-Xtr-132819	Xenopus tropicalis	68.84	0.00e+00	1623.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence