iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059529

Ensembl Protein ID

ENSMGAP00000009784.2

UniProt Accession

G1NB26; G1NB26_MELGA

Protein Name

Tyrosine-protein kinase

Gene Name

BTK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000009438.2	ENSMGAT00000010619.2	ENSMGAP00000009784.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.00e-11	44.3	104	161

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +++kv +ly+y + n  +L+l+kG+  l++  ee    W+k+ ++ +g++G +P+n+v++ 
   Q: 104  EMKKVVALYNYVPMNVQDLQLQKGEEYLIL--EESHLPWWKA-RDKNGREGYIPSNYVTET 161
           689**************************9..888999****.5**************975 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

PLYVFSPTEE LRKRWIHQLK SVIRYNSDLV QKYHPCFWID GQYLCCSQTA KNAMGCKILE 60
SRNGSLKAGR SHRKTKKPLP PTPEEDMMVM KPLPPEPAPS AAGEMKKVVA LYNYVPMNVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCTCTATG TCTTCTCCCC GACAGAGGAG CTGCGCAAAC GCTGGATCCA TCAGCTGAAG 60
AGCGGTGAGT TATGGGGCAC CCAGCTGCGT GTGCGGCGTG ACTCAGAGCA CTGGGTTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00402--TECBTKDOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0002344--P:B cell affinity maturation
GO:0048469--P:cell maturation
GO:0098761--P:cellular response to interleukin-7
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0030889--P:negative regulation of B cell proliferation
GO:0001818--P:negative regulation of cytokine production

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001365	Ailuropoda melanoleuca	86.18	0.00e+00	984.00
IUUC-Apl-003907	Anas platyrhynchos	95.59	0.00e+00	1072.00
IUUC-Aca-004978	Anolis carolinensis	77.09	0.00e+00	885.00
IUUC-Bta-012467	Bos taurus	85.82	0.00e+00	981.00
IUUC-Cja-018841	Callithrix jacchus	85.27	0.00e+00	974.00
IUUC-Cfa-020983	Canis familiaris	85.82	0.00e+00	957.00
IUUC-Cpo-021307	Cavia porcellus	86.36	0.00e+00	987.00
IUUC-Csa-023508	Chlorocebus sabaeus	84.10	0.00e+00	845.00
IUUC-Dno-029828	Dasypus novemcinctus	86.00	0.00e+00	974.00
IUUC-Dor-030102	Dipodomys ordii	81.63	0.00e+00	874.00
IUUC-Ete-032981	Echinops telfairi	77.45	0.00e+00	860.00
IUUC-Eca-033594	Equus caballus	85.82	0.00e+00	981.00
IUUC-Eeu-035281	Erinaceus europaeus	81.38	0.00e+00	716.00
IUUC-Fca-035495	Felis catus	85.09	0.00e+00	950.00
IUUC-Fal-036719	Ficedula albicollis	95.62	0.00e+00	1080.00
IUUC-Gga-041193	Gallus gallus	99.45	0.00e+00	1120.00
IUUC-Hsa-045931	Homo sapiens	85.45	0.00e+00	956.00
IUUC-Itr-048061	Ictidomys tridecemlineatus	86.00	0.00e+00	984.00
IUUC-Lch-049868	Latimeria chalumnae	74.77	0.00e+00	886.00
IUUC-Laf-053516	Loxodonta africana	85.33	0.00e+00	977.00
IUUC-Mcc-054795	Macaca mulatta	85.45	0.00e+00	957.00
IUUC-Meu-056157	Macropus eugenii	77.84	0.00e+00	818.00
IUUC-Mmr-060824	Microcebus murinus	85.27	0.00e+00	956.00
IUUC-Mdo-063036	Monodelphis domestica	86.25	0.00e+00	952.00
IUUC-Mmu-064047	Mus musculus	85.64	0.00e+00	981.00
IUUC-Mpu-066810	Mustela putorius furo	85.82	0.00e+00	983.00
IUUC-Mlu-067671	Myotis lucifugus	85.45	0.00e+00	955.00
IUUC-Nle-069108	Nomascus leucogenys	85.45	0.00e+00	957.00
IUUC-Opr-070505	Ochotona princeps	68.42	7.00e-174	603.00
IUUC-Oan-073495	Ornithorhynchus anatinus	85.22	0.00e+00	1005.00
IUUC-Ocu-074416	Oryctolagus cuniculus	85.82	0.00e+00	982.00
IUUC-Oga-088995	Otolemur garnettii	85.45	0.00e+00	956.00
IUUC-Oar-089632	Ovis aries	85.45	0.00e+00	981.00
IUUC-Ptr-090941	Pan troglodytes	85.45	0.00e+00	956.00
IUUC-Pan-091900	Papio anubis	82.55	0.00e+00	914.00
IUUC-Psi-093048	Pelodiscus sinensis	90.38	0.00e+00	1021.00
IUUC-Pab-097587	Pongo abelii	85.45	0.00e+00	957.00
IUUC-Pca-100374	Procavia capensis	73.84	3.00e-97	348.00
IUUC-Pva-102583	Pteropus vampyrus	85.82	0.00e+00	956.00
IUUC-Rno-104868	Rattus norvegicus	83.67	0.00e+00	951.00
IUUC-Sha-106744	Sarcophilus harrisii	85.82	0.00e+00	977.00
IUUC-Sar-113041	Sorex araneus	85.61	0.00e+00	913.00
IUUC-Ssc-115294	Sus scrofa	85.64	0.00e+00	981.00
IUUC-Tsy-118945	Tarsius syrichta	85.21	0.00e+00	770.00
IUUC-Ttr-128769	Tursiops truncatus	75.09	0.00e+00	828.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence