iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040822

Ensembl Protein ID

ENSGALP00000026839.4

UniProt Accession

E1BYL7; E1BYL7_CHICK

Genbank Protein ID

ENSGALP00000026839

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AADN04000289

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000016661.5	ENSGALT00000026890.5	ENSGALP00000026839.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-14	54.4	52	109

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +  v++lyd+ a++d +L+l kG++++++   +++++W+ +++  +gk+G +P+nFv+ ++
   Q: 52   DTIVIALYDFAASSDRDLELVKGEKLQIL---SNEGDWWLAKSLRSGKKGYIPSNFVALVD 109
           6789*************************...99***********************9886 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MGLIGSKNQL MSNEKFTSGS NPKNRSRPPP APPKGRQFIS LSHLNQASAQ DDTIVIALYD 60
FAASSDRDLE LVKGEKLQIL SNEGDWWLAK SLRSGKKGYI PSNFVALVDS LEQEKWFFKT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGGGGTTG ATTGGGAGCA AAAACCAGCT GATGTCCAAT GAGAAATTTA CGTCAGGAAG 60
CAATCCGAAA AACAGGAGTA GACCTCCTCC TGCCCCACCC AAAGTAAGTC TCCAGCTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032024--P:positive regulation of insulin secretion
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	73.32	0.00e+00	748.00
IUUC-Apl-003307	Anas platyrhynchos	94.41	0.00e+00	887.00
IUUC-Aca-004357	Anolis carolinensis	75.68	0.00e+00	723.00
IUUC-Ame-010642	Astyanax mexicanus	71.93	0.00e+00	706.00
IUUC-Bta-012400	Bos taurus	70.44	0.00e+00	749.00
IUUC-Cfa-021056	Canis familiaris	70.69	0.00e+00	753.00
IUUC-Cpo-021779	Cavia porcellus	71.40	0.00e+00	748.00
IUUC-Csa-023557	Chlorocebus sabaeus	75.72	0.00e+00	744.00
IUUC-Dre-027517	Danio rerio	70.96	0.00e+00	714.00
IUUC-Eca-034218	Equus caballus	73.53	0.00e+00	749.00
IUUC-Eeu-035095	Erinaceus europaeus	53.45	7.00e-153	533.00
IUUC-Fca-036015	Felis catus	68.71	0.00e+00	734.00
IUUC-Fal-036946	Ficedula albicollis	86.85	0.00e+00	889.00
IUUC-Gmo-038861	Gadus morhua	67.57	0.00e+00	642.00
IUUC-Ggo-044608	Gorilla gorilla	74.47	0.00e+00	696.00
IUUC-Hsa-046719	Homo sapiens	71.79	0.00e+00	736.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	69.84	0.00e+00	744.00
IUUC-Lch-050114	Latimeria chalumnae	75.17	0.00e+00	739.00
IUUC-Loc-052326	Lepisosteus oculatus	72.61	0.00e+00	731.00
IUUC-Laf-053387	Loxodonta africana	69.50	0.00e+00	744.00
IUUC-Mcc-055026	Macaca mulatta	73.99	0.00e+00	747.00
IUUC-Mga-059427	Meleagris gallopavo	98.44	0.00e+00	917.00
IUUC-Mmr-061660	Microcebus murinus	70.36	0.00e+00	753.00
IUUC-Mdo-062318	Monodelphis domestica	69.03	0.00e+00	736.00
IUUC-Mmu-063325	Mus musculus	70.75	0.00e+00	757.00
IUUC-Mpu-066582	Mustela putorius furo	73.11	0.00e+00	747.00
IUUC-Nle-069624	Nomascus leucogenys	76.18	0.00e+00	741.00
IUUC-Ont-072266	Oreochromis niloticus	66.20	0.00e+00	701.00
IUUC-Ocu-073907	Oryctolagus cuniculus	71.57	0.00e+00	743.00
IUUC-Ola-086668	Oryzias latipes	70.11	0.00e+00	677.00
IUUC-Oga-088057	Otolemur garnettii	70.24	0.00e+00	744.00
IUUC-Oar-089332	Ovis aries	66.93	0.00e+00	702.00
IUUC-Ptr-091551	Pan troglodytes	70.83	0.00e+00	700.00
IUUC-Pan-092173	Papio anubis	76.63	0.00e+00	744.00
IUUC-Psi-093895	Pelodiscus sinensis	83.22	0.00e+00	803.00
IUUC-Pfo-096608	Poecilia formosa	70.39	0.00e+00	699.00
IUUC-Pab-097598	Pongo abelii	77.03	0.00e+00	745.00
IUUC-Pva-102135	Pteropus vampyrus	73.35	0.00e+00	734.00
IUUC-Rno-104891	Rattus norvegicus	70.52	0.00e+00	746.00
IUUC-Sha-107192	Sarcophilus harrisii	76.56	0.00e+00	740.00
IUUC-Ssc-115696	Sus scrofa	70.87	0.00e+00	755.00
IUUC-Tgu-117056	Taeniopygia guttata	90.97	0.00e+00	852.00
IUUC-Tru-117621	Takifugu rubripes	66.52	0.00e+00	668.00
IUUC-Ttr-128457	Tursiops truncatus	69.88	0.00e+00	741.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence