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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046040
UUCD1 version UUC-HoS-00206
Ensembl Protein ID ENSP00000355028.3
UniProt Accession Q86Y13; B3KN01; O75162; Q6P3R9; Q6PH82; Q86Y14; Q86Y15; Q86Y16; Q8IWI0; Q96RS9; DZIP3_HUMAN
Genbank Protein ID AAO72967.1; AAO72968.1; AAO72969.1; AAO72970.1; BAA31650.2; BAG51163.1; AAH39018.1; AAH56674.1; AAH63882.1; AAK69484.1
Protein Name E3 ubiquitin-protein ligase DZIP3; DAZ-interacting protein 3; RING-type E3 ubiquitin transferase DZIP3; RNA-binding ubiquitin ligase of 138 kDa
Genbank Nucleotide ID AY227651; AY227652; AY227653; AY227654; AB014575; AK023138; BC039018; BC056674; BC063882; AF279370
Gene Name DZIP3; KIAA0675
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000198919.12 ENST00000361582.7 ENSP00000355028.3
ENSG00000198919.12 ENST00000495008.5 ENSP00000418871.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18206970
Classification
Family E-value Score Start End
E3 activity/RING/RING 7.40e-06 28.1 1148 1188
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+e +  ++ + vlpC H fha+C+  w       +++ +CP+Cr
   Q: 1148 CVICHENLspEN-LSVLPCAHKFHAQCIRPW------LMQQGTCPTCR 1188
           ******887566.999***************......**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.
 E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.
Protein Sequence
(Fasta)
MDSLPDEFFV RHPAVEDQRK EETENKLEKS SGQLNKQEND IPTDLVPVNL LLEVKKLLNA 60
INTLPKGVVP HIKKFLQEDF SFQTMQREVA ANSQNGEEIV PALTLRFLIT QLEAALRNIQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046040|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTCTCGGGAG AGGAATCGGT TAGGAGAAGG GGGATTCCTC ACTCAGCTGT GCGCTCTGAT 60
TTCGTGCGCT TCCTCGTCCT TCATGTTGGA TGGCCAGTTT TTCGTTTGTG CGTCATCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046040|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR033103--DZIP3
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0000836--C:Hrd1p ubiquitin ligase complex
GO:0019902--F:phosphatase binding
GO:0031593--F:polyubiquitin binding
GO:0003723--F:RNA binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:1990381--F:ubiquitin-specific protease binding
GO:0051082--F:unfolded protein binding
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:9666
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001766 Ailuropoda melanoleuca 91.07 0.00e+00 2134.00
IUUC-Atr-003023 Amborella trichopoda 27.59 1.00e-10 60.50
IUUC-Bta-012849 Bos taurus 81.98 0.00e+00 947.00
IUUC-Cja-019435 Callithrix jacchus 94.70 0.00e+00 2274.00
IUUC-Cfa-020407 Canis familiaris 90.90 0.00e+00 2130.00
IUUC-Cpo-022069 Cavia porcellus 85.88 0.00e+00 1991.00
IUUC-Csa-023670 Chlorocebus sabaeus 96.94 0.00e+00 2315.00
IUUC-Cho-024981 Choloepus hoffmanni 80.73 0.00e+00 1037.00
IUUC-Dno-029663 Dasypus novemcinctus 86.67 0.00e+00 2023.00
IUUC-Dor-030336 Dipodomys ordii 85.02 0.00e+00 921.00
IUUC-Ete-033022 Echinops telfairi 70.94 0.00e+00 1622.00
IUUC-Eca-033762 Equus caballus 92.14 0.00e+00 2107.00
IUUC-Eeu-034742 Erinaceus europaeus 64.76 0.00e+00 1404.00
IUUC-Fca-035996 Felis catus 89.99 0.00e+00 2123.00
IUUC-Gmo-039198 Gadus morhua 59.52 5.00e-13 65.50
IUUC-Gac-042289 Gasterosteus aculeatus 35.65 4.00e-18 84.00
IUUC-Ggo-044674 Gorilla gorilla 93.71 0.00e+00 2165.00
IUUC-Itr-048975 Ictidomys tridecemlineatus 91.47 0.00e+00 2099.00
IUUC-Laf-054563 Loxodonta africana 83.77 0.00e+00 989.00
IUUC-Mcc-055852 Macaca mulatta 97.02 0.00e+00 2280.00
IUUC-Meu-056900 Macropus eugenii 52.44 3.00e-140 493.00
IUUC-Mmr-060578 Microcebus murinus 92.63 0.00e+00 2189.00
IUUC-Mdo-061988 Monodelphis domestica 54.05 1.00e-148 521.00
IUUC-Mmu-063804 Mus musculus 82.73 0.00e+00 1974.00
IUUC-Mpu-066754 Mustela putorius furo 90.24 0.00e+00 2147.00
IUUC-Mlu-067935 Myotis lucifugus 84.60 0.00e+00 1879.00
IUUC-Nle-069158 Nomascus leucogenys 98.34 0.00e+00 2311.00
IUUC-Opr-070900 Ochotona princeps 86.13 0.00e+00 661.00
IUUC-Ocu-074846 Oryctolagus cuniculus 88.75 0.00e+00 2039.00
IUUC-Oba-075490 Oryza barthii 48.89 1.00e-09 57.00
IUUC-Ola-087392 Oryzias latipes 34.94 2.00e-27 114.00
IUUC-Oga-088711 Otolemur garnettii 93.13 0.00e+00 2175.00
IUUC-Oar-090116 Ovis aries 87.33 0.00e+00 2009.00
IUUC-Ptr-091540 Pan troglodytes 98.51 0.00e+00 2321.00
IUUC-Pan-092398 Papio anubis 97.27 0.00e+00 2287.00
IUUC-Pfo-096061 Poecilia formosa 35.67 2.00e-25 107.00
IUUC-Pab-098081 Pongo abelii 95.87 0.00e+00 2227.00
IUUC-Pca-100213 Procavia capensis 61.76 3.00e-133 469.00
IUUC-Pva-102391 Pteropus vampyrus 81.37 0.00e+00 1857.00
IUUC-Pgr-103287 Puccinia graminis 41.67 5.00e-08 50.80
IUUC-Rno-105915 Rattus norvegicus 81.01 0.00e+00 1861.00
IUUC-Sha-106951 Sarcophilus harrisii 50.96 5.00e-140 492.00
IUUC-Sit-109816 Setaria italica 46.77 4.00e-11 60.50
IUUC-Sar-113346 Sorex araneus 75.75 0.00e+00 1601.00
IUUC-Ssc-116155 Sus scrofa 89.09 0.00e+00 1761.00
IUUC-Tru-117647 Takifugu rubripes 59.62 1.00e-16 77.80
IUUC-Tsy-119539 Tarsius syrichta 85.08 0.00e+00 1962.00
IUUC-Tbe-127383 Tupaia belangeri 86.39 0.00e+00 650.00
IUUC-Ttr-129021 Tursiops truncatus 89.66 0.00e+00 2083.00
IUUC-Vpa-130403 Vicugna pacos 85.37 0.00e+00 1982.00
Created Date 25-Jun-2017

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