iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053387

Ensembl Protein ID

ENSLAFP00000005724.2

UniProt Accession

G3SYW8; G3SYW8_LOXAF

Protein Name

Tyrosine-protein kinase

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000006812.2	ENSLAFT00000006811.2	ENSLAFP00000005724.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.70e-14	53.9	55	112

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++ v +lydy+a++d +L++ kG++++++   ++ ++W+ +++  +g++G +P+nFv+++e
   Q: 55   EHFVVALYDYNAVDDQDLQMLKGEKLQIL---KETGDWWLAKSLITGREGYVPSNFVARVE 112
           57799************************...88899**********************97 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MGVVSSKKQV KEKDKGRWSP LRISTQSKAP PPLPPLVVFN HLASPPADKH LDREEHFVVA 60
LYDYNAVDDQ DLQMLKGEKL QILKETGDWW LAKSLITGRE GYVPSNFVAR VETLEVEKWF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAGTGG TGAGCAGCAA AAAGCAGGTC AAGGAGAAGG ATAAGGGCCG ATGGAGCCCC 60
TTGAGGATCA GCACCCAGAG CAAGGCTCCC CCACCACTGC CACCCCTGGT GAGTGATCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0050853--P:B cell receptor signaling pathway
GO:0032024--P:positive regulation of insulin secretion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	89.60	0.00e+00	893.00
IUUC-Apl-003307	Anas platyrhynchos	74.33	0.00e+00	724.00
IUUC-Aca-004357	Anolis carolinensis	69.73	0.00e+00	675.00
IUUC-Ame-010642	Astyanax mexicanus	70.00	0.00e+00	684.00
IUUC-Bta-012400	Bos taurus	87.23	0.00e+00	881.00
IUUC-Cja-019717	Callithrix jacchus	84.58	0.00e+00	690.00
IUUC-Cfa-021056	Canis familiaris	89.00	0.00e+00	910.00
IUUC-Cpo-021779	Cavia porcellus	84.20	0.00e+00	849.00
IUUC-Csa-023557	Chlorocebus sabaeus	86.14	0.00e+00	885.00
IUUC-Dre-027517	Danio rerio	69.26	0.00e+00	691.00
IUUC-Eca-034218	Equus caballus	88.82	0.00e+00	878.00
IUUC-Eeu-035095	Erinaceus europaeus	65.20	0.00e+00	633.00
IUUC-Fca-036015	Felis catus	88.60	0.00e+00	903.00
IUUC-Fal-036946	Ficedula albicollis	75.06	0.00e+00	722.00
IUUC-Gga-040822	Gallus gallus	75.06	0.00e+00	734.00
IUUC-Ggo-044608	Gorilla gorilla	88.97	0.00e+00	807.00
IUUC-Hsa-046719	Homo sapiens	85.54	0.00e+00	879.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	87.00	0.00e+00	867.00
IUUC-Lch-050114	Latimeria chalumnae	71.30	0.00e+00	690.00
IUUC-Loc-052326	Lepisosteus oculatus	70.72	0.00e+00	699.00
IUUC-Mcc-055026	Macaca mulatta	86.34	0.00e+00	886.00
IUUC-Mga-059427	Meleagris gallopavo	74.16	0.00e+00	721.00
IUUC-Mmr-061660	Microcebus murinus	86.20	0.00e+00	877.00
IUUC-Mdo-062318	Monodelphis domestica	75.50	0.00e+00	785.00
IUUC-Mmu-063325	Mus musculus	85.00	0.00e+00	873.00
IUUC-Mpu-066582	Mustela putorius furo	89.40	0.00e+00	889.00
IUUC-Nle-069624	Nomascus leucogenys	87.76	0.00e+00	862.00
IUUC-Opr-070656	Ochotona princeps	82.00	0.00e+00	802.00
IUUC-Ont-072266	Oreochromis niloticus	67.53	0.00e+00	672.00
IUUC-Ocu-073907	Oryctolagus cuniculus	84.80	0.00e+00	857.00
IUUC-Oga-088057	Otolemur garnettii	86.03	0.00e+00	882.00
IUUC-Oar-089332	Ovis aries	82.83	0.00e+00	841.00
IUUC-Ptr-091551	Pan troglodytes	84.57	0.00e+00	838.00
IUUC-Pan-092173	Papio anubis	85.74	0.00e+00	865.00
IUUC-Psi-093895	Pelodiscus sinensis	72.73	0.00e+00	729.00
IUUC-Pfo-096608	Poecilia formosa	68.79	0.00e+00	682.00
IUUC-Pab-097598	Pongo abelii	85.94	0.00e+00	849.00
IUUC-Pva-102135	Pteropus vampyrus	88.96	0.00e+00	864.00
IUUC-Rno-104891	Rattus norvegicus	84.00	0.00e+00	852.00
IUUC-Sha-107192	Sarcophilus harrisii	78.13	0.00e+00	811.00
IUUC-Ssc-115696	Sus scrofa	88.42	0.00e+00	902.00
IUUC-Tgu-117056	Taeniopygia guttata	74.10	0.00e+00	717.00
IUUC-Tru-117621	Takifugu rubripes	67.71	0.00e+00	647.00
IUUC-Tbe-127520	Tupaia belangeri	89.18	0.00e+00	681.00
IUUC-Ttr-128457	Tursiops truncatus	88.22	0.00e+00	899.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence