iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-035846

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AANG02090335

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000018440.2	ENSFCAT00000018510.2	ENSFCAP00000015835.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.30e-96	322.6	13	360

Active Site

Position(s)	Description	Evidence
100	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
176	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 13   MTGNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 90
           788999************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + +++++    +++af
   Q: 91   FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDAKTSAK----EEDAF 175
           ****************************************************************************9887....79*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvv............................raflerikllesdeirfnll 239
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v                             +f  +ik ++++eirfnl+
   Q: 176  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPViekriqnqferkccktwqvvmehqpqgcCDF--KIK-YSEGEIRFNLM 260
           **************************9.78899****************************99998765233..566.999******** PP
   S: 240  aivadrrviktlrlnvlkid.........keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilr 319
           aiv+dr++i+++++  l+ +          +  ++l++i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l 
   Q: 261  AIVSDRKMIYEQKIAELQRQlaeeepmdtDQGNNMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLI 349
           *************9766665778888887444589****************************************************** PP
   S: 320  klveetisevrefg 333
            lve+    + +++
   Q: 350  PLVEKA---KEKQN 360
           ***993...33344 PP

Organism

Felis catus

Protein Sequence
(Fasta)

ALGGAGWCVA GAMTGNAGEW CLMESDPGVF TELIKGFGCR GAQVEEIWSL EPENFEKLKP 60
VHGLIFLFKW QPGEEPAGSV VQDSRLDTIF FAKQVINNAC ATQAIVSVLL NCTHQDVHLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTTAGGTG GAGCGGGTTG GTGTGTGGCC GGGGCCATGA CGGGCAATGC CGGGGAGTGG 60
TGCCTCATGG AAAGCGACCC CGGGGTCTTC ACCGAGCTCA TTAAAGGATT CGGTGAGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	43.73	5.00e-80	291.00
IUUC-Aml-001866	Ailuropoda melanoleuca	92.06	0.00e+00	635.00
IUUC-Atr-002966	Amborella trichopoda	42.63	6.00e-76	277.00
IUUC-Apl-003306	Anas platyrhynchos	87.15	1.00e-180	625.00
IUUC-Aca-004763	Anolis carolinensis	87.39	9.00e-175	605.00
IUUC-Aly-005581	Arabidopsis lyrata	44.66	5.00e-75	274.00
IUUC-Ath-007283	Arabidopsis thaliana	44.94	4.00e-78	284.00
IUUC-Ago-007999	Ashbya gossypii	40.29	1.00e-31	130.00
IUUC-Acl-008231	Aspergillus clavatus	38.81	6.00e-48	184.00
IUUC-Afl-008557	Aspergillus flavus	34.53	4.00e-50	191.00
IUUC-Afu-008988	Aspergillus fumigatus	40.45	4.00e-50	191.00
IUUC-Ani-009420	Aspergillus nidulans	34.87	4.00e-48	184.00
IUUC-Ang-009859	Aspergillus niger	36.76	7.00e-45	174.00
IUUC-Aor-010145	Aspergillus oryzae	34.53	4.00e-50	191.00
IUUC-Ate-010347	Aspergillus terreus	37.72	1.00e-48	186.00
IUUC-Ame-010791	Astyanax mexicanus	83.43	5.00e-177	613.00
IUUC-Bgr-012298	Blumeria graminis	34.44	1.00e-44	173.00
IUUC-Bta-013251	Bos taurus	91.18	0.00e+00	625.00
IUUC-Bci-013786	Botrytis cinerea	34.97	3.00e-53	201.00
IUUC-Bdi-014132	Brachypodium distachyon	45.30	2.00e-77	282.00
IUUC-Bol-015611	Brassica oleracea	45.92	8.00e-80	290.00
IUUC-Bra-017769	Brassica rapa	45.92	7.00e-80	290.00
IUUC-Cel-018604	Caenorhabditis elegans	43.40	5.00e-77	280.00
IUUC-Cja-019768	Callithrix jacchus	90.93	0.00e+00	657.00
IUUC-Cfa-020207	Canis familiaris	92.06	0.00e+00	635.00
IUUC-Cpo-021925	Cavia porcellus	88.24	2.00e-175	607.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	41.83	3.00e-69	254.00
IUUC-Csa-023958	Chlorocebus sabaeus	91.30	0.00e+00	634.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	3.00e-42	165.00
IUUC-Cin-025771	Ciona intestinalis	50.00	5.00e-95	340.00
IUUC-Csv-026149	Ciona savignyi	53.03	7.00e-98	350.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	34.11	2.00e-47	182.00
IUUC-Cne-026955	Cryptococcus neoformans	35.07	1.00e-50	192.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.25	1.00e-45	176.00
IUUC-Dre-027409	Danio rerio	82.58	1.00e-173	602.00
IUUC-Dno-028921	Dasypus novemcinctus	91.47	0.00e+00	631.00
IUUC-Dse-031170	Dothistroma septosporum	36.47	4.00e-54	204.00
IUUC-Dme-031677	Drosophila melanogaster	55.00	1.00e-109	389.00
IUUC-Ete-032707	Echinops telfairi	63.92	1.00e-119	422.00
IUUC-Eca-033776	Equus caballus	91.11	4.00e-167	580.00
IUUC-Eeu-035305	Erinaceus europaeus	79.59	3.00e-87	315.00
IUUC-Fal-037597	Ficedula albicollis	87.62	2.00e-154	537.00
IUUC-Fox-037670	Fusarium oxysporum	39.64	5.00e-51	194.00
IUUC-Fso-038243	Fusarium solani	39.58	2.00e-50	192.00
IUUC-Gmo-038499	Gadus morhua	77.35	2.00e-156	544.00
IUUC-Ggr-039975	Gaeumannomyces graminis	37.00	1.00e-43	170.00
IUUC-Gga-040904	Gallus gallus	87.11	0.00e+00	630.00
IUUC-Gac-042058	Gasterosteus aculeatus	81.76	1.00e-165	575.00
IUUC-Gma-043030	Glycine max	45.33	7.00e-81	293.00
IUUC-Ggo-044699	Gorilla gorilla	85.93	7.00e-166	576.00
IUUC-Hsa-046227	Homo sapiens	91.47	0.00e+00	632.00
IUUC-Hvu-047359	Hordeum vulgare	43.18	2.00e-78	285.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	91.85	0.00e+00	657.00
IUUC-Lch-049829	Latimeria chalumnae	85.29	4.00e-170	590.00
IUUC-Lpe-050899	Leersia perrieri	44.77	7.00e-74	270.00
IUUC-Loc-052264	Lepisosteus oculatus	83.58	2.00e-168	584.00
IUUC-Lma-053110	Leptosphaeria maculans	35.26	7.00e-44	171.00
IUUC-Laf-053639	Loxodonta africana	92.06	0.00e+00	635.00
IUUC-Mcc-055506	Macaca mulatta	91.30	0.00e+00	633.00
IUUC-Mor-057001	Magnaporthe oryzae	40.75	1.00e-50	193.00
IUUC-Mpo-057608	Magnaporthe poae	40.64	1.00e-32	132.00
IUUC-Mtr-057731	Medicago truncatula	45.86	8.00e-81	293.00
IUUC-Mla-059016	Melampsora laricipopulina	43.28	1.00e-43	169.00
IUUC-Mga-060178	Meleagris gallopavo	87.61	4.00e-169	586.00
IUUC-Mvi-060353	Microbotryum violaceum	35.91	9.00e-50	190.00
IUUC-Mmr-060738	Microcebus murinus	91.47	0.00e+00	632.00
IUUC-Mdo-062266	Monodelphis domestica	98.03	6.00e-119	419.00
IUUC-Mmu-063619	Mus musculus	88.82	3.00e-178	617.00
IUUC-Mac-065301	Musa acuminata	46.80	2.00e-83	301.00
IUUC-Mpu-066058	Mustela putorius furo	91.76	0.00e+00	634.00
IUUC-Mlu-067292	Myotis lucifugus	90.00	2.00e-178	617.00
IUUC-Nfi-068275	Neosartorya fischeri	34.51	1.00e-50	193.00
IUUC-Ncr-068713	Neurospora crassa	35.86	1.00e-53	203.00
IUUC-Nle-069013	Nomascus leucogenys	90.34	0.00e+00	639.00
IUUC-Opr-070628	Ochotona princeps	86.96	3.00e-174	603.00
IUUC-Ont-072688	Oreochromis niloticus	82.46	5.00e-166	576.00
IUUC-Oan-073004	Ornithorhynchus anatinus	87.18	3.00e-137	480.00
IUUC-Ocu-074303	Oryctolagus cuniculus	91.43	0.00e+00	651.00
IUUC-Oba-075002	Oryza barthii	45.13	2.00e-77	282.00
IUUC-Obr-076392	Oryza brachyantha	45.06	5.00e-75	274.00
IUUC-Ogl-077271	Oryza glaberrima	45.13	2.00e-77	282.00
IUUC-Ogu-078493	Oryza glumaepatula	44.85	7.00e-78	283.00
IUUC-Oin-080084	Oryza indica	44.85	7.00e-78	283.00
IUUC-Olo-080803	Oryza longistaminata	44.57	1.00e-77	282.00
IUUC-Ome-081146	Oryza meridionalis	44.01	2.00e-76	278.00
IUUC-Oni-082146	Oryza nivara	44.85	7.00e-78	283.00
IUUC-Opu-083633	Oryza punctata	45.35	7.00e-74	270.00
IUUC-Oru-084789	Oryza rufipogon	44.85	7.00e-78	283.00
IUUC-Osa-086196	Oryza sativa	44.85	7.00e-78	283.00
IUUC-Ola-087126	Oryzias latipes	82.35	9.00e-163	565.00
IUUC-Olu-087665	Ostreococcus lucimarinus	38.10	1.00e-64	239.00
IUUC-Oga-089140	Otolemur garnettii	92.06	0.00e+00	646.00
IUUC-Oar-090296	Ovis aries	90.88	0.00e+00	627.00
IUUC-Ptr-090566	Pan troglodytes	91.47	0.00e+00	632.00
IUUC-Pan-092052	Papio anubis	91.30	0.00e+00	633.00
IUUC-Psi-093723	Pelodiscus sinensis	87.30	9.00e-161	558.00
IUUC-Pma-094568	Petromyzon marinus	55.87	1.00e-101	362.00
IUUC-Pno-095120	Phaeosphaeria nodorum	36.06	2.00e-45	176.00
IUUC-Ppa-095761	Physcomitrella patens	44.17	1.00e-79	290.00
IUUC-Pfo-096210	Poecilia formosa	82.35	5.00e-167	580.00
IUUC-Pab-098463	Pongo abelii	90.91	0.00e+00	648.00
IUUC-Pop-099109	Populus trichocarpa	44.78	4.00e-80	291.00
IUUC-Pca-100108	Procavia capensis	89.01	3.00e-140	491.00
IUUC-Ppe-101176	Prunus persica	47.35	2.00e-81	295.00
IUUC-Pva-102629	Pteropus vampyrus	86.96	2.00e-148	518.00
IUUC-Pgr-103419	Puccinia graminis	36.81	2.00e-52	199.00
IUUC-Pte-104207	Pyrenophora teres	44.38	6.00e-33	133.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	36.14	2.00e-52	199.00
IUUC-Rno-105579	Rattus norvegicus	80.00	2.00e-157	548.00
IUUC-Sha-106894	Sarcophilus harrisii	85.81	3.00e-151	527.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	35.67	1.00e-54	206.00
IUUC-Spo-108371	Schizosaccharomyces pombe	38.48	4.00e-55	207.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	34.98	5.00e-43	167.00
IUUC-Smo-109396	Selaginella moellendorffii	47.44	6.00e-84	303.00
IUUC-Sit-110630	Setaria italica	45.76	7.00e-82	296.00
IUUC-Sly-110972	Solanum lycopersicum	46.47	3.00e-76	278.00
IUUC-Stu-112185	Solanum tuberosum	47.08	2.00e-84	305.00
IUUC-Sar-113294	Sorex araneus	81.87	4.00e-167	580.00
IUUC-Sbi-113951	Sorghum bicolor	46.05	3.00e-82	298.00
IUUC-Ssc-115501	Sus scrofa	90.12	4.00e-170	590.00
IUUC-Tgu-117152	Taeniopygia guttata	87.30	2.00e-154	537.00
IUUC-Tru-118388	Takifugu rubripes	81.47	9.00e-166	575.00
IUUC-Tsy-119109	Tarsius syrichta	91.71	0.00e+00	651.00
IUUC-Tni-120048	Tetraodon nigroviridis	81.47	3.00e-166	577.00
IUUC-Tca-121750	Theobroma cacao	45.48	8.00e-84	303.00
IUUC-Tre-122130	Trichoderma reesei	36.09	4.00e-51	194.00
IUUC-Tvi-122284	Trichoderma virens	36.28	2.00e-48	186.00
IUUC-Tae-124082	Triticum aestivum	44.01	1.00e-78	286.00
IUUC-Tur-126366	Triticum urartu	39.94	4.00e-62	231.00
IUUC-Tme-127187	Tuber melanosporum	37.27	2.00e-53	202.00
IUUC-Tbe-127619	Tupaia belangeri	82.80	1.00e-140	492.00
IUUC-Ttr-128867	Tursiops truncatus	88.16	2.00e-124	437.00
IUUC-Vda-129912	Verticillium dahliae	33.95	4.00e-48	184.00
IUUC-Vpa-130552	Vicugna pacos	79.61	2.00e-139	488.00
IUUC-Vvi-130881	Vitis vinifera	46.98	7.00e-80	290.00
IUUC-Xtr-131934	Xenopus tropicalis	79.21	1.00e-168	585.00
IUUC-Xma-133312	Xiphophorus maculatus	82.35	2.00e-166	577.00
IUUC-Yli-134487	Yarrowia lipolytica	36.15	4.00e-44	171.00
IUUC-Zma-135462	Zea mays	40.34	4.00e-67	248.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence