iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049829

Ensembl Protein ID

ENSLACP00000008182.2

UniProt Accession

H3AEW1; H3AEW1_LATCH

Genbank Protein ID

ENSLACP00000008182

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AFYH01219003

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000007245.2	ENSLACT00000008248.2	ENSLACP00000008182.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	6.00e-99	331.9	1	322

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
164	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m + + ew+ +esdPg+ft+l++ fg+k+  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 1    MAGSAGEWCLMESDPGVFTELIKGFGCKGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 78
           667789************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc++  l+lG+tls++ke++ ++++ +k+lal+n++v++++hns+ar+++++ + +++++    +++af
   Q: 79   FAKQVINNACATQAIVSVLLNCNHSDLQLGETLSEFKEFSLSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKTSAK----DEDAF 163
           *****************************************************************************888....69*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg ++ +e++ + ++ v+   +ri++++++eirfnl+aiv+dr++i++++++ l+ +        
   Q: 164  HFVSYVPVNGRLYELDGLREGPIDLGVCC-QEDWISSVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIRELQRQlseeepmd 249
           **************************965.789*********..******************************987776678888888 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgv 334
             +  ++l+ i+se++k +  +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + ++++
   Q: 250  tDQSSNMLSSIQSEIAKFQLLIEEENQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQNA 322
           755678***********************************************************93...333554 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MAGSAGEWCL MESDPGVFTE LIKGFGCKGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP 60
GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC NHSDLQLGET LSEFKEFSLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACCATAGAA ACCGTTGAAA GGAAAGCGGA AGGGAGGGCA GTCTGTCTGG CGGCGCGGGG 60
GATGTCGGGA AGGTTTGTGA GTCGAGCTGT GCGACGAGTG GCCGACAGTA AATATTGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0031011--C:Ino80 complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lcm:102350317

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	47.29	2.00e-84	305.00
IUUC-Aml-001866	Ailuropoda melanoleuca	92.65	1.00e-175	608.00
IUUC-Atr-002966	Amborella trichopoda	47.13	3.00e-81	295.00
IUUC-Apl-003306	Anas platyrhynchos	84.36	1.00e-173	602.00
IUUC-Aca-004763	Anolis carolinensis	93.27	9.00e-177	612.00
IUUC-Aly-005581	Arabidopsis lyrata	48.63	2.00e-78	285.00
IUUC-Ath-007283	Arabidopsis thaliana	48.33	2.00e-80	292.00
IUUC-Ago-007999	Ashbya gossypii	41.05	7.00e-32	130.00
IUUC-Acl-008231	Aspergillus clavatus	43.51	4.00e-52	197.00
IUUC-Afl-008557	Aspergillus flavus	38.69	2.00e-55	208.00
IUUC-Afu-008988	Aspergillus fumigatus	45.19	1.00e-53	203.00
IUUC-Ani-009420	Aspergillus nidulans	38.89	6.00e-55	207.00
IUUC-Ang-009859	Aspergillus niger	42.62	7.00e-51	194.00
IUUC-Aor-010145	Aspergillus oryzae	38.69	2.00e-55	208.00
IUUC-Ate-010347	Aspergillus terreus	42.29	5.00e-53	201.00
IUUC-Ame-010791	Astyanax mexicanus	91.49	0.00e+00	630.00
IUUC-Bgr-012298	Blumeria graminis	38.49	6.00e-51	194.00
IUUC-Bta-013251	Bos taurus	92.33	8.00e-174	602.00
IUUC-Bci-013786	Botrytis cinerea	38.35	8.00e-59	220.00
IUUC-Bdi-014132	Brachypodium distachyon	49.38	2.00e-81	295.00
IUUC-Bol-015611	Brassica oleracea	50.00	2.00e-84	305.00
IUUC-Bra-017769	Brassica rapa	50.00	3.00e-84	304.00
IUUC-Cel-018604	Caenorhabditis elegans	47.45	4.00e-84	304.00
IUUC-Cja-019768	Callithrix jacchus	83.87	4.00e-168	583.00
IUUC-Cfa-020207	Canis familiaris	92.65	1.00e-175	608.00
IUUC-Cpo-021925	Cavia porcellus	89.14	2.00e-167	581.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.65	1.00e-73	270.00
IUUC-Csa-023958	Chlorocebus sabaeus	91.69	5.00e-172	596.00
IUUC-Cho-024928	Choloepus hoffmanni	93.51	3.00e-39	155.00
IUUC-Cin-025771	Ciona intestinalis	53.73	5.00e-98	350.00
IUUC-Csv-026149	Ciona savignyi	57.41	4.00e-102	364.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	36.13	9.00e-51	193.00
IUUC-Cne-026955	Cryptococcus neoformans	36.39	1.00e-53	203.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.24	1.00e-48	186.00
IUUC-Dre-027409	Danio rerio	91.19	0.00e+00	627.00
IUUC-Dno-028921	Dasypus novemcinctus	92.97	4.00e-176	610.00
IUUC-Dse-031170	Dothistroma septosporum	39.24	4.00e-59	221.00
IUUC-Dme-031677	Drosophila melanogaster	61.25	8.00e-115	406.00
IUUC-Ete-032707	Echinops telfairi	65.20	5.00e-112	397.00
IUUC-Eca-033776	Equus caballus	93.06	2.00e-160	558.00
IUUC-Eeu-035305	Erinaceus europaeus	73.94	1.00e-77	282.00
IUUC-Fca-035846	Felis catus	85.29	3.00e-170	590.00
IUUC-Fal-037597	Ficedula albicollis	93.40	2.00e-156	544.00
IUUC-Fox-037670	Fusarium oxysporum	49.35	9.00e-55	206.00
IUUC-Fso-038243	Fusarium solani	40.91	1.00e-53	202.00
IUUC-Gmo-038499	Gadus morhua	86.58	1.00e-164	572.00
IUUC-Ggr-039975	Gaeumannomyces graminis	40.96	6.00e-47	181.00
IUUC-Gga-040904	Gallus gallus	93.35	0.00e+00	640.00
IUUC-Gac-042058	Gasterosteus aculeatus	91.05	2.00e-173	600.00
IUUC-Gma-043030	Glycine max	48.66	2.00e-85	308.00
IUUC-Ggo-044699	Gorilla gorilla	85.99	2.00e-157	548.00
IUUC-Hsa-046227	Homo sapiens	92.01	1.00e-174	605.00
IUUC-Hvu-047359	Hordeum vulgare	48.02	6.00e-84	303.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	84.30	4.00e-170	590.00
IUUC-Lpe-050899	Leersia perrieri	48.58	9.00e-78	283.00
IUUC-Loc-052264	Lepisosteus oculatus	92.04	4.00e-174	603.00
IUUC-Lma-053110	Leptosphaeria maculans	38.41	2.00e-48	186.00
IUUC-Laf-053639	Loxodonta africana	92.65	1.00e-175	608.00
IUUC-Mcc-055506	Macaca mulatta	91.69	7.00e-172	596.00
IUUC-Mor-057001	Magnaporthe oryzae	44.96	2.00e-54	205.00
IUUC-Mpo-057608	Magnaporthe poae	41.18	4.00e-33	134.00
IUUC-Mtr-057731	Medicago truncatula	49.85	2.00e-85	309.00
IUUC-Mla-059016	Melampsora laricipopulina	43.78	5.00e-44	170.00
IUUC-Mga-060178	Meleagris gallopavo	93.75	5.00e-171	592.00
IUUC-Mvi-060353	Microbotryum violaceum	39.70	8.00e-56	210.00
IUUC-Mmr-060738	Microcebus murinus	92.01	1.00e-174	604.00
IUUC-Mdo-062266	Monodelphis domestica	94.12	3.00e-115	406.00
IUUC-Mmu-063619	Mus musculus	90.10	2.00e-171	594.00
IUUC-Mac-065301	Musa acuminata	51.74	3.00e-89	321.00
IUUC-Mpu-066058	Mustela putorius furo	92.97	4.00e-176	609.00
IUUC-Mlu-067292	Myotis lucifugus	91.69	3.00e-172	597.00
IUUC-Nfi-068275	Neosartorya fischeri	39.55	4.00e-56	211.00
IUUC-Ncr-068713	Neurospora crassa	38.80	2.00e-59	222.00
IUUC-Nle-069013	Nomascus leucogenys	91.37	1.00e-171	595.00
IUUC-Opr-070628	Ochotona princeps	81.18	3.00e-159	553.00
IUUC-Ont-072688	Oreochromis niloticus	90.16	2.00e-171	594.00
IUUC-Oan-073004	Ornithorhynchus anatinus	93.42	2.00e-135	474.00
IUUC-Ocu-074303	Oryctolagus cuniculus	92.97	3.00e-176	611.00
IUUC-Oba-075002	Oryza barthii	49.10	1.00e-82	299.00
IUUC-Obr-076392	Oryza brachyantha	49.53	2.00e-80	292.00
IUUC-Ogl-077271	Oryza glaberrima	49.10	1.00e-82	299.00
IUUC-Ogu-078493	Oryza glumaepatula	49.10	3.00e-83	301.00
IUUC-Oin-080084	Oryza indica	49.10	3.00e-83	301.00
IUUC-Olo-080803	Oryza longistaminata	48.80	6.00e-83	300.00
IUUC-Ome-081146	Oryza meridionalis	47.59	7.00e-82	296.00
IUUC-Oni-082146	Oryza nivara	49.10	3.00e-83	301.00
IUUC-Opu-083633	Oryza punctata	48.90	5.00e-79	287.00
IUUC-Oru-084789	Oryza rufipogon	49.10	3.00e-83	301.00
IUUC-Osa-086196	Oryza sativa	49.10	3.00e-83	301.00
IUUC-Ola-087126	Oryzias latipes	91.05	3.00e-168	583.00
IUUC-Olu-087665	Ostreococcus lucimarinus	42.01	3.00e-69	254.00
IUUC-Oga-089140	Otolemur garnettii	84.12	7.00e-169	586.00
IUUC-Oar-090296	Ovis aries	92.01	5.00e-174	603.00
IUUC-Ptr-090566	Pan troglodytes	92.01	1.00e-174	605.00
IUUC-Pan-092052	Papio anubis	91.69	8.00e-172	596.00
IUUC-Psi-093723	Pelodiscus sinensis	93.75	2.00e-162	564.00
IUUC-Pma-094568	Petromyzon marinus	61.81	2.00e-107	381.00
IUUC-Pno-095120	Phaeosphaeria nodorum	39.02	4.00e-49	188.00
IUUC-Ppa-095761	Physcomitrella patens	48.25	2.00e-85	308.00
IUUC-Pfo-096210	Poecilia formosa	90.10	3.00e-172	597.00
IUUC-Pab-098463	Pongo abelii	92.01	4.00e-174	603.00
IUUC-Pop-099423	Populus trichocarpa	48.37	2.00e-84	305.00
IUUC-Pca-100108	Procavia capensis	91.06	1.00e-133	469.00
IUUC-Ppe-101176	Prunus persica	50.90	5.00e-85	307.00
IUUC-Pva-102629	Pteropus vampyrus	90.08	4.00e-140	490.00
IUUC-Pgr-103419	Puccinia graminis	40.85	7.00e-58	217.00
IUUC-Pte-104207	Pyrenophora teres	44.38	1.00e-32	131.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.34	2.00e-56	212.00
IUUC-Rno-105579	Rattus norvegicus	80.80	3.00e-151	527.00
IUUC-Sha-106894	Sarcophilus harrisii	90.94	1.00e-149	521.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	40.20	7.00e-59	220.00
IUUC-Spo-108371	Schizosaccharomyces pombe	42.57	3.00e-61	228.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	39.49	5.00e-49	187.00
IUUC-Smo-109396	Selaginella moellendorffii	52.00	9.00e-89	320.00
IUUC-Sit-110630	Setaria italica	50.46	2.00e-86	312.00
IUUC-Sly-110972	Solanum lycopersicum	50.16	1.00e-80	293.00
IUUC-Stu-112185	Solanum tuberosum	49.70	6.00e-89	320.00
IUUC-Sar-113294	Sorex araneus	77.34	3.00e-155	541.00
IUUC-Sbi-113951	Sorghum bicolor	50.76	1.00e-86	313.00
IUUC-Ssc-115501	Sus scrofa	91.92	1.00e-163	568.00
IUUC-Tgu-117152	Taeniopygia guttata	93.06	2.00e-156	544.00
IUUC-Tru-118388	Takifugu rubripes	91.05	4.00e-174	603.00
IUUC-Tsy-119109	Tarsius syrichta	92.33	6.00e-175	606.00
IUUC-Tni-120048	Tetraodon nigroviridis	91.05	1.00e-174	605.00
IUUC-Tca-121750	Theobroma cacao	49.11	1.00e-88	319.00
IUUC-Tre-122130	Trichoderma reesei	39.33	4.00e-56	211.00
IUUC-Tvi-122284	Trichoderma virens	38.87	7.00e-52	197.00
IUUC-Tae-124082	Triticum aestivum	48.32	4.00e-83	301.00
IUUC-Tur-126366	Triticum urartu	43.58	5.00e-68	251.00
IUUC-Tme-127187	Tuber melanosporum	41.91	7.00e-60	223.00
IUUC-Tbe-127619	Tupaia belangeri	83.62	8.00e-134	469.00
IUUC-Ttr-128867	Tursiops truncatus	82.45	3.00e-116	410.00
IUUC-Vda-129912	Verticillium dahliae	37.16	2.00e-53	202.00
IUUC-Vpa-130552	Vicugna pacos	93.30	3.00e-118	417.00
IUUC-Vvi-130881	Vitis vinifera	50.74	2.00e-84	305.00
IUUC-Xtr-131934	Xenopus tropicalis	86.02	1.00e-173	602.00
IUUC-Xma-133312	Xiphophorus maculatus	90.10	1.00e-171	595.00
IUUC-Yli-134487	Yarrowia lipolytica	40.43	4.00e-47	181.00
IUUC-Zma-135462	Zea mays	44.62	5.00e-72	264.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence