iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072688

Ensembl Protein ID

ENSONIP00000013777.1

UniProt Accession

I3JY32; I3JY32_ORENI

Genbank Protein ID

ENSONIP00000013777

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AERX01031367

Gene Name

uchl5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000010950.1	ENSONIT00000013787.1	ENSONIP00000013777.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.00e-93	314.8	1	318

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
166	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++ + ew+ +esdPg+ft+l++ fg+++  qvee++s++pen++ + +pv+gl++lFk+++ +e +          ++v+++ ++ if
   Q: 1    MSGSAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSMEPENFENL-KPVHGLIFLFKWQPGEEPAG---------SIVQDSRLDHIF 78
           678889************************.****************.*******************9.........8899******** PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc++  + lG+tl +++e+++++++ +k+lal+n++v++++hns+a+  ++  +   d++++ ++++af
   Q: 79   FAKQVINNACATQAIISVLLNCSHPDMLLGDTLTEFREFSQSFDAAMKGLALSNSEVIRQVHNSFASCRQQMFE--FDAKSSAKDEDAF 165
           *****************************************************************977666555..456667779**** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i++ ++  l+ +        
   Q: 166  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYERKIAELQAQltedepmd 251
           **************************9.78999*********..******************************987777777788888 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveet 325
             +   +l+ i+se++k++  +++e++k k++ki++irR++ny  fi++++k+la+ ++l  lve+ 
   Q: 252  tDQSSTFLSSIQSEIAKYQLLIEEENQKLKRYKIENIRRKHNYLPFIMELLKTLAEYQQLIPLVEKA 318
           7556789*********************************************************984 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MSGSAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSMEP ENFENLKPVH GLIFLFKWQP 60
GEEPAGSIVQ DSRLDHIFFA KQVINNACAT QAIISVLLNC SHPDMLLGDT LTEFREFSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTGGAA GTGCAGGAGA GTGGTGTCTC ATGGAGAGCG ACCCCGGGGT TTTCACGGAG 60
CTCATAAAAG GTTTCGGTGA GTGACTCGTA GGGTGACGCT AGAGGCTCAT TGAATGTAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0031011--C:Ino80 complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	45.97	3.00e-81	295.00
IUUC-Aml-001866	Ailuropoda melanoleuca	89.52	3.00e-171	594.00
IUUC-Atr-002966	Amborella trichopoda	46.57	5.00e-80	291.00
IUUC-Apl-003306	Anas platyrhynchos	82.22	1.00e-169	588.00
IUUC-Aca-004763	Anolis carolinensis	91.72	2.00e-174	604.00
IUUC-Aly-005581	Arabidopsis lyrata	46.67	3.00e-78	285.00
IUUC-Ath-007283	Arabidopsis thaliana	47.27	3.00e-80	291.00
IUUC-Ago-007999	Ashbya gossypii	34.08	4.00e-33	135.00
IUUC-Acl-008231	Aspergillus clavatus	42.50	6.00e-52	197.00
IUUC-Afl-008557	Aspergillus flavus	37.46	7.00e-54	204.00
IUUC-Afu-008988	Aspergillus fumigatus	43.98	3.00e-52	198.00
IUUC-Ani-009420	Aspergillus nidulans	36.78	6.00e-52	197.00
IUUC-Ang-009859	Aspergillus niger	39.75	1.00e-47	183.00
IUUC-Aor-010145	Aspergillus oryzae	37.46	7.00e-54	204.00
IUUC-Ate-010347	Aspergillus terreus	41.50	6.00e-52	197.00
IUUC-Ame-010791	Astyanax mexicanus	93.35	0.00e+00	643.00
IUUC-Bgr-012298	Blumeria graminis	37.25	2.00e-48	186.00
IUUC-Bta-013251	Bos taurus	89.52	9.00e-170	589.00
IUUC-Bci-013786	Botrytis cinerea	37.24	4.00e-55	208.00
IUUC-Bdi-014132	Brachypodium distachyon	46.95	3.00e-79	288.00
IUUC-Bol-015611	Brassica oleracea	48.32	5.00e-82	297.00
IUUC-Bra-017769	Brassica rapa	48.32	7.00e-82	297.00
IUUC-Cel-018604	Caenorhabditis elegans	46.44	2.00e-79	289.00
IUUC-Cja-019768	Callithrix jacchus	81.34	2.00e-164	571.00
IUUC-Cfa-020207	Canis familiaris	89.52	3.00e-171	594.00
IUUC-Cpo-021925	Cavia porcellus	85.40	9.00e-162	562.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.96	3.00e-73	268.00
IUUC-Csa-023958	Chlorocebus sabaeus	89.21	1.00e-168	586.00
IUUC-Cho-024928	Choloepus hoffmanni	87.01	2.00e-37	149.00
IUUC-Cin-025771	Ciona intestinalis	54.63	9.00e-100	356.00
IUUC-Csv-026149	Ciona savignyi	57.32	1.00e-102	366.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.32	2.00e-50	192.00
IUUC-Cne-026955	Cryptococcus neoformans	35.99	3.00e-51	195.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.70	2.00e-50	192.00
IUUC-Dre-027409	Danio rerio	93.66	0.00e+00	645.00
IUUC-Dno-028921	Dasypus novemcinctus	88.89	4.00e-170	590.00
IUUC-Dse-031170	Dothistroma septosporum	37.85	2.00e-54	205.00
IUUC-Dme-031677	Drosophila melanogaster	60.25	1.00e-111	396.00
IUUC-Ete-032707	Echinops telfairi	61.99	1.00e-106	379.00
IUUC-Eca-033776	Equus caballus	89.66	6.00e-156	543.00
IUUC-Eeu-035305	Erinaceus europaeus	71.05	3.00e-75	275.00
IUUC-Fca-035846	Felis catus	82.46	8.00e-166	576.00
IUUC-Fal-037597	Ficedula albicollis	91.03	4.00e-153	533.00
IUUC-Fox-037670	Fusarium oxysporum	47.84	6.00e-52	197.00
IUUC-Fso-038243	Fusarium solani	48.28	4.00e-52	198.00
IUUC-Gmo-038499	Gadus morhua	90.16	6.00e-171	593.00
IUUC-Ggr-039975	Gaeumannomyces graminis	42.17	3.00e-46	178.00
IUUC-Gga-040904	Gallus gallus	90.39	0.00e+00	625.00
IUUC-Gac-042058	Gasterosteus aculeatus	95.87	0.00e+00	629.00
IUUC-Gma-043763	Glycine max	48.52	2.00e-84	305.00
IUUC-Ggo-044699	Gorilla gorilla	83.17	1.00e-153	535.00
IUUC-Hsa-046227	Homo sapiens	89.21	6.00e-171	593.00
IUUC-Hvu-047359	Hordeum vulgare	45.62	6.00e-80	291.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	81.50	2.00e-165	575.00
IUUC-Lch-049829	Latimeria chalumnae	90.16	2.00e-171	594.00
IUUC-Lpe-050899	Leersia perrieri	47.02	1.00e-75	276.00
IUUC-Loc-052264	Lepisosteus oculatus	93.04	7.00e-175	606.00
IUUC-Lma-053110	Leptosphaeria maculans	36.81	2.00e-45	176.00
IUUC-Laf-053639	Loxodonta africana	89.52	3.00e-171	594.00
IUUC-Mcc-055506	Macaca mulatta	89.21	9.00e-169	586.00
IUUC-Mor-057001	Magnaporthe oryzae	43.88	9.00e-52	197.00
IUUC-Mpo-057608	Magnaporthe poae	41.18	9.00e-31	126.00
IUUC-Mtr-057731	Medicago truncatula	48.51	2.00e-84	305.00
IUUC-Mla-059016	Melampsora laricipopulina	41.38	3.00e-40	158.00
IUUC-Mga-060178	Meleagris gallopavo	90.85	4.00e-167	580.00
IUUC-Mvi-060353	Microbotryum violaceum	38.69	2.00e-53	202.00
IUUC-Mmr-060738	Microcebus murinus	89.52	1.00e-171	595.00
IUUC-Mdo-062266	Monodelphis domestica	90.78	7.00e-113	399.00
IUUC-Mmu-063619	Mus musculus	88.25	7.00e-169	586.00
IUUC-Mac-065301	Musa acuminata	50.31	1.00e-87	316.00
IUUC-Mpu-066058	Mustela putorius furo	89.84	1.00e-171	595.00
IUUC-Mlu-067292	Myotis lucifugus	88.57	1.00e-167	582.00
IUUC-Nfi-068275	Neosartorya fischeri	37.70	5.00e-54	204.00
IUUC-Ncr-068713	Neurospora crassa	38.49	7.00e-58	217.00
IUUC-Nle-069013	Nomascus leucogenys	88.89	3.00e-168	584.00
IUUC-Opr-070628	Ochotona princeps	78.65	5.00e-155	540.00
IUUC-Oan-073004	Ornithorhynchus anatinus	89.11	2.00e-131	461.00
IUUC-Ocu-074303	Oryctolagus cuniculus	89.84	2.00e-171	595.00
IUUC-Oba-075002	Oryza barthii	47.31	6.00e-80	290.00
IUUC-Obr-076392	Oryza brachyantha	47.96	2.00e-77	282.00
IUUC-Ogl-077271	Oryza glaberrima	47.31	6.00e-80	290.00
IUUC-Ogu-078493	Oryza glumaepatula	47.31	1.00e-80	293.00
IUUC-Oin-080084	Oryza indica	47.31	1.00e-80	293.00
IUUC-Olo-080803	Oryza longistaminata	47.01	3.00e-80	291.00
IUUC-Ome-081146	Oryza meridionalis	47.01	4.00e-80	291.00
IUUC-Oni-082146	Oryza nivara	47.31	1.00e-80	293.00
IUUC-Opu-083633	Oryza punctata	47.65	4.00e-76	278.00
IUUC-Oru-084789	Oryza rufipogon	47.31	1.00e-80	293.00
IUUC-Osa-086196	Oryza sativa	47.31	1.00e-80	293.00
IUUC-Ola-087126	Oryzias latipes	95.87	1.00e-176	612.00
IUUC-Olu-087665	Ostreococcus lucimarinus	40.69	4.00e-66	244.00
IUUC-Oga-089140	Otolemur garnettii	81.87	1.00e-165	575.00
IUUC-Oar-090296	Ovis aries	88.89	2.00e-169	587.00
IUUC-Ptr-090566	Pan troglodytes	89.21	6.00e-171	593.00
IUUC-Pan-092052	Papio anubis	89.21	1.00e-168	585.00
IUUC-Psi-093723	Pelodiscus sinensis	91.72	2.00e-159	554.00
IUUC-Pma-094568	Petromyzon marinus	61.72	5.00e-107	380.00
IUUC-Pno-095120	Phaeosphaeria nodorum	37.58	2.00e-47	182.00
IUUC-Ppa-095761	Physcomitrella patens	46.94	1.00e-82	300.00
IUUC-Pfo-096210	Poecilia formosa	96.83	0.00e+00	637.00
IUUC-Pab-098463	Pongo abelii	89.21	2.00e-170	592.00
IUUC-Pop-099423	Populus trichocarpa	47.34	4.00e-84	304.00
IUUC-Pca-100108	Procavia capensis	88.71	4.00e-131	461.00
IUUC-Ppe-101176	Prunus persica	49.25	6.00e-83	300.00
IUUC-Pva-102629	Pteropus vampyrus	86.74	9.00e-136	476.00
IUUC-Pgr-103419	Puccinia graminis	43.37	2.00e-52	199.00
IUUC-Pte-104207	Pyrenophora teres	39.41	5.00e-29	120.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	36.60	3.00e-52	199.00
IUUC-Rno-105579	Rattus norvegicus	79.08	1.00e-148	519.00
IUUC-Sha-106894	Sarcophilus harrisii	87.41	5.00e-145	506.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	39.73	7.00e-57	214.00
IUUC-Spo-108371	Schizosaccharomyces pombe	39.26	3.00e-58	218.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	37.32	1.00e-46	180.00
IUUC-Smo-109396	Selaginella moellendorffii	51.07	2.00e-86	312.00
IUUC-Sit-110630	Setaria italica	48.33	6.00e-84	304.00
IUUC-Sly-110972	Solanum lycopersicum	47.45	8.00e-79	286.00
IUUC-Stu-112185	Solanum tuberosum	47.76	1.00e-87	316.00
IUUC-Sar-113294	Sorex araneus	73.65	4.00e-148	517.00
IUUC-Sbi-113951	Sorghum bicolor	49.08	4.00e-84	305.00
IUUC-Ssc-115501	Sus scrofa	88.63	6.00e-159	553.00
IUUC-Tgu-117152	Taeniopygia guttata	90.69	4.00e-153	533.00
IUUC-Tru-118388	Takifugu rubripes	94.60	1.00e-179	622.00
IUUC-Tsy-119109	Tarsius syrichta	89.52	3.00e-171	594.00
IUUC-Tni-120048	Tetraodon nigroviridis	94.92	0.00e+00	626.00
IUUC-Tca-121750	Theobroma cacao	49.26	3.00e-88	318.00
IUUC-Tre-122130	Trichoderma reesei	38.74	2.00e-53	202.00
IUUC-Tvi-122284	Trichoderma virens	38.87	8.00e-51	194.00
IUUC-Tae-124082	Triticum aestivum	45.92	1.00e-79	290.00
IUUC-Tur-126366	Triticum urartu	41.84	4.00e-65	241.00
IUUC-Tme-127187	Tuber melanosporum	38.81	4.00e-58	218.00
IUUC-Tbe-127619	Tupaia belangeri	79.93	1.00e-130	458.00
IUUC-Ttr-128867	Tursiops truncatus	80.97	2.00e-114	405.00
IUUC-Vda-129912	Verticillium dahliae	37.37	3.00e-52	199.00
IUUC-Vpa-130552	Vicugna pacos	91.00	9.00e-117	413.00
IUUC-Vvi-130881	Vitis vinifera	48.52	3.00e-82	298.00
IUUC-Xtr-131934	Xenopus tropicalis	84.29	4.00e-170	590.00
IUUC-Xma-133312	Xiphophorus maculatus	96.51	0.00e+00	632.00
IUUC-Yli-134487	Yarrowia lipolytica	36.84	3.00e-44	172.00
IUUC-Zma-135462	Zea mays	42.81	9.00e-71	260.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence