iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133122

Ensembl Protein ID

ENSXMAP00000009762.1

UniProt Accession

M4A5L8; M4A5L8_XIPMA

Genbank Protein ID

ENSXMAP00000009762

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGAJ01023342

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000009731.1	ENSXMAT00000009776.1	ENSXMAP00000009762.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.40e-106	354.4	568	894

Active Site

Position(s)	Description	Evidence
863	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e  +  ++  ++s+    e++  ++++G++lg+a++++ +ld+
   Q: 568  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEHTRLFWFN-SSSF----ENEGQYTLIGIVLGLAIYNNCILDV 651
           689******************************************9998888875.5555....57899******************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+slke+ e+ e ++ee  + +tf++s++  +g++  ++L ++G++ipVtneN++++v l+ 
   Q: 652  HFPMVVYRKLMGKKGTFRDLADANPVLYQSLKELVEY-EGNVEED-MMITFQISQTDpFGNRLMYDLRENGDKIPVTNENRKDFVALYS 738
           *************************************.6688775.999999665545******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           ey+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggy++ds+ i+ Fwe+l++fs+e+++ fLq
   Q: 739  EYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYNKDSRIIKEFWETLHSFSEEQKRLFLQ 827
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d drlP+s+TCfn+L LPeYs++++l+e+Ll Ai+++kgF++
   Q: 828  FTTGTDRAPVGGLGKLK---MIIAKNGPDtDRLPTSHTCFNVLLLPEYSNMDKLRERLLKAITYAKGFGM 894
           *****************...8888866666**************************************97 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MNSDEKEDCE CATPQAETSP ARGAAREQEE PDIENPEASR MKRAAAKHLI ERYYHQLTEG 60
CGNESCSNSW CASSAGFSRM DNNAAAVKAL ELYKVNAKLC DPHPSKKGTA STYPESSAHS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATTCCG ACGAGAAGGA GGACTGTGAG TGTGCGACAC CACAGGCCGA GACCAGCCCC 60
GCCAGAGGAG CTGCTAGGTG AGGAAGCCGA GAGGAGGGAG CCGGGGCTGC CGGGGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

xma:102231350

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	85.03	0.00e+00	1435.00
IUUC-Apl-003742	Anas platyrhynchos	83.64	0.00e+00	1458.00
IUUC-Aca-004873	Anolis carolinensis	84.50	0.00e+00	1466.00
IUUC-Ame-011166	Astyanax mexicanus	86.25	0.00e+00	1463.00
IUUC-Bgr-011981	Blumeria graminis	38.39	6.00e-80	292.00
IUUC-Bta-013286	Bos taurus	84.23	0.00e+00	1414.00
IUUC-Cja-019707	Callithrix jacchus	84.78	0.00e+00	1444.00
IUUC-Cfa-020154	Canis familiaris	84.27	0.00e+00	1437.00
IUUC-Cpo-021292	Cavia porcellus	85.13	0.00e+00	1420.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	50.31	3.00e-83	301.00
IUUC-Csa-023378	Chlorocebus sabaeus	84.19	0.00e+00	1446.00
IUUC-Cho-025059	Choloepus hoffmanni	81.43	0.00e+00	1354.00
IUUC-Cin-025643	Ciona intestinalis	43.47	0.00e+00	687.00
IUUC-Csv-026282	Ciona savignyi	44.64	0.00e+00	649.00
IUUC-Dre-027901	Danio rerio	85.90	0.00e+00	1457.00
IUUC-Dno-029320	Dasypus novemcinctus	83.79	0.00e+00	1447.00
IUUC-Dor-030756	Dipodomys ordii	90.48	0.00e+00	631.00
IUUC-Dme-032035	Drosophila melanogaster	43.98	6.00e-166	578.00
IUUC-Eca-033843	Equus caballus	85.50	0.00e+00	1407.00
IUUC-Eeu-035109	Erinaceus europaeus	83.14	0.00e+00	1385.00
IUUC-Fca-036344	Felis catus	84.36	0.00e+00	1444.00
IUUC-Fal-036747	Ficedula albicollis	83.64	0.00e+00	1458.00
IUUC-Fox-037941	Fusarium oxysporum	37.63	1.00e-86	315.00
IUUC-Gga-040399	Gallus gallus	83.75	0.00e+00	1460.00
IUUC-Gac-041933	Gasterosteus aculeatus	93.00	0.00e+00	1523.00
IUUC-Ggo-044804	Gorilla gorilla	84.78	0.00e+00	1445.00
IUUC-Hsa-045727	Homo sapiens	84.78	0.00e+00	1445.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	81.85	0.00e+00	1335.00
IUUC-Lch-050197	Latimeria chalumnae	84.42	0.00e+00	1453.00
IUUC-Loc-052743	Lepisosteus oculatus	85.76	0.00e+00	1513.00
IUUC-Lma-053245	Leptosphaeria maculans	33.42	4.00e-56	213.00
IUUC-Laf-053615	Loxodonta africana	84.92	0.00e+00	1430.00
IUUC-Mcc-054934	Macaca mulatta	85.47	0.00e+00	1443.00
IUUC-Meu-056061	Macropus eugenii	81.87	0.00e+00	1304.00
IUUC-Mor-057045	Magnaporthe oryzae	36.15	5.00e-79	290.00
IUUC-Mga-059271	Meleagris gallopavo	84.52	0.00e+00	1440.00
IUUC-Mmr-061288	Microcebus murinus	85.70	0.00e+00	1449.00
IUUC-Mdo-062975	Monodelphis domestica	84.87	0.00e+00	1462.00
IUUC-Mmu-063674	Mus musculus	82.67	0.00e+00	1395.00
IUUC-Mpu-066568	Mustela putorius furo	84.02	0.00e+00	1452.00
IUUC-Mlu-067522	Myotis lucifugus	79.23	0.00e+00	1359.00
IUUC-Nle-069505	Nomascus leucogenys	84.78	0.00e+00	1445.00
IUUC-Opr-070570	Ochotona princeps	78.00	0.00e+00	1290.00
IUUC-Ont-071527	Oreochromis niloticus	90.80	0.00e+00	1617.00
IUUC-Oan-073446	Ornithorhynchus anatinus	83.61	0.00e+00	964.00
IUUC-Ocu-074922	Oryctolagus cuniculus	82.29	0.00e+00	1436.00
IUUC-Ola-086996	Oryzias latipes	90.66	0.00e+00	1573.00
IUUC-Oga-088261	Otolemur garnettii	85.26	0.00e+00	1430.00
IUUC-Oar-090024	Ovis aries	84.23	0.00e+00	1414.00
IUUC-Ptr-090455	Pan troglodytes	84.78	0.00e+00	1445.00
IUUC-Pan-092509	Papio anubis	82.91	0.00e+00	1283.00
IUUC-Psi-092974	Pelodiscus sinensis	83.73	0.00e+00	1439.00
IUUC-Pma-094643	Petromyzon marinus	70.29	0.00e+00	1229.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.06	2.00e-56	214.00
IUUC-Ppa-095354	Physcomitrella patens	46.83	1.00e-110	394.00
IUUC-Pfo-096905	Poecilia formosa	99.33	0.00e+00	1725.00
IUUC-Pab-097840	Pongo abelii	83.18	0.00e+00	1393.00
IUUC-Pca-100869	Procavia capensis	84.48	0.00e+00	1418.00
IUUC-Pva-103040	Pteropus vampyrus	88.39	1.00e-179	624.00
IUUC-Rno-105453	Rattus norvegicus	83.09	0.00e+00	1406.00
IUUC-Sha-107651	Sarcophilus harrisii	84.87	0.00e+00	1462.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	36.01	4.00e-75	276.00
IUUC-Smo-108858	Selaginella moellendorffii	48.46	3.00e-112	399.00
IUUC-Sar-113293	Sorex araneus	85.26	0.00e+00	1440.00
IUUC-Ssc-115979	Sus scrofa	84.54	0.00e+00	1431.00
IUUC-Tgu-116901	Taeniopygia guttata	83.64	0.00e+00	1457.00
IUUC-Tru-118368	Takifugu rubripes	93.53	0.00e+00	1571.00
IUUC-Tsy-119516	Tarsius syrichta	81.17	0.00e+00	1325.00
IUUC-Tni-120143	Tetraodon nigroviridis	93.53	0.00e+00	1569.00
IUUC-Tbe-127484	Tupaia belangeri	79.40	0.00e+00	964.00
IUUC-Ttr-129078	Tursiops truncatus	85.15	0.00e+00	1415.00
IUUC-Vda-129969	Verticillium dahliae	37.31	8.00e-82	299.00
IUUC-Vpa-130312	Vicugna pacos	77.76	0.00e+00	1198.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence