iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073453

UUCD1 version

UUC-OrA-00662

Ensembl Protein ID

ENSOANP00000017578.2

UniProt Accession

F7FCJ7; F7FCJ7_ORNAN

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Gene Name

WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000011097.3	ENSOANT00000017581.3	ENSOANP00000017578.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-42	142.5	341	376
UBD/Beta-Prp	4.00e-48	164.3	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++  +    l+sGs D+ +k+WD+r+++
   Q: 341  HTGWVTSVKWspTHeQQLISGSLDNIVKLWDTRSCK 376
           **********9533678**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t+++++tl+gh++ + s+ +s   + + s+s+d ti+vwd e+g   + tl+g++ v nc++++p ++ l+sGs+Dr +rlWd +t++ 
   Q: 246  TRTPIVTLSGHNEAISSVLWSD-AEEICSASWDHTIKVWDAESGGLKS-TLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWDPRTKDG 331
           67899****************9.99**********************9.***987.99**************************88764 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ ht+ v+s++++++  ++l+sgsld+ vklwd +  +  ++ l +h+d v sv+ + ++ +l+sg++D+ ++ +
   Q: 332  SLVLlslTS-HTGWVTSVKWSPTHeQQLISGSLDNIVKLWDTRsCKAPLYDLAAHEDKVFSVDWT-ETGLLLSGGADNKLYSY 412
           444444387.************9889*****************54566****************9.999********999876 PP

Organism

Ornithorhynchus anatinus

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MAQLQVRFFT DNKKYTVDDV PFSVPATSEI TDLSNIINKL LEAKNGAHKH VEFDFLIQGQ 60
FLRMALVKHM ELENVSTEDV VEIEYVEKYT APQPEECMLH DDWISSIEAT EEWILTGCYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGATTGGC CGAGGCGGCG GCGATGACGC ACTCTCTTTC TCCTTTAAGG CTAGGCCCGG 60
CTAATCAATC GCTCCTCGAT GGGATCGTCG ATCGATGACT CTGGTCTAGG CCCAAGTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000460--P:maturation of 5.8S rRNA
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470--P:maturation of LSU-rRNA
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

KEGG

oaa:100077374

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	33.89	1.00e-65	242.00
IUUC-Aml-001997	Ailuropoda melanoleuca	89.51	0.00e+00	724.00
IUUC-Atr-002544	Amborella trichopoda	32.38	4.00e-60	224.00
IUUC-Apl-003981	Anas platyrhynchos	88.83	0.00e+00	682.00
IUUC-Aca-004370	Anolis carolinensis	84.94	0.00e+00	748.00
IUUC-Aly-006455	Arabidopsis lyrata	34.60	2.00e-65	242.00
IUUC-Ath-006669	Arabidopsis thaliana	33.33	1.00e-60	226.00
IUUC-Ago-007864	Ashbya gossypii	30.00	3.00e-44	172.00
IUUC-Acl-008177	Aspergillus clavatus	27.43	1.00e-41	163.00
IUUC-Afl-008617	Aspergillus flavus	26.85	3.00e-41	162.00
IUUC-Afu-008752	Aspergillus fumigatus	27.00	3.00e-38	152.00
IUUC-Ani-009136	Aspergillus nidulans	28.72	4.00e-40	158.00
IUUC-Ang-009701	Aspergillus niger	26.16	4.00e-39	155.00
IUUC-Aor-009884	Aspergillus oryzae	26.85	8.00e-41	160.00
IUUC-Ame-011432	Astyanax mexicanus	77.30	0.00e+00	706.00
IUUC-Bgr-012218	Blumeria graminis	27.19	7.00e-37	147.00
IUUC-Bta-012829	Bos taurus	90.07	0.00e+00	753.00
IUUC-Bci-013953	Botrytis cinerea	28.95	2.00e-39	155.00
IUUC-Bdi-014351	Brachypodium distachyon	35.93	6.00e-63	234.00
IUUC-Bol-015618	Brassica oleracea	34.97	4.00e-61	228.00
IUUC-Bra-017876	Brassica rapa	34.40	3.00e-63	234.00
IUUC-Cel-018569	Caenorhabditis elegans	32.93	3.00e-52	198.00
IUUC-Cja-019468	Callithrix jacchus	88.65	0.00e+00	728.00
IUUC-Cfa-020471	Canis familiaris	89.13	0.00e+00	722.00
IUUC-Cpo-022260	Cavia porcellus	88.65	0.00e+00	732.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	30.23	8.00e-45	173.00
IUUC-Csa-023989	Chlorocebus sabaeus	88.65	0.00e+00	729.00
IUUC-Cho-024426	Choloepus hoffmanni	86.67	2.00e-156	544.00
IUUC-Cin-025789	Ciona intestinalis	44.87	2.00e-105	375.00
IUUC-Cne-027063	Cryptococcus neoformans	23.64	6.00e-24	104.00
IUUC-Dre-027907	Danio rerio	78.96	0.00e+00	724.00
IUUC-Dno-029225	Dasypus novemcinctus	87.00	0.00e+00	733.00
IUUC-Dor-031082	Dipodomys ordii	74.70	1.00e-166	578.00
IUUC-Dse-031308	Dothistroma septosporum	26.12	6.00e-41	160.00
IUUC-Dme-032189	Drosophila melanogaster	42.48	1.00e-103	369.00
IUUC-Ete-032247	Echinops telfairi	81.80	0.00e+00	684.00
IUUC-Eca-034285	Equus caballus	90.07	0.00e+00	753.00
IUUC-Eeu-035322	Erinaceus europaeus	80.15	0.00e+00	634.00
IUUC-Fca-036114	Felis catus	89.13	0.00e+00	747.00
IUUC-Fal-036891	Ficedula albicollis	87.85	0.00e+00	637.00
IUUC-Fox-037965	Fusarium oxysporum	24.95	1.00e-37	150.00
IUUC-Fso-038244	Fusarium solani	24.31	5.00e-37	148.00
IUUC-Gmo-039040	Gadus morhua	76.83	0.00e+00	719.00
IUUC-Ggr-040093	Gaeumannomyces graminis	23.19	5.00e-19	88.20
IUUC-Gga-040610	Gallus gallus	85.58	0.00e+00	747.00
IUUC-Gac-042117	Gasterosteus aculeatus	77.54	0.00e+00	699.00
IUUC-Gma-043146	Glycine max	36.45	3.00e-73	268.00
IUUC-Ggo-045179	Gorilla gorilla	88.65	0.00e+00	724.00
IUUC-Hsa-046114	Homo sapiens	88.89	0.00e+00	725.00
IUUC-Hvu-047331	Hordeum vulgare	34.02	4.00e-60	224.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	89.83	0.00e+00	751.00
IUUC-Kpa-049304	Komagataella pastoris	30.67	4.00e-49	187.00
IUUC-Lch-050655	Latimeria chalumnae	77.29	5.00e-154	536.00
IUUC-Lpe-051675	Leersia perrieri	34.75	4.00e-66	244.00
IUUC-Loc-052868	Lepisosteus oculatus	82.98	0.00e+00	724.00
IUUC-Lma-053258	Leptosphaeria maculans	25.11	6.00e-38	152.00
IUUC-Laf-053993	Loxodonta africana	87.71	0.00e+00	739.00
IUUC-Mcc-055128	Macaca mulatta	72.58	6.00e-167	579.00
IUUC-Meu-056501	Macropus eugenii	77.75	2.00e-166	577.00
IUUC-Mor-057114	Magnaporthe oryzae	26.00	3.00e-31	129.00
IUUC-Mtr-058367	Medicago truncatula	36.36	3.00e-68	251.00
IUUC-Mla-059107	Melampsora laricipopulina	27.86	4.00e-38	151.00
IUUC-Mga-059745	Meleagris gallopavo	83.76	0.00e+00	723.00
IUUC-Mvi-060362	Microbotryum violaceum	28.79	1.00e-37	150.00
IUUC-Mdo-062257	Monodelphis domestica	84.52	0.00e+00	739.00
IUUC-Mmu-063546	Mus musculus	87.94	0.00e+00	741.00
IUUC-Mac-065540	Musa acuminata	33.49	5.00e-61	228.00
IUUC-Mpu-066284	Mustela putorius furo	90.31	0.00e+00	754.00
IUUC-Mlu-067241	Myotis lucifugus	88.42	0.00e+00	743.00
IUUC-Nfi-068260	Neosartorya fischeri	26.22	1.00e-39	156.00
IUUC-Ncr-068719	Neurospora crassa	26.16	3.00e-33	135.00
IUUC-Nle-068981	Nomascus leucogenys	88.65	0.00e+00	705.00
IUUC-Opr-071218	Ochotona princeps	80.65	0.00e+00	649.00
IUUC-Ont-071646	Oreochromis niloticus	76.96	0.00e+00	701.00
IUUC-Ocu-074008	Oryctolagus cuniculus	89.13	0.00e+00	748.00
IUUC-Oba-075712	Oryza barthii	29.76	1.00e-47	183.00
IUUC-Obr-076721	Oryza brachyantha	34.74	1.00e-65	243.00
IUUC-Ogl-077229	Oryza glaberrima	34.04	6.00e-65	240.00
IUUC-Ogu-078977	Oryza glumaepatula	29.76	7.00e-48	184.00
IUUC-Oin-079683	Oryza indica	34.04	3.00e-65	241.00
IUUC-Olo-080291	Oryza longistaminata	29.90	6.00e-35	140.00
IUUC-Ome-081834	Oryza meridionalis	34.28	6.00e-66	244.00
IUUC-Oni-082507	Oryza nivara	32.46	1.00e-59	223.00
IUUC-Opu-083396	Oryza punctata	34.04	3.00e-65	241.00
IUUC-Oru-085220	Oryza rufipogon	32.70	4.00e-59	221.00
IUUC-Osa-085767	Oryza sativa	34.04	3.00e-65	241.00
IUUC-Ola-087420	Oryzias latipes	78.96	0.00e+00	717.00
IUUC-Olu-087740	Ostreococcus lucimarinus	28.44	3.00e-43	168.00
IUUC-Oga-088264	Otolemur garnettii	87.71	0.00e+00	721.00
IUUC-Oar-089335	Ovis aries	89.83	0.00e+00	749.00
IUUC-Ptr-091320	Pan troglodytes	88.89	0.00e+00	725.00
IUUC-Pan-092833	Papio anubis	88.18	0.00e+00	724.00
IUUC-Psi-093504	Pelodiscus sinensis	87.47	0.00e+00	744.00
IUUC-Pma-094189	Petromyzon marinus	69.81	4.00e-179	619.00
IUUC-Pno-094929	Phaeosphaeria nodorum	24.89	1.00e-37	150.00
IUUC-Ppa-095429	Physcomitrella patens	34.97	2.00e-69	255.00
IUUC-Pfo-096337	Poecilia formosa	77.07	0.00e+00	725.00
IUUC-Pab-097571	Pongo abelii	88.42	0.00e+00	724.00
IUUC-Pop-099977	Populus trichocarpa	35.10	3.00e-70	258.00
IUUC-Pca-100394	Procavia capensis	83.86	0.00e+00	657.00
IUUC-Ppe-101848	Prunus persica	36.58	5.00e-71	260.00
IUUC-Pva-102921	Pteropus vampyrus	87.04	5.00e-112	397.00
IUUC-Pgr-103637	Puccinia graminis	27.31	3.00e-41	162.00
IUUC-Ptt-103781	Puccinia triticina	28.48	8.00e-41	160.00
IUUC-Pte-104135	Pyrenophora teres	26.07	4.00e-38	153.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	25.71	7.00e-38	150.00
IUUC-Rno-105114	Rattus norvegicus	87.47	0.00e+00	739.00
IUUC-Sce-106401	Saccharomyces cerevisiae	30.55	8.00e-47	180.00
IUUC-Sha-107122	Sarcophilus harrisii	84.67	0.00e+00	700.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.24	1.00e-55	209.00
IUUC-Spo-108134	Schizosaccharomyces pombe	30.73	3.00e-47	182.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	28.54	3.00e-41	162.00
IUUC-Smo-108720	Selaginella moellendorffii	31.98	4.00e-59	221.00
IUUC-Sit-110311	Setaria italica	36.20	6.00e-64	237.00
IUUC-Sly-111178	Solanum lycopersicum	33.83	1.00e-64	239.00
IUUC-Stu-112778	Solanum tuberosum	35.08	3.00e-68	251.00
IUUC-Sar-113596	Sorex araneus	74.94	1.00e-168	584.00
IUUC-Sbi-114193	Sorghum bicolor	34.45	2.00e-63	235.00
IUUC-Sre-115002	Sporisorium reilianum	26.72	1.00e-18	87.00
IUUC-Ssc-116066	Sus scrofa	89.83	0.00e+00	748.00
IUUC-Tgu-117048	Taeniopygia guttata	86.44	0.00e+00	669.00
IUUC-Tsy-119573	Tarsius syrichta	57.31	2.00e-125	441.00
IUUC-Tni-119820	Tetraodon nigroviridis	76.83	0.00e+00	698.00
IUUC-Tca-121605	Theobroma cacao	35.58	1.00e-69	256.00
IUUC-Tre-121947	Trichoderma reesei	26.28	4.00e-39	155.00
IUUC-Tvi-122481	Trichoderma virens	26.50	8.00e-41	160.00
IUUC-Tae-125861	Triticum aestivum	34.12	1.00e-65	243.00
IUUC-Tur-126586	Triticum urartu	34.27	3.00e-62	231.00
IUUC-Tme-126900	Tuber melanosporum	30.50	2.00e-52	199.00
IUUC-Tbe-127736	Tupaia belangeri	67.09	2.00e-142	498.00
IUUC-Ttr-129041	Tursiops truncatus	78.96	0.00e+00	642.00
IUUC-Uma-129628	Ustilago maydis	24.75	5.00e-16	78.60
IUUC-Vpa-130260	Vicugna pacos	89.83	0.00e+00	751.00
IUUC-Vvi-131009	Vitis vinifera	35.24	7.00e-69	253.00
IUUC-Xtr-132083	Xenopus tropicalis	80.85	0.00e+00	699.00
IUUC-Xma-133094	Xiphophorus maculatus	76.36	0.00e+00	718.00
IUUC-Yli-134531	Yarrowia lipolytica	23.14	4.00e-24	105.00
IUUC-Zma-135509	Zea mays	33.57	4.00e-65	241.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence