iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093496

Ensembl Protein ID

ENSPSIP00000017069.1

UniProt Accession

K7G9V8; K7G9V8_PELSI

Genbank Protein ID

ENSPSIP00000017069

Protein Name

MICOS complex subunit

Genbank Nucleotide ID

AGCU01015308

Gene Name

KLHL15

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000015199.1	ENSPSIT00000017147.1	ENSPSIP00000017069.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.90e-18	66.0	32	96

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           Dv+lv+++ +f+ahk+ La++S++F+ +f+ +++e++ ++++++k++ ++ f+++l+F+Y g++++
   Q: 32   DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERD-QDKIHLKGLTATGFSHVLQFMYYGTIEL 96
           9***********************************9.************************9876 PP

Organism

Pelodiscus sinensis

Functional Description
(View)

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

Protein Sequence
(Fasta)

MAGDVEGFSS SIHDTSVSAG FRALYEEGLL LDVTLVIEDH QFQAHKALLA TQSDYFRIMF 60
TADMRERDQD KIHLKGLTAT GFSHVLQFMY YGTIELSMNT VHEILQAAMY VQLIEVVKFC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGGGG ACGTGGAAGG GTTTAGCTCC TCCATCCATG ATACCAGTGT CTCTGCTGGG 60
TTCAGAGCAC TGTATGAGGA AGGATTGCTT CTTGACGTCA CGCTTGTCAT TGAAGACCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR030597--KLHL15
IPR019166--MIC26/MIC27
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF09769--ApoO
PF07707--BACK
PF00651--BTB

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0061617--C:MICOS complex
GO:0005634--C:nucleus
GO:0042407--P:cristae formation
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001418	Ailuropoda melanoleuca	94.90	2.00e-155	541.00
IUUC-Apl-003970	Anas platyrhynchos	98.98	5.00e-161	560.00
IUUC-Aca-005217	Anolis carolinensis	97.28	5.00e-158	550.00
IUUC-Ame-011065	Astyanax mexicanus	81.63	6.00e-149	520.00
IUUC-Bta-012443	Bos taurus	93.88	5.00e-154	537.00
IUUC-Cja-019831	Callithrix jacchus	95.24	8.00e-156	543.00
IUUC-Cfa-020941	Canis familiaris	95.24	7.00e-156	543.00
IUUC-Cpo-021730	Cavia porcellus	94.90	1.00e-155	542.00
IUUC-Csa-023247	Chlorocebus sabaeus	94.90	2.00e-155	542.00
IUUC-Dre-028474	Danio rerio	80.61	7.00e-147	514.00
IUUC-Dno-029411	Dasypus novemcinctus	95.58	6.00e-156	543.00
IUUC-Dor-030576	Dipodomys ordii	94.22	9.00e-155	540.00
IUUC-Ete-032327	Echinops telfairi	89.12	1.00e-142	499.00
IUUC-Eca-033477	Equus caballus	94.22	3.00e-154	538.00
IUUC-Fca-035546	Felis catus	94.90	1.00e-155	543.00
IUUC-Fal-037370	Ficedula albicollis	98.98	5.00e-161	560.00
IUUC-Gmo-038961	Gadus morhua	79.52	3.00e-130	458.00
IUUC-Gga-041049	Gallus gallus	98.98	5.00e-161	560.00
IUUC-Gac-042003	Gasterosteus aculeatus	78.84	2.00e-131	462.00
IUUC-Ggo-044451	Gorilla gorilla	94.90	2.00e-155	542.00
IUUC-Hsa-045874	Homo sapiens	94.90	1.00e-155	542.00
IUUC-Itr-048357	Ictidomys tridecemlineatus	95.24	1.00e-155	543.00
IUUC-Lch-049603	Latimeria chalumnae	91.10	3.00e-130	457.00
IUUC-Loc-052300	Lepisosteus oculatus	87.07	3.00e-155	541.00
IUUC-Laf-054459	Loxodonta africana	95.24	3.00e-155	541.00
IUUC-Mcc-054846	Macaca mulatta	94.90	2.00e-155	542.00
IUUC-Meu-056797	Macropus eugenii	98.21	1.00e-116	412.00
IUUC-Mga-059446	Meleagris gallopavo	98.98	5.00e-161	560.00
IUUC-Mmr-061125	Microcebus murinus	94.22	3.00e-154	538.00
IUUC-Mdo-062947	Monodelphis domestica	97.96	8.00e-159	553.00
IUUC-Mmu-063708	Mus musculus	95.24	1.00e-155	543.00
IUUC-Mpu-066447	Mustela putorius furo	95.24	6.00e-156	543.00
IUUC-Mlu-066999	Myotis lucifugus	89.93	2.00e-130	459.00
IUUC-Nle-069918	Nomascus leucogenys	94.90	2.00e-155	542.00
IUUC-Ont-071446	Oreochromis niloticus	80.20	3.00e-133	468.00
IUUC-Oan-072872	Ornithorhynchus anatinus	91.16	3.00e-162	564.00
IUUC-Ocu-073969	Oryctolagus cuniculus	94.56	3.00e-155	541.00
IUUC-Ola-087557	Oryzias latipes	80.24	6.00e-115	406.00
IUUC-Oga-088567	Otolemur garnettii	95.24	1.00e-155	543.00
IUUC-Oar-089882	Ovis aries	93.88	5.00e-154	537.00
IUUC-Ptr-091229	Pan troglodytes	94.98	7.00e-147	513.00
IUUC-Pan-091977	Papio anubis	94.90	2.00e-155	542.00
IUUC-Pfo-096759	Poecilia formosa	79.52	1.00e-131	463.00
IUUC-Pab-098480	Pongo abelii	94.90	2.00e-155	542.00
IUUC-Rno-105500	Rattus norvegicus	95.24	1.00e-155	543.00
IUUC-Sha-106521	Sarcophilus harrisii	97.62	2.00e-158	552.00
IUUC-Ssc-116372	Sus scrofa	94.56	6.00e-155	540.00
IUUC-Tgu-116481	Taeniopygia guttata	98.98	5.00e-161	560.00
IUUC-Tru-118542	Takifugu rubripes	78.16	3.00e-129	455.00
IUUC-Tsy-118848	Tarsius syrichta	85.96	7.00e-116	410.00
IUUC-Tni-119989	Tetraodon nigroviridis	79.65	2.00e-127	449.00
IUUC-Tbe-127485	Tupaia belangeri	95.24	1.00e-155	543.00
IUUC-Ttr-129214	Tursiops truncatus	94.56	1.00e-154	539.00
IUUC-Vpa-130261	Vicugna pacos	89.12	9.00e-143	499.00
IUUC-Xtr-132092	Xenopus tropicalis	90.59	1.00e-143	503.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence