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Tag Content
UUCD2 ID IUUC-Nle-069997
UUCD1 version UUC-NoL-01076
Ensembl Protein ID ENSNLEP00000007105.2
UniProt Accession G1R1N3; G1R1N3_NOMLE
Genbank Protein ID ENSNLEP00000007105
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID ADFV01170470
Gene Name USP13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSNLEG00000005851.1 ENSNLET00000007457.1 ENSNLEP00000007105.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 7.60e-58 196.3 271 795
UBD/Alpha-Helix/UBA 1.30e-20 72.9 665 702
Active Site
Position(s) Description Evidence
280 Nucleophile {ECO:0000256|PIRSR:PIRSR016308-1}
758 Proton acceptor {ECO:0000256|PIRSR:PIRSR016308-1}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 271  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQQNG 358
           7******************************788777765.79*****************8888888888888877765543388888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 359  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 418
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++e++++   ++++  ++k+  +
   Q: 419  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaeanrralpelvrakiPFSACLQAFSEPENVDD---FWSSALQAKSAGV 504
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 505  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddsknrlmnqlidpsdidess 592
           *********************997.*******************999889999999999999999998888888888888888877777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 593  vmqlaemgfpleacrkavyftgnmgaevafnwiivhmeepdfaepltmpgyggaasagasvfgasgldnqppeeivaiitsmgfqrnqa 681
           77777777777777777777777777777777777777777777777777777777777777766666666666666666666666666 PP
   S: 268  ..........peekqke............................................kkkYeLiavvvHsG.slssGHYvayvkn 301
                           e                                            + +YeL+a ++H+G s+ sGHY++++k+
   Q: 682  iqalratnnnL-----EraldwifshpefeedsdfviemennananiiseakpegprvkdgSGTYELFAFISHMGtSTMSGHYICHIKK 765
           65555555550.....055555555555555556666666666677788888888888888**************************** PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 766  -EGRWVIYNDHKVCAS--ERPPK---DLGYMYFYRR 795
           .9***********999..78888...99******98 PP
   

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra+nnnle+A+++++++
   Q: 665  EEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSH 702
           899*********************************97 PP
   
Organism Nomascus leucogenys
Protein Sequence
(Fasta)
MNTFLAFGRE HVERHFRKTG QSVYMHLKRH VREKVRGASG GALPKRRNSK IFLDLDTDDD 60
LNSDDYEYED EAKLVIFPDH YEIALPNIEE LPALVTIACD AVLSSKSPYR KQDPDTWENE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Nle-069997|DUB,USP;UBD,UBA|Nomascus leucogenys
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTCCGAACT GCACGTTGCA GATCGTTTGC GTCCTCCCCG GGGCAGAGCG CAGGGCGGGT 60
AGGTGGATGG GATGATCGCC CCACACCCCC GGACACACAG TCCTTCTTTT TCTGGGACTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Nle-069997|DUB,USP;UBD,UBA|Nomascus leucogenys
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP
SMART

SM00165--UBA
SM00290--ZnF_UBP
Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001356 Ailuropoda melanoleuca 98.12 0.00e+00 1486.00
IUUC-Apl-003712 Anas platyrhynchos 83.79 0.00e+00 1342.00
IUUC-Aca-004634 Anolis carolinensis 84.39 0.00e+00 1316.00
IUUC-Ame-011470 Astyanax mexicanus 73.89 0.00e+00 1206.00
IUUC-Bta-013349 Bos taurus 97.87 0.00e+00 1519.00
IUUC-Cja-019021 Callithrix jacchus 98.25 0.00e+00 1483.00
IUUC-Cfa-020614 Canis familiaris 98.49 0.00e+00 1491.00
IUUC-Cpo-022484 Cavia porcellus 98.37 0.00e+00 1492.00
IUUC-Csa-024078 Chlorocebus sabaeus 99.37 0.00e+00 1501.00
IUUC-Cho-024522 Choloepus hoffmanni 81.33 0.00e+00 1167.00
IUUC-Cme-027335 Cyanidioschyzon merolae 26.62 3.00e-49 190.00
IUUC-Dre-027651 Danio rerio 74.29 0.00e+00 1266.00
IUUC-Dno-028975 Dasypus novemcinctus 98.00 0.00e+00 1486.00
IUUC-Dor-030130 Dipodomys ordii 73.06 0.00e+00 1033.00
IUUC-Ete-032251 Echinops telfairi 82.46 0.00e+00 1264.00
IUUC-Eca-033568 Equus caballus 98.75 0.00e+00 1496.00
IUUC-Eeu-034612 Erinaceus europaeus 79.57 0.00e+00 1135.00
IUUC-Fca-036280 Felis catus 98.62 0.00e+00 1493.00
IUUC-Fal-036610 Ficedula albicollis 84.39 0.00e+00 1334.00
IUUC-Gmo-038906 Gadus morhua 72.37 0.00e+00 1175.00
IUUC-Gga-041215 Gallus gallus 83.92 0.00e+00 1334.00
IUUC-Gac-042441 Gasterosteus aculeatus 71.84 0.00e+00 1192.00
IUUC-Ggo-044446 Gorilla gorilla 99.37 0.00e+00 1501.00
IUUC-Hsa-046546 Homo sapiens 99.62 0.00e+00 1501.00
IUUC-Itr-048147 Ictidomys tridecemlineatus 91.60 0.00e+00 1412.00
IUUC-Lch-050425 Latimeria chalumnae 77.98 0.00e+00 1284.00
IUUC-Loc-052072 Lepisosteus oculatus 77.18 0.00e+00 1225.00
IUUC-Laf-053909 Loxodonta africana 96.50 0.00e+00 1481.00
IUUC-Mcc-054686 Macaca mulatta 99.37 0.00e+00 1501.00
IUUC-Meu-056361 Macropus eugenii 80.27 0.00e+00 1226.00
IUUC-Mga-059972 Meleagris gallopavo 79.49 0.00e+00 1285.00
IUUC-Mmr-060916 Microcebus murinus 97.87 0.00e+00 1486.00
IUUC-Mdo-062302 Monodelphis domestica 89.14 0.00e+00 1421.00
IUUC-Mmu-063639 Mus musculus 95.86 0.00e+00 1510.00
IUUC-Mpu-066533 Mustela putorius furo 98.49 0.00e+00 1491.00
IUUC-Mlu-067786 Myotis lucifugus 91.44 0.00e+00 1401.00
IUUC-Ont-071859 Oreochromis niloticus 71.94 0.00e+00 1190.00
IUUC-Oan-072959 Ornithorhynchus anatinus 89.12 2.00e-129 454.00
IUUC-Ocu-074265 Oryctolagus cuniculus 98.37 0.00e+00 1491.00
IUUC-Ola-087344 Oryzias latipes 71.03 0.00e+00 1197.00
IUUC-Oga-088734 Otolemur garnettii 98.12 0.00e+00 1484.00
IUUC-Oar-089636 Ovis aries 97.87 0.00e+00 1554.00
IUUC-Ptr-090982 Pan troglodytes 99.62 0.00e+00 1504.00
IUUC-Pan-091991 Papio anubis 99.50 0.00e+00 1503.00
IUUC-Psi-093509 Pelodiscus sinensis 87.27 0.00e+00 1369.00
IUUC-Pfo-096029 Poecilia formosa 73.84 0.00e+00 1243.00
IUUC-Pab-098672 Pongo abelii 94.99 0.00e+00 1401.00
IUUC-Pca-100860 Procavia capensis 73.94 0.00e+00 1041.00
IUUC-Pva-102545 Pteropus vampyrus 89.97 0.00e+00 1354.00
IUUC-Rno-105210 Rattus norvegicus 94.99 0.00e+00 1489.00
IUUC-Sar-113733 Sorex araneus 96.46 0.00e+00 756.00
IUUC-Tgu-116591 Taeniopygia guttata 85.27 0.00e+00 1339.00
IUUC-Tru-118627 Takifugu rubripes 70.22 0.00e+00 1201.00
IUUC-Tsy-119278 Tarsius syrichta 89.85 0.00e+00 1338.00
IUUC-Tni-120804 Tetraodon nigroviridis 73.32 0.00e+00 1227.00
IUUC-Tbe-127699 Tupaia belangeri 79.19 0.00e+00 876.00
IUUC-Ttr-128295 Tursiops truncatus 89.11 0.00e+00 1338.00
IUUC-Vpa-130170 Vicugna pacos 86.84 0.00e+00 1315.00
IUUC-Xtr-132809 Xenopus tropicalis 74.03 0.00e+00 1184.00
Created Date 25-Jun-2017

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