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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105210
UUCD1 version UUC-RaN-01113
Ensembl Protein ID ENSRNOP00000039985.4
UniProt Accession D3ZDI9; D3ZDI9_RAT
Genbank Protein ID ADM34981.1; EDM01211.1
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID AABR07009979; CH473961
Gene Name Usp13; Usp13_predicted; rCG_41305
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000030639.5 ENSRNOT00000048030.5 ENSRNOP00000039985.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.00e-56 193.0 334 855
UBD/Alpha-Helix/UBA 4.20e-18 65.3 725 762
Active Site
Position(s) Description Evidence
343 Nucleophile {ECO:0000256|PIRSR:PIRSR016308-1}
818 Proton acceptor {ECO:0000256|PIRSR:PIRSR016308-1}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 334  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQQNG 421
           7******************************788777765.79*****************8888888888888877765543388888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 422  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 481
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f++++++++   ++++  ++k+  +
   Q: 482  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayelmrreaetnrrplpelvrakiPFSACLQAFAEPDNVDD---FWSSALQAKSAGV 567
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+s+  ++                                        
   Q: 568  KTSRFASFPEYLVVQIKKFTFGLD-WVPRKFDVSIDMPDLLDISHLRARglqpgeeelpdisppivipddskdrlmnqlidpsdidess 655
           *********************997.*******************999889999999999999999998888888888888888888887 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 656  vmqlaemgfpleacrkavyftgntgaevafnwiivhmeepdfaeplaipgyggagasafgatgldnqppeeivaiitamgfqrsqavqa 744
           77777777777777777777777777777777777777777777777777777777777777776666666666666666666666666 PP
   S: 268  ........peekqke...........................................kkkYeLiavvvHsG.slssGHYvayvknekg 304
                   +     +                                           +  YeL+a ++H+G s+ sGHYv+++k+ +g
   Q: 745  lqatnhnlE-----RaldwifshpefeedsdfviemennananimseakpegprvkdgSGMYELFAFISHMGtSTMSGHYVCHIKK-EG 827
           555555550.....05555555555555555556666666667778888888888888****************************.9* PP
   S: 305  kWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 828  RWVIYNDHKVCAS--ERPPK---DLGYMYFYRR 855
           **********999..78888...99******98 PP
   

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaL+a+n nle+A+++++++
   Q: 725  EEIVAIITAMGFQRSQAVQALQATNHNLERALDWIFSH 762
           899*********************************97 PP
   
Organism Rattus norvegicus
Protein Sequence
(Fasta)
MQRRGALFSV PGGGGKMAAG DLGELLVPHM PTIRVPRSGD RVYKNECAFS YDSPNSEGGL 60
YVCMNTFLAF GREHVERHFR KTGQSVYMHL KRHMREKVRG ASGGALPKRR NSKLFLDLDM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105210|DUB,USP;UBD,UBA|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATCCTCAGCC CGCGCGGCCG CTACGTCCAG GTCCTGCTCT CCCACTGCGC CGCGTTCCTC 60
CCCAGGCCCG CTGCGCTCAG CGGCCATGCA GCGCCGGGGC GCCCTGTTCA GCGTGCCGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105210|DUB,USP;UBD,UBA|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP
SMART

SM00165--UBA
SM00290--ZnF_UBP
Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG rno:310306
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001356 Ailuropoda melanoleuca 94.76 0.00e+00 1558.00
IUUC-Apl-003712 Anas platyrhynchos 82.74 0.00e+00 1330.00
IUUC-Aca-004634 Anolis carolinensis 82.08 0.00e+00 1365.00
IUUC-Ame-011470 Astyanax mexicanus 73.63 0.00e+00 1261.00
IUUC-Bta-013349 Bos taurus 94.55 0.00e+00 1598.00
IUUC-Cja-019021 Callithrix jacchus 94.08 0.00e+00 1554.00
IUUC-Cfa-020614 Canis familiaris 95.01 0.00e+00 1568.00
IUUC-Cpo-022484 Cavia porcellus 95.45 0.00e+00 1479.00
IUUC-Csa-024078 Chlorocebus sabaeus 95.02 0.00e+00 1568.00
IUUC-Cho-024522 Choloepus hoffmanni 78.93 0.00e+00 1138.00
IUUC-Cme-027335 Cyanidioschyzon merolae 25.45 6.00e-52 199.00
IUUC-Dre-027651 Danio rerio 74.01 0.00e+00 1325.00
IUUC-Dno-028975 Dasypus novemcinctus 95.38 0.00e+00 1571.00
IUUC-Dor-030130 Dipodomys ordii 71.69 0.00e+00 1050.00
IUUC-Ete-032251 Echinops telfairi 80.67 0.00e+00 1248.00
IUUC-Eca-033568 Equus caballus 95.54 0.00e+00 1471.00
IUUC-Eeu-034612 Erinaceus europaeus 77.70 0.00e+00 1129.00
IUUC-Fca-036280 Felis catus 95.41 0.00e+00 1467.00
IUUC-Fal-036610 Ficedula albicollis 83.52 0.00e+00 1310.00
IUUC-Gmo-038906 Gadus morhua 71.85 0.00e+00 1233.00
IUUC-Gga-041215 Gallus gallus 82.50 0.00e+00 1415.00
IUUC-Gac-042441 Gasterosteus aculeatus 71.35 0.00e+00 1243.00
IUUC-Ggo-044446 Gorilla gorilla 94.90 0.00e+00 1572.00
IUUC-Hsa-046546 Homo sapiens 95.25 0.00e+00 1576.00
IUUC-Itr-048147 Ictidomys tridecemlineatus 87.32 0.00e+00 1398.00
IUUC-Lch-050425 Latimeria chalumnae 77.26 0.00e+00 1342.00
IUUC-Loc-052072 Lepisosteus oculatus 76.81 0.00e+00 1285.00
IUUC-Laf-053909 Loxodonta africana 94.34 0.00e+00 1571.00
IUUC-Mcc-054686 Macaca mulatta 95.25 0.00e+00 1573.00
IUUC-Meu-056361 Macropus eugenii 80.02 0.00e+00 1285.00
IUUC-Mga-059972 Meleagris gallopavo 78.15 0.00e+00 1277.00
IUUC-Mmr-060916 Microcebus murinus 94.89 0.00e+00 1576.00
IUUC-Mdo-062302 Monodelphis domestica 88.22 0.00e+00 1472.00
IUUC-Mmu-063639 Mus musculus 98.83 0.00e+00 1626.00
IUUC-Mpu-066533 Mustela putorius furo 95.13 0.00e+00 1570.00
IUUC-Mlu-067786 Myotis lucifugus 88.85 0.00e+00 1435.00
IUUC-Nle-069997 Nomascus leucogenys 95.24 0.00e+00 1454.00
IUUC-Ont-071859 Oreochromis niloticus 71.44 0.00e+00 1245.00
IUUC-Oan-072959 Ornithorhynchus anatinus 87.03 4.00e-125 440.00
IUUC-Ocu-074265 Oryctolagus cuniculus 94.99 0.00e+00 1552.00
IUUC-Ola-087344 Oryzias latipes 70.80 0.00e+00 1257.00
IUUC-Oga-088734 Otolemur garnettii 95.31 0.00e+00 1517.00
IUUC-Oar-089636 Ovis aries 94.80 0.00e+00 1531.00
IUUC-Ptr-090982 Pan troglodytes 95.02 0.00e+00 1572.00
IUUC-Pan-091991 Papio anubis 95.13 0.00e+00 1571.00
IUUC-Psi-093509 Pelodiscus sinensis 85.03 0.00e+00 1424.00
IUUC-Pfo-096029 Poecilia formosa 73.23 0.00e+00 1291.00
IUUC-Pab-098672 Pongo abelii 90.73 0.00e+00 1471.00
IUUC-Pca-100860 Procavia capensis 72.29 0.00e+00 1016.00
IUUC-Pva-102545 Pteropus vampyrus 87.25 0.00e+00 1426.00
IUUC-Sar-113733 Sorex araneus 94.55 0.00e+00 758.00
IUUC-Tgu-116591 Taeniopygia guttata 83.99 0.00e+00 1412.00
IUUC-Tru-118627 Takifugu rubripes 69.47 0.00e+00 1252.00
IUUC-Tsy-119278 Tarsius syrichta 86.62 0.00e+00 1311.00
IUUC-Tni-120804 Tetraodon nigroviridis 72.98 0.00e+00 1283.00
IUUC-Tbe-127699 Tupaia belangeri 77.35 0.00e+00 865.00
IUUC-Ttr-128295 Tursiops truncatus 86.76 0.00e+00 1422.00
IUUC-Vpa-130170 Vicugna pacos 84.62 0.00e+00 1296.00
IUUC-Xtr-132809 Xenopus tropicalis 73.37 0.00e+00 1242.00
Created Date 25-Jun-2017

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