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Tag Content
iUUCD ID IUUC-Ame-010969
Ensembl Protein ID ENSAMXP00000020631.1
UniProt Accession W5LLB9; W5LLB9_ASTMX
Genbank Protein ID ENSAMXP00000020631
Protein Name Lissencephaly-1 homolog
Genbank Nucleotide ID APWO01120436
Gene Name pafah1b1b; PAFAH1B1; LIS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAMXG00000020039.1 ENSAMXT00000020631.1 ENSAMXP00000020631.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 9.10e-60 196.2 336 374
UBD/Beta-Prp 8.50e-95 317.6 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++v+++ f ++ +++vs++dD+t+++WD++ ++ k
   Q: 336 GHDNWVRGVLFhPGgKFIVSCADDKTLRIWDYKNKRCMK 374
    8***********999****************99998876 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h s++t v f+p s+++++s+d+tikvwd++ g++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
    5668888********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd++vs+s+d+ti++w++ tg+c++ t++gh+++v++v+ ++dg ll+s+s+D+tvr+W +t+++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIVSASRDKTIKMWEVATGYCVK-TFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVAATKECKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    s+ +++ ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v f+p ++++vs+++D+++riWd++++
   Q: 283 SWAPESahptileatgsenkksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHPGGKFIVSCADDKTLRIWDYKNKR 371
    ***************************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 372 CMKTLSAHEHFVTSLDF-HKTSPYVVTGSVDQTVKVWECR 410
    *****************.999****************985 PP
   

Organism Astyanax mexicanus
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAEIDMN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEIT LGGPVGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Ame-010969|E3,WD_repeat;UBD,Beta-Prp|Astyanax mexicanus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AATTTTTTTT CCAGAGCTGT ATATATGTGT GTATATATAT AATCAGCTGG TAAAATCCAG 60
ATGTTTTGGA GGTGAGGCGG TTGAGCAGTA ACTACAGCTG CTCCTTAAGA CGCGCGCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ame-010969|E3,WD_repeat;UBD,Beta-Prp|Astyanax mexicanus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 94.74 0.00e+00 800.00
IUUC-Apl-004024 Anas platyrhynchos 94.63 0.00e+00 821.00
IUUC-Aca-004564 Anolis carolinensis 94.15 0.00e+00 813.00
IUUC-Ago-007862 Ashbya gossypii 27.23 1.00e-38 153.00
IUUC-Acl-008360 Aspergillus clavatus 46.04 2.00e-104 372.00
IUUC-Afu-008848 Aspergillus fumigatus 46.94 5.00e-106 377.00
IUUC-Bta-013106 Bos taurus 94.88 0.00e+00 822.00
IUUC-Bci-013615 Botrytis cinerea 45.43 2.00e-99 355.00
IUUC-Cel-018459 Caenorhabditis elegans 57.42 6.00e-149 520.00
IUUC-Cja-018755 Callithrix jacchus 92.44 0.00e+00 802.00
IUUC-Cfa-020749 Canis familiaris 94.88 0.00e+00 822.00
IUUC-Cpo-022371 Cavia porcellus 94.88 0.00e+00 822.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 36.71 1.00e-52 199.00
IUUC-Csa-023524 Chlorocebus sabaeus 93.62 0.00e+00 687.00
IUUC-Cho-024764 Choloepus hoffmanni 84.37 0.00e+00 648.00
IUUC-Csv-025817 Ciona savignyi 70.24 0.00e+00 642.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 47.93 5.00e-99 354.00
IUUC-Cne-027087 Cryptococcus neoformans 51.41 6.00e-112 397.00
IUUC-Dre-028314 Danio rerio 97.07 0.00e+00 842.00
IUUC-Dno-029050 Dasypus novemcinctus 94.63 0.00e+00 821.00
IUUC-Dor-030222 Dipodomys ordii 86.83 0.00e+00 740.00
IUUC-Dme-031745 Drosophila melanogaster 70.56 3.00e-174 604.00
IUUC-Ete-032508 Echinops telfairi 78.78 0.00e+00 661.00
IUUC-Eca-034288 Equus caballus 94.24 0.00e+00 795.00
IUUC-Eeu-034984 Erinaceus europaeus 86.59 0.00e+00 737.00
IUUC-Fca-036498 Felis catus 94.88 0.00e+00 822.00
IUUC-Fal-036920 Ficedula albicollis 94.63 0.00e+00 821.00
IUUC-Gmo-039166 Gadus morhua 95.12 0.00e+00 827.00
IUUC-Gga-040623 Gallus gallus 94.63 0.00e+00 821.00
IUUC-Ggo-045410 Gorilla gorilla 84.21 0.00e+00 692.00
IUUC-Hsa-046358 Homo sapiens 94.63 0.00e+00 820.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 94.88 0.00e+00 822.00
IUUC-Kpa-049351 Komagataella pastoris 29.14 2.00e-43 170.00
IUUC-Lch-049936 Latimeria chalumnae 95.12 0.00e+00 823.00
IUUC-Loc-052476 Lepisosteus oculatus 97.24 0.00e+00 815.00
IUUC-Lma-053170 Leptosphaeria maculans 46.19 1.00e-99 356.00
IUUC-Laf-053713 Loxodonta africana 92.91 0.00e+00 802.00
IUUC-Mcc-054628 Macaca mulatta 94.39 0.00e+00 818.00
IUUC-Meu-055927 Macropus eugenii 80.51 5.00e-133 466.00
IUUC-Mla-058819 Melampsora laricipopulina 48.09 4.00e-118 418.00
IUUC-Mga-059945 Meleagris gallopavo 94.39 0.00e+00 820.00
IUUC-Mmr-061289 Microcebus murinus 94.74 0.00e+00 800.00
IUUC-Mdo-061912 Monodelphis domestica 94.15 0.00e+00 815.00
IUUC-Mmu-063253 Mus musculus 94.88 0.00e+00 822.00
IUUC-Mpu-066638 Mustela putorius furo 94.88 0.00e+00 822.00
IUUC-Mlu-067267 Myotis lucifugus 93.38 0.00e+00 804.00
IUUC-Nfi-068571 Neosartorya fischeri 45.81 2.00e-99 355.00
IUUC-Nle-069087 Nomascus leucogenys 94.93 0.00e+00 669.00
IUUC-Opr-070579 Ochotona princeps 94.63 0.00e+00 821.00
IUUC-Ont-072432 Oreochromis niloticus 95.37 0.00e+00 826.00
IUUC-Oan-073072 Ornithorhynchus anatinus 94.88 0.00e+00 822.00
IUUC-Ocu-074180 Oryctolagus cuniculus 94.63 0.00e+00 821.00
IUUC-Ola-086772 Oryzias latipes 95.85 0.00e+00 828.00
IUUC-Oga-088219 Otolemur garnettii 92.67 0.00e+00 802.00
IUUC-Oar-090394 Ovis aries 94.88 0.00e+00 822.00
IUUC-Ptr-091517 Pan troglodytes 94.88 0.00e+00 822.00
IUUC-Pan-092421 Papio anubis 94.39 0.00e+00 818.00
IUUC-Psi-093370 Pelodiscus sinensis 94.39 0.00e+00 819.00
IUUC-Pma-094319 Petromyzon marinus 87.11 0.00e+00 640.00
IUUC-Pfo-097089 Poecilia formosa 96.10 0.00e+00 833.00
IUUC-Pab-098421 Pongo abelii 94.88 0.00e+00 822.00
IUUC-Pca-100120 Procavia capensis 69.55 1.00e-157 548.00
IUUC-Pva-102960 Pteropus vampyrus 94.63 0.00e+00 818.00
IUUC-Pgr-103538 Puccinia graminis 47.43 2.00e-118 419.00
IUUC-Ptt-103990 Puccinia triticina 42.46 1.00e-44 174.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 47.68 1.00e-103 370.00
IUUC-Rno-105123 Rattus norvegicus 94.88 0.00e+00 822.00
IUUC-Sce-106208 Saccharomyces cerevisiae 27.90 3.00e-36 146.00
IUUC-Sha-107010 Sarcophilus harrisii 93.90 0.00e+00 813.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 32.80 2.00e-65 242.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 45.57 6.00e-100 357.00
IUUC-Sar-113309 Sorex araneus 93.98 0.00e+00 791.00
IUUC-Ssc-116148 Sus scrofa 94.88 0.00e+00 822.00
IUUC-Tgu-117299 Taeniopygia guttata 94.39 0.00e+00 818.00
IUUC-Tru-117721 Takifugu rubripes 95.12 0.00e+00 823.00
IUUC-Tsy-119493 Tarsius syrichta 94.15 0.00e+00 811.00
IUUC-Tni-120355 Tetraodon nigroviridis 95.12 0.00e+00 799.00
IUUC-Tme-127031 Tuber melanosporum 48.64 2.00e-104 372.00
IUUC-Ttr-128929 Tursiops truncatus 94.88 0.00e+00 820.00
IUUC-Vpa-130532 Vicugna pacos 80.83 0.00e+00 636.00
IUUC-Xtr-131985 Xenopus tropicalis 94.15 0.00e+00 818.00
IUUC-Xma-133314 Xiphophorus maculatus 96.34 0.00e+00 834.00
Created Date 25-Jun-2017

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