iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105137

Ensembl Protein ID

ENSRNOP00000065274.2

UniProt Accession

M0R756; M0R756_RAT

Genbank Protein ID

ENSRNOP00000065274

Protein Name

Protein HIRA

Genbank Nucleotide ID

AABR07034732

Gene Name

LOC100911837

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000049255.2	ENSRNOT00000071462.2	ENSRNOP00000065274.2

Annotation

mRNA Expression
GEO
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-20	71.9	64	93

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H + v+c+++ ++  +l+sG+dD+ i+vW 
   Q: 64   HLACVNCVRWsNSgMYLASGGDDKLIMVWK 93
           8899******955699*************7 PP

Organism

Rattus norvegicus

Functional Description
(View)

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

Protein Sequence
(Fasta)

MCLSLFPGKP IFSVDIHPDG TKFATGGQGQ DSGKVVIWNM SPVLQEDDEK DENIPKMLCQ 60
MDNHLACVNC VRWSNSGMYL ASGGDDKLIM VWKRATYIGP STVFGSSGKL ANVEQWRCVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTTCAGGA GTACGGGTGA GGGGTTACAT ACAGGAGTAT GGATGACTCA AAGACAGCTG 60
CATCTCCAAA AGCCCACCCT GGCCTGGGTG ACAGCTACTG AAAGCTGGGA CCTGGAGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0000790--C:nuclear chromatin
GO:0031491--F:nucleosome binding
GO:0003714--F:transcription corepressor activity
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0031935--P:regulation of chromatin silencing
GO:0006351--P:transcription, DNA-templated

KEGG

rno:100911837

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001723	Ailuropoda melanoleuca	94.45	0.00e+00	1741.00
IUUC-Apl-003197	Anas platyrhynchos	83.27	0.00e+00	1587.00
IUUC-Ani-009272	Aspergillus nidulans	32.31	5.00e-53	203.00
IUUC-Bta-013320	Bos taurus	89.49	0.00e+00	1733.00
IUUC-Cfa-020132	Canis familiaris	94.07	0.00e+00	1737.00
IUUC-Dno-029557	Dasypus novemcinctus	82.36	0.00e+00	1078.00
IUUC-Eca-033430	Equus caballus	93.83	0.00e+00	1721.00
IUUC-Fal-036817	Ficedula albicollis	82.46	0.00e+00	1594.00
IUUC-Hvu-047587	Hordeum vulgare	37.12	2.00e-80	293.00
IUUC-Itr-048910	Ictidomys tridecemlineatus	100.00	8.00e-176	608.00
IUUC-Mcc-055621	Macaca mulatta	95.07	0.00e+00	1689.00
IUUC-Mpu-066732	Mustela putorius furo	94.44	0.00e+00	1777.00
IUUC-Opr-070808	Ochotona princeps	93.50	0.00e+00	1419.00
IUUC-Oin-080085	Oryza indica	34.52	2.00e-80	294.00
IUUC-Oga-087935	Otolemur garnettii	93.89	0.00e+00	1736.00
IUUC-Oar-089229	Ovis aries	68.95	0.00e+00	1035.00
IUUC-Pan-092318	Papio anubis	95.44	0.00e+00	1765.00
IUUC-Pca-100558	Procavia capensis	92.00	0.00e+00	721.00
IUUC-Sar-113222	Sorex araneus	87.99	0.00e+00	1522.00
IUUC-Ssc-116364	Sus scrofa	92.68	0.00e+00	1809.00
IUUC-Tgu-116645	Taeniopygia guttata	82.59	0.00e+00	1613.00
IUUC-Tsy-119212	Tarsius syrichta	90.14	0.00e+00	987.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence