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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063121
Ensembl Protein ID ENSMUSP00000027856.7
UniProt Accession Q9DC22; Q8BK50; DCAF6_MOUSE
Genbank Protein ID BAB23414.1; BAC36701.1
Protein Name DDB1- and CUL4-associated factor 6; IQ motif and WD repeat-containing protein 1; Nuclear receptor interaction protein
Genbank Nucleotide ID AK004618; AK077238
Gene Name Dcaf6; Iqwd1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026571.12 ENSMUST00000027856.12 ENSMUSP00000027856.7
ENSMUSG00000026571.12 ENSMUST00000194869.5 ENSMUSP00000141401.1
ENSMUSG00000026571.12 ENSMUST00000195220.1 ENSMUSP00000141292.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
miRNAMapRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.90e-17 62.8 92 120
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf...sd.tllvsGsdDgti 25
           gH + +++ +f   +d + +vs+s+Dg+i
   Q: 92   GHRANIFSAKFlpcTDdKQIVSCSGDGVI 120
           8************9666**********98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity).
 Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity).
Protein Sequence
(Fasta)
MARSGSCPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH DGCVNTICWN 60
DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA KFLPCTDDKQ IVSCSGDGVI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063121|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCGATCTCT AGATGTTCTG GGTAGTCTGA GGAGAGTATG AGGCGAGCCG TGGCCCGGGT 60
ACCTCTCCGC TCCCGGGGAG AAGGCGCGGC CGTGGCTGCC GCCCTCTGAG TCGCGGCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063121|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR000048--IQ_motif_EF-hand-BS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50096--IQ
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0005634--C:nucleus
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
KEGG mmu:74106
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001399 Ailuropoda melanoleuca 89.15 0.00e+00 825.00
IUUC-Apl-003181 Anas platyrhynchos 75.37 0.00e+00 1169.00
IUUC-Aca-004953 Anolis carolinensis 87.96 0.00e+00 674.00
IUUC-Acl-008211 Aspergillus clavatus 27.17 2.00e-26 115.00
IUUC-Afu-008828 Aspergillus fumigatus 27.58 1.00e-27 119.00
IUUC-Ate-010555 Aspergillus terreus 26.26 9.00e-26 112.00
IUUC-Ame-011314 Astyanax mexicanus 85.75 0.00e+00 667.00
IUUC-Bta-013552 Bos taurus 84.04 0.00e+00 1395.00
IUUC-Cja-019015 Callithrix jacchus 92.61 0.00e+00 834.00
IUUC-Cfa-021249 Canis familiaris 91.09 0.00e+00 809.00
IUUC-Cpo-021903 Cavia porcellus 91.74 0.00e+00 843.00
IUUC-Csa-023744 Chlorocebus sabaeus 92.17 0.00e+00 834.00
IUUC-Cho-024527 Choloepus hoffmanni 77.04 4.00e-169 588.00
IUUC-Dre-028040 Danio rerio 86.44 0.00e+00 665.00
IUUC-Dno-029777 Dasypus novemcinctus 91.52 0.00e+00 822.00
IUUC-Dor-030879 Dipodomys ordii 84.13 0.00e+00 768.00
IUUC-Ete-032607 Echinops telfairi 71.01 6.00e-131 461.00
IUUC-Eca-033396 Equus caballus 86.40 0.00e+00 1310.00
IUUC-Eeu-034944 Erinaceus europaeus 63.18 4.00e-128 452.00
IUUC-Fca-036020 Felis catus 82.56 0.00e+00 1366.00
IUUC-Fal-037527 Ficedula albicollis 76.37 0.00e+00 799.00
IUUC-Gmo-039347 Gadus morhua 82.68 0.00e+00 637.00
IUUC-Gga-040564 Gallus gallus 76.26 0.00e+00 1177.00
IUUC-Gac-042029 Gasterosteus aculeatus 83.70 0.00e+00 649.00
IUUC-Ggo-045634 Gorilla gorilla 81.61 5.00e-171 595.00
IUUC-Hsa-045743 Homo sapiens 85.84 0.00e+00 1392.00
IUUC-Itr-048064 Ictidomys tridecemlineatus 87.57 0.00e+00 1369.00
IUUC-Lch-050457 Latimeria chalumnae 83.66 0.00e+00 695.00
IUUC-Loc-052880 Lepisosteus oculatus 87.50 0.00e+00 665.00
IUUC-Lma-053032 Leptosphaeria maculans 29.74 2.00e-27 118.00
IUUC-Laf-053836 Loxodonta africana 81.12 0.00e+00 1041.00
IUUC-Mcc-055749 Macaca mulatta 92.17 0.00e+00 832.00
IUUC-Mga-059293 Meleagris gallopavo 74.24 0.00e+00 1091.00
IUUC-Mmr-060923 Microcebus murinus 92.61 0.00e+00 829.00
IUUC-Mdo-063056 Monodelphis domestica 76.39 0.00e+00 1254.00
IUUC-Mpu-066035 Mustela putorius furo 88.45 0.00e+00 743.00
IUUC-Mlu-067903 Myotis lucifugus 83.16 0.00e+00 1326.00
IUUC-Nfi-068606 Neosartorya fischeri 27.48 4.00e-27 117.00
IUUC-Nle-069415 Nomascus leucogenys 92.52 0.00e+00 784.00
IUUC-Opr-070809 Ochotona princeps 68.97 1.00e-121 431.00
IUUC-Ont-071470 Oreochromis niloticus 84.75 0.00e+00 648.00
IUUC-Oan-072748 Ornithorhynchus anatinus 94.21 2.00e-129 455.00
IUUC-Ocu-073865 Oryctolagus cuniculus 83.82 0.00e+00 1318.00
IUUC-Ola-086755 Oryzias latipes 83.62 0.00e+00 642.00
IUUC-Oga-088309 Otolemur garnettii 77.56 0.00e+00 685.00
IUUC-Oar-090264 Ovis aries 92.17 0.00e+00 834.00
IUUC-Ptr-090603 Pan troglodytes 92.61 0.00e+00 837.00
IUUC-Pan-092480 Papio anubis 85.17 0.00e+00 1405.00
IUUC-Psi-092973 Pelodiscus sinensis 75.92 0.00e+00 921.00
IUUC-Pfo-096506 Poecilia formosa 84.18 0.00e+00 643.00
IUUC-Pab-097581 Pongo abelii 78.74 0.00e+00 1260.00
IUUC-Pca-100155 Procavia capensis 84.31 0.00e+00 723.00
IUUC-Pva-103022 Pteropus vampyrus 86.89 0.00e+00 701.00
IUUC-Pte-104187 Pyrenophora teres 29.81 2.00e-28 122.00
IUUC-Pyt-104546 Pyrenophora triticirepentis 29.81 2.00e-27 118.00
IUUC-Rno-105851 Rattus norvegicus 96.95 0.00e+00 890.00
IUUC-Sha-106790 Sarcophilus harrisii 75.03 0.00e+00 1227.00
IUUC-Sja-107779 Schizosaccharomyces japonicus 31.95 1.00e-34 141.00
IUUC-Spo-108129 Schizosaccharomyces pombe 31.53 3.00e-33 137.00
IUUC-Ssc-115801 Sus scrofa 70.40 3.00e-103 367.00
IUUC-Tgu-116760 Taeniopygia guttata 74.85 0.00e+00 1120.00
IUUC-Tru-118422 Takifugu rubripes 83.43 0.00e+00 642.00
IUUC-Tni-120340 Tetraodon nigroviridis 83.15 0.00e+00 640.00
IUUC-Tbe-127997 Tupaia belangeri 72.77 2.00e-162 566.00
IUUC-Ttr-129311 Tursiops truncatus 84.60 0.00e+00 719.00
IUUC-Vpa-130145 Vicugna pacos 91.10 0.00e+00 754.00
IUUC-Xtr-132496 Xenopus tropicalis 71.03 0.00e+00 700.00
IUUC-Xma-133610 Xiphophorus maculatus 85.03 0.00e+00 645.00
Created Date 25-Jun-2017

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