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Tag Content
UUCD2 ID IUUC-Bta-012627
UUCD1 version UUC-BoT-00839
Ensembl Protein ID ENSBTAP00000009395.3
UniProt Accession Q0V8J1; WSB2_BOVIN
Genbank Protein ID ABG67066.1
Protein Name WD repeat and SOCS box-containing protein 2
Genbank Nucleotide ID BT026227
Gene Name WSB2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000007139.3 ENSBTAT00000009395.3 ENSBTAP00000009395.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 7.40e-15 54.7 358 405
E3 adaptor/Cullin RING/DCX/DWD 1.70e-32 110.2 153 186
UBD/Beta-Prp 4.00e-46 157.7 127 362
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 358  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 405
           689****************************...***************86 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 153  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 186
           8***********6556779*************85 PP
   

   UBD/Beta-Prp
   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklv 110
           +latg  dg ik+w+v+tg ll  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+  gk++++l+gh + v+++s+sp+ + l 
   Q: 127  ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLC 215
           79****************************************9****************9789********************99**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvyslsf 188
           s+   + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lr l           +  h +s +s+ f
   Q: 216  SAAGEKSVFLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLhhtqlnppmddSDVHISSLRSVCF 303
           ********************.********************************************9999**99999778999999999* PP
   S: 189  dsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +++g +l+++++d+ +++w l+ ++   +  +  +n ++  f+p++  +++g+ Dg +++W
   Q: 304  SPEGLYLATVADDRLLRIWALELKT--PIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 362
           *********************9885..7899****************************** PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MLSPAPEEPL LLAELKPGRP HQFDWKSSCE TWSVAFSPDG SWFAWSQGHC IVKLIPWPLE 60
EQFIPKGFEA KSRSSKNETK GRGSPKEKTL DCGQIVWGLA FSPWPSPPSK KLWARHHPQV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012627|E3,SOCS;E3,WD_repeat;UBD,Beta-Prp|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGGGGGACTG GGCTCTGCCC TTTCCGGTGA GGCACGGGTG CCTTCTTGAA GTATGCTATC 60
TCCTGCCCCA GAGGAGCCGC TGCTGCTGGC CGAACTCAAG CCCGGGCGCC CCCACCAGTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012627|E3,SOCS;E3,WD_repeat;UBD,Beta-Prp|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF07525--SOCS_box
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40
Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination
KEGG bta:508388
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002221 Ailuropoda melanoleuca 98.03 0.00e+00 821.00
IUUC-Apl-004107 Anas platyrhynchos 68.77 1.00e-131 462.00
IUUC-Aca-004354 Anolis carolinensis 73.88 3.00e-169 587.00
IUUC-Cja-018897 Callithrix jacchus 97.17 0.00e+00 780.00
IUUC-Cfa-020122 Canis familiaris 98.28 0.00e+00 821.00
IUUC-Cpo-022540 Cavia porcellus 97.54 0.00e+00 788.00
IUUC-Csa-023719 Chlorocebus sabaeus 98.45 0.00e+00 790.00
IUUC-Cho-024367 Choloepus hoffmanni 97.65 8.00e-173 598.00
IUUC-Dno-029021 Dasypus novemcinctus 98.52 0.00e+00 796.00
IUUC-Dor-030321 Dipodomys ordii 97.42 0.00e+00 783.00
IUUC-Ete-032955 Echinops telfairi 97.49 0.00e+00 782.00
IUUC-Eca-033485 Equus caballus 98.72 0.00e+00 770.00
IUUC-Fca-035389 Felis catus 98.46 0.00e+00 793.00
IUUC-Fal-037184 Ficedula albicollis 84.45 4.00e-143 500.00
IUUC-Gga-041014 Gallus gallus 76.74 3.00e-177 614.00
IUUC-Ggo-045585 Gorilla gorilla 98.72 0.00e+00 798.00
IUUC-Hsa-046344 Homo sapiens 98.77 0.00e+00 799.00
IUUC-Itr-049085 Ictidomys tridecemlineatus 97.94 0.00e+00 790.00
IUUC-Lch-050131 Latimeria chalumnae 69.76 3.00e-168 584.00
IUUC-Loc-052807 Lepisosteus oculatus 53.83 7.00e-117 414.00
IUUC-Laf-053528 Loxodonta africana 98.03 0.00e+00 773.00
IUUC-Mcc-055665 Macaca mulatta 98.77 0.00e+00 799.00
IUUC-Meu-056054 Macropus eugenii 87.88 0.00e+00 697.00
IUUC-Mga-059326 Meleagris gallopavo 77.19 0.00e+00 630.00
IUUC-Mmr-060815 Microcebus murinus 96.55 0.00e+00 782.00
IUUC-Mdo-062000 Monodelphis domestica 90.57 0.00e+00 746.00
IUUC-Mmu-063927 Mus musculus 96.40 0.00e+00 780.00
IUUC-Mpu-065726 Mustela putorius furo 96.92 0.00e+00 779.00
IUUC-Mlu-067527 Myotis lucifugus 97.14 3.00e-119 420.00
IUUC-Nle-069680 Nomascus leucogenys 98.21 0.00e+00 791.00
IUUC-Opr-070356 Ochotona princeps 97.49 0.00e+00 798.00
IUUC-Oan-073647 Ornithorhynchus anatinus 83.94 2.00e-136 478.00
IUUC-Ocu-073973 Oryctolagus cuniculus 97.04 0.00e+00 781.00
IUUC-Oga-088797 Otolemur garnettii 98.28 0.00e+00 789.00
IUUC-Oar-089187 Ovis aries 100.00 0.00e+00 785.00
IUUC-Ptr-091317 Pan troglodytes 98.72 0.00e+00 798.00
IUUC-Pan-092694 Papio anubis 91.17 0.00e+00 682.00
IUUC-Psi-093392 Pelodiscus sinensis 79.90 0.00e+00 643.00
IUUC-Pab-098145 Pongo abelii 98.45 0.00e+00 790.00
IUUC-Pca-100454 Procavia capensis 89.47 0.00e+00 723.00
IUUC-Pva-102986 Pteropus vampyrus 89.72 0.00e+00 725.00
IUUC-Rno-104931 Rattus norvegicus 95.36 0.00e+00 771.00
IUUC-Sha-106476 Sarcophilus harrisii 91.77 0.00e+00 744.00
IUUC-Ssc-115643 Sus scrofa 99.23 0.00e+00 794.00
IUUC-Tgu-117522 Taeniopygia guttata 64.29 4.00e-137 480.00
IUUC-Tsy-119301 Tarsius syrichta 98.75 0.00e+00 812.00
IUUC-Ttr-128683 Tursiops truncatus 99.48 0.00e+00 796.00
Created Date 25-Jun-2017

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