iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004707

UUCD1 version

UUC-AnC-00248

Ensembl Protein ID

ENSACAP00000010552.2

UniProt Accession

H9GGR3; H9GGR3_ANOCA

Protein Name

Uncharacterized protein

Gene Name

WDR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000010583.2	ENSACAT00000010770.2	ENSACAP00000010552.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-42	141.5	250	280
UBD/Beta-Prp	1.50e-62	211.4	72	291

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H+++++++++ +d ++l+s+s+D t k+WD+
   Q: 250  HEGGIYAISWsPDgNRLLSASGDRTAKIWDV 280
           9**********999****************7 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD....rtikvwdlstgkcvht 89
           ++h +++ + k++p++ ++a+g ++g++++wd+t++  l ++  +   ++++++ + +d+k ++ ++e     +   v+  +tg+ v  
   Q: 72   TEHAHQVVVAKYAPSGFYIASGDASGKLRIWDTTQQEHLLKYeyQPFAGKIKDIAWTEDSKRIAAVGEGreifG--TVFLWDTGSSVGE 158
           4566667778*************************999877742334567*******************65444..5556669****** PP
   S: 90   lkghedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.. 175
           + gh++ + s+++ +++ ++l++Gs+d+     + +  +    t ++h+++vncv+++pdgn l+++++D+++ ++d ktg+ ++ l  
   Q: 159  IIGHNKVINSVDIKQTRpYRLATGSDDNSSAFSEGPPFKFKF-TMRNHSRFVNCVRFSPDGNRLATAGADGQIFIYDGKTGEKVTALgg 246
           ***************999***********9999999988888.********************************************99 PP
   S: 176  tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng 220
            ++h++ +y +s++++g++l+s+s d+t k+wd+ ++++v t+n 
   Q: 247  NKAHEGGIYAISWSPDGNRLLSASGDRTAKIWDVGANSVVTTFNM 291
           777***********************************9999984 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

REGGGGNSIR SSSSSGKMPH ELKKVFASLP QVERGVAKVL GGDPKGKNFL YTNGKCVIIR 60
NIDNPAIADI YTEHAHQVVV AKYAPSGFYI ASGDASGKLR IWDTTQQEHL LKYEYQPFAG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGAGGGAG GAGGGGGGAA TAGGGAAGAG CTGTGCGTGC GGCGCTTCCT GGTTGCCTGA 60
AGCACTGTGC GCGAGCCCCA GGACTTGGGC GGCGGGTGGG CGCGTGCGTG TGTGCATTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0042643--C:actomyosin, actin portion
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0051015--F:actin filament binding
GO:0030042--P:actin filament depolymerization
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0040011--P:locomotion
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000457	Aegilops tauschii	34.20	2.00e-83	303.00
IUUC-Aml-002368	Ailuropoda melanoleuca	83.03	0.00e+00	1033.00
IUUC-Atr-003160	Amborella trichopoda	37.75	3.00e-119	422.00
IUUC-Apl-004012	Anas platyrhynchos	83.86	0.00e+00	1032.00
IUUC-Aly-006465	Arabidopsis lyrata	37.72	9.00e-116	410.00
IUUC-Ath-006740	Arabidopsis thaliana	37.85	4.00e-115	408.00
IUUC-Ago-007920	Ashbya gossypii	28.78	2.00e-78	286.00
IUUC-Acl-008262	Aspergillus clavatus	37.07	1.00e-111	396.00
IUUC-Afl-008471	Aspergillus flavus	31.27	7.00e-69	254.00
IUUC-Afu-008989	Aspergillus fumigatus	38.24	6.00e-99	354.00
IUUC-Ani-009167	Aspergillus nidulans	38.89	1.00e-117	416.00
IUUC-Ang-009595	Aspergillus niger	39.66	6.00e-106	377.00
IUUC-Aor-009908	Aspergillus oryzae	38.97	8.00e-105	374.00
IUUC-Ate-010580	Aspergillus terreus	38.68	5.00e-114	406.00
IUUC-Ame-011269	Astyanax mexicanus	59.75	4.00e-129	454.00
IUUC-Bgr-011996	Blumeria graminis	34.70	2.00e-106	379.00
IUUC-Bta-013278	Bos taurus	83.50	0.00e+00	1076.00
IUUC-Bci-013925	Botrytis cinerea	35.77	1.00e-107	383.00
IUUC-Bdi-014659	Brachypodium distachyon	35.08	2.00e-103	369.00
IUUC-Bol-016043	Brassica oleracea	36.60	1.00e-110	393.00
IUUC-Bra-017139	Brassica rapa	36.66	2.00e-113	402.00
IUUC-Cel-018417	Caenorhabditis elegans	40.39	3.00e-123	435.00
IUUC-Cja-019952	Callithrix jacchus	82.21	0.00e+00	1020.00
IUUC-Cfa-020225	Canis familiaris	83.66	0.00e+00	1052.00
IUUC-Cpo-021900	Cavia porcellus	82.53	0.00e+00	1039.00
IUUC-Csa-023028	Chlorocebus sabaeus	83.50	0.00e+00	1030.00
IUUC-Cho-025030	Choloepus hoffmanni	60.67	0.00e+00	667.00
IUUC-Cin-025152	Ciona intestinalis	56.35	3.00e-81	294.00
IUUC-Csv-025986	Ciona savignyi	37.42	5.00e-93	334.00
IUUC-Cgl-026597	Colletotrichum gloeosporioides	37.30	2.00e-109	389.00
IUUC-Cne-026814	Cryptococcus neoformans	34.25	1.00e-97	350.00
IUUC-Dre-027498	Danio rerio	81.03	2.00e-94	337.00
IUUC-Dno-029383	Dasypus novemcinctus	81.85	0.00e+00	1009.00
IUUC-Dor-030633	Dipodomys ordii	80.50	0.00e+00	948.00
IUUC-Dse-031526	Dothistroma septosporum	37.64	4.00e-114	404.00
IUUC-Dme-031597	Drosophila melanogaster	47.77	7.00e-168	583.00
IUUC-Ete-032780	Echinops telfairi	74.75	0.00e+00	935.00
IUUC-Eca-034306	Equus caballus	82.03	0.00e+00	1009.00
IUUC-Eeu-034531	Erinaceus europaeus	65.62	9.00e-119	420.00
IUUC-Fca-036301	Felis catus	83.36	0.00e+00	1065.00
IUUC-Fal-037361	Ficedula albicollis	84.25	0.00e+00	1079.00
IUUC-Fox-037924	Fusarium oxysporum	35.47	2.00e-103	369.00
IUUC-Fso-038199	Fusarium solani	34.75	4.00e-98	352.00
IUUC-Gmo-039238	Gadus morhua	69.19	0.00e+00	857.00
IUUC-Ggr-039830	Gaeumannomyces graminis	35.04	8.00e-97	347.00
IUUC-Gga-040235	Gallus gallus	84.84	0.00e+00	1061.00
IUUC-Gac-042363	Gasterosteus aculeatus	70.51	0.00e+00	904.00
IUUC-Gma-043218	Glycine max	36.54	7.00e-116	410.00
IUUC-Ggo-044632	Gorilla gorilla	81.38	0.00e+00	997.00
IUUC-Hsa-045792	Homo sapiens	83.17	0.00e+00	1045.00
IUUC-Hvu-047517	Hordeum vulgare	34.37	2.00e-110	392.00
IUUC-Itr-048076	Ictidomys tridecemlineatus	83.36	0.00e+00	1035.00
IUUC-Kpa-049183	Komagataella pastoris	32.73	9.00e-89	320.00
IUUC-Lch-050428	Latimeria chalumnae	74.84	0.00e+00	981.00
IUUC-Lpe-051306	Leersia perrieri	36.17	3.00e-112	398.00
IUUC-Loc-052096	Lepisosteus oculatus	69.85	0.00e+00	875.00
IUUC-Lma-053313	Leptosphaeria maculans	38.63	3.00e-114	407.00
IUUC-Laf-054060	Loxodonta africana	80.56	0.00e+00	1015.00
IUUC-Mcc-055619	Macaca mulatta	81.67	0.00e+00	1003.00
IUUC-Meu-056689	Macropus eugenii	72.11	1.00e-168	586.00
IUUC-Mor-056940	Magnaporthe oryzae	35.01	2.00e-95	343.00
IUUC-Mpo-057557	Magnaporthe poae	30.42	2.00e-68	252.00
IUUC-Mtr-057922	Medicago truncatula	35.47	3.00e-114	405.00
IUUC-Mla-059103	Melampsora laricipopulina	33.62	6.00e-78	285.00
IUUC-Mga-060150	Meleagris gallopavo	84.88	0.00e+00	1048.00
IUUC-Mvi-060448	Microbotryum violaceum	33.33	8.00e-83	301.00
IUUC-Mmr-061226	Microcebus murinus	81.52	0.00e+00	1022.00
IUUC-Mdo-062674	Monodelphis domestica	84.49	0.00e+00	1070.00
IUUC-Mmu-064170	Mus musculus	83.50	0.00e+00	1055.00
IUUC-Mac-065124	Musa acuminata	36.95	3.00e-115	408.00
IUUC-Mpu-066001	Mustela putorius furo	79.97	0.00e+00	1026.00
IUUC-Mlu-067253	Myotis lucifugus	83.19	0.00e+00	1045.00
IUUC-Nfi-068550	Neosartorya fischeri	38.29	2.00e-114	405.00
IUUC-Ncr-068948	Neurospora crassa	36.44	5.00e-111	394.00
IUUC-Nle-070115	Nomascus leucogenys	79.65	0.00e+00	932.00
IUUC-Opr-070254	Ochotona princeps	80.33	0.00e+00	967.00
IUUC-Ont-071666	Oreochromis niloticus	73.27	0.00e+00	934.00
IUUC-Oan-073594	Ornithorhynchus anatinus	82.88	2.00e-149	521.00
IUUC-Ocu-074824	Oryctolagus cuniculus	80.86	0.00e+00	991.00
IUUC-Oba-075010	Oryza barthii	36.33	2.00e-112	399.00
IUUC-Obr-076364	Oryza brachyantha	36.82	9.00e-114	404.00
IUUC-Ogl-077019	Oryza glaberrima	36.33	2.00e-112	399.00
IUUC-Ogu-078496	Oryza glumaepatula	36.33	2.00e-112	399.00
IUUC-Oin-080116	Oryza indica	36.50	1.00e-112	400.00
IUUC-Olo-080290	Oryza longistaminata	36.33	5.00e-112	398.00
IUUC-Ome-081969	Oryza meridionalis	36.33	3.00e-112	399.00
IUUC-Oni-082075	Oryza nivara	36.33	2.00e-112	399.00
IUUC-Opu-083959	Oryza punctata	36.33	4.00e-112	398.00
IUUC-Oru-084711	Oryza rufipogon	36.33	2.00e-112	399.00
IUUC-Osa-085958	Oryza sativa	36.50	1.00e-112	400.00
IUUC-Ola-086968	Oryzias latipes	73.64	0.00e+00	939.00
IUUC-Oga-089108	Otolemur garnettii	82.03	0.00e+00	1066.00
IUUC-Oar-089986	Ovis aries	77.70	0.00e+00	982.00
IUUC-Ptr-091281	Pan troglodytes	83.50	0.00e+00	1039.00
IUUC-Pan-092585	Papio anubis	83.50	0.00e+00	1030.00
IUUC-Psi-093811	Pelodiscus sinensis	83.89	0.00e+00	1074.00
IUUC-Pma-094542	Petromyzon marinus	67.71	0.00e+00	870.00
IUUC-Pno-095086	Phaeosphaeria nodorum	37.14	9.00e-110	390.00
IUUC-Ppa-095876	Physcomitrella patens	35.19	6.00e-112	397.00
IUUC-Pfo-096973	Poecilia formosa	73.60	0.00e+00	971.00
IUUC-Pab-098391	Pongo abelii	83.17	0.00e+00	1028.00
IUUC-Pop-098850	Populus trichocarpa	37.25	2.00e-115	409.00
IUUC-Pca-100257	Procavia capensis	53.31	1.00e-78	287.00
IUUC-Ppe-101578	Prunus persica	38.40	2.00e-118	419.00
IUUC-Pva-102872	Pteropus vampyrus	78.25	0.00e+00	1000.00
IUUC-Pgr-103593	Puccinia graminis	33.22	2.00e-84	306.00
IUUC-Pte-104365	Pyrenophora teres	38.34	6.00e-109	387.00
IUUC-Pyt-104689	Pyrenophora triticirepentis	38.01	2.00e-111	395.00
IUUC-Rno-105737	Rattus norvegicus	84.32	0.00e+00	1082.00
IUUC-Sce-106383	Saccharomyces cerevisiae	29.13	4.00e-71	262.00
IUUC-Sha-107084	Sarcophilus harrisii	82.89	0.00e+00	932.00
IUUC-Sja-107688	Schizosaccharomyces japonicus	35.63	8.00e-114	404.00
IUUC-Spo-108309	Schizosaccharomyces pombe	33.28	9.00e-99	353.00
IUUC-Ssl-108408	Sclerotinia sclerotiorum	35.77	5.00e-107	381.00
IUUC-Smo-109383	Selaginella moellendorffii	34.25	5.00e-99	355.00
IUUC-Sit-109962	Setaria italica	36.82	1.00e-113	403.00
IUUC-Sly-110897	Solanum lycopersicum	38.13	1.00e-117	416.00
IUUC-Stu-111971	Solanum tuberosum	38.13	3.00e-117	415.00
IUUC-Sar-113415	Sorex araneus	65.68	1.00e-100	360.00
IUUC-Sbi-114857	Sorghum bicolor	36.33	8.00e-111	394.00
IUUC-Sre-114900	Sporisorium reilianum	33.33	3.00e-92	332.00
IUUC-Tgu-117256	Taeniopygia guttata	83.89	0.00e+00	1077.00
IUUC-Tru-117871	Takifugu rubripes	68.76	0.00e+00	874.00
IUUC-Tsy-119172	Tarsius syrichta	83.68	2.00e-121	429.00
IUUC-Tni-120339	Tetraodon nigroviridis	69.31	0.00e+00	909.00
IUUC-Tca-121609	Theobroma cacao	37.07	1.00e-113	403.00
IUUC-Tre-122076	Trichoderma reesei	36.18	8.00e-98	350.00
IUUC-Tvi-122528	Trichoderma virens	34.43	5.00e-99	354.00
IUUC-Tae-124549	Triticum aestivum	35.13	2.00e-111	395.00
IUUC-Tur-126845	Triticum urartu	34.43	1.00e-82	300.00
IUUC-Tme-127217	Tuber melanosporum	35.56	3.00e-109	389.00
IUUC-Tbe-127526	Tupaia belangeri	79.47	0.00e+00	1011.00
IUUC-Ttr-128898	Tursiops truncatus	75.12	0.00e+00	958.00
IUUC-Uma-129631	Ustilago maydis	31.81	2.00e-95	342.00
IUUC-Vda-129732	Verticillium dahliae	34.18	2.00e-88	320.00
IUUC-Vvi-131217	Vitis vinifera	37.62	7.00e-116	410.00
IUUC-Xtr-132860	Xenopus tropicalis	71.96	0.00e+00	915.00
IUUC-Xma-133830	Xiphophorus maculatus	74.09	0.00e+00	976.00
IUUC-Yli-134335	Yarrowia lipolytica	31.97	3.00e-72	265.00
IUUC-Zma-135907	Zea mays	36.01	6.00e-111	394.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence