• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063785
Ensembl Protein ID ENSMUSP00000102853.1
UniProt Accession Q921E6; P97462; EED_MOUSE
Genbank Protein ID AAB38319.1; AAC53302.1; BAC36938.1; BAE20916.1; BAE21915.1; AAH12966.1
Protein Name Polycomb protein EED
Genbank Nucleotide ID U78103; U97675; AK077664; AK131976; AK133890; BC012966
Gene Name Eed
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000030619.9 ENSMUST00000107234.2 ENSMUSP00000102853.1
ENSMUSG00000030619.9 ENSMUST00000207980.1 ENSMUSP00000146892.1
ENSMUSG00000030619.9 ENSMUST00000208977.1 ENSMUSP00000146812.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-14 54.5 188 225
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           gH + ++ l+f   d +ll+s s D+ +++W++ t++l
   Q: 188  GHGNAINELKFhpRDpNLLLSVSKDHALRLWNIQTDTL 225
           899*********9888****************999876 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.
 Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.
Protein Sequence
(Fasta)
MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP 60
NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063785|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTTGCAGCG GGTCGGAGAT CGAAGGATTG AGCCAATTGC GGATGAAACG TCTTGGCCAG 60
GAAGGGGGTG AGGGAGCAGC CCTTTGAGTT CCGCCTCGTC TCTAGGCGCT GGTGGGGAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063785|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0024--Alternative initiation
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0035098--C:ESC/E(Z) complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0045120--C:pronucleus
GO:0001739--C:sex chromatin
GO:0003682--F:chromatin binding
GO:0042054--F:histone methyltransferase activity
GO:0042802--F:identical protein binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0016571--P:histone methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:2000011--P:regulation of adaxial/abaxial pattern formation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0021510--P:spinal cord development
GO:0006351--P:transcription, DNA-templated
KEGG mmu:13626
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000689 Aegilops tauschii 41.01 9.00e-76 277.00
IUUC-Aml-001510 Ailuropoda melanoleuca 99.32 0.00e+00 864.00
IUUC-Atr-002496 Amborella trichopoda 40.40 3.00e-69 255.00
IUUC-Apl-003768 Anas platyrhynchos 96.36 0.00e+00 829.00
IUUC-Aca-004382 Anolis carolinensis 98.35 0.00e+00 823.00
IUUC-Aly-005980 Arabidopsis lyrata 40.71 1.00e-76 279.00
IUUC-Ath-006579 Arabidopsis thaliana 40.71 1.00e-76 280.00
IUUC-Ame-010987 Astyanax mexicanus 92.74 0.00e+00 803.00
IUUC-Bta-013432 Bos taurus 99.77 0.00e+00 875.00
IUUC-Bci-013970 Botrytis cinerea 33.47 1.00e-30 127.00
IUUC-Bdi-014553 Brachypodium distachyon 43.14 1.00e-77 283.00
IUUC-Bol-016522 Brassica oleracea 40.22 8.00e-76 277.00
IUUC-Bra-017137 Brassica rapa 40.22 6.00e-76 277.00
IUUC-Cel-018494 Caenorhabditis elegans 24.36 1.00e-29 124.00
IUUC-Cja-019066 Callithrix jacchus 100.00 0.00e+00 878.00
IUUC-Cfa-021261 Canis familiaris 100.00 0.00e+00 877.00
IUUC-Cpo-022375 Cavia porcellus 94.33 0.00e+00 811.00
IUUC-Csa-024005 Chlorocebus sabaeus 100.00 0.00e+00 877.00
IUUC-Cho-024881 Choloepus hoffmanni 86.69 3.00e-158 551.00
IUUC-Cin-025697 Ciona intestinalis 61.06 6.00e-142 497.00
IUUC-Csv-026221 Ciona savignyi 63.31 3.00e-145 508.00
IUUC-Cgl-026519 Colletotrichum gloeosporioides 26.24 2.00e-24 107.00
IUUC-Cne-026877 Cryptococcus neoformans 30.20 8.00e-28 119.00
IUUC-Cme-027353 Cyanidioschyzon merolae 44.83 4.00e-33 135.00
IUUC-Dre-028346 Danio rerio 91.42 0.00e+00 785.00
IUUC-Dno-029319 Dasypus novemcinctus 99.09 0.00e+00 869.00
IUUC-Dor-030746 Dipodomys ordii 71.67 0.00e+00 647.00
IUUC-Dse-031324 Dothistroma septosporum 26.55 6.00e-27 115.00
IUUC-Dme-032029 Drosophila melanogaster 60.82 8.00e-138 483.00
IUUC-Ete-032880 Echinops telfairi 80.50 7.00e-134 470.00
IUUC-Eca-034272 Equus caballus 100.00 0.00e+00 800.00
IUUC-Eeu-035303 Erinaceus europaeus 92.06 0.00e+00 829.00
IUUC-Fca-036008 Felis catus 100.00 0.00e+00 849.00
IUUC-Fal-037577 Ficedula albicollis 98.01 0.00e+00 785.00
IUUC-Fso-038294 Fusarium solani 24.66 3.00e-27 116.00
IUUC-Gmo-039008 Gadus morhua 89.66 0.00e+00 760.00
IUUC-Ggr-039894 Gaeumannomyces graminis 30.83 5.00e-25 108.00
IUUC-Gga-040859 Gallus gallus 98.35 0.00e+00 821.00
IUUC-Gac-041667 Gasterosteus aculeatus 87.56 0.00e+00 756.00
IUUC-Gma-043832 Glycine max 39.89 3.00e-75 275.00
IUUC-Ggo-045624 Gorilla gorilla 94.64 0.00e+00 863.00
IUUC-Hsa-046505 Homo sapiens 100.00 0.00e+00 877.00
IUUC-Hvu-047228 Hordeum vulgare 37.77 6.00e-33 133.00
IUUC-Itr-048381 Ictidomys tridecemlineatus 99.77 0.00e+00 875.00
IUUC-Lch-050492 Latimeria chalumnae 96.30 0.00e+00 824.00
IUUC-Lpe-050807 Leersia perrieri 37.78 1.00e-72 266.00
IUUC-Loc-052361 Lepisosteus oculatus 92.78 0.00e+00 808.00
IUUC-Lma-053058 Leptosphaeria maculans 28.15 2.00e-21 97.40
IUUC-Laf-053941 Loxodonta africana 92.52 0.00e+00 827.00
IUUC-Mcc-055518 Macaca mulatta 94.64 0.00e+00 863.00
IUUC-Mor-056944 Magnaporthe oryzae 26.87 1.00e-27 118.00
IUUC-Mtr-058716 Medicago truncatula 42.51 1.00e-71 263.00
IUUC-Mga-059469 Meleagris gallopavo 98.35 0.00e+00 822.00
IUUC-Mmr-061026 Microcebus murinus 94.42 0.00e+00 862.00
IUUC-Mdo-062346 Monodelphis domestica 98.19 0.00e+00 862.00
IUUC-Mac-064681 Musa acuminata 41.03 1.00e-79 290.00
IUUC-Mpu-066862 Mustela putorius furo 100.00 0.00e+00 877.00
IUUC-Mlu-067103 Myotis lucifugus 92.56 0.00e+00 727.00
IUUC-Ncr-068782 Neurospora crassa 30.89 5.00e-26 112.00
IUUC-Nle-069472 Nomascus leucogenys 100.00 0.00e+00 877.00
IUUC-Opr-070376 Ochotona princeps 96.94 4.00e-126 444.00
IUUC-Ont-071513 Oreochromis niloticus 91.84 0.00e+00 818.00
IUUC-Oan-073202 Ornithorhynchus anatinus 98.76 0.00e+00 790.00
IUUC-Ocu-074012 Oryctolagus cuniculus 99.77 0.00e+00 876.00
IUUC-Oba-075030 Oryza barthii 42.51 2.00e-80 292.00
IUUC-Obr-076895 Oryza brachyantha 41.98 2.00e-78 285.00
IUUC-Ogl-077522 Oryza glaberrima 42.78 9.00e-80 290.00
IUUC-Ogu-078250 Oryza glumaepatula 38.84 3.00e-68 252.00
IUUC-Oin-079886 Oryza indica 42.23 8.00e-80 290.00
IUUC-Olo-080238 Oryza longistaminata 42.51 2.00e-80 292.00
IUUC-Ome-081204 Oryza meridionalis 39.37 4.00e-67 248.00
IUUC-Oni-082388 Oryza nivara 38.63 2.00e-70 259.00
IUUC-Opu-083537 Oryza punctata 42.09 9.00e-79 287.00
IUUC-Oru-084863 Oryza rufipogon 39.12 4.00e-69 255.00
IUUC-Osa-085622 Oryza sativa 42.43 1.00e-80 293.00
IUUC-Ola-087426 Oryzias latipes 89.70 0.00e+00 802.00
IUUC-Olu-087788 Ostreococcus lucimarinus 29.89 3.00e-44 172.00
IUUC-Oga-088228 Otolemur garnettii 99.55 0.00e+00 874.00
IUUC-Oar-090139 Ovis aries 99.75 0.00e+00 798.00
IUUC-Pan-092874 Papio anubis 100.00 7.00e-159 552.00
IUUC-Psi-093927 Pelodiscus sinensis 98.51 0.00e+00 789.00
IUUC-Pma-094740 Petromyzon marinus 84.29 4.00e-138 483.00
IUUC-Pno-095072 Phaeosphaeria nodorum 28.32 2.00e-20 93.60
IUUC-Ppa-095871 Physcomitrella patens 39.02 1.00e-72 266.00
IUUC-Pfo-097208 Poecilia formosa 92.64 0.00e+00 821.00
IUUC-Pab-097658 Pongo abelii 100.00 0.00e+00 877.00
IUUC-Pop-098930 Populus trichocarpa 41.30 2.00e-78 285.00
IUUC-Ppe-101807 Prunus persica 40.65 3.00e-76 278.00
IUUC-Pva-103191 Pteropus vampyrus 85.19 0.00e+00 756.00
IUUC-Pgr-103619 Puccinia graminis 25.87 7.00e-19 88.60
IUUC-Pte-104406 Pyrenophora teres 29.19 1.00e-28 121.00
IUUC-Pyt-104821 Pyrenophora triticirepentis 26.53 8.00e-23 101.00
IUUC-Rno-105854 Rattus norvegicus 100.00 0.00e+00 877.00
IUUC-Sha-107426 Sarcophilus harrisii 97.73 0.00e+00 858.00
IUUC-Smo-109638 Selaginella moellendorffii 40.17 1.00e-75 276.00
IUUC-Sit-110481 Setaria italica 41.85 9.00e-79 286.00
IUUC-Sly-111464 Solanum lycopersicum 39.89 2.00e-75 276.00
IUUC-Stu-112910 Solanum tuberosum 39.89 2.00e-75 276.00
IUUC-Sar-113754 Sorex araneus 92.20 0.00e+00 660.00
IUUC-Sbi-114023 Sorghum bicolor 42.13 9.00e-80 290.00
IUUC-Ssc-115386 Sus scrofa 100.00 0.00e+00 877.00
IUUC-Tgu-117123 Taeniopygia guttata 97.44 0.00e+00 824.00
IUUC-Tru-117720 Takifugu rubripes 88.13 0.00e+00 801.00
IUUC-Tsy-119584 Tarsius syrichta 94.64 0.00e+00 863.00
IUUC-Tni-119695 Tetraodon nigroviridis 91.20 0.00e+00 821.00
IUUC-Tca-121787 Theobroma cacao 41.58 6.00e-78 284.00
IUUC-Tvi-122409 Trichoderma virens 24.81 9.00e-23 101.00
IUUC-Tae-124454 Triticum aestivum 41.01 9.00e-76 277.00
IUUC-Tme-126906 Tuber melanosporum 29.69 3.00e-34 139.00
IUUC-Tbe-127557 Tupaia belangeri 80.04 0.00e+00 736.00
IUUC-Vda-129774 Verticillium dahliae 25.15 5.00e-21 95.50
IUUC-Vpa-130256 Vicugna pacos 85.55 0.00e+00 717.00
IUUC-Vvi-131201 Vitis vinifera 41.58 1.00e-76 280.00
IUUC-Xtr-132206 Xenopus tropicalis 94.05 0.00e+00 818.00
IUUC-Xma-134102 Xiphophorus maculatus 92.64 0.00e+00 821.00
IUUC-Zma-135593 Zea mays 42.70 2.00e-80 292.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved