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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105431
Ensembl Protein ID ENSRNOP00000060074.3
UniProt Accession Q9QY17; Q9QY18; Q9QY19; Q9QY20; PACN2_RAT
Genbank Protein ID AAF22211.1; AAF22212.1; AAF22213.1; AAF22214.1
Protein Name Protein kinase C and casein kinase substrate in neurons 2 protein; Synaptic dynamin-associated protein II; Syndapin-2; Syndapin-II
Genbank Nucleotide ID AF139492; AF139493; AF139494; AF139495
Gene Name Pacsin2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000009756.8 ENSRNOT00000013428.7 ENSRNOP00000013428.6
ENSRNOG00000009756.8 ENSRNOT00000088125.1 ENSRNOP00000072822.1
ENSRNOG00000009756.8 ENSRNOT00000067913.4 ENSRNOP00000060074.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.90e-16 60.1 432 488
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++lydye+q+ deL++k+Gd ++ i ++e ++gW+kg + ++g+ Gl P+n+ve ++
   Q: 432  RVRALYDYEGQEHDELSFKAGDELTKI-EDEDEQGWCKG-RLDSGQVGLYPANYVEAIQ 488
           799************************.9**********.59*************9885 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.
 Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.
Protein Sequence
(Fasta)
MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCGD LMNCLHERAR IEKAYAQQLT 60
EWARRWRQLV EKGPQYGTVE KAWMAVMSEA ERVSELHLEV KASLMNEDFE KIKNWQKEAF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105431|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGAGCGGAA CGGAAAGGGG TCGGAGTCGC ATCCCGGCCG GAGCGGCGTG CTCAGTGGGA 60
CCCGAGGTGA GCGGCGGCCG AGGTGAGGGG TGAGCCGCGA CGGTTGGGAC ACGGGTCGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105431|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR028521--PACSIN2
IPR001452--SH3_domain
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF00018--SH3_1
PRINTS

PR00452--SH3DOMAIN
SMART

SM00055--FCH
SM00326--SH3
Gene Ontology

GO:0005901--C:caveola
GO:0005911--C:cell-cell junction
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0019898--C:extrinsic component of membrane
GO:0005925--C:focal adhesion
GO:0016607--C:nuclear speck
GO:0055038--C:recycling endosome membrane
GO:0032587--C:ruffle membrane
GO:0070300--F:phosphatidic acid binding
GO:0030036--P:actin cytoskeleton organization
GO:0070836--P:caveola assembly
GO:0072584--P:caveolin-mediated endocytosis
GO:0048858--P:cell projection morphogenesis
GO:0045806--P:negative regulation of endocytosis
GO:0097320--P:plasma membrane tubulation
GO:0036010--P:protein localization to endosome
GO:0030100--P:regulation of endocytosis
KEGG rno:124461
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001887 Ailuropoda melanoleuca 93.03 0.00e+00 865.00
IUUC-Apl-003574 Anas platyrhynchos 85.48 0.00e+00 777.00
IUUC-Aca-004251 Anolis carolinensis 81.72 0.00e+00 754.00
IUUC-Ame-011756 Astyanax mexicanus 66.47 0.00e+00 681.00
IUUC-Bta-013193 Bos taurus 90.98 0.00e+00 825.00
IUUC-Cel-018168 Caenorhabditis elegans 31.01 4.00e-59 222.00
IUUC-Cja-018756 Callithrix jacchus 93.65 0.00e+00 837.00
IUUC-Cfa-020545 Canis familiaris 93.65 0.00e+00 900.00
IUUC-Cpo-022000 Cavia porcellus 89.75 0.00e+00 909.00
IUUC-Csa-024030 Chlorocebus sabaeus 93.06 0.00e+00 750.00
IUUC-Cin-025707 Ciona intestinalis 43.27 1.00e-107 382.00
IUUC-Csv-026244 Ciona savignyi 42.86 3.00e-55 207.00
IUUC-Dre-028104 Danio rerio 62.75 2.00e-164 572.00
IUUC-Dno-029429 Dasypus novemcinctus 92.98 0.00e+00 801.00
IUUC-Dor-030122 Dipodomys ordii 87.50 0.00e+00 784.00
IUUC-Dme-032120 Drosophila melanogaster 43.91 2.00e-106 379.00
IUUC-Eca-033367 Equus caballus 90.57 0.00e+00 839.00
IUUC-Eeu-034821 Erinaceus europaeus 76.43 0.00e+00 686.00
IUUC-Fca-036079 Felis catus 92.55 0.00e+00 856.00
IUUC-Fal-036682 Ficedula albicollis 85.59 0.00e+00 771.00
IUUC-Gmo-039681 Gadus morhua 63.95 5.00e-153 534.00
IUUC-Gga-040717 Gallus gallus 85.38 0.00e+00 773.00
IUUC-Gac-042262 Gasterosteus aculeatus 63.47 6.00e-172 597.00
IUUC-Ggo-044841 Gorilla gorilla 93.44 0.00e+00 808.00
IUUC-Hsa-046411 Homo sapiens 93.24 0.00e+00 807.00
IUUC-Itr-049063 Ictidomys tridecemlineatus 94.26 0.00e+00 836.00
IUUC-Loc-051975 Lepisosteus oculatus 69.94 0.00e+00 690.00
IUUC-Laf-053839 Loxodonta africana 89.81 0.00e+00 832.00
IUUC-Mcc-055783 Macaca mulatta 93.44 0.00e+00 810.00
IUUC-Mga-060087 Meleagris gallopavo 79.66 0.00e+00 702.00
IUUC-Mvi-060548 Microbotryum violaceum 41.51 4.00e-07 50.80
IUUC-Mmr-060827 Microcebus murinus 94.67 0.00e+00 873.00
IUUC-Mmu-064109 Mus musculus 97.54 0.00e+00 898.00
IUUC-Mpu-066591 Mustela putorius furo 93.44 0.00e+00 870.00
IUUC-Mlu-067826 Myotis lucifugus 93.03 0.00e+00 868.00
IUUC-Nle-069797 Nomascus leucogenys 93.44 0.00e+00 808.00
IUUC-Oan-073076 Ornithorhynchus anatinus 82.71 6.00e-155 540.00
IUUC-Ocu-074425 Oryctolagus cuniculus 93.24 0.00e+00 838.00
IUUC-Ola-087556 Oryzias latipes 64.79 4.00e-164 570.00
IUUC-Oga-089009 Otolemur garnettii 85.71 0.00e+00 791.00
IUUC-Oar-089806 Ovis aries 90.98 0.00e+00 825.00
IUUC-Ptr-091111 Pan troglodytes 93.03 0.00e+00 804.00
IUUC-Pan-091749 Papio anubis 90.70 0.00e+00 794.00
IUUC-Psi-093704 Pelodiscus sinensis 86.44 0.00e+00 796.00
IUUC-Pfo-096680 Poecilia formosa 62.38 1.00e-168 586.00
IUUC-Pva-102649 Pteropus vampyrus 92.01 0.00e+00 833.00
IUUC-Sha-106641 Sarcophilus harrisii 89.32 0.00e+00 820.00
IUUC-Sar-113461 Sorex araneus 80.33 0.00e+00 726.00
IUUC-Ssc-115349 Sus scrofa 91.79 0.00e+00 827.00
IUUC-Tgu-116876 Taeniopygia guttata 85.38 0.00e+00 772.00
IUUC-Tru-118306 Takifugu rubripes 67.13 1.00e-176 612.00
IUUC-Tsy-118901 Tarsius syrichta 82.79 2.00e-153 535.00
IUUC-Tni-120120 Tetraodon nigroviridis 67.34 5.00e-179 620.00
IUUC-Xtr-132925 Xenopus tropicalis 80.78 0.00e+00 753.00
Created Date 25-Jun-2017

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